Items where Division is "09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)"

2024

Bravo, Patricia Isabel. When evolution meets drug discovery in "plasmodium falciparum". 2024, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

Stabler, Thomas Carl. Using whole Plasmodium falciparum genomes for monitoring of escape from diagnosis, drug treatment and vaccine-induced immunity in Central-West Africa. 2024, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

Vahekeni, Nina. Valorization of Angolan traditional herbal preparations used against trypanosomiasis. 2024, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

2023

Beilstein, Sabina. Waltheriones and trypanosoma cruzi – elucidating potential mechanisms of action. 2023, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

Colina-Vegas, L. and da Cruz, B. Silva M. and de Souza Pereira, C. and Isis Barros, A. and Araújo Nobrega, J. and Navarro, M. and Rottmann, M. and D'Alessandro, S. and Basilico, N. and Azevedo Batista, A. and Moreira, D. R. M.. (2023) Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the plasmodium life cycle. Chemistry, 29 (55). e202301642.

Corbel, V. and Kont, M. D. and Ahumada, M. L. and Andreo, L. and Bayili, B. and Bayili, K. and Brooke, B. and Pinto Caballero, J. A. and Lambert, B. and Churcher, T. S. and Duchon, S. and Etang, J. and Flores, A. E. and Gunasekaran, K. and Juntarajumnong, W. and Kirby, M. and Davies, R. and Lees, R. S. and Lenhart, A. and Lima, J. B. P. and Martins, A. J. and Muller, P. and N'Guessan, R. and Ngufor, C. and Praulins, G. and Quinones, M. and Raghavendra, K. and Verma, V. and Rus, A. C. and Samuel, M. and Ying, K. S. and Sungvornyothin, S. and Uragayala, S. and Velayudhan, R. and Yadav, R. S.. (2023) A new WHO bottle bioassay method to assess the susceptibility of mosquito vectors to public health insecticides: results from a WHO-coordinated multi-centre study. Parasit Vectors, 16. p. 21.

Davies, H. and Bergmann, B. and Walloch, P. and Nerlich, C. and Hansen, C. and Wittlin, S. and Spielmann, T. and Treeck, M. and Beitz, E.. (2023) The plasmodium lactate/H+ transporter PfFNT is essential and druggable in vivo. Antimicrob Agents Chemother, 67 (8). e0035623.

Farahat, A. A. and Kumar, A. and Wenzler, T. and Brun, R. and Paul, A. and Guo, P. and Wilson, W. D. and Boykin, D. W.. (2023) Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity. Eur J Med Chem, 252. p. 115287.

Imlay, L. S. and Lawong, A. K. and Gahalawat, S. and Kumar, A. and Xing, C. and Mittal, N. and Wittlin, S. and Churchyard, A. and Niederstrasser, H. and Crespo-Fernandez, B. and Posner, B. A. and Gamo, F. J. and Baum, J. and Winzeler, E. A. and Laleu, B. and Ready, J. M. and Phillips, M. A.. (2023) Fast-killing tyrosine amide ((S)-SW228703) with blood- and liver-stage antimalarial activity associated with the cyclic amine resistance locus (PfCARL). ACS Infect Dis, 9 (3). pp. 527-539.

Kruth, S. and Zimmermann, C. J. M. and Kuhr, K. and HIller, W. and Lütz, S. and Pietruszka, J. and Kaiser, M. and Nett, M.. (2023) Generation of aurachin derivatives by whole-cell biotransformation and evaluation of their antiprotozoal properties. Molecules, 28. p. 1066.

Nguyen, W. and Dans, M. G. and Currie, I. and Awalt, J. K. and Bailey, B. L. and Lumb, C. and Ngo, A. and Favuzza, P. and Palandri, J. and Ramesh, S. and Penington, J. and Jarman, K. E. and Mukherjee, P. and Chakraborty, A. and Maier, A. G. and van Dooren, G. G. and Papenfuss, T. and Wittlin, S. and Churchyard, A. and Baum, J. and Winzeler, E. A. and Baud, D. and Brand, S. and Jackson, P. F. and Cowman, A. F. and Sleebs, B. E.. (2023) 7-N-substituted-3-oxadiazole quinolones with potent antimalarial activity target the cytochrome bc1 complex. ACS Infect Dis, 9 (3). pp. 668-691.

Probst, Alexandra Christina. Investigations on new and forgotten antischistosomal drugs and praziquantel pharmacokinetics in opisthorchiasis patients. 2023, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

Rao, S. P. S. and Gould, M. K. and Noeske, J. and Saldivia, M. and Jumani, R. S. and Ng, P. S. and Rene, O. and Chen, Y. L. and Kaiser, M. and Ritchie, R. and Francisco, A. F. and Johnson, N. and Patra, D. and Cheung, H. and Deniston, C. and Schenk, A. D. and Cortopassi, W. A. and Schmidt, R. S. and Wiedemar, N. and Thomas, B. and Palkar, R. and Ghafar, N. A. and Manoharan, V. and Luu, C. and Gable, J. E. and Wan, K. F. and Myburgh, E. and Mottram, J. C. and Barnes, W. and Walker, J. and Wartchow, C. and Aziz, N. and Osborne, C. and Wagner, J. and Sarko, C. and Kelly, J. M. and Manjunatha, U. H. and Mäser, P. and Jiricek, J. and Lakshminarayana, S. B. and Barrett, M. P. and Diagana, T. T.. (2023) Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380 (6652). pp. 1349-1356.

Seebacher, W. and Kaiser, M. and Mäser, P. and Saf, R. and Pferschy-Wenzig, E. M. and Weis, R.. (2023) Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity. Monatshefte fuÌ�r Chemie, 154. pp. 105-114.

Sevik Kilicaslan, O. and Cretton, S. and Hausmann, E. and Quirós-Guerrero, L. and Karimou, S. and Kaiser, M. and Mäser, P. and Christen, P. and Cuendet, M.. (2023) Antiprotozoal activity of natural products from Nigerien plants used in folk medicine. Front Pharmacol, 14. p. 1190241.

Walz, A. and Duffey, M. and Aljayyoussi, G. and Sax, S. and Leroy, D. and Besson, A. and Burrows, J. N. and Cherkaoui-Rbati, M. H. and Gobeau, N. and Westwood, M.-A. and Siethoff, C. and Gamo, S. and Mäser, P. and Wittlin, S.. (2023) The Parasite Reduction Ratio (PRR) assay version 2: standardized assessment of Plasmodium falciparum viability after antimalarial treatment in vitro. Pharmaceuticals (Basel), 16 (2). p. 163.

Walz, Annabelle. New efficacy testing systems towards novel antimalarials. 2023, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

2022

Beilstein, S. and El Phil, R. and Sahraoui, S. S. and Scapozza, L. and Kaiser, M. and Mäser, P.. (2022) Laboratory selection of trypanosomatid pathogens for drug resistance. Pharmaceuticals (Basel), 15 (2). p. 135.

Bernhard, S. and Kaiser, M. and Burri, C. and Mäser, P.. (2022) Fexinidazole for human African trypanosomiasis, the fruit of a successful public-private partnership. Diseases, 10 (4). p. 90.

Dolensky, J. and Hinteregger, C. and Leitner, A. and Seebacher, W. and Saf, R. and Belaj, F. and Mäser, P. and Kaiser, M. and Weis, R.. (2022) Antiprotozoal activity of azabicyclo-nonanes linked to tetrazole or sulfonamide cores. Molecules, 27 (19). p. 6217.

Dong, Y. and Sonawane, Y. and Maher, S. P. and Zeeman, A. M. and Chaumeau, V. and Vantaux, A. and Cooper, C. A. and Chiu, F. C. K. and Ryan, E. and McLaren, J. and Chen, G. and Wittlin, S. and Witkowski, B. and Nosten, F. and Sriraghavan, K. and Kyle, D. E. and Kocken, C. H. M. and Charman, S. A. and Vennerstrom, J. L.. (2022) Metabolic, pharmacokinetic, and activity profile of the liver stage antimalarial (RC-12). ACS Omega, 7 (14). pp. 12401-12411.

Gaudry, A. and Huber, F. and Nothias, L. F. and Cretton, S. and Kaiser, M. and Wolfender, J. L. and Allard, P. M.. (2022) MEMO: mass spectrometry-based sample vectorization to explore chemodiverse datasets. Front Bioinform, 2. p. 842964.

Hermann, T. and Wallner, R. and Dolensky, J. and Seebacher, W. and Pferschy-Wenzig, E. -M. and Kaiser, M. and Mäser, P. and Weis, R.. (2022) New derivatives of the multi-stage active Malaria Box compound MMV030666 and their antiplasmodial potencies. Pharmaceuticals (Basel), 15 (12). p. 1503.

Hinteregger, C. and Dolensky, J. and Seebacher, W. and Saf, R. and Mäser, P. and Kaiser, M. and Weis, R.. (2022) Synthesis and antiprotozoal activity of azabicyclo-nonane pyrimidine hybrids. Molecules, 28. p. 307.

Hirsch, A. K. H. and Diamanti, E. and Hamed, M. M. and Lacour, A. and Bravo, P. and Illarionov, B. and Fischer, M. and Rottmann, M. and Witschel, M.. (2022) Targeting the IspD enzyme in the MEP pathway: identification of a novel fragment class. ChemMedChem, 17. e202100679.

Hsu, C. S. and Gonçalves, C. and Tona, V. and Pons, A. and Kaiser, M. and Maulide, N.. (2022) Leveraging electron-deficient iminium intermediates in a general synthesis of valuable amines. Angewandte Chemie, 61 (20). e202115435.

Khandelwal, A. and Arez, F. and Alves, P. M. and Badolo, L. and Brito, C. and Fischli, C. and Fontinha, D. and Oeuvray, C. and Prudêncio, M. and Rottmann, M. and Wilkins, J. and Yalkinoglu, Ö. and Bagchus, W. M. and Spangenberg, T.. (2022) Translation of liver stage activity of M5717, a; Plasmodium; elongation factor 2 inhibitor: from bench to bedside. Malar J, 21. p. 151.

Laleu, B. and Rubiano, K. and Yeo, T. and Hallyburton, I. and Anderson, M. and Crespo-Fernandez, B. and Gamo, F. J. and Antonova-Koch, Y. and Orjuela-Sanchez, P. and Wittlin, S. and Jana, G. P. and Maity, B. C. and Chenu, E. and Duffy, J. and Sjo, P. and Waterson, D. and Winzeler, E. and Guantai, E. and Fidock, D. A. and Hansson, T.. (2022) Exploring a tetrahydroquinoline antimalarial hit from the medicines for malaria pathogen box and the identification of its mode of resistance as PfeEF2. ChemMedChem, 17 (22). e202200393.

Lombe, B. K. and Winand, L. and Diettrich, J. and Tobermann, M. and Hiller, W. and Kaiser, M. and Nett, M.. (2022) Discovery, biosynthetic origin, and heterologous production of massinidine, an antiplasmodial alkaloid. Organic letters, 24 (15). pp. 2935-2939.

Lowe, M. A. and Cardenas, A. and Valentin, J. P. and Zhu, Z. and Abendroth, J. and Castro, J. L. and Class, R. and Delaunois, A. and Fleurance, R. and Gerets, H. and Gryshkova, V. and King, L. and Lorimer, D. D. and MacCoss, M. and Rowley, J. H. and Rosseels, M. L. and Royer, L. and Taylor, R. D. and Wong, M. and Zaccheo, O. and Chavan, V. P. and Ghule, G. A. and Tapkir, B. K. and Burrows, J. N. and Duffey, M. and Rottmann, M. and Wittlin, S. and Angulo-Barturen, I. and Jiménez-Díaz, M. B. and Striepen, J. and Fairhurst, K. J. and Yeo, T. and Fidock, D. A. and Cowman, A. F. and Favuzza, P. and Crespo-Fernandez, B. and Gamo, F. J. and Goldberg, D. E. and Soldati-Favre, D. and Laleu, B. and de Haro, T.. (2022) Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of UCB7362. Journal of medicinal chemistry, 65 (20). pp. 14121-14143.

Mabuza, J. M. and Kaiser, M. and Bapela, M. J.. (2022) In vitro antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from Pappea capensis EckI & Zeyh. (Sapindaceae). J Ethnopharmacol, 298. p. 115659.

Majer, T. and Bhattarai, K. and Straetener, J. and Pohlmann, J. and Cahill, P. and Zimmermann, M. O. and Hübner, M. P. and Kaiser, M. and Svenson, J. and Schindler, M. and Brötz-Oesterhelt, H. and Boeckler, F. M. and Gross, H.. (2022) Discovery of Ircinianin Lactones B and C: two new cyclic sesterterpenes from the marine sponge Ircinia wistarii. Mar Drugs, 20 (8). p. 532.

Mambwe, D. and Korkor, CM. and Mabhula, A. and Ngqumba, Z. and Cloete, C. and Kumar, M. and Barros, PL. and Leshabane, M. and Coertzen, D. and Taylor, D. and Gibhard, L. and Njoroge, M. and Lawrence, N. and Reader, J. and Moreira, DR. and Birkholtz, LM. and Wittlin, S. and Egan, TJ. and Chibale, K.. (2022) Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and; in vivo; efficacy in a; Plasmodium berghei; mouse malaria infection model. Journal of medicinal chemistry, 65 (24). pp. 16695-16715.

Mousavi, A. and Foroumadi, P. and Emamgholipour, Z. and Mäser, P. and Kaiser, M. and Foroumadi, A.. (2022) 2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: in vitro and in vivo study. Molecules, 27. p. 5559.

Mäser, P.. (2022) Filariae as organisms. In: Human and animal filariases: Landscape, challenges, and control. Hoboken, New Jersey, pp. 17-32.

Perieteanu, M. C. and McGee, L. M. C. and Shaw, C. D. and MacMillan, D. S. and Khalaf, A. I. and Gillingwater, K. and Beveridge, R. and Carter, K. C. and Suckling, C. J. and Scott, F. J.. (2022) Selective anti-leishmanial strathclyde minor groove binders using an N-oxide tail-group modification. Int J Mol Sci, 23 (19). p. 11912.

Radohery, G. F. R. and Walz, A. and Gumpp, C. and Cherkaoui-Rbati, M. H. and Gobeau, N. and Gower, J. and Davenport, M. P. and Rottmann, M. and McCarthy, J. S. and Möhrle, J. J. and Rebelo, M. and Demarta-Gatsi, C. and Khoury, D. S.. (2022) Parasite viability as a measure of in vivo drug activity in preclinical and early clinical antimalarial drug assessment. Antimicrob Agents Chemother, 66 (7). e0011422.

Ragu�, L. and Peng, C. C. and Kaiser, M. and Görls, H. and Beemelmanns, C.. (2022) A modular approach to the antifungal sphingofungin family: concise total synthesis of sphingofungin A and C. Angewandte Chemie, 61 (5). e202112616.

Ren, R. and Wang, X. and Leas, D. A. and Häberli, C. and Cal, M. and Dong, Y. and Kaiser, M. and Keiser, J. and Vennerstrom, J. L.. (2022) Antischistosomal tetrahydro-γ-carboline sulfonamides. Bioorganic & medicinal chemistry letters, 59. p. 128546.

Scheiber, N. and Blaser, G. and Pferschy-Wenzig, E. M. and Kaiser, M. and Mäser, P. and Presser, A.. (2022) Efficient oxidative dearomatisations of substituted phenols using hypervalent iodine (iii) reagents and antiprotozoal evaluation of the resulting cyclohexadienones against T. b. rhodesiense and P. falciparum Strain NF54. Molecules, 27 (19). p. 6559.

Sevik Kilicaslan, O. and Cretton, S. and Quiros-Guerrero, L. and Bella, M. A. and Kaiser, M. and Mäser, P. and Ndongo, J. T. and Cuendet, M.. (2022) Isolation and structural elucidation of compounds from Pleiocarpa bicarpellata and their in vitro antiprotozoal activity. Molecules, 27 (7). p. 2200.

Sykes, M. L. and Kennedy, E. K. and Read, K. D. and Kaiser, M. and Avery, V. M.. (2022) Temporal and wash-out studies identify medicines for malaria venture pathogen box compounds with fast-acting activity against both Trypanosoma cruzi and Trypanosoma brucei. Microorganisms, 10 (7). p. 1287.

Wicha, S. G. and Walz, A. and Cherkaoui-Rbati, M. H. and Bundgaard, N. and Kuritz, K. and Gumpp, C. and Gobeau, N. and Möhrle, J. and Rottmann, M. and Demarta-Gatsi, C.. (2022) New in vitro interaction-parasite reduction ratio assay for early derisk in clinical development of antimalarial combinations. Antimicrob Agents Chemother, 66 (11). e0055622.

Xie, S. C. and Metcalfe, R. D. and Dunn, E. and Morton, C. J. and Huang, S. C. and Puhalovich, T. and Du, Y. and Wittlin, S. and Nie, S. and Luth, M. R. and Ma, L. and Kim, M. S. and Pasaje, C. F. A. and Kumpornsin, K. and Giannangelo, C. and Houghton, F. J. and Churchyard, A. and Famodimu, M. T. and Barry, D. C. and Gillett, D. L. and Dey, S. and Kosasih, C. C. and Newman, W. and Niles, J. C. and Lee, M. C. S. and Baum, J. and Ottilie, S. and Winzeler, E. A. and Creek, D. J. and Williamson, N. and Parker, M. W. and Brand, S. and Langston, S. P. and Dick, L. R. and Griffin, M. D. W. and Gould, A. E. and Tilley, L.. (2022) Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science, 376 (6597). pp. 1074-1079.

de Vries, L. E. and Jansen, P. A. M. and Barcelo, C. and Munro, J. and Verhoef, J. M. J. and Pasaje, C. F. A. and Rubiano, K. and Striepen, J. and Abla, N. and Berning, L. and Bolscher, J. M. and Demarta-Gatsi, C. and Henderson, R. W. M. and Huijs, T. and Koolen, K. M. J. and Tumwebaze, P. K. and Yeo, T. and Aguiar, A. C. C. and Angulo-Barturen, I. and Churchyard, A. and Baum, J. and Fernandez, B. C. and Fuchs, A. and Gamo, F. J. and Guido, R. V. C. and Jimenez-Diaz, M. B. and Pereira, D. B. and Rochford, R. and Roesch, C. and Sanz, L. M. and Trevitt, G. and Witkowski, B. and Wittlin, S. and Cooper, R. A. and Rosenthal, P. J. and Sauerwein, R. W. and Schalkwijk, J. and Hermkens, P. H. H. and Bonnert, R. V. and Campo, B. and Fidock, D. A. and Llinas, M. and Niles, J. C. and Kooij, T. W. A. and Dechering, K. J.. (2022) Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. Nat Commun, 13. p. 2158.

2021

Arafa, R. K. and Ismail, M. A. and Wenzler, T. and Brun, R. and Paul, A. and Wilson, W. D. and Alakhdar, A. A. and Boykin, D. W.. (2021) New antiparasitic flexible triaryl diamidines, their prodrugs and aza analogues: synthesis,; in vitro; and; in vivo; biological evaluation, and molecular modelling studies. European journal of medicinal chemistry, 222. p. 113625.

Arbués, A. and Kammüller, M. and Portevin, D.. (2021) Generating three-dimensional human granulomas in vitro to study Mycobacterium tuberculosis-host interaction. Bio-protocol, 10 (22). e3820.

Barth-Jaeggi, T. and Mäser, P.. (2021) Leishmaniasis in Europe and Central Asia: epidemiology, impact of habitat and lifestyle changes, HIV coinfection. In: Neglected tropical diseases - Europe and Central Asia. Cham, pp. 83-100.

Bevkal, Shubha and Naguleswaran, Arunasalam and Rehmann, Ruth and Kaiser, Marcel and Heller, Manfred and Roditi, Isabel. (2021) An Alba-domain protein required for proteome remodelling during trypanosome differentiation and host transition. PLoS Pathogens, 17. e1009239.

Boberg, M. and Cal, M. and Kaiser, M. and Jansson-Lofmark, R. and Mäser, P. and Ashton, M.. (2021) Enantiospecific antitrypanosomal in vitro activity of eflornithine. PLoS Negl Trop Dis, 15 (7). e0009583.

Boss, C. and Wittlin, S.. (2021) Our exciting journey to ACT-451840. Chimia, 75 (11). pp. 916-922.

Brand, M. and Wang, L. and Agnello, S. and Gazzola, S. and Gall, F. M. and Raguz, L. and Kaiser, M. and Schmidt, R. S. and Ritschl, A. and Jelk, J. and Hemphill, A. and Mäser, P. and Butikofer, P. and Adams, M. and Riedl, R.. (2021) Antiprotozoal structure-activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action. Angewandte Chemie, 60 (28). pp. 15613-15621.

Brooke, D. P. and McGee, L. M. C. and Giordani, F. and Cross, J. M. and Khalaf, A. I. and Irving, C. and Gillingwater, K. and Shaw, C. D. and Carter, K. C. and Barrett, M. P. and Suckling, C. J. and Scott, F. J.. (2021) Correction: Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype. RSC Med Chem, 12 (12). p. 2071.

Brooke, D. P. and McGee, L. M. C. and Giordani, F. and Cross, J. M. and Khalaf, A. I. and Irving, C. and Gillingwater, K. and Shaw, C. D. and Carter, K. C. and Barrett, M. P. and Suckling, C. J. and Scott, F. J.. (2021) Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype. RSC Medicinal Chemistry, 12 (8). pp. 1391-1401.

Brown, R. W. and Abdel-Megeed, A. M. and Keller, P. A. and Jones, A. J. and Sykes, M. L. and Kaiser, M. and Baell, J. B. and Avery, V. M. and Hyland, C. J. T.. (2021) Investigation of thiazolyl-benzothiophenamides as potential agents for African sleeping sickness. RSC Medicinal Chemistry, 11 (12). pp. 1413-1422.

Cheuka, P. M. and Centani, L. and Arendse, L. B. and Fienberg, S. and Wambua, L. and Renga, S. S. and Dziwornu, G. A. and Kumar, M. and Lawrence, N. and Taylor, D. and Wittlin, S. and Coertzen, D. and Reader, J. and van der Watt, M. and Birkholtz, L. M. and Chibale, K.. (2021) New amidated 3,6-diphenylated imidazopyridazines with potent antiplasmodium activity are dual inhibitors of; Plasmodium; phosphatidylinositol-4-kinase and cGMP-dependent protein kinase. ACS Infect Dis, 7 (1). pp. 34-46.

Cretton, S. and Genta-Jouve, G. and Kaiser, M. and Mäser, P. and Muñoz, O. and Bürgi, T. and Cuendet, M. and Christen, P.. (2021) Hygroline derivatives from Schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities. Phytochemistry, 192. p. 112957.

Doganc, F. and Celik, I. and Eren, G. and Kaiser, M. and Brun, R. and Goker, H.. (2021) Synthesis, in vitro antiprotozoal activity, molecular docking and molecular dynamics studies of some new monocationic guanidinobenzimidazoles. European journal of medicinal chemistry, 221. p. 113545.

Dziwornu, G. A. and Coertzen, D. and Leshabane, M. and Korkor, C. M. and Cloete, C. K. and Njoroge, M. and Gibhard, L. and Lawrence, N. and Reader, J. and van der Watt, M. and Wittlin, S. and Birkholtz, L. M. and Chibale, K.. (2021) Antimalarial benzimidazole derivatives incorporating phenolic mannich base side chains inhibit microtubule and hemozoin formation: structure-activity relationship and in vivo oral efficacy studies. Journal of medicinal chemistry, 64 (8). pp. 5198-5215.

Fesser, A. and Kaiser, M. and Mäser, P.. (2021) Neue Parameter für die Wirkstofftestung gegen Trypanosoma cruzi. Biospektrum (Heidelb), 27 (2). pp. 168-170.

Fesser, AF. Every parasite counts?! Improving in vitro assay design for Chagas’ disease drug discovery. 2021, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

Flittner, D. and Kaiser, M. and Mäser, P. and Lopes, N. P. and Schmidt, T. J.. (2021) The alkaloid-enriched fraction of; The alkaloid-enriched fraction of Pachysandra terminalis (Buxaceae) shows prominent activity against Trypanosoma brucei rhodesiensePachysandra terminalis; (Buxaceae) shows prominent activity against; Trypanosoma brucei rhodesiense. Molecules, 26 (3). p. 591.

Greve, H. L. and Kaiser, M. and Mäser, P. and Schmidt, T. J.. (2021) Boswellic acids show in vitro activity against Leishmania donovani. Molecules, 26 (12). p. 3651.

Hermann, T. and Hochegger, P. and Dolensky, J. and Seebacher, W. and Pferschy-Wenzig, E. M. and Saf, R. and Kaiser, M. and Mäser, P. and Weis, R.. (2021) Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity. Pharmaceuticals (Basel), 14. p. 1109.

Hermann, T. and Hochegger, P. and Dolensky, J. and Seebacher, W. and Saf, R. and Kaiser, M. and Mäser, P. and Weis, R.. (2021) New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities. Pharmaceuticals (Basel), 14 (5). p. 412.

Hitz, E. and Wiedemar, N. and Passecker, A. and Graça, B. A. S. and Scheurer, C. and Wittlin, S. and Brancucci, N. M. B. and Vakonakis, I. and Mäser, P. and Voss, T. S.. (2021) The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites. PLoS Biol, 19 (12). e3001483.

Hochegger, P. and Dolensky, J. and Seebacher, W. and Saf, R. and Kaiser, M. and Mäser, P. and Weis, R.. (2021) 8-amino-6-methoxyquinoline-tetrazole hybrids: Impact of linkers on antiplasmodial activity. Molecules, 26 (18). p. 5530.

Hoffelner, M. H. and Seebacher, W. and Kaiser, M. and Mäser, P. and Pferschy-Wenzig, E. M. and Saf, R. and Belaj, F. and Kretschmer, N. and Alajlani, M. and Brantner, A. and Bauer, R. and Weis, R.. (2021) Unexpected ring‑opening of 2,3‑dihydropyridines. Monatshefte für Chemie, 152. pp. 1347-1359.

Knaab, T. C. and Held, J. and Burckhardt, B. B. and Rubiano, K. and Okombo, J. and Yeo, T. and Mok, S. and Uhlemann, A. C. and Lungerich, B. and Fischli, C. and Pessanha de Carvalho, L. and Mordmüller, B. and Wittlin, S. and Fidock, D. A. and Kurz, T.. (2021) 3-Hydroxy-propanamidines, a new class of orally active antimalarials targeting Plasmodium falciparum. Journal of medicinal chemistry, 64 (6). pp. 3035-3047.

Laleu, B. and Akao, Y. and Ochida, A. and Duffy, S. and Lucantoni, L. and Shackleford, D. M. and Chen, G. and Katneni, K. and Chiu, F. C. K. and White, K. L. and Chen, X. and Sturm, A. and Dechering, K. J. and Crespo, B. and Sanz, L. M. and Wang, B. and Wittlin, S. and Charman, S. A. and Avery, V. M. and Cho, N. and Kamaura, M.. (2021) Discovery and structure-activity relationships of quinazolinone-2-carboxamide derivatives as novel orally efficacious antimalarials. Journal of medicinal chemistry, 64 (17). pp. 12582-12602.

Lawong, A. and Gahalawat, S. and Okombo, J. and Striepen, J. and Yeo, T. and Mok, S. and Deni, I. and Bridgford, J. L. and Niederstrasser, H. and Zhou, A. and Posner, B. and Wittlin, S. and Gamo, F. J. and Crespo, B. and Churchyard, A. and Baum, J. and Mittal, N. and Winzeler, E. and Laleu, B. and Palmer, M. J. and Charman, S. A. and Fidock, D. A. and Ready, J. M. and Phillips, M. A.. (2021) Novel antimalarial tetrazoles and amides active against the hemoglobin degradation pathway in Plasmodium falciparum. Journal of medicinal chemistry, 64 (5). pp. 2739-2761.

Le Manach, C. and Dam, J. and Woodland, J. G. and Kaur, G. and Khonde, L. P. and Brunschwig, C. and Njoroge, M. and Wicht, K. J. and Horatscheck, A. and Paquet, T. and Boyle, G. A. and Gibhard, L. and Taylor, D. and Lawrence, N. and Yeo, T. and Mok, S. and Eastman, R. T. and Dorjsuren, D. and Talley, D. C. and Guo, H. and Simeonov, A. and Reader, J. and van der Watt, M. and Erlank, E. and Venter, N. and Zawada, J. W. and Aswat, A. and Nardini, L. and Coetzer, T. L. and Lauterbach, S. B. and Bezuidenhout, B. C. and Theron, A. and Mancama, D. and Koekemoer, L. L. and Birkholtz, L. M. and Wittlin, S. and Delves, M. and Ottilie, S. and Winzeler, E. A. and von Geldern, T. W. and Smith, D. and Fidock, D. A. and Street, L. J. and Basarab, G. S. and Duffy, J. and Chibale, K.. (2021) Identification and profiling of a novel diazaspiro[3.4]octane chemical series active against multiple stages of the human malaria parasite Plasmodium falciparum and optimization efforts. Journal of medicinal chemistry, 64 (4). pp. 2291-2309.

Leas, D. A. and Sanford, A. G. and Wu, J. and Cal, M. and Kaiser, M. and Wittlin, S. and Hemsley, R. M. and Darner, E. B. and Lui, L. M. and Davis, P. H. and Vennerstrom, J. L.. (2021) Diaryl ureas as an antiprotozoal chemotype. ACS Infect Dis, 7 (6). pp. 1578-1583.

Llurba Montesino, N. and Kaiser, M. and Mäser, P. and Schmidt, T. J.. (2021) Nucleic acid amplification techniques for the detection of Schistosoma mansoni infection in humans and the intermediate snail host: a structured review and meta-analysis of diagnostic accuracy. Molecules, 26 (11). p. 3226.

Lombe, B. K. and Feineis, D. and Mudogo, V. and Kaiser, M. and Bringmann, G.. (2021) Spirombandakamine A3 and cyclombandakamines A8 and A9, polycyclic naphthylisoquinoline dimers, with antiprotozoal activity, from a Congolese Ancistrocladus plant. Journal of natural products, 84 (4). pp. 1335-1344.

Lores-Motta, L. and van Beek, A. E. and Willems, E. and Zandstra, J. and van Mierlo, G. and Einhaus, A. and Mary, J. L. and Stucki, C. and Bakker, B. and Hoyng, C. B. and Fauser, S. and Clark, S. J. and de Jonge, M. I. and Nogoceke, E. and Koertvely, E. and Jongerius, I. and Kuijpers, T. W. and den Hollander, A. I.. (2021) Common haplotypes at the; CFH; locus and low-frequency variants in; CFHR2; and; CFHR5; associate with systemic FHR concentrations and age-related macular degeneration. American journal of human genetics, 108 (8). pp. 1367-1384.

Mahmoud, A. B. and Abd Algaffar, S. and van de Sande, W. and Khalid, S. and Kaiser, M. and Mäser, P.. (2021) Niclosamide is active in vitro against mycetoma pathogens. Molecules, 26 (13). p. 4005.

Mizukawa, Y. and Ikegami-Kawai, M. and Horiuchi, M. and Kaiser, M. and Kojima, M. and Sakanoue, S. and Miyagi, S. and Nanga Chick, C. and Togashi, H. and Tsubuki, M. and Ihara, M. and Usuki, T. and Itoh, I.. (2021) Quest for a potent antimalarial drug lead: synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines. Bioorganic & medicinal chemistry, 33. p. 116018.

Murithi, J. M. and Pascal, C. and Bath, J. and Boulenc, X. and Gnadig, N. F. and Pasaje, C. F. A. and Rubiano, K. and Yeo, T. and Mok, S. and Klieber, S. and Desert, P. and Jimenez-Diaz, M. B. and Marfurt, J. and Rouillier, M. and Cherkaoui-Rbati, M. H. and Gobeau, N. and Wittlin, S. and Uhlemann, A. C. and Price, R. N. and Wirjanata, G. and Noviyanti, R. and Tumwebaze, P. and Cooper, R. A. and Rosenthal, P. J. and Sanz, L. M. and Gamo, F. J. and Joseph, J. and Singh, S. and Bashyam, S. and Augereau, J. M. and Giraud, E. and Bozec, T. and Vermat, T. and Tuffal, G. and Guillon, J. M. and Menegotto, J. and Salle, L. and Louit, G. and Cabanis, M. J. and Nicolas, M. F. and Doubovetzky, M. and Merino, R. and Bessila, N. and Angulo-Barturen, I. and Baud, D. and Bebrevska, L. and Escudie, F. and Niles, J. C. and Blasco, B. and Campbell, S. and Courtemanche, G. and Fraisse, L. and Pellet, A. and Fidock, D. A. and Leroy, D.. (2021) The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance. Sci Transl Med, 13 (603). eabg6013.

Okaniwa, M. and Shibata, A. and Ochida, A. and Akao, Y. and White, K. L. and Shackleford, D. M. and Duffy, S. and Lucantoni, L. and Dey, S. and Striepen, J. and Yeo, T. and Mok, S. and Aguiar, A. C. C. and Sturm, A. and Crespo, B. and Sanz, L. M. and Churchyard, A. and Baum, J. and Pereira, D. B. and Guido, R. V. C. and Dechering, K. J. and Wittlin, S. and Uhlemann, A. C. and Fidock, D. A. and Niles, J. C. and Avery, V. M. and Charman, S. A. and Laleu, B.. (2021) Repositioning and characterization of 1-(pyridin-4-yl)pyrrolidin-2-one derivatives as Plasmodium cytoplasmic prolyl-trna synthetase inhibitors. ACS Infect Dis, 7 (6). pp. 1680-1689.

Palmer, M. J. and Deng, X. and Watts, S. and Krilov, G. and Gerasyuto, A. and Kokkonda, S. and El Mazouni, F. and White, J. and White, K. L. and Striepen, J. and Bath, J. and Schindler, K. A. and Yeo, T. and Shackleford, D. M. and Mok, S. and Deni, I. and Lawong, A. and Huang, A. and Chen, G. and Wang, W. and Jayaseelan, J. and Katneni, K. and Patil, R. and Saunders, J. and Shahi, S. P. and Chittimalla, R. and Angulo-Barturen, I. and Jimenez-Diaz, M. B. and Wittlin, S. and Tumwebaze, P. K. and Rosenthal, P. J. and Cooper, R. A. and Aguiar, A. C. C. and Guido, R. V. C. and Pereira, D. B. and Mittal, N. and Winzeler, E. A. and Tomchick, D. R. and Laleu, B. and Burrows, J. N. and Rathod, P. K. and Fidock, D. A. and Charman, S. A. and Phillips, M. A.. (2021) Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series. Journal of medicinal chemistry, 64 (9). pp. 6085-6136.

Petritsch, M. and Seebacher, W. and Mohsin, N. U. and Dolensky, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Belaj, F. and Saf, R. and Kretschmer, N. and Alajlani, M. and Brantner, A. and Bauer, R. and Schuhly, W. and Weis, R.. (2021) Preparation of new 1,3-dibenzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. Eur J Med Chem, 210. p. 112969.

Rocha-Hasler, M. and de Oliveira, G. M. and da Gama, A. N. and Fiuza, L. F. A. and Fesser, A. F. and Cal, M. and Rocchetti, R. and Peres, R. B. and Guan, X. L. and Kaiser, M. and Soeiro, M. N. C. and Mäser, P.. (2021) Combination with tomatidine improves the potency of posaconazole against Trypanosoma cruzi. Front Cell Infect Microbiol, 11. p. 617917.

Ropponen, H. K. and Bader, C. D. and Diamanti, E. and Illarionov, B. and Rottmann, M. and Fischer, M. and Witschel, M. and Müller, R. and Hirsch, A. K. H.. (2021) Search for the active ingredients from a 2-aminothiazole DMSO stock solution with antimalarial activity. ChemMedChem, 16. pp. 2089-2093.

Ropponen, H. K. and Diamanti, E. and Siemens, A. and Illarionov, B. and Haupenthal, J. and Fischer, M. and Rottmann, M. and Witschel, M. and Hirsch, A. K. H.. (2021) Assessment of the rules related to gaining activity against gram-negative bacteria. RSC Med Chem, 12 (4). pp. 593-601.

Seebacher, W. and Mohsin, N. U. A. and Dolensky, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Saf, R. and Schuster, D. and Temml, V. and Weis, R.. (2021) Modifications and hybrids of 1,2,3,4‑tetrahydropyridinium salts and their antiprotozoal potencies. Monatshefte fuÌ�r Chemie, 152. pp. 1347-1359.

Shackleford, D. M. and Chiu, F. C. K. and Katneni, K. and Blundell, S. and McLaren, J. and Wang, X. and Zhou, L. and Sriraghavan, K. and Alker, A. M. and Hunziker, D. and Scheurer, C. and Zhao, Q. and Dong, Y. and Mohrle, J. J. and Abla, N. and Matile, H. and Wittlin, S. and Vennerstrom, J. L. and Charman, S. A.. (2021) Cytochrome P450-mediated metabolism and CYP Inhibition for the synthetic peroxide antimalarial OZ439. ACS Infect Dis, 7 (7). pp. 1885-1893.

Szabó, L. U. and Kaiser, M. and Mäser, P. and Schmidt, T. J.. (2021) Antiprotozoal Nor-triterpene alkaloids from Buxus sempervirens L. Antibiotics (Basel), 10 (6). p. 696.

Szabó, L. U. and Kaiser, M. and Mäser, P. and Schmidt, T. J.. (2021) Identification of antiprotozoal compounds from Buxus sempervirens L. by PLS-prediction. Molecules, 26 (20). p. 6181.

Uth, J. F. and Borgel, F. and Lehmkuhl, K. and Schepmann, D. and Kaiser, M. and Jabor, V. A. P. and Nonato, M. C. and Krauth-Siegel, R. L. and Schmidt, T. J. and Wunsch, B.. (2021) Synthesis and biological evaluation of natural-product-inspired, aminoalkyl-substituted 1-benzopyrans as novel antiplasmodial agents. Journal of medicinal chemistry, 64 (9). pp. 6397-6409.

Winand, L. and Schneider, P. and Kruth, S. and Greven, N.-J- and Hiller, W. and Kaiser, M. and Pietruszka, J. and Nett, M.. (2021) Mutasynthesis of physostigmines in Myxococcus xanthus. Organic letters, 23 (16). pp. 6563-6567.

Wipf, Nadja. Development and field-evaluation of vector surveillance tools for identifying arbovirus circulation, mosquito species and insecticide resistance. 2021, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

Wittlin, S. and Mäser, P.. (2021) From magic bullet to magic bomb: reductive bioactivation of antiparasitic agents. ACS Infect Dis, 7 (10). pp. 2777-2786.

Xie, S. C. and Metcalfe, R. D. and Mizutani, H. and Puhalovich, T. and Hanssen, E. and Morton, C. J. and Du, Y. and Dogovski, C. and Huang, S. C. and Ciavarri, J. and Hales, P. and Griffin, R. J. and Cohen, L. H. and Chuang, B. C. and Wittlin, S. and Deni, I. and Yeo, T. and Ward, K. E. and Barry, D. C. and Liu, B. and Gillett, D. L. and Crespo-Fernandez, B. F. and Ottilie, S. and Mittal, N. and Churchyard, A. and Ferguson, D. and Aguiar, A. C. C. and Guido, R. V. C. and Baum, J. and Hanson, K. K. and Winzeler, E. A. and Gamo, F. J. and Fidock, D. A. and Baud, D. and Parker, M. W. and Brand, S. and Dick, L. R. and Griffin, M. D. W. and Gould, A. E. and Tilley, L.. (2021) Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc Natl Acad Sci U S A, 118 (39). e2107213118.

Zeelen, J. and van Straaten, M. and Verdi, J. and Hempelmann, A. and Hashemi, H. and Perez, K. and Jeffrey, P. D. and Hälg, S. and Wiedemar, N. and Mäser, P. and Papavasiliou, F. N. and Stebbins, C. E.. (2021) Structure of trypanosome coat protein VSGsur and function in suramin resistance. Nat Microbiol, 6 (3). pp. 392-400.

Zhao, L. and Le Chapelain, C. and Brachmann, A. O. and Kaiser, M. and Groll, M. and Bode, H. B.. (2021) Activation, structure, biosynthesis and bioactivity of glidobactin-like proteasome inhibitors from Photorhabdus laumondii. Chembiochem, 22 (9). pp. 1582-1588.

2020

Ahenkorah, S. and Coertzen, D. and Tong, J. X. and Fridianto, K. and Wittlin, S. and Birkholtz, L. M. and Tan, K. S. W. and Lam, Y. and Go, M. L. and Haynes, R. K.. (2020) Antimalarial N1,N3-dialkyldioxonaphthoimidazoliums: synthesis, biological activity, and structure-activity relationships. ACS medicinal chemistry letters, 11. pp. 49-55.

Babanezhad Harikandei, K. and Salehi, P. and Ebrahimi, S. N. and Bararjanian, M. and Kaiser, M. and Al-Harrasi , A.. (2020) Synthesis, in-vitro antiprotozoal activity and molecular docking study of isothiocyanate derivatives. Bioorganic & medicinal chemistry, 28 (1). p. 115185.

Bernal, Freddy A. and Gerhards, Marcel and Kaiser, Marcel and Wünsch, Bernhard and Schmidt, Thomas J.. (2020) (+/-)-trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: synthesis, in vitro evaluation and SAR analysis. European journal of medicinal chemistry, 205. p. 112493.

Bernal, Freddy A. and Kaiser, Marcel and Wünsch, Bernhard and Schmidt, Thomas J.. (2020) Structure-activity relationships of cinnamate ester analogues as potent antiprotozoal agents. ChemMedChem, 15. pp. 68-78.

Burgert, Lydia and Rottmann, Matthias and Wittlin, Sergio and Gobeau, Nathalie and Krause, Andreas and Dingemanse, Jasper and Möhrle, Jörg J. and Penny, Melissa A.. (2020) Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development. Scientific reports, 10. p. 4410.

Chung, J. H. and Tang, A. H. and Geraghty, K. and Corcilius, L. and Kaiser, M. and Payne, R.J.. (2020) Total synthesis and antitrypanosomal activity of janadolide and simplified analogues. Organic letters, 22. pp. 3089-3093.

Cretton, S. and Kaiser, M. and Karimou, S. and Ebrahimi, S. N. and Mäser, P. and Cuendet, M. and Christen, P.. (2020) Pyridine-4(1H)-one alkaloids from Waltheria indica as antitrypanosomatid agents. Journal of natural products, 83 (11). pp. 3363-3371.

Douglas, Robert L. and Haltiwanger, Brett M. and Albisetti, Anna and Wu, Haiming and Jeng, Robert L. and Mancuso, Joel and Cande, W. Zacheus and Welch, Matthew D.. (2020) Trypanosomes have divergent kinesin-2 proteins that function differentially in flagellum biosynthesis and cell viability. Journal of cell science, 133 (13). jcs129213.

Evack, Jennifer Giovanoli and Schmidt, Remo S. and Boltryk, Sylwia D. and Voss, Till S. and Batil, Annour A. and Ngandolo, Bongo N. and Greter, Helena and Utzinger, Jürg and Zinsstag, Jakob and Balmer, Oliver. (2020) Molecular confirmation of a Fasciola gigantica x Fasciola hepatica hybrid in a Chadian bovine. Journal of parasitology : official organ of the American Society of Parasitologists, 106 (2). pp. 316-322.

Favuzza, Paola and de Lera Ruiz, Manuel and Thompson, Jennifer K. and Triglia, Tony and Ngo, Anna and Steel, Ryan W. J. and Vavrek, Marissa and Christensen, Janni and Healer, Julie and Boyce, Christopher and Guo, Zhuyan and Hu, Mengwei and Khan, Tanweer and Murgolo, Nicholas and Zhao, Lianyun and Penington, Jocelyn Sietsma and Reaksudsan, Kitsanapong and Jarman, Kate and Dietrich, Melanie H. and Richardson, Lachlan and Guo, Kai-Yuan and Lopaticki, Sash and Tham, Wai-Hong and Rottmann, Matthias and Papenfuss, Tony and Robbins, Jonathan A. and Boddey, Justin A. and Sleebs, Brad E. and Sabroux, Hélène Jousset and McCauley, John A. and Olsen, David B. and Cowman, Alan F.. (2020) Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle. Cell host & microbe, 27 (4). pp. 642-658.e12.

Fesser, Anna F. and Braissant, Olivier and Olmo, Francisco and Kelly, John M. and Mäser, Pascal and Kaiser, Marcel. (2020) Non-invasive monitoring of drug action: a new live in vitro assay design for Chagas' disease drug discovery. PLoS Neglected Tropical Diseases, 14 (7). e0008487.

Greve, Hippolyt L. and Kaiser, Marcel and Schmidt, Thomas J.. (2020) Investigation of antiplasmodial effects of terpenoid compounds isolated from myrrh. Planta medica, 86 (9). pp. 643-654.

Hagen, James P. and Darner, Grant and Anderson, Samuel and Higgins, Katie and Leas, Derek A. and Mitra, Ananya and Mashinson, Victoria and Wol, Tasloach and Vera-Esquivel, Carlos and Belter, Bret and Cal, Monica and Kaiser, Marcel and Wallick, Alexander and Warner, Rosalie C. and Davis, Paul H.. (2020) Activity of diphenyl ether benzyl amines against Human African Trypanosomiasis. Bioorganic chemistry, 97. p. 103590.

Harrison, Justin R. and Sarkar, Sandipan and Hampton, Shahienaz and Riley, Jennifer and Stojanovski, Laste and Sahlberg, Christer and Appelqvist, Pia and Erath, Jessey and Mathan, Vinodhini and Rodriguez, Ana and Kaiser, Marcel and Pacanowska, Dolores Gonzalez and Read, Kevin D. and Johansson, Nils Gunnar and Gilbert, Ian H.. (2020) Discovery and optimization of a compound series active against Trypanosoma cruzi, the causative agent of chagas disease. Journal of medicinal chemistry, 63 (6). pp. 3066-3089.

Hoffelner, M. and Hassan, U. and Seebacher, W. and Dolensky, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Saf, R. and Weis, R.. (2020) New 2‑aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities. Monatshefte für Chemie, 151. pp. 1375-1385.

Horatscheck, A. and Andrijevic, A. and Nchinda, A. T. and Le Manach, C. and Paquet, T. and Khonde, L. P. and Dam, J. and Pawar, K. and Taylor, D. and Lawrence, N. and Brunschwig, C. and Gibhard, L. and Njoroge, M. and Reader, J. and van der Watt, M. and Wicht, K. and de Sousa, A. C. C. and Okombo, J. and Maepa, K. and Egan, T. J. and Birkholtz, L. M. and Basarab, G. S. and Wittlin, S. and Fish, P. V. and Street, L. J. and Duffy, J. and Chibale, K.. (2020) Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast-killing kinetics and in vivo efficacy in the Plasmodium falciparum NSG mouse model. Journal of medicinal chemistry, 63 (21). pp. 13013-13030.

Kaiser, M. and Mäser, P.. (2020) In Vitro drug efficacy testing against Trypanosoma brucei. In: Trypanosomatids. Methods and Protocols, 2116. New York, pp. 781-789.

Kalt, M. M. and Schuehly, W. and Saf, R. and Ochensberger, S. and Solnier, J. and Bucar, F. and Kaiser, M. and Presser, A.. (2020) Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents. Eur J Med Chem, 207. p. 112837.

Kokkonda, Sreekanth and Deng, Xiaoyi and White, Karen L. and El Mazouni, Farah and White, John and Shackleford, David M. and Katneni, Kasiram and Chiu, Francis C. K. and Barker, Helena and McLaren, Jenna and Crighton, Elly and Chen, Gong and Angulo-Barturen, Inigo and Jimenez-Diaz, Maria Belen and Ferrer, Santiago and Huertas-Valentin, Leticia and Martinez-Martinez, Maria Santos and Lafuente-Monasterio, Maria Jose and Chittimalla, Rajesh and Shahi, Shatrughan P. and Wittlin, Sergio and Waterson, David and Burrows, Jeremy N. and Matthews, Dave and Tomchick, Diana and Rathod, Pradipsinh K. and Palmer, Michael J. and Charman, Susan A. and Phillips, Margaret A.. (2020) Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of malaria. Journal of medicinal chemistry, 63 (9). pp. 4929-4956.

Mahmoud, Abdelhalim Babiker and Danton, Ombeline and Kaiser, Marcel and Han, Sohee and Moreno, Aitor and Abd Algaffar, Shereen and Khalid, Sami and Oh, Won Keun and Hamburger, Matthias and Mäser, Pascal. (2020) Lignans, amides, and saponins from Haplophyllum tuberculatum and their antiprotozoal activity. Molecules, 25 (12). p. 2825.

Mahmoud, Abdelhalim Babiker and Danton, Ombeline and Kaiser, Marcel and Khalid, Sami and Hamburger, Matthias and Mäser, Pascal. (2020) HPLC-based activity profiling for antiprotozoal compounds in Croton gratissimus and Cuscuta hyalina. Frontiers in Pharmacology, 11. p. 1246.

Mahmoud, Abdelhalim Babiker and Mäser, Pascal and Kaiser, Marcel and Hamburger, Matthias and Khalid, Sami. (2020) Mining sudanese medicinal plants for antiprotozoal agents. Frontiers in pharmacology, 11. p. 865.

Mahmoud, Abdelhalim Babiker Mohamed. Mining Sudanese Medicinal Plants for Natural Compounds against Malaria and Neglected Tropical Diseases. 2020, Doctoral Thesis, University of Basel, Faculty of Science.

Mueller, Rudolf and Reddy, Virsinha and Nchinda, Aloysius T. and Mebrahtu, Fanuel and Taylor, Dale and Lawrence, Nina and Tanner, Lloyd and Barnabe, Marine and Eyermann, Charles J. and Zou, Bin and Kondreddi, Ravinder R. and Lakshminarayana, Suresh B. and Rottmann, Matthias and Street, Leslie J. and Chibale, Kelly. (2020) Lerisetron analogues with antimalarial properties: synthesis, structure-activity relationship studies, and biological assessment. ACS Omega, 5 (12). pp. 6967-6982.

Pellisson, Mélanie. Targeting the Hypnozoites: Towards an in vitro System for Malaria Drug Discovery. 2020, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

Ponzi, Simona and Bresciani, Alberto and Kaiser, Marcel and Nardi, Valentina and Nizi, Emanuela and Ontoria, Jesus M. and Pace, Paola and Paonessa, Giacomo and Summa, Vincenzo and Harper, Steven. (2020) Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors. Bioorganic & medicinal chemistry letters, 30 (8). p. 127052.

Potluri, V. and Shandil, R. K. and Gavara, R. and Sambasivam, G. and Campo, B. and Wittlin, S. and Narayanan, S.. (2020) Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria. Malar J, 19. p. 365.

Pérez, Irene and Uranga, Santiago and Sayes, Fadel and Frigui, Wafa and Samper, Sofía and Arbués, Ainhoa and Aguiló, Nacho and Brosch, Roland and Martín, Carlos and Gonzalo-Asensio, Jesús. (2020) Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro-American genetic background confers optimal vaccine potential. EBioMedicine, 55. p. 102761.

Robinson, W. J. and Taylor, A. E. and Lauga-Cami, S. and Weaver, G. W. and Arroo, R. R. J. and Kaiser, M. and Gul, S. and Kuzikov, M. and Ellinger, B. and Singh, K. and Schirmeister, T. and Botana, A. and Eurtivong, C. and Bhambra, A. S.. (2020) The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines. Eur J Med Chem, 209. p. 112871.

Rottmann, Matthias and Jonat, Brian and Gumpp, Christin and Dhingra, Satish K. and Giddins, Marla J. and Yin, Xiaoyan and Badolo, Lassina and Greco, Beatrice and Fidock, David A. and Oeuvray, Claude and Spangenberg, Thomas. (2020) Preclinical antimalarial combination studies: the case of M5717, a P. falciparum elongation factor 2 inhibitor and pyronaridine, a hemozoin formation inhibitor. Antimicrobial agents and chemotherapy, 64 (4). e02181-19.

Saldivia, M. and Fang, E. and Ma, X. and Myburgh, E. and Carnielli, JBT. and Bower-Lepts, C. and Brown, E. and Ritchie, R. and Lakshminarayana, SB. and Chen, YL. and Patra, D. and Ornelas, E. and Koh, HXY. and Williams, SL. and Supek, F. and Paape, D. and McCulloch, R. and Kaiser, M. and Barrett, MP. and Jiricek, J. and Diagana, TT. and Mottram, JC. and Rao, SPS.. (2020) Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nat Microbiol, 5 (10). pp. 1207-1216.

Singh, B. and Diaz-Gonzalez, R. and Ceballos-Perez, G. and Rojas-Barros, D. I. and Gunaganti, N. and Gillingwater, K. and Martinez-Martinez, M. S. and Manzano, P. and Navarro, M. and Pollastri, M. P.. (2020) Medicinal chemistry optimization of a diaminopurine chemotype: toward a lead for Trypanosoma brucei inhibitors. Journal of medicinal chemistry, 63 (17). pp. 9912-9927.

Soroury, S. and Alilou, M. and Gelbrich, T. and Tabefam, M. and Danton, O. and Ebrahimi, S. N. and Kaiser, M. and Hamburger, M. and Stuppner, H. and Moridi Farimani, M.. (2020) Unusual derivatives from Hypericum scabrum. Scientific Reports, 10. p. 22181.

Tamborrini, Marco and Hauser, Julia and Schäfer, Anja and Amacker, Mario and Favuzza, Paola and Kyungtak, Kwak and Fleury, Sylvain and Pluschke, Gerd. (2020) Vaccination with virosomally formulated recombinant CyRPA elicits protective anti against Plasmodium falciparum parasites in preclinical in vitro and in vivo modelsbodies. NPJ vaccines, 5. p. 9.

Tasdemir, Deniz and MacIntosh, Andrew J. J. and Stergiou, Polyxeni and Kaiser, Marcel and Mansour, Nuha R. and Bickle, Quentin and Huffman, Michael A.. (2020) Antiprotozoal and antihelminthic properties of plants ingested by wild Japanese macaques (Macaca fuscata yakui) in Yakushima Island. Journal of Ethnopharmacology, 247. p. 112270.

Warryn, Louisa and Dangy, Jean-Pierre and Gersbach, Philipp and Gehringer, Matthias and Schäfer, Anja and Ruf, Marie-Thérèse and Ruggli, Nicolas and Altmann, Karl-Heinz and Pluschke, Gerd. (2020) Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans. PLoS Neglected Tropical Diseases, 14 (6). e0008357.

Wiedemar, Natalie and Hauser, Dennis A. and Mäser, Pascal. (2020) 100 years of Suramin. Antimicrobial agents and chemotherapy, 64 (3). e01168-19.

Zadali, Reza and Ebrahimi, Samad Nejad and Tofighi, Zahra and Es-haghi, Ali and Hamburger, Matthias and Kaiser, Marcel and D'Ambola, Massimiliano and De Tommasi, Nunziatina and Hadjiakhoondi, Abbas. (2020) Antiprotozoal activity of diterpenoids isolated from Zhumeria majdae - absolute configuration by circular dichroism. DARU Journal of Pharmaceutical Sciences, 28 (2). pp. 455-462.

Zhao, L. and Vo, T. D. and Kaiser, M. and Bode, H. B.. (2020) Phototemtide A, a cyclic lipopeptide heterologously expressed from Photorhabdus temperata Meg1, shows selective antiprotozoal activity. ChemBioChem, 21 (9). pp. 1288-1292.

2019

Arez, Francisca and Rebelo, Sofia P. and Fontinha, Diana and Simão, Daniel and Martins, Tatiana R. and Machado, Marta and Fischli, Christoph and Oeuvray, Claude and Badolo, Lassina and Carrondo, Manuel J. T. and Rottmann, Matthias and Spangenberg, Thomas and Brito, Catarina and Greco, Beatrice and Prudêncio, Miguel and Alves, Paula M.. (2019) Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting plasmodium hepatic infection. ACS infectious diseases, 5 (11). pp. 1831-1842.

Attram, H. D. and Wittlin, S. and Chibale, K.. (2019) Incorporation of an intramolecular hydrogen bonding motif in the side chain of antimalarial benzimidazoles. MedChemComm , 10 (3). pp. 450-455.

Baartzes, N. and Stringer, T. and Seldon, R. and Warner, D. F. and Taylor, D. and Wittlin, S. and Chibale, K. and Smith, G. S.. (2019) Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids : antimicrobial evaluation and mechanistic insights. European journal of medicinal chemistry, 180. pp. 121-133.

Babanezhad Harikandei, Kosar and Salehi, Peyman and Ebrahimi, Samad Nejad and Bararjanian, Morteza and Kaiser, Marcel and Khavasi, Hamid Reza and Al-Harrasi, Ahmed. (2019) N-substituted noscapine derivatives as new antiprotozoal agents: synthesis, antiparasitic activity and molecular docking study. Bioorganic chemistry, 91. p. 103116.

Baragaña, Beatriz and Forte, Barbara and Choi, Ryan and Nakazawa Hewitt, Stephen and Bueren-Calabuig, Juan A. and Pisco, João Pedro and Peet, Caroline and Dranow, David M. and Robinson, David A. and Jansen, Chimed and Norcross, Neil R. and Vinayak, Sumiti and Anderson, Mark and Brooks, Carrie F. and Cooper, Caitlin A. and Damerow, Sebastian and Delves, Michael and Dowers, Karen and Duffy, James and Edwards, Thomas E. and Hallyburton, Irene and Horst, Benjamin G. and Hulverson, Matthew A. and Ferguson, Liam and Jiménez-Díaz, María Belén and Jumani, Rajiv S. and Lorimer, Donald D. and Love, Melissa S. and Maher, Steven and Matthews, Holly and McNamara, Case W. and Miller, Peter and O'Neill, Sandra and Ojo, Kayode K. and Osuna-Cabello, Maria and Pinto, Erika and Post, John and Riley, Jennifer and Rottmann, Matthias and Sanz, Laura M. and Scullion, Paul and Sharma, Arvind and Shepherd, Sharon M. and Shishikura, Yoko and Simeons, Frederick R. C. and Stebbins, Erin E. and Stojanovski, Laste and Straschil, Ursula and Tamaki, Fabio K. and Tamjar, Jevgenia and Torrie, Leah S. and Vantaux, Amélie and Witkowski, Benoît and Wittlin, Sergio and Yogavel, Manickam and Zuccotto, Fabio and Angulo-Barturen, Iñigo and Sinden, Robert and Baum, Jake and Gamo, Francisco-Javier and Mäser, Pascal and Kyle, Dennis E. and Winzeler, Elizabeth A. and Myler, Peter J. and Wyatt, Paul G. and Floyd, David and Matthews, David and Sharma, Amit and Striepen, Boris and Huston, Christopher D. and Gray, David W. and Fairlamb, Alan H. and Pisliakov, Andrei V. and Walpole, Chris and Read, Kevin D. and Van Voorhis, Wesley C. and Gilbert, Ian H.. (2019) Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proceedings of the National Academy of Sciences of the United States of America, 116 (14). pp. 7015-7020.

De Gasparo, Raoul and Halgas, Ondrej and Harangozo, Dora and Kaiser, Marcel and Pai, Emil F. and Krauth-Siegel, R. Luise and Diederich, François. (2019) Targeting a large active site : structure-based design of nanomolar inhibitors of Trypanosoma brucei trypanothione reductase. Chemistry - A European Journal, 25 (49). pp. 11416-11421.

Fayez, Shaimaa and Li, Jun and Feineis, Doris and Aké Assi, Laurent and Kaiser, Marcel and Brun, Reto and Anany, Mohamed A. and Wajant, Harald and Bringmann, Gerhard. (2019) A Near-Complete Series of Four Atropisomeric Jozimine A; 2; -Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from; Ancistrocladus abbreviatus;. Journal of natural products, 82 (11). pp. 3033-3046.

GIordani, F. and Khalaf, A. I. and Gillingwater, K. and Munday, J. C. and De Koning, H. P. and Suckling, C. J. and Barrett, M. P. and Scott, F. J.. (2019) Novel minor groove binders cure animal african trypanosomiasis in an in vivo mouse model. Journal of medicinal chemistry, 62 (6). pp. 3021-3035.

Galkina, Anna and Krause, Nico and Lenz, Mairin and Daniliuc, Constantin G. and Kaiser, Marcel and Schmidt, Thomas J.. (2019) Antitrypanosomal activity of sesquiterpene lactones from Helianthus tuberosus L. including a new furanoheliangolide with an unusual structure. Molecules, 24 (6). p. 1068.

Gilson, Paul R. and Nguyen, William and Poole, William A. and Teixeira, Jose E. and Thompson, Jennifer K. and Guo, Kaiyuan and Stewart, Rebecca J. and Ashton, Trent D. and White, Karen L. and Sanz, Laura M. and Gamo, Francisco-Javier and Charman, Susan A. and Wittlin, Sergio and Duffy, James and Tonkin, Christopher J. and Tham, Wai-Hong and Crabb, Brendan S. and Cooke, Brian M. and Huston, Christopher D. and Cowman, Alan F. and Sleebs, Brad E.. (2019) Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Evaluation of 4-amino 2-anilinoquinazolines against Plasmodium and other apicomplexan parasites in vitro and in a P. falciparum humanized NOD-scid IL2Rynull mouse model of malaria. Antimicrobial agents and chemotherapy, 63 (3). e01804-18.

Hochegger, Patrick and Faist, Johanna and Seebacher, Werner and Saf, Robert and Mäser, Pascal and Kaiser, Marcel and Weis, Robert. (2019) Antiprotozoal activities of tetrazole-quinolines with aminopiperidine linker. Medicinal chemistry (Shariqah (United Arab Emirates)), 15 (4). pp. 409-416.

Hochegger, Patrick and Faist, Johanna and Seebacher, Werner and Saf, Robert and Mäser, Pascal and Kaiser, Marcel and Weis, Robert. (2019) Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity. Bioorganic & medicinal chemistry, 27 (10). pp. 2052-2065.

Hooft van Huijsduijnen, R. and Wells, T. and Tanner, M. and Wittlin, S.. (2019) Two successful decades of Swiss collaborations to develop new anti-malarials. Malaria journal, 18. p. 94.

Jourdan, Joëlle and Walz, Annabelle and Matile, Hugues and Schmidt, Alexander and Wu, Jianbo and Wang, Xiaofang and Dong, Yuxiang and Vennerstrom, Jonathan L. and Schmidt, Remo S. and Wittlin, Sergio and Mäser, Pascal. (2019) Stochastic protein alkylation by antimalarial peroxides. ACS Infectious Diseases, 5 (12). pp. 2067-2075.

Kimani, Njogu M. and Backhaus, Solveig and Matasyoh, Josphat C. and Kaiser, Marcel and Herrmann, Fabian C. and Schmidt, Thomas J. and Langer, Klaus. (2019) Preparation of sesquiterpene lactone-loaded pla nanoparticles and evaluation of their antitrypanosomal activity. Molecules, 24 (11). E2110.

Krieg, R. and Jortzik, E. and Goetz, A. A. and Blandin, S. and Wittlin, S. and Elhabiri, M. and Rahbari, M. and Nuryyeva, S. and Voigt, K. and Dahse, H. M. and Brakhage, A. and Beckmann, S. and Quack, T. and Grevelding, C. G. and Pinkerton, A. B. and Schonecker, B. and Burrows, J. and Davioud-Charvet , E. and Rahlfs, S. and Becker, K.. (2019) Author correction: Arylmethylamino steroids as antiparasitic agents. Nature Communications, 10. p. 2997.

Kumar, Malkeet and Okombo, John and Mambwe, Dickson and Taylor, Dale and Lawrence, Nina and Reader, Janette and van der Watt, Mariëtte and Fontinha, Diana and Sanches-Vaz, Margarida and Bezuidenhout, Belinda C. and Lauterbach, Sonja B. and Liebenberg, Dale and Birkholtz, Lyn-Marie and Coetzer, Theresa L. and Prudêncio, Miguel and Egan, Timothy J. and Wittlin, Sergio and Chibale, Kelly. (2019) Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action. ACS infectious diseases, 5 (2). pp. 303-315.

Mayoka, Godfrey and Njoroge, Mathew and Okombo, John and Gibhard, Liezl and Sanches-Vaz, Margarida and Fontinha, Diana and Birkholtz, Lyn-Marie and Reader, Janette and van der Watt, Mariëtte and Coetzer, Theresa L. and Lauterbach, Sonja and Churchyard, Alisje and Bezuidenhout, Belinda and Egan, Timothy J. and Yeates, Clive Leonard and Wittlin, Sergio and Prudêncio, Miguel and Chibale, Kelly. (2019) Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria. Journal of medicinal chemistry, 62 (2). pp. 1022-1035.

Mofidi Tabatabaei, Sahar and Nejad Ebrahimi, Samad and Salehi, Peyman and Sonboli, Ali and Tabefam, Marzieh and Kaiser, Marcel and Hamburger, Matthias and Moridi Farimani, Mahdi. (2019) Antiprotozoal germacranolide sesquiterpene lactones from Tanacetum sonbolii. Planta medica, 85 (5). pp. 424-430.

Mohsin, N. U. A. and Seebacher, W. and Hochegger, P. and Faist, J. and Saf, R. and Kaiser, M. and Mäser, P. and Weis, R.. (2019) Synthesis of new 1-benzyl tetrahydropyridin-4-ylidene piperidinium salts and their antiplasmodial and antitrypanosomal activities. Medicinal chemistry research, 28 (5). pp. 742-753.

Mufusama, J. P. and Feineis, D. and Mudodo, V. and Kaiser, M. and Brun, R. and Bringmann, G.. (2019) Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,80'-coupled monomeric alkaloids, ikelacongolines A-D, from a Congolese Ancistrocladus liana. RSC advances, 9 (21). pp. 12034-12046.

Mäser, P.. (2019) Parasiten machen Geschichte. In: Gespräche im Garten: Kultur - Natur - Gutes Leben: Tusculum auf Mapprach. Basel, pp. 127-131.

Okombo, John and Brunschwig, Christel and Singh, Kawaljit and Dziwornu, Godwin Akpeko and Barnard, Linley and Njoroge, Mathew and Wittlin, Sergio and Chibale, Kelly. (2019) Antimalarial pyrido[1,2-a]benzimidazole derivatives with mannich base side chains: synthesis, pharmacological evaluation and reactive metabolite trapping studies. ACS infectious diseases, 5 (3). pp. 372-384.

Pérez-Moreno , G. and Sánchez-Carrasco , P. and Ruiz-Pérez , L.M. and Johansson, N. G. and Muller, S. and Baragaña, B. and Hampton, S. E. and Gilbert, I. H. and Kaiser, M. and Sarkar, S. and Pandurangan, T. and Kumar, V. and Gonzalez-Pacanowska , D.. (2019) Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity. Malaria journal, 18. p. 392.

Rao, Srinivasa P. S. and Barrett, Michael P. and Dranoff, Glenn and Faraday, Christopher J. and Gimpelewicz, Claudio R. and Hailu, Asrat and Jones, Catherine L. and Kelly, John M. and Lazdins-Helds, Janis K. and Mäser, Pascal and Mengel, Jose and Mottram, Jeremy C. and Mowbray, Charles E. and Sacks, David L. and Scott, Phillip and Späth, Gerald F. and Tarleton, Rick L. and Spector, Jonathan M. and Diagana, Thierry T.. (2019) Drug discovery for kinetoplastid diseases : future directions. ACS infectious diseases, 5 (2). pp. 152-157.

Renggli, Sabine and Mayumana, Iddy and Mboya, Dominick and Charles, Christopher and Mshana, Christopher and Kessy, Flora and Glass, Tracy R. and Lengeler, Christian and Schulze, Alexander and Aerts, Ann and Pfeiffer, Constanze. (2019) Towards improved health service quality in Tanzania: contribution of a supportive supervision approach to increased quality of primary healthcare. BMC health services research, 19. p. 848.

Saccoliti, Francesco and Madia, Valentina Noemi and Tudino, Valeria and De Leo, Alessandro and Pescatori, Luca and Messore, Antonella and De Vita, Daniela and Scipione, Luigi and Brun, Reto and Kaiser, Marcel and Mäser, Pascal and Calvet Alvarez, Claudia Magalhaes and Jennings, Gareth K. and Podust, Larissa M. and Pepe, Giacomo and Cirilli, Roberto and Faggi, Cristina and Di Marco, Annalise and Battista, Maria Rosaria and Summa, Vincenzo and Costi, Roberta and Di Santo, Roberto. (2019) Design, synthesis, and biological evaluation of new 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives as antiprotozoal agents. Journal of Medicinal Chemistry, 62 (3). pp. 1330-1347.

Schalkwijk, Joost and Allman, Erik L. and Jansen, Patrick A. M. and de Vries, Laura E. and Verhoef, Julie M. J. and Jackowski, Suzanne and Botman, Peter N. M. and Beuckens-Schortinghuis, Christien A. and Koolen, Karin M. J. and Bolscher, Judith M. and Vos, Martijn W. and Miller, Karen and Reeves, Stacy A. and Pett, Helmi and Trevitt, Graham and Wittlin, Sergio and Scheurer, Christian and Sax, Sibylle and Fischli, Christoph and Angulo-Barturen, Iñigo and Jiménez-Diaz, Mariá Belén and Josling, Gabrielle and Kooij, Taco W. A. and Bonnert, Roger and Campo, Brice and Blaauw, Richard H. and Rutjes, Floris P. J. T. and Sauerwein, Robert W. and Llinás, Manuel and Hermkens, Pedro H. H. and Dechering, Koen J.. (2019) Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum. Science Translational Medicine, 11 (510). eaas9917.

Schindler, T. Robaina and T. Sax, J. Raso and Bieri, J. Mpina and M. Gondwe, L. Acuche and L. Garcia, G. Cortes and C. Maas, C. Daubenberger. (2019) Molecular monitoring of the diversity of human pathogenic malaria species in blood donations on Bioko Island, Equatorial Guinea. Malaria journal, 18. p. 9.

Shi, Yan-Ni and Pusch, Stefan and Shi, Yi-Ming and Richter, Christian and Maciá-Vicente, Jose G. and Schwalbe, Harald and Kaiser, Marcel and Opatz, Till and Bode, Helge B.. (2019) (+/-)-Alternarlactones A and B, two antiparasitic alternariol-like dimers from the fungus Alternaria alternata p1210 isolated from the halophyte Salicornia sp. Journal of Organic Chemistry, 84 (17). pp. 11203-11209.

Smeilus, T. and Mousavizadh, F. and Kriger, J. and Tu, X. and Kaiser, M. and Giannis, A.. (2019) Synthesis and biological investigation of (+)-3-hydroxymethylartemisinin. Journal of Organic Chemistry, 15. pp. 567-570.

Tasdemir, D. and Kaiser, M. and Demirci, B. and Demirci, F. and Baser, K. H. C.. (2019) Antiprotozoal activity of turkish Origanum onites essential oil and its components. Molecules, 24 (23). p. 4421.

Tshitenge, Dieudonné Tshitenge and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2019) An unusually broad series of seven cyclombandakamines, bridged dimeric naphthylisoquinoline alkaloids from the congolese liana ancistrocladus ealaensis. Scientific reports, 9. p. 9812.

Tshitenge, Dieudonné Tshitenge and Bruhn, Torsten and Feineis, Doris and Schmidt, David and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Würthner, Frank and Awale, Suresh and Bringmann, Gerhard. (2019) Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana; Ancistrocladus ealaensis; , Targeting Pancreatic Cancer Cells. Journal of natural products, 82 (11). pp. 3150-3164.

Vu Van , T. and Pham-Duc , P. and Winkler, M. S. and Zurbrügg, C. and Zinsstag, J. and Tran, B. H. and Nguyen-Viet , H.. (2019) New derivatives of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Monatshefte für Chemie, 150 (11). pp. 1959-1972.

Walz, A. and Leroy, D. and Andenmatten, N. and Mäser, P. and Wittlin, S.. (2019) Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay. Malaria journal, 18. p. 427.

Wang, X. and Cal, M. and Kaiser, M. and Buckner, F. S. and Lepesheva, G. I. and Sanford, A. G. and Wallick, A. I. and Davis, P. H. and Vennerstrom, J. L.. (2019) A new chemotype with promise against Trypanosoma cruzi. Bioorganic & medicinal chemistry letters, 30. p. 126778.

Wiedemar, Natalie. Suramin resistance in African Trypanosomes. 2019, Doctoral Thesis, University of Basel, Faculty of Science.

Wiedemar, Natalie and Zwyer, Michaela and Zoltner, Martin and Cal, Monica and Field, Mark C. and Mäser, Pascal. (2019) Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in Trypanosoma brucei. FASEB bioAdvances, 1 (10). pp. 595-608.

Zhao, L. and Awori, R. M. and Kaiser, M. and Gross, J. and Opatz, T. and Bode, H. B.. (2019) Structure, biosynthesis, and bioactivity of photoditritide from Photorhabdus temperata meg1. Journal of natural products, 82 (12). pp. 3499-3503.

2018

Begolo, Daniela and Vincent, Isabel M. and Giordani, Federica and Pöhner, Ina and Witty, Michael J. and Rowan, Timothy G. and Bengaly, Zakaria and Gillingwater, Kirsten and Freund, Yvonne and Wade, Rebecca C. and Barrett, Michael P. and Clayton, Christine. (2018) The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. PLoS Pathogens, 14 (9). e1007315.

Boss, C. and Wittlin, S.. (2018) Recent trends in malaria research. In: 2018 Medicinal chemistry reviews: from the medicinal chemistry division of the ACS, 53. Minneapolis, pp. 293-311.

Brunschwig, C. Lawrence and N. Taylor, D. Abay and E. Njoroge, M. Basarab and G. S. Le Manach, C. Paquet and T. Gonzalez Cabrera, D. Nchinda and A. T. de Kock, C. Wiesner and L. Denti, P. Waterson and D. Blasco, B. Leroy and D. Witty, M. J. Donini and C. Duffy, J. Wittlin and S. White, K. L. Charman and S. A. Jimenez-Diaz, M. B. Angulo-Barturen and I. Herreros, E. Gamo and F. J. Rochford, R. Mancama and D. Coetzer, T. L. van der Watt and M. E. Reader, J. Birkholtz and L. M. Marsh, K. C. Solapure and S. M. Burke, J. E. McPhail and J. A. Vanaerschot, M. Fidock and D. A. Fish, P. V. Siegl and P. Smith, D. A. Wirjanata and G. Noviyanti, R. Price and R. N. Marfurt, J. Silue and K. D. Street, L. J. Chibale. (2018) Erratum for Brunschwig et al., "UCT943, a next-generation Plasmodium falciparum PI4K Inhibitor rreclinical candidate for the treatment of malaria". Antimicrobial agents and chemotherapy, 62 (11). e01941-18.

Brunschwig, Christel and Lawrence, Nina and Taylor, Dale and Abay, Efrem and Njoroge, Mathew and Basarab, Gregory S. and Le Manach, Claire and Paquet, Tanya and Cabrera, Diego Gonzàlez and Nchinda, Aloysius T. and de Kock, Carmen and Wiesner, Lubbe and Denti, Paolo and Waterson, David and Blasco, Benjamin and Leroy, Didier and Witty, Michael J. and Donini, Cristina and Duffy, James and Wittlin, Sergio and White, Karen L. and Charman, Susan A. and Jiménez-Díaz, Maria Belén and Angulo-Barturen, Iñigo and Herreros, Esperanza and Gamo, Francisco Javier and Rochford, Rosemary and Mancama, Dalu and Coetzer, Theresa L. and van der Watt, Mariëtte E. and Reader, Janette and Birkholtz, Lyn-Marie and Marsh, Kennan C. and Solapure, Suresh M. and Burke, John E. and McPhail, Jacob A. and Vanaerschot, Manu and Fidock, David A. and Fish, Paul V. and Siegl, Peter and Smith, Dennis A. and Wirjanata, Grennady and Noviyanti, Rintis and Price, Ric N. and Marfurt, Jutta and Silue, Kigbafori D. and Street, Leslie J. and Chibale, Kelly. (2018) UCT943, a next generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria. Antimicrobial agents and chemotherapy, 62 (9). e00012-e00018.

Cheuka, P. M. and Larence, N. and Taylor, D. and Wittlin, S. and Chibale, K.. (2018) Antiplasmodial imidazopyridazines : structure-activity relationship studies lead to the identification of analogues with improved solubility and hERG profiles. MedChemComm , 9 (10). pp. 1733-1745.

Cretton, Sylvian and Oyarzún, Alejandra and Righi, Davide and Sahib, Lamia and Kaiser, Marcel and Christen, Philippe and Fajardo, Victor. (2018) A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea. Natural Product Research, 32 (6). pp. 695-701.

De Gasparo, Raoul and Brodbeck-Persch, Elke and Bryson, Steve and Hentzen, Nina B. and Kaiser, Marcel and Pai, Emil F. and Krauth-Siegel, R. Luise and Diederich, François. (2018) Biological evaluation and x-ray co-crystal structures of cyclohexylpyrrolidine ligands for trypanothione reductase, an enzyme from the redox metabolism of trypanosoma. ChemMedChem, 13 (9). pp. 957-967.

Ebiloma, Godwin U. and Ayuga, Teresa Díaz and Balogun, Emmanuel O. and Gil, Lucía Abad and Donachie, Anne and Kaiser, Marcel and Herraiz, Tomás and Inaoka, Daniel K. and Shiba, Tomoo and Harada, Shigeharu and Kita, Kiyoshi and de Koning, Harry P. and Dardonville, Christophe. (2018) Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense. European journal of medicinal chemistry, 150. pp. 385-402.

Farahat, Abdelbasset A. and Ismail, Mohamed A. and Kumar, Arvind and Wenzler, Tanja and Brun, Reto and Paul, Ananya and Wilson, W. David and Boykin, David W.. (2018) Indole and benzimidazole bichalcophenes: synthesis, DNA binding and antiparasitic activity. European Journal of Medicinal Chemistry, 143. pp. 1590-1596.

Farimani, Mahdi M. and Khodaei, Bahareh and Moradi, Hanzaleh and Aliabadi, Abbas and Ebrahimi, Samad N. and De Mieri, Maria and Kaiser, Marcel and Hamburger, Matthias. (2018) Phytochemical study of Salvia leriifolia roots : rearranged abietane diterpenoids with antiprotozoal activity. Journal of natural products, 81 (6). pp. 1384-1390.

Fayez, Shaimaa and Feineis, Doris and Aké Assi, Laurent and Kaiser, Marcel and Brun, Reto and Awale, Suresh and Bringmann, Gerhard. (2018) Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells. Fitoterapia, 131. pp. 245-259.

Ferrigno, Federica and Biancofiore, Ilaria and Malancona, Savina and Ponzi, Simona and Paonessa, Giacomo and Graziani, Rita and Bresciani, Alberto and Gennari, Nadia and Di Marco, Annalise and Kaiser, Marcel and Summa, Vincenzo and Harper, Steven and Ontoria, Jesus M.. (2018) Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro. Bioorganic & medicinal chemistry letters, 28 (23-24). pp. 3689-3692.

Ferrins, Lori and Sharma, Amrita and Thomas, Sarah M. and Mehta, Naimee and Erath, Jessey and Tanghe, Scott and Leed, Susan E. and Rodriguez, Ana and Mensa-Wilmot, Kojo and Sciotti, Richard J. and Gillingwater, Kirsten and Pollastri, Michael P.. (2018) Anilinoquinoline based inhibitors of trypanosomatid proliferation. PLoS Neglected Tropical Diseases, 12 (11). e0006834.

Gibhard, Liezl and Njoroge, Mathew and Paquet, Tanya and Brunschwig, Christel and Taylor, Dale and Lawrence, Nina and Abay, Efrem and Wittlin, Sergio and Wiesner, Lubbe and Street, Leslie J. and Chibale, Kelly and Basarab, Gregory S.. (2018) Investigating sulfoxide to sulfone conversion as a prodrug strategy for a PI4K inhibitor in a humanized mouse model of malaria. Antimicrobial agents and chemotherapy, 62 (12). e00261-18.

Gillingwater, Kirsten. (2018) In vitro and in vivo efficacy of diamidines against Trypanosoma equiperdum strains. Parasitology, 145 (7). pp. 953-960.

Giroud, Maude and Dietzel, Uwe and Anselm, Lilli and Banner, David and Kuglstatter, Andreas and Benz, Jörg and Blanc, Jean-Baptiste and Gaufreteau, Delphine and Liu, Haixia and Lin, Xianfeng and Stich, August and Kuhn, Bernd and Schuler, Franz and Kaiser, Marcel and Brun, Reto and Schirmeister, Tanja and Kisker, Caroline and Diederich, François and Haap, Wolfgang. (2018) Repurposing a library of human cathepsin L ligands : identification of macrocyclic lactams as potent rhodesain and Trypanosoma brucei inhibitors. Journal of medicinal chemistry, 61 (8). pp. 3350-3369.

Giroud, Maude and Kuhn, Bernd and Saint-Auret, Sarah and Kuratli, Christoph and Martin, Rainer E. and Schuler, Franz and Diederich, François and Kaiser, Marcel and Brun, Reto and Schirmeister, Tanja and Haap, Wolfgang. (2018) 2 H-1,2,3-Triazole-based dipeptidyl nitriles : potent, selective, and Trypanocidal rhodesain inhibitors by structure-based design. Journal of medicinal chemistry, 61 (8). pp. 3370-3388.

Grogg, Marcel and Hilvert, Donald and Ebert, Marc-Olivier and Beck, Albert K. and Seebach, Dieter and Kurth, Felix and Dittrich, Petra S. and Sparr, Christof and Wittlin, Sergio and Rottmann, Matthias and Mäser, Pascal. (2018) Cell penetration, herbicidal activity, and in-vivo-toxicity of oligo-arginine derivatives and of novel guanidinium-rich compounds derived from the biopolymer cyanophycin. Helvetica Chimica Acta, 101 (10). e1800112.

Guo, H. and Benndorf, R. and Konig, S. and Leichnitz, D. and Weigel, C. and Peschel, G. and Berthel, P. and Kaiser, M. and Steinbeck, C. and Werz, O. and Pulsen, M. and Beemelmanns, C.. (2018) Expanding the rubterolone Family : intrinsic reactivity and directed diversification of PKS-derived pyrans. Chemistry - A European Journal, 24 (44). pp. 11319-11324.

Guo, Huijuan and Schmidt, Alexander and Stephan, Philipp and Raguž, Luka and Braga, Daniel and Kaiser, Marcel and Dahse, Hans-Martin and Weigel, Christiane and Lackner, Gerald and Beemelmanns, Christine. (2018) Precursor-directed diversification of cyclic tetrapeptidic pseudoxylallemycins. ChemBioChem, 19 (21). pp. 2307-2311.

Gysin, M. and Braissant, O. and Gillingwater, K. and Brun, R. and Mäser, P. and Wenzler, T.. (2018) Isothermal microcalorimetry - a quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time. International journal for parasitology. Drugs and drug resistance, 8 (2). pp. 159-164.

Kalel, Vishal C. and Mäser, Pascal and Sattler, Michael and Erdmann, Ralf and Popowicz, Grzegorz M.. (2018) Come, sweet death : targeting glycosomal protein import for antitrypanosomal drug development. Current Opinion in Microbiology, 46. pp. 116-122.

Kaur, Gurminder and Pavadai, Elumalai and Wittlin, Sergio and Chibale, Kelly. (2018) 3D-QSAR modeling and synthesis of new fusidic acid derivatives as antiplasmodial agents. Journal of Chemical Information and Modeling, 58 (8). pp. 1553-1560.

Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2018) Antiprotozoal sesquiterpene lactones and other constituents from Tarchonanthus camphoratus and Schkuhria pinnata. Journal of natural products, 81 (1). pp. 124-130.

Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2018) Sesquiterpene lactones from Vernonia cinerascens sch. bip. and their in vitro antitrypanosomal activity. Molecules: A Journal of Synthetic Chemistry and Natural Product Chemistry , 23 (2). E248.

Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Nogueira, Mauro S. and Trossini, Gustavo H. G. and Schmidt, Thomas J.. (2018) Complementary quantitative structure-activity relationship models for the antitrypanosomal activity of sesquiterpene lactones. International journal of molecular sciences, 19 (12). p. 3271.

Krieger, Johannes and Smeilus, Toni and Kaiser, Marcel and Seo, Ean-Jeong and Efferth, Thomas and Giannis, Athanassios. (2018) Total synthesis and biological investigation of (-)-artemisinin : the antimalarial activity of artemisinin is not stereospecific. Angewandte Chemie, 57 (27). pp. 8293-8296.

Le Manach, Claire and Paquet, Tanya and Wicht, Kathryn and Nchinda, Aloysius T. and Brunschwig, Christel and Njoroge, Mathew and Gibhard, Liezl and Taylor, Dale and Lawrence, Nina and Wittlin, Sergio and Eyermann, Charles J. and Basarab, Gregory S. and Duffy, James and Fish, Paul V. and Street, Leslie J. and Chibale, Kelly. (2018) Antimalarial lead-optimization studies on a 2,6-imidazopyridine series within a constrained chemical space to circumvent atypical dose-response curves against multidrug resistant parasite strains. Journal of medicinal chemistry, 61 (20). pp. 9371-9385.

Levatić, Jurica and Pavić, Kristina and Perković, Ivana and Uzelac, Lidija and Ester, Katja and Kralj, Marijeta and Kaiser, Marcel and Rottmann, Matthias and Supek, Fran and Zorc, Branka. (2018) Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity. European journal of medicinal chemistry, 146. pp. 651-667.

Lombe, B. K. and Feineis, D. and Mudogo, V. and Brun, R. and Awale, S. and Bringmann, G.. (2018) Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells. RSC advances, 8 (10). pp. 5243-5254.

Martí Coma-Cros, Elisabet and Biosca, Arnau and Marques, Joana and Carol, Laura and Urbán, Patricia and Berenguer, Diana and Riera, Maria Cristina and Delves, Michael and Sinden, Robert E. and Valle-Delgado, Juan José and Spanos, Lefteris and Siden-Kiamos, Inga and Pérez, Paula and Paaijmans, Krijn and Rottmann, Matthias and Manfredi, Amedea and Ferruti, Paolo and Ranucci, Elisabetta and Fernàndez-Busquets, Xavier. (2018) Polyamidoamine nanoparticles for the oral administration of antimalarial drugs. Pharmaceutics, 10 (4). p. 225.

Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Saf, R. and Weis, R.. (2018) The antiplasmodial and antitrypanosomal activities of novel piperazine derivatives of 3-azabicyclo[3.2.2]nonanes. Monatshefte für Chemie, 149 (1). pp. 99-109.

Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Kretschmer, N. and Bauer, R. and Saf, R. and Kaiser, M. and Mäser, P. and Weis, R.. (2018) Modifications on tetrahydropyridin-4-ylidene ammonium salts and their antiprotozoal activities. Monatshefte für Chemie, 149 (4). pp. 801-812.

Mäser, Pascal. (2018) Host-microbe interactions: Parasitology Vol 46. Current opinion in microbiology, 46. pp. 6-8.

Nchinda, Aloysius T. and Le Manach, Claire and Paquet, Tanya and Gonzàlez Cabrera, Diego and Wicht, Kathryn J. and Brunschwig, Christel and Njoroge, Mathew and Abay, Efrem and Taylor, Dale and Lawrence, Nina and Wittlin, Sergio and Jiménez-Díaz, María-Belén and Santos Martínez, María and Ferrer, Santiago and Angulo-Barturen, Iñigo and Lafuente-Monasterio, Maria Jose and Duffy, James and Burrows, Jeremy and Street, Leslie J. and Chibale, Kelly. (2018) Identification of fast-acting 2,6-disubstituted imidazopyridines that are efficacious in the In Vivo humanized Plasmodium falciparum nodscidil2rgamma (null) mouse model of malaria. Journal of medicinal chemistry, 61 (9). pp. 4213-4227.

Nefertiti, A. S. G. and Batista, M. M. and Da Silva, P. B. and Batista, D. G. J. and Da Silva, C. F. and Peres, R. B. and Torres-Santos, E. C. and Cunha-Junior, E. F. and Holt, E. and Boykin, D. W. and Brun, R. and Wenzler, T. and Soeiro, M. N. C.. (2018) In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines. Antimicrobial Agents and Chemotherapy, 62 (2). e01936-17.

O' Donovan, Daniel H. and Aillard, Paul and Berger, Martin and de la Torre, Aurélien and Petkova, Desislava and Knittl-Frank, Christian and Geerdink, Danny and Kaiser, Marcel and Maulide, Nuno. (2018) C-H activation enables a concise total synthesis of quinine and analogues with enhanced antimalarial activity. Angewandte Chemie (International ed. in English), 57 (33). pp. 10737-10741.

Oufir, M. Gillingwater and K. Hamburger, M. Roditi and I. Brun, R. Mäser and P. Wenzler, T.. (2018) Pharmacokinetic profiles reconcile in vitro and in vivo activities of novel trypanocidal compounds. Matters. 07000009.

Presser, Armin and Lainer, Gunda and Kretschmer, Nadine and Schuehly, Wolfgang and Saf, Robert and Kaiser, Marcel and Kalt, Marc-Manuel. (2018) Synthesis of jacaranone-derived nitrogenous cyclohexadienones and their antiproliferative and antiprotozoal activities. Molecules, 23 (11). E2902.

Royo, Santiago and Schirmeister, Tanja and Kaiser, Marcel and Jung, Sascha and Rodríguez, Santiago and Bautista, José Manuel and González, Florenci V.. (2018) Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates. Bioorganic & medicinal chemistry, 26 (16). pp. 4624-4634.

Saccoliti, Francesco and Madia, Valentina Noemi and Tudino, Valeria and De Leo, Alessandro and Pescatori, Luca and Messore, Antonella and De Vita, Daniela and Scipione, Luigi and Brun, Reto and Kaiser, Marcel and Mäser, Pascal and Calvet, Claudia Magalhaes and Jennings, Gareth K. and Podust, Larissa M. and Costi, Roberta and Di Santo, Roberto. (2018) Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents. European journal of medicinal chemistry, 156. pp. 53-60.

Schies, C. and Seupel, R. and Feineis, D. and Gehrold, A. and Schraut, M. and Kaiser, M. and Brun, R. and Bringmann, G.. (2018) Biomimetic total synthesis of mbandakamine A and further antiplasmodial naphthylisoquinoline dimers. ChemistrySelect, 3. pp. 940-945.

Schmidt, Remo S. and Macêdo, Juan P. and Steinmann, Michael E. and Salgado, Amaia González and Bütikofer, Peter and Sigel, Erwin and Rentsch, Doris and Mäser, Pascal. (2018) Transporters of Trypanosoma brucei : phylogeny, physiology, pharmacology. The FEBS journal, 285 (6). pp. 1012-1023.

Schwertz, Geoffrey and Witschel, Matthias C. and Rottmann, Matthias and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Jaruwat, Aritsara and Amornwatcharapong, Watcharee and Ittarat, Wanwipa and Schäfer, Anja and Aponte, Raphael A. and Trapp, Nils and Chaiyen, Pimchai and Diederich, François. (2018) Potent inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) featuring a spirocyclic scaffold. ChemMedChem, 13 (9). pp. 931-943.

Shi, Y. M. and Richter, C. and Challinor, V. L. and Grun, P. Girela Del Rio and Kaiser, M. and Schuffler, A. and Piepenbring, M. and Schwalbe, H. and Bode, H. B.. (2018) Georatusin, a specific antiparasitic polyketide-peptide hybrid from the gungus Geomyces auratus. Organic Letters, 20 (6). pp. 1563-1567.

Subramaniam, Suvitha and Schmid, Christoph D. and Guan, Xue Li and Mäser, Pascal. (2018) Using yeast synthetic lethality to inform drug combination for Malaria. Antimicrobial Agents and Chemotherapy, 62 (4). e01533-17.

Tabefam, M. and Farimani, M. M. and Danton, O. and Ramseyer, J. and Ebrahimi, S. N. and Neuburger, M. and Kaiser, M. and Salehi, P. and Potterat, O. and Hamburger, M.. (2018) Antiprotozoal isoprenoids from Salvia hydrangea. Journal of natural products, 81. pp. 2682-2691.

Tallini, Luciana R. and Torras-Claveria, Laura and Borges, Warley de Souza and Kaiser, Marcel and Viladomat, Francesc and Zuanazzi, José Angelo S. and Bastida, Jaume. (2018) N-oxide alkaloids from Crinum amabile (Amaryllidaceae). Molecules, 23 (6). E1277.

Tshitenge, Dieudonné Tshitenge and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas and Bringmann, Gerhard. (2018) Mbandakamine-type naphthylisoquinoline dimers and related alkaloids from the central African liana ancistrocladus ealaensis with antiparasitic and antileukemic activities. Journal of natural products, 81 (4). pp. 918-933.

Uliassi, Elisa and Piazzi, Lorna and Belluti, Federica and Mazzanti, Andrea and Kaiser, Marcel and Brun, Reto and Moraes, Carolina B. and Freitas-Junior, Lucio H. and Gul, Sheraz and Kuzikov, Maria and Ellinger, Bernhard and Borsari, Chiara and Costi, Maria Paola and Bolognesi, Maria Laura. (2018) Development of a focused library of triazole-linked privileged-structure-based conjugates leading to the discovery of novel phenotypic hits against protozoan parasitic infections. ChemMedChem, 13 (7). pp. 678-683.

Wesche, Frank and Adihou, Hélène and Kaiser, Astrid and Wurglics, Mario and Schubert-Zsilavecz, Manfred and Kaiser, Marcel and Bode, Helge B.. (2018) Combined approach of backbone amide linking and on-resin n-methylation for the synthesis of bioactive and metabolically stable peptides. Journal of medicinal chemistry, 61 (9). pp. 3930-3938.

Wiedemar, Natalie and Graf, Fabrice E. and Zwyer, Michaela and Ndomba, Emiliana and Kunz Renggli, Christina and Cal, Monica and Schmidt, Remo S. and Wenzler, Tanja and Mäser, Pascal. (2018) Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei. Molecular Microbiology, 107 (1). pp. 57-67.

Zhang, Huaisheng and Collins, Jasmine and Nyamwihura, Rogers and Ware, Shelbi and Kaiser, Marcel and Ogungbe, Ifedayo Victor. (2018) Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent. Bioorganic & medicinal chemistry, 28 (9). pp. 1647-1651.

Zhao, Lei and Cai, Xiaofeng and Kaiser, Marcel and Bode, Helge B.. (2018) Methionine-containing rhabdopeptide/xenortide-like peptides from heterologous expression of the biosynthetic gene cluster kj12ABC in Escherichia coli. Journal of natural products, 81 (10). pp. 2292-2295.

Zhao, Lei and Kaiser, Marcel and Bode, Helge B.. (2018) Rhabdopeptide/Xenortide-like peptides from Xenorhabdus innexi with terminal amines showing potent antiprotozoal activity. Organic Letters, 20 (17). pp. 5116-5120.

2017

Abla, Nada and Bashyam, Sridevi and Charman, Susan A. and Greco, Béatrice and Hewitt, Philip and Jiménez-Díaz, Maria Belén and Katneni, Kasiram and Kubas, Holger and Picard, Didier and Sambandan, Yuvaraj and Sanz, Laura and Smith, Dennis and Wang, Tai and Willis, Paul and Wittlin, Sergio and Spangenberg, Thomas. (2017) Long-lasting and fast-acting in vivo efficacious antiplasmodial azepanylcarbazole amino alcohol. ACS medicinal chemistry letters, 8 (12). pp. 1304-1308.

Akama, T. and Zhang, Y. K. and Freund, Y. R. and Berry, P. and Lee, J. and Easom, E. E. and Jacobs, R. T. and Plattner, J. J. and Witty, M. J. and Peter, R. and Rowan, T. G. and Gillingwater, K. and Brun, R. and Nare, B. and Mercer, L. and Xu, M. and Wang, J. and Liang, H.. (2017) Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). Bioorganic and Medicinal Chemistry Letters, 28. pp. 6-10.

Althaus, Julia B. and Malyszek, Claudine and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Alkamides from Anacyclus pyrethrum L. and their in vitro antiprotozoal activity. Molecules, 22 (5). p. 796.

Bapela, M. J. and Kaiser, M. and Meyer, J. J. M.. (2017) Antileishmanial activity of selected South African plant species. South African journal of botany, 108. pp. 342-345.

Bode, Edna and He, Yue and Vo, Tien Duy and Schultz, Roland and Kaiser, Marcel and Bode, Helge B.. (2017) Biosynthesis and function of simple amides in Xenorhabdus doucetiae. Environmental Microbiology, 19 (11). pp. 4564-4575.

Bringmann, Gerhard and Seupel, Raina and Feineis, Doris and Xu, Minjuan and Zhang, Guoliang and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas. (2017) Antileukemic ancistrobenomine B and related 5,1'-coupled naphthylisoquinoline alkaloids from the Chinese liana Ancistrocladus tectorius. Fitoterapia, 121. pp. 76-85.

Bruno, Stefano and Uliassi, Elisa and Zaffagnini, Mirko and Prati, Federica and Bergamini, Christian and Amorati, Riccardo and Paredi, Gianluca and Margiotta, Marilena and Conti, Paola and Costi, Maria Paola and Kaiser, Marcel and Cavalli, Andrea and Fato, Romana and Bolognesi, Maria Laura. (2017) Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule. Chemical Biology and Drug Design, 90 (2). pp. 225-235.

Cadelis, Melissa M. and Bourguet-Kondracki, Marie-Lise and Dubois, Joëlle and Kaiser, Marcel and Brunel, Jean Michel and Barker, David and Copp, Brent R.. (2017) Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase. Bioorganic & medicinal chemistry, 25 (16). pp. 4433-4443.

Cai, Xiaofeng and Challinor, Victoria L. and Zhao, Lei and Reimer, Daniela and Adihou, Hélène and Grün, Peter and Kaiser, Marcel and Bode, Helge B.. (2017) Biosynthesis of the antibiotic nematophin and its elongated derivatives in entomopathogenic bacteria. Organic letters, 19 (4). pp. 806-809.

Cai, Xiaofeng and Nowak, Sarah and Wesche, Frank and Bischoff, Iris and Kaiser, Marcel and Fürst, Robert and Bode, Helge B.. (2017) Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design. Nature Chemistry, 9 (4). pp. 379-386.

Cai, Xiaofeng and Shi, Yi-Ming and Pöhlmann, Nicole and Revermann, Ole and Bahner, Isabel and Pidot, Sacha J. and Wesche, Frank and Lackner, Helmut and Büchel, Claudia and Kaiser, Marcel and Richter, Christian and Schwalbe, Harald and Stinear, Timothy P. and Zeeck, Axel and Bode, Helge B.. (2017) Structure and biosynthesis of isatropolones, bioactive amine-scavenging fluorescent natural products from streptomyces Go66. Angewandte Chemie International Edition, 56 (18). pp. 4945-4949.

Chianese, Giuseppina and Silber, Johanna and Luciano, Paolo and Merten, Christian and Erpenbeck, Dirk and Topaloglu, Bülent and Kaiser, Marcel and Tasdemir, Deniz. (2017) Antiprotozoal linear furanosesterterpenoids from the marine sponge Ircinia oros. Journal of natural products, 80 (9). pp. 2566-2571.

Dawidowski, M. and Emmanouilidis, L. and Kalel, V. C. and Tripsianes, K. and Schorpp, K. and Hadian, K. and Kaiser, M. and Mäser, P. and Kolonko, M. and Tanghe, S. and Rodriguez, A. and Schliebs, W. and Erdmann, R. and Sattler, M. and Popowicz, G. M.. (2017) Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science, 355 (6332). pp. 1416-1420.

De Mieri, M. and Smiesko, M. and Ismajili, I. and Kaiser, M. and Hamburger, M.. (2017) Acid-induced rearrangement of epoxygermacranolides: synthesis of furanoheliangolides and cadinanes from nobilin. Molecules, 22 (12). E2252.

De Mieri, Maria and Monteleone, Giannicola and Ismajili, Isidor and Kaiser, Marcel and Hamburger, Matthias. (2017) Antiprotozoal activity-based profiling of a dichloromethane extract from anthemis nobilis flowers. Journal of Natural Products, 80 (2). pp. 459-470.

Dong, Yuxiang and Wang, Xiaofang and Kamaraj, Sriraghavan and Bulbule, Vivek J. and Chiu, Francis C. K. and Chollet, Jacques and Dhanasekaran, Manickam and Hein, Christopher D. and Papastogiannidis, Petros and Morizzi, Julia and Shackleford, David M. and Barker, Helena and Ryan, Eileen and Scheurer, Christian and Tang, Yuanqing and Zhao, Qingjie and Zhou, Lin and White, Karen L. and Urwyler, Heinrich and Charman, William N. and Matile, Hugues and Wittlin, Sergio and Charman, Susan A. and Vennerstrom, Jonathan L.. (2017) Structure-activity relationship of the antimalarial ozonide artefenomel (OZ439). Journal of medicinal chemistry, 60 (7). pp. 2654-2668.

Espinoza-Moraga, Marlene and Singh, Kawaljit and Njoroge, Mathew and Kaur, Gurminder and Okombo, John and De Kock, Carmen and Smith, Peter J. and Wittlin, Sergio and Chibale, Kelly. (2017) Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents. Bioorganic & medicinal chemistry, 27 (3). pp. 658-661.

Faist, Johanna and Hinteregger, Clemens and Seebacher, Werner and Saf, Robert and Mäser, Pascal and Kaiser, Marcel and Weis, Robert. (2017) New derivatives of 7-chloroquinolin-4-amine with antiprotozoal activity. Bioorganic & medicinal chemistry, 25 (3). pp. 941-948.

Farahat, A. A. and Kumar, A. and Say, M. and Wenzler, T. and Brun, R. and Paul, A. and Wilson, D. W. and Boykin, D. W.. (2017) Exploration of DAPI analogues : synthesis, antitrypanosomal activity, DNA binding and fluorescence properties. European journal of medicinal chemistry, 128. pp. 70-78.

Gillingwater, Kirsten and Kunz, Christina and Braghiroli, Christiane and Boykin, David W. and Tidwell, Richard R. and Brun, Reto. (2017) In vitro, ex vivo and in vivo activity of diamidines against Trypanosoma congolense and Trypanosoma vivax. Antimicrobial agents and chemotherapy, 61 (5). e02356-16.

Greve, H. L. and Kaiser, M. and Brun, R. and Schmidt, Tj. (2017) Erratum: terpenoids from the oleo-gum-resin of boswellia serrata and their antiplasmodial effects in vitro. Planta medica, 83 (14-15). E4.

Greve, Hippolyt L. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Terpenoids from the oleo-gum-resin of Boswellia serrata and their antiplasmodial effects In Vitro. Planta medica, 83 (14-15). pp. 1214-1226.

Guan, Xue Li and Mäser, Pascal. (2017) Comparative sphingolipidomics of disease-causing trypanosomatids reveal unique lifecycle- and taxonomy-specific lipid chemistries. Scientific reports, 7. p. 13617.

Jeacock, Laura and Baker, Nicola and Wiedemar, Natalie and Mäser, Pascal and Horn, David. (2017) Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity. PLoS Pathogens, 13 (3). e1006307.

Jourdan, Joëlle. Mode of action of synthetic antimalarial peroxides. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

Krieg, Reimar and Jortzik, Esther and Goetz, Alice-Anne and Blandin, Stéphanie and Wittlin, Sergio and Elhabiri, Mourad and Rahbari, Mahsa and Nuryyeva, Selbi and Voigt, Kerstin and Dahse, Hans-Martin and Brakhage, Axel and Beckmann, Svenja and Quack, Thomas and Grevelding, Christoph G. and Pinkerton, Anthony B. and Schönecker, Bruno and Burrows, Jeremy and Davioud-Charvet, Elisabeth and Rahlfs, Stefan and Becker, Katja. (2017) Arylmethylamino steroids as antiparasitic agents. Nature communications, 8. p. 14478.

Leven, Michael and Knaab, Tanja C. and Held, Jana and Duffy, Sandra and Meister, Stephan and Fischli, Christoph and Meitzner, Diane and Lehmann, Ursula and Lungerich, Beate and Kuna, Krystina and Stahlke, Petra and Delves, Michael J. and Buchholz, Mirko and Winzeler, Elizabeth A. and Avery, Vicky M. and Mordmüller, Benjamin and Wittlin, Sergio and Kurz, Thomas. (2017) 3-hydroxy-N'-arylidenepropanehydrazonamides with halo-substituted phenanthrene scaffolds cure P. berghei infected mice when administered perorally. Journal of Medicinal Chemistry, 60 (14). pp. 6036-6044.

Li, Jun and Seupel, Raina and Bruhn, Torsten and Feineis, Doris and Kaiser, Marcel and Brun, Reto and Mudogo, Virima and Awale, Suresh and Bringmann, Gerhard. (2017) Jozilebomines A and B, naphthylisoquinoline dimers from the congolese liana ancistrocladus ileboensis, with antiausterity activities against the PANC-1 human pancreatic cancer cell line. Journal of natural products, 80 (10). pp. 2807-2817.

Li, Jun and Seupel, Raina and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Brünnert, Daniela and Chatterjee, Manik and Seo, Ean-Jeong and Efferth, Thomas and Bringmann, Gerhard. (2017) Dioncophyllines C2, D2, and F and related naphthylisoquinoline alkaloids from the congolese liana Ancistrocladus ileboensis with potent activities against Plasmodium falciparum and against multiple myeloma and leukemia cell lines. Journal of natural products, 80 (2). pp. 443-458.

Lombe, Blaise Kimbadi and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Brun, Reto and Bringmann, Gerhard. (2017) Antiprotozoal spirombandakamines A1 and A2, fused naphthylisoquinoline dimers from a congolese Ancistrocladus plant. Organic Letters, 19 (24). pp. 6740-6743.

Lombe, Blaise Kimbadi and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Brun, Reto and Bringmann, Gerhard. (2017) Cyclombandakamines A1 and A2, oxygen-bridged naphthylisoquinoline dimers from a congolese Ancistrocladus liana. Organic letters, 19 (6). pp. 1342-1345.

Mathieu, Christoph and Macêdo, Juan P. and Hürlimann, Daniel and Wirdnam, Corina and Haindrich, Alexander C. and Suter Grotemeyer, Marianne and González-Salgado, Amaia and Schmidt, Remo S. and Inbar, Ehud and Mäser, Pascal and Bütikofer, Peter and Zilberstein, Dan and Rentsch, Doris. (2017) Arginine and lysine transporters are essential for Trypanosoma brucei. PLoS ONE, 12. e0168775.

Mohsin, Noor-Ul-Amin and Seebacher, Werner and Faist, Johanna and Hochegger, Patrick and Kaiser, Marcel and Mäser, Pascal and Belaj, Ferdinand and Saf, Robert and Kretschmer, Nadine and Alajlani, Muaaz and Turek, Ivana and Brantner, Adelheid and Bauer, Rudolf and Bucar, Franz and Weis, Robert. (2017) Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. European journal of medicinal chemistry, 143. pp. 97-106.

Mäser, Pascal. (2017) Cherchez l'electron. Molecular microbiology, 106 (2). pp. 183-185.

Ndjakou Lenta, B. and Ngatchou, J. and Frese, M. and Ladoh-Yemeda, F. and Nardella, F. and Michalek, C. and Wibberg, D. and Ngouela, S. and Tsamo, E. and Kaiser, M. and Kalinowski, J. and Sewald, N.. (2017) Purpureone, an antileishmanial ergochrome from the endophytic fungus Purpureocillium lilacinum. Zeitschrift für Naturforschung. Sect. B, Chemical sciences, 71 (11). pp. 1159-1167.

Nnadi, Charles Okeke and Nwodo, Ngozi Justina and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense. Molecules, 22 (7). E1129.

Pagliero, Romina J. and Kaiser, Marcel and Brun, Reto and Nieto, Marcelo J. and Mazzieri, María R.. (2017) Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles. Bioorganic & medicinal chemistry, 27 (17). pp. 3945-3949.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Kaiser, Marcel. (2017) The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines. European Journal of Medicinal Chemistry, 138. pp. 1106-1113.

Paquet, Tanya and Le Manach, Claire and Cabrera, Diego González and Younis, Yassir and Henrich, Philipp P. and Abraham, Tara S. and Lee, Marcus C. S. and Basak, Rajshekhar and Ghidelli-Disse, Sonja and Lafuente-Monasterio, María José and Bantscheff, Marcus and Ruecker, Andrea and Blagborough, Andrew M. and Zakutansky, Sara E. and Zeeman, Anne-Marie and White, Karen L. and Shackleford, David M. and Mannila, Janne and Morizzi, Julia and Scheurer, Christian and Angulo-Barturen, Iñigo and Martínez, María Santos and Ferrer, Santiago and Sanz, Laura María and Gamo, Francisco Javier and Reader, Janette and Botha, Mariette and Dechering, Koen J. and Sauerwein, Robert W. and Tungtaeng, Anchalee and Vanachayangkul, Pattaraporn and Lim, Chek Shik and Burrows, Jeremy and Witty, Michael J. and Marsh, Kennan C. and Bodenreider, Christophe and Rochford, Rosemary and Solapure, Suresh M. and Jiménez-Díaz, María Belén and Wittlin, Sergio and Charman, Susan A. and Donini, Cristina and Campo, Brice and Birkholtz, Lyn-Marie and Hanson, Kirsten K. and Drewes, Gerard and Kocken, Clemens H. M. and Delves, Michael J. and Leroy, Didier and Fidock, David A. and Waterson, David and Street, Leslie J. and Chibale, Kelly. (2017) Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Science translational medicine, 9 (387). eaad9735.

Pavadai, E. and Kaur, G. and Wittlin, S. and Chibale, K.. (2017) Identification of steroid-like natural products as antiplasmodial agents by 2D and 3D similarity-based virtual screening. MedChemComm , 8 (6). pp. 1152-1157.

Pearce, A. Norrie and Kaiser, Marcel and Copp, Brent R.. (2017) Synthesis and antimalarial evaluation of artesunate-polyamine and trioxolane-polyamine conjugates. European journal of medicinal chemistry, 140. pp. 595-603.

Schwertz, Geoffrey and Frei, Michelle S. and Witschel, Matthias C. and Rottmann, Matthias and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Jaruwat, Aritsara and Ittarat, Wanwipa and Schäfer, Anja and Aponte, Raphael A. and Trapp, Nils and Mark, Kerstin and Chaiyen, Pimchai and Diederich, François. (2017) Conformational aspects in the design of inhibitors for serine hydroxymethyltransferase (SHMT): biphenyl, aryl sulfonamide, and aryl sulfone motifs. Chemistry - A European Journal, 23 (57). pp. 14345-14357.

Schwertz, Geoffrey and Witschel, Matthias C. and Rottmann, Matthias and Bonnert, Roger and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Jaruwat, Aritsara and Ittarat, Wanwipa and Schäfer, Anja and Aponte, Raphael A. and Charman, Susan A. and White, Karen L. and Kundu, Abhijit and Sadhukhan, Surajit and Lloyd, Mel and Freiberg, Gail M. and Srikumaran, Myron and Siggel, Marc and Zwyssig, Adrian and Chaiyen, Pimchai and Diederich, François. (2017) Antimalarial inhibitors rargeting serine hydroxymethyltransferase (SHMT) with in vivo efficacy and analysis of their binding mode based on X-ray cocrystal structures. Journal of Medicinal Chemistry, 60 (12). pp. 4840-4860.

Scott, Fraser J. and Nichol, Ryan J. O. and Khalaf, Abedawn I. and Giordani, Federica and Gillingwater, Kirsten and Ramu, Soumya and Elliott, Alysha and Zuegg, Johannes and Duffy, Paula and Rosslee, Michael-Jon and Hlaka, Lerato and Kumar, Santosh and Ozturk, Mumin and Brombacher, Frank and Barrett, Michael and Guler, Reto and Suckling, Colin J.. (2017) An evaluation of minor groove binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136. pp. 561-572.

Seebacher, W. and Belaj, F. and Faist, J. and Saf, R. and Bucar, F. and Turek, I. and Branter, A. and Alajlani, M. and Kaiser, M. and Mäser, P. and Weis, R.. (2017) Synthesis of new pyrido-benzodiazepine salts and their antimicrobial activities. Monatshefte für Chemie, 148 (2). pp. 263-274.

Singh, Kawaljit and Okombo, John and Brunschwig, Christel and Ndubi, Ferdinand and Barnard, Linley and Wilkinson, Chad and Njogu, Peter M. and Njoroge, Mathew and Laing, Lizahn and Machado, Marta and Prudêncio, Miguel and Reader, Janette and Botha, Mariette and Nondaba, Sindisiwe and Birkholtz, Lyn-Marie and Lauterbach, Sonja and Churchyard, Alisje and Coetzer, Theresa L. and Burrows, Jeremy N. and Yeates, Clive and Denti, Paolo and Wiesner, Lubbe and Egan, Timothy J. and Wittlin, Sergio and Chibale, Kelly. (2017) Antimalarial pyrido[1,2-a]benzimidazoles : lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and in vivo oral efficacy in a mouse model. Journal of medicinal chemistry, 60 (4). pp. 1432-1448.

Smyrniotopoulos, Vangelis and Merten, Christian and Kaiser, Marcel and Tasdemir, Deniz. (2017) Bifurcatriol, a new antiprotozoal acyclic diterpene from the brown alga Bifurcaria bifurcata. Marine drugs, 15 (8). p. 245.

Steiniger, Charlotte and Hoffmann, Sylvester and Mainz, Andi and Kaiser, Marcel and Voigt, Kerstin and Meyer, Vera and Süssmuth, Roderich D.. (2017) Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering. Chemical Science, 8 (11). pp. 7834-7843.

Steinmann, Michael E. and Schmidt, Remo S. and Bütikofer, Peter and Mäser, Pascal and Sigel, Erwin. (2017) TbIRK is a signature sequence free potassium channel from Trypanosoma brucei locating to acidocalcisomes. Scientific Reports, 7 (1). p. 656.

Steinmann, Michael E. and Schmidt, Remo S. and Macêdo, Juan P. and Kunz Renggli, Christina and Bütikofer, Peter and Rentsch, Doris and Mäser, Pascal and Sigel, Erwin. (2017) Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei. PLoS ONE, 12 (12). e0188219.

Tallini, Luciana R. and Andrade, Jean Paulo de and Kaiser, Marcel and Viladomat, Francesc and Nair, Jerald J. and Zuanazzi, José Angelo S. and Bastida, Jaume. (2017) Alkaloid constituents of the amaryllidaceae plant amaryllis belladonna L. Molecules, 22 (9). p. 1437.

Tallini, Luciana R. and Osorio, Edison H. and Santos, Vanessa Dias Dos and Borges, Warley de Souza and Kaiser, Marcel and Viladomat, Francesc and Zuanazzi, José Angelo S. and Bastida, Jaume. (2017) Hippeastrum reticulatum (Amaryllidaceae): alkaloid profiling, biological activities and molecular docking. Molecules, 22 (12). E2191.

Tshitenge, Dieudonné Tshitenge and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2017) Antiplasmodial ealapasamines A-C,'mixed' naphthylisoquinoline dimers from the Central African liana Ancistrocladus ealaensis. Scientific Reports, 7. p. 5767.

Waldsö, I. and Hallén, D. and Jansoon, M. and Suurkuusk, J. and Wenzler, T. and Braissant, O.. (2017) A well-plate format isothermal multi-channel microcalorimeter for monitoring the activity of living cells and tissues. Thermochimica acta, 652. pp. 141-149.

Xu, Ze-Jun and Wittlin, Sergio and Wu, Yikang. (2017) Probing the peroxycarbenium [3+2] cycloaddition reactions with 1,2-disubstituted ethylenes: results and insights. Chemistry (Weinheim an der Bergstrasse, Germany), 23 (9). pp. 2031-2034.

2016

Ahmad, Sarfraz and Seebacher, Werner and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2016) The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, 39 (10). pp. 1391-1403.

Atay, Irem and Kirmizibekmez, Hasan and Kaiser, Marcel and Akaydin, Galip and Yesilada, Erdem and Tasdemir, Deniz. (2016) Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites. Pharmaceutical biology, 54 (9). pp. 1808-1814.

Boss, Christoph and Aissaoui, Hamed and Amaral, Nathalie and Bauer, Aude and Bazire, Stephanie and Binkert, Christoph and Brun, Reto and Bürki, Cédric and Ciana, Claire-Lise and Corminboeuf, Olivier and Delahaye, Stephane and Dollinger, Claire and Fischli, Christoph and Fischli, Walter and Flock, Alexandre and Frantz, Marie-Céline and Girault, Malory and Grisostomi, Corinna and Friedli, Astrid and Heidmann, Bibia and Hinder, Claire and Jacob, Gael and Le Bihan, Amelie and Malrieu, Sophie and Mamzed, Saskia and Merot, Aurelien and Meyer, Solange and Peixoto, Sabrina and Petit, Nolwenn and Siegrist, Romain and Trollux, Julien and Weller, Thomas and Wittlin, Sergio. (2016) Discovery and characterization of ACT-451840 : an antimalarial drug with a novel mechanism of action. ChemMedChem, 11 (18). pp. 1995-2014.

Cal, Monica and Ioset, Jean-Robert and Fügi, Matthia A. and Mäser, Pascal and Kaiser, Marcel. (2016) Assessing anti-T. cruzi candidates in vitro for sterile cidality. International journal for parasitology. Drugs and drug resistance, 6 (3). pp. 165-170.

Faist, J. and Seebacher, W. and Saf, R. and Brun, R. and Kaiser, M. and Weis, R.. (2016) New derivatives of bicyclic diamines with antiprotozoal activity. Monatshefte für Chemie, 147 (2). pp. 369-381.

Faist, Johanna and Seebacher, Werner and Saf, Robert and Brun, Reto and Kaiser, Marcel and Weis, Robert. (2016) Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead. Bioorganic & medicinal chemistry, 24 (16). pp. 3781-3789.

Farahat, Abdelbasset A. and Bennett-Vaughn, Cheree and Mineva, Ekaterina M. and Kumar, Arvind and Wenzler, Tanja and Brun, Reto and Liu, Yang and Wilson, W. David and Boykin, David W.. (2016) Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI. Bioorganic & medicinal chemistry letters, 26 (24). pp. 5907-5910.

Graf, Fabrice E. and Ludin, Philipp and Arquint, Christian and Schmidt, Remo S. and Schaub, Nadia and Kunz Renggli, Christina and Munday, Jane C. and Krezdorn, Jessica and Baker, Nicola and Horn, David and Balmer, Oliver and Caccone, Adalgisa and de Koning, Harry P. and Mäser, Pascal. (2016) Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular and molecular life sciences, 73 (17). pp. 3387-3400.

Hiltensperger, Georg and Hecht, Nina and Kaiser, Marcel and Rybak, Jens-Christoph and Hoerst, Alexander and Dannenbauer, Nicole and Müller-Buschbaum, Klaus and Bruhn, Heike and Esch, Harald and Lehmann, Leane and Meinel, Lorenz and Holzgrabe, Ulrike. (2016) Quinolone amides as anti-trypanosomal lead compounds with in vivo activity. Antimicrobial agents and chemotherapy, 60 (8). pp. 4442-4452.

Houël, Emeline and Nardella, Flore and Jullian, Valérie and Valentin, Alexis and Vonthron-Sénécheau, Catherine and Villa, Pascal and Obrecht, Adeline and Kaiser, Marcel and Bourreau, Eliane and Odonne, Guillaume and Fleury, Marie and Bourdy, Geneviève and Eparvier, Véronique and Deharo, Eric and Stien, Didier. (2016) Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians. Journal of ethnopharmacology, 187. pp. 241-248.

Karaaslan, Cigdem and Kaiser, Marcel and Brun, Reto and Göker, Hakan. (2016) Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenz-imidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense. Bioorganic and Medicinal Chemistry, 24 (18). pp. 4038-4044.

Kedzierska, Ewa and Orzelska, Jolanta and Perković, Ivana and Knežević, Danijel and Fidecka, Sylwia and Kaiser, Marcel and Zorc, Branka. (2016) Pharmacological effects of primaquine ureas and semicarbazides on the central nervous system in mice and antimalarial activity in vitro. Fundamental and clinical pharmacology, 30. pp. 58-69.

Le Bihan, Amélie and de Kanter, Ruben and Angulo-Barturen, Iñigo and Binkert, Christoph and Boss, Christoph and Brun, Reto and Brunner, Ralf and Buchmann, Stephan and Burrows, Jeremy and Dechering, Koen J. and Delves, Michael and Ewerling, Sonja and Ferrer, Santiago and Fischli, Christoph and Gamo-Benito, Francisco Javier and Gnädig, Nina F. and Heidmann, Bibia and Jiménez-Díaz, María Belén and Leroy, Didier and Martínez, Maria Santos and Meyer, Solange and Moehrle, Joerg J. and Ng, Caroline L. and Noviyanti, Rintis and Ruecker, Andrea and Sanz, Laura María and Sauerwein, Robert W. and Scheurer, Christian and Schleiferboeck, Sarah and Sinden, Robert and Snyder, Christopher and Straimer, Judith and Wirjanata, Grennady and Marfurt, Jutta and Price, Ric N. and Weller, Thomas and Fischli, Walter and Fidock, David A. and Clozel, Martine and Wittlin, Sergio. (2016) Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling. PLoS medicine, 13 (10). e1002138.

Le Manach, Claire and Nchinda, Aloysius T. and Paquet, Tanya and Gonzàlez Cabrera, Diego and Younis, Yassir and Han, Ze and Bashyam, Sridevi and Zabiulla, Mohammed and Taylor, Dale and Lawrence, Nina and White, Karen L. and Charman, Susan A. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Botha, Mariëtte E. and Nondaba, Sindisiswe H. and Reader, Janette and Birkholtz, Lyn-Marie and Jiménez-Díaz, María Belén and Martínez, María Santos and Ferrer, Santiago and Angulo-Barturen, Iñigo and Meister, Stephan and Antonova-Koch, Yevgeniya and Winzeler, Elizabeth A. and Street, Leslie J. and Chibale, Kelly. (2016) Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle. Journal of medicinal chemistry, 59 (21). pp. 9890-9905.

Mir Mohseni, M. and Hover, T. and Barra, L. and Kaiser, M. and Dorrestein, P. C. and Dickschat, J. S. and Schaberle, T. F.. (2016) Discovery of a mosaic-like biosynthetic assembly line with a decarboxylative off-loading mechanism through a combination of genome mining and imaging. Angewandte Chemie. International edition in English, 55 (43). pp. 13611-13614.

Ng, Caroline L. and Siciliano, Giulia and Lee, Marcus C. S. and de Almeida, Mariana J. and Corey, Victoria C. and Bopp, Selina E. and Bertuccini, Lucia and Wittlin, Sergio and Kasdin, Rachel G. and Le Bihan, Amélie and Clozel, Martine and Winzeler, Elizabeth A. and Alano, Pietro and Fidock, David A.. (2016) CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs. Molecular microbiology, 101 (3). pp. 381-393.

Nogueira, Mauro S. and Da Costa, Fernando B. and Brun, Reto and Kaiser, Marcel and Schmidt, Thomas J.. (2016) Ent-pimarane and ent-kaurane diterpenes from Aldama discolor (asteraceae) and their antiprotozoal activity. Molecules, 21 (9). p. 1237.

Norcross, Neil R. and Baragaña, Beatriz and Wilson, Caroline and Hallyburton, Irene and Osuna-Cabello, Maria and Norval, Suzanne and Riley, Jennifer and Stojanovski, Laste and Simeons, Frederick R. C. and Porzelle, Achim and Grimaldi, Raffaella and Wittlin, Sergio and Duffy, Sandra and Avery, Vicky M. and Meister, Stephan and Sanz, Laura and Jiménez-Díaz, Belén and Angulo-Barturen, Iñigo and Ferrer, Santiago and Martínez, María Santos and Gamo, Francisco Javier and Frearson, Julie A. and Gray, David W. and Fairlamb, Alan H. and Winzeler, Elizabeth A. and Waterson, David and Campbell, Simon F. and Willis, Paul and Read, Kevin D. and Gilbert, Ian H.. (2016) Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. Journal of Medicinal Chemistry, 59 (13). pp. 6101-6120.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Wilkinson, Shane R. and Szular, Joanna and Kaiser, Marcel. (2016) Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds. European journal of medicinal chemistry, 117. pp. 179-186.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Wilkinson, Shane R. and Szular, Joanna and Kaiser, Marcel. (2016) Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity. European journal of medicinal chemistry, 123. pp. 895-904.

Patrick, Donald A. and Wenzler, Tanja and Yang, Sihyung and Weiser, Patrick T. and Wang, Michael Zhuo and Brun, Reto and Tidwell, Richard R.. (2016) Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense. Bioorganic & medicinal chemistry, 24 (11). pp. 2451-2465.

Pavadai, Elumalai and El Mazouni, Farah and Wittlin, Sergio and de Kock, Carmen and Phillips, Margaret A. and Chibale, Kelly. (2016) Identification of new human malaria parasite Plasmodium falciparum dihydroorotate dehydrogenase inhibitors by pharmacophore and structure-based virtual screening. Journal of chemical information and modeling, 56 (3). pp. 548-562.

Pirttimaa, Minni and Nasereddin, Abedelmajeed and Kopelyanskiy, Dmitry and Kaiser, Marcel and Yli-Kauhaluoma, Jari and Oksman-Caldentey, Kirsi-Marja and Brun, Reto and Jaffe, Charles L. and Moreira, Vânia M. and Alakurtti, Sami. (2016) Abietane-type diterpenoid amides with highly potent and selective activity against Leishmania donovani and Trypanosoma cruzi. Journal of natural products, 79 (2). pp. 362-368.

Russell, Stephanie and Rahmani, Raphaël and Jones, Amy J. and Newson, Harriet L. and Neilde, Kevin and Cotillo, Ignacio and Rahmani Khajouei, Marzieh and Ferrins, Lori and Qureishi, Sana and Nguyen, Nghi and Martinez-Martinez, Maria S. and Weaver, Donald F. and Kaiser, Marcel and Riley, Jennifer and Thomas, John and De Rycker, Manu and Read, Kevin D. and Flematti, Gavin R. and Ryan, Eileen and Tanghe, Scott and Rodriguez, Ana and Charman, Susan A. and Kessler, Albane and Avery, Vicky M. and Baell, Jonathan B. and Piggott, Matthew J.. (2016) Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides. Journal of Medicinal Chemistry, 59 (21). pp. 9686-9720.

Seupel, Raina and Hertlein-Amslinger, Barbara and Gulder, Tanja and Stawski, Philipp and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2016) Directed synthesis of all four pure stereoisomers of the N,C-Coupled naphthylisoquinoline alkaloid ancistrocladinium A. Organic letters, 18 (24). pp. 6508-6511.

Silveira, Narjara and Saar, Julia and Santos, Alan Diego C. and Barison, Andersson and Sandjo, Louis P. and Kaiser, Marcel and Schmidt, Thomas J. and Biavatti, Maique W.. (2016) A new alkamide with an endoperoxide structure from acmella ciliata (asteraceae) and its in vitro antiplasmodial activity. Molecules, 21 (6). pp. 1-10.

Tasdemir, D. and Sen, R. and Bergonzi, M. C. and Demirci, B. and Bilia, A. R. and Baser, K. H. C. and Brun, R. and Chatterjee, M.. (2016) Rapid chemical analysis and antiprotozoal effect of the solvent extracts and the essential oil of Artemisia indica. Planta medica, 81 (16). pp. 1547-1548.

Vahermo, M. and Krogerus, S. and Nasereddin, A. and Kaiser, M. and Brun, R. and Jaffe, C. L. and Yli-Kauhaluoma, J. and Moreira, V. M.. (2016) Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania denovani and Trypanosoma cruzi. MedChemComm, 7 (3). pp. 457-463.

Vanden Eynde, J. J. and Mayence, A. and Mottamal, M. and Bacchi, C. J. and Yarlett, N. and Kaiser, M. and Brun, R. and Huang, T. L.. (2016) Alkanediamide-linked bisbenzamidines are promising antiparasitic agents. Pharmaceuticals, 9 (2). pp. 1-11.

Wang, Tai and Mäser, Pascal and Picard, Didier. (2016) Inhibition of Plasmodium falciparum Hsp90 contributes to the antimalarial activities of aminoalcohol-carbazoles. Journal of Medicinal Chemistry, 59 (13). pp. 6344-6352.

Wenzler, Tanja and Schumann Burkard, Gabriela and S. Schmidt, Remo and Mäser, Pascal and Bergner, Andreas and Roditi, Isabel and Brun, Reto. (2016) A new approach to chemotherapy : drug-induced differentiation kills African trypanosomes. Scientific Reports, 6. p. 22451.

Williamson, Alice E. and Ylioja, Paul M. and Robertson, Murray N. and Antonova-Koch, Yevgeniya and Avery, Vicky and Baell, Jonathan B. and Batchu, Harikrishna and Batra, Sanjay and Burrows, Jeremy N. and Bhattacharyya, Soumya and Calderon, Felix and Charman, Susan A. and Clark, Julie and Crespo, Benigno and Dean, Matin and Debbert, Stefan L. and Delves, Michael and Dennis, Adelaide S. M. and Deroose, Frederik and Duffy, Sandra and Fletcher, Sabine and Giaever, Guri and Hallyburton, Irene and Gamo, Francisco-Javier and Gebbia, Marinella and Guy, R. Kiplin and Hungerford, Zoe and Kirk, Kiaran and Lafuente-Monasterio, Maria J. and Lee, Anna and Meister, Stephan and Nislow, Corey and Overington, John P. and Papadatos, George and Patiny, Luc and Pham, James and Ralph, Stuart A. and Ruecker, Andrea and Ryan, Eileen and Southan, Christopher and Srivastava, Kumkum and Swain, Chris and Tarnowski, Matthew J. and Thomson, Patrick and Turner, Peter and Wallace, Iain M. and Wells, Timothy N. C. and White, Karen and White, Laura and Willis, Paul and Winzeler, Elizabeth A. and Wittlin, Sergio and Todd, Matthew H.. (2016) Open source drug discovery : highly potent antimalarial compounds derived from the tres cantos arylpyrroles. ACS central science, 2 (10). pp. 687-701.

Wolkinger, V. and Ahmad, S. and Seebacher, W. and Faist, J. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2016) New diaryl-substituted azabicyclo[3.2.2]nonanes and their antiprotozoal potencies. Monatshefte für Chemie, 147 (10). pp. 1721-1735.

Zheng, Zhaoyan and Tran, Huu-Anh and Manivannan, Srinivasan and Wen, Xianghui and Kaiser, Marcel and Brun, Reto and Snyder, Floyd F. and Back, Thomas G.. (2016) Novel nucleoside-based antimalarial compounds. Bioorganic & medicinal chemistry letters, 26 (12). pp. 2861-2865.

2015

Ahmad, Sarfraz and Seebacher, Werner and Wolkinger, Volker and Presser, Armin and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2015) Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, Vol. 38, H. 8. pp. 1455-1467.

Baragaña, Beatriz and Hallyburton, Irene and Lee, Marcus C. S. and Norcross, Neil R. and Grimaldi, Raffaella and Otto, Thomas D. and Proto, William R. and Blagborough, Andrew M. and Meister, Stephan and Wirjanata, Grennady and Ruecker, Andrea and Upton, Leanna M. and Abraham, Tara S. and Almeida, Mariana J. and Pradhan, Anupam and Porzelle, Achim and Martínez, María Santos and Bolscher, Judith M. and Woodland, Andrew and Norval, Suzanne and Zuccotto, Fabio and Thomas, John and Simeons, Frederick and Stojanovski, Laste and Osuna-Cabello, Maria and Brock, Paddy M. and Churcher, Tom S. and Sala, Katarzyna A. and Zakutansky, Sara E. and Jiménez-Díaz, María Belén and Sanz, Laura Maria and Riley, Jennifer and Basak, Rajshekhar and Campbell, Michael and Avery, Vicky M. and Sauerwein, Robert W. and Dechering, Koen J. and Noviyanti, Rintis and Campo, Brice and Frearson, Julie A. and Angulo-Barturen, Iñigo and Ferrer-Bazaga, Santiago and Gamo, Francisco Javier and Wyatt, Paul G. and Leroy, Didier and Siegl, Peter and Delves, Michael J. and Kyle, Dennis E. and Wittlin, Sergio and Marfurt, Jutta and Price, Ric N. and Sinden, Robert E. and Winzeler, Elizabeth A. and Charman, Susan A. and Bebrevska, Lidiya and Gray, David W. and Campbell, Simon and Fairlamb, Alan H. and Willis, Paul A. and Rayner, Julian C. and Fidock, David A. and Read, Kevin D. and Gilbert, Ian H.. (2015) A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature, Vol. 522, H. 7556. pp. 315-320.

Bode, Edna and Brachmann, Alexander O. and Kegler, Carsten and Simsek, Rukayye and Dauth, Christina and Zhou, Qiuqin and Kaiser, Marcel and Klemmt, Petra and Bode, Helge B.. (2015) Simple "on-demand" production of bioactive natural products. ChemBioChem, Vol. 16, H. 7. pp. 1115-1119.

Bode, Helge B. and Brachmann, Alexander O. and Jadhav, Kirtikumar B. and Seyfarth, Lydia and Dauth, Christina and Fuchs, Sebastian W. and Kaiser, Marcel and Waterfield, Nick R. and Sack, Holger and Heinemann, Stefan H. and Arndt, Hans-Dieter. (2015) Structure elucidation and activity of kolossin A, the D-/L-Pentadecapeptide product of a giant nonribosomal peptide synthetase. Angewandte Chemie, Jg. 54, Nr. 35. pp. 10352-10355.

Brücher, Karin and Gräwert, Tobias and Konzuch, Sarah and Held, Jana and Lienau, Claudia and Behrendt, Christoph and Illarionov, Boris and Maes, Louis and Bacher, Adelbert and Wittlin, Sergio and Mordmüller, Benjamin and Fischer, Markus and Kurz, Thomas. (2015) Prodrugs of reverse fosmidomycin analogues. Journal of medicinal chemistry, 58 (4). pp. 2025-2035.

Bürstner, Nathalie and Roggo, Silvio and Ostermann, Nils and Blank, Jutta and Delmas, Cecile and Freuler, Felix and Gerhartz, Bernd and Hinniger, Alexandra and Hoepfner, Dominic and Liechty, Brigitta and Mihalic, Manuel and Murphy, Jason and Pistorius, Dominik and Rottmann, Matthias and Thomas, Jason R. and Schirle, Markus and Schmitt, Esther K.. (2015) Gift from nature : cyclomarin s kills Mycobacteria and malaria parasites by distinct modes of action. ChemBioChem, 16 (17). pp. 2433-2436.

Cheikh-Ali, Zakaria and Glynou, Kyriaki and Ali, Tahir and Ploch, Sebastian and Kaiser, Marcel and Thines, Marco and Bode, Helge B. and Maciá-Vicente, Jose G.. (2015) Diversity of exophillic acid derivatives in strains of an endophytic Exophiala sp. Phytochemistry : an international journal of plant biochemistry, 118. pp. 83-93.

Chugh, Monika and Scheurer, Christian and Sax, Sibylle and Bilsland, Elizabeth and van Schalkwyk, Donelly A. and Wicht, Kathryn J. and Hofmann, Natalie and Sharma, Anil and Bashyam, Sridevi and Singh, Shivendra and Oliver, Stephen G. and Egan, Timothy J. and Malhotra, Pawan and Sutherland, Colin J. and Beck, Hans-Peter and Wittlin, Sergio and Spangenberg, Thomas and Ding, Xavier C.. (2015) Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 1110-1118.

Cretton, Sylvian and Bréant, Lise and Pourrez, Lucie and Ambuehl, Chiara and Perozzo, Remo and Marcourt, Laurence and Kaiser, Marcel and Cuendet, Muriel and Christen, Philippe. (2015) Chemical constituents from Waltheria indica exert in vitro activity against Trypanosoma brucei and T. cruzi. Fitoterapia, 105. pp. 55-60.

Daeppen, Christophe and Kaiser, Marcel and Neuburger, Markus and Gademann, Karl. (2015) Preparation of antimalarial endoperoxides by a formal [2 + 2 + 2] cycloaddition. Organic letters, 17 (21). pp. 5420-5423.

De Mieri, M. and Kaiser, M. and Brun, R. and Thormann, U. and Imanidis, G. and Hamburger, M.. (2015) Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin. Bioorganic & medicinal chemistry, 23 (7). pp. 1521-1529.

Ellendorff, Therese and Brun, Reto and Kaiser, Marcel and Sendker, Jandirk and Schmidt, Thomas J.. (2015) PLS-prediction and confirmation of hydrojuglone glucoside as the antitrypanosomal constituent of "Juglans spp.". Molecules, Vol. 20, H. 6. pp. 10082-10094.

Gonzàlez Cabrera, Diego and Douelle, Frederic and Le Manach, Claire and Han, Ze and Paquet, Tanya and Taylor, Dale and Njoroge, Mathew and Lawrence, Nina and Wiesner, Lubbe and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Street, Leslie J. and Chibale, Kelly. (2015) Structure-activity relationship studies of orally active antimalarial 2,4-diamino-thienopyrimidines. Journal of medicinal chemistry, 58 (18). pp. 7572-7579.

Graf, Fabrice. Drug resistance in Trypanosoma brucei : comparative genomics of melarsoprol-pentamidine cross-resistance and the role of aquaglyceroporin 2 in clinical resistance. 2015, Doctoral Thesis, University of Basel, Faculty of Science.

Graf, Fabrice E. and Baker, Nicola and Munday, Jane C. and de Koning, Harry P. and Horn, David and Mäser, Pascal. (2015) Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. International journal for parasitology. Drugs and drug resistance, Vol. 5, H. 2. pp. 65-68.

Hemberger, Yasmin and Zhang, Guoliang and Brun, Reto and Kaiser, Marcel and Bringmann, Gerhard. (2015) Highly antiplasmodial non-natural oxidative products of dioncophylline A: synthesis, absolute configuration, and conformational stability. Chemistry, a European journal, 21 (41). pp. 14507-14518.

Herrmann, Fabian C. and Lenz, Mairin and Jose, Joachim and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2015) In silico identification and in vitro activity of novel natural inhibitors of Trypanosoma brucei glyceraldehyde-3-phosphate-dehydrogenase. Molecules, Vol. 20, H. 9. pp. 16154-16169.

Inahashi, Yuki and Iwatsuki, Masato and Ishiyama, Aki and Matsumoto, Atsuko and Hirose, Tomoyasu and Oshita, Jun and Sunazuka, Toshiaki and Panbangred, Watanalai and Takahashi, Yoko and Kaiser, Marcel and Otoguro, Kazuhiko and O̅mura, Satoshi. (2015) Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, actinoallomurus fulvus MK10-036. Organic letters, Vol. 17, H. 4. pp. 864-867.

Jones, Amy J. and Kaiser, Marcel and Avery, Vicky M.. (2015) Identification and characterization of FTY720 for the treatment of human African trypanosomiasis. Antimicrobial agents and chemotherapy, 60 (3). pp. 1859-1861.

Jortzik, Esther and Zocher, Kathleen and Isernhagen, Antje and Mailu, Boniface M. and Rahlfs, Stefan and Viola, Giampietro and Wittlin, Sergio and Hunt, Nicholas H. and Ihmels, Heiko and Becker, Katja. (2015) Benzo[b]quinolizinium derivatives have a strong antimalarial activity and inhibit indoleamine dioxygenase. Antimicrobial agents and chemotherapy, 60 (1). pp. 115-125.

Kaiser, Marcel and Maes, Louis and Tadoori, Leela Pavan and Spangenberg, Thomas and Ioset, Jean-Robert. (2015) Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids. Journal of biomolecular screening, Vol. 20, H. 5. pp. 634-645.

Kaiser, Marcel and Mäser, Pascal and Tadoori, Leela Pavan and Ioset, Jean-Robert and Brun, Reto. (2015) Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning. PLoS ONE, Vol. 10, H. 8 , e0135556.

Kaur, G. and Singh, K. and Pavadai, E. and Njoroge, M. and Espinoza-Moraga, M. and de Kock, C. and Smith, P. J. and Wittlin, S. and Chibale, K.. (2015) Synthesis of fusidic acid bioisosteres as antiplasmodial agents and molecular docking studies in the binding site of elongation factor-G. MedChemComm, 6 (11). pp. 2023-2028.

Keller, Lena and Plaza, Alberto and Dubiella, Christian and Groll, Michael and Kaiser, Marcel and Müller, Rolf. (2015) Macyranones : structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome. The journal of the American Chemical Society, Vol. 137, H. 25. pp. 8121-8130.

Lakshminarayana, Suresh B. and Freymond, Céline and Fischli, Christoph and Yu, Jing and Weber, Sebastian and Goh, Anne and Yeung, Bryan K. S. and Ho, Paul C. and Dartois, Véronique and Diagana, Thierry T. and Rottmann, Matthias and Blasco, Francesca. (2015) Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 1200-1210.

Le Manach, Claire and Paquet, Tanya and Brunschwig, Christel and Njoroge, Mathew and Han, Ze and Gonzàlez Cabrera, Diego and Bashyam, Sridevi and Dhinakaran, Rajkumar and Taylor, Dale and Reader, Janette and Botha, Mariette and Churchyard, Alisje and Lauterbach, Sonja and Coetzer, Theresa L. and Birkholtz, Lyn-Marie and Meister, Stephan and Winzeler, Elizabeth A. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Jiménez-Díaz, María-Belén and Santos Martínez, María and Ferrer, Santiago and Angulo-Barturen, Iñigo and Street, Leslie J. and Chibale, Kelly. (2015) A novel pyrazolopyridine with in vivo activity in Plasmodium berghei- and Plasmodium falciparum-infected mouse models from structure-activity relationship studies around the core of recently identified antimalarial imidazopyridazines. Journal of medicinal chemistry, 58 (21). pp. 8713-8722.

Malmquist, Nicholas A. and Sundriyal, Sandeep and Caron, Joachim and Chen, Patty and Witkowski, Benoit and Menard, Didier and Suwanarusk, Rossarin and Renia, Laurent and Nosten, Francois and Jiménez-Díaz, María Belén and Angulo-Barturen, Iñigo and Martínez, María Santos and Ferrer, Santiago and Sanz, Laura M. and Gamo, Francisco-Javier and Wittlin, Sergio and Duffy, Sandra and Avery, Vicky M. and Ruecker, Andrea and Delves, Michael J. and Sinden, Robert E. and Fuchter, Matthew J. and Scherf, Artur. (2015) Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 950-959.

Manos-Turvey, A. and Watson, E. E. and Sykes, M. L. and Jones, A. J. and Baell, J. B. and Kaiser, M. and Avery, V. M. and Payne, R. J.. (2015) Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. MedChemComm, Vol. 6, H. 3. pp. 403-406.

Mital, Alka and Murugesan, Dinakaran and Kaiser, Marcel and Yeates, Clive and Gilbert, Ian H.. (2015) Discovery and optimisation studies of antimalarial phenotypic hits. European journal of medicinal chemistry, 103. pp. 530-538.

Montalvo-Quirós, Sandra and Taladriz-Sender, Andrea and Kaiser, Marcel and Dardonville, Christophe. (2015) Antiprotozoal activity and DNA binding of dicationic acridones. Journal of medicinal chemistry, 58 (4). pp. 1940-1949.

Montesino, Núria Llurba and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2015) Search for antiprotozoal activity in herbal medicinal preparations : new natural leads against neglected tropical diseases. Molecules, Vol. 20, H. 8. pp. 14118-14138.

Nollmann, Friederike I. and Dauth, Christina and Mulley, Geraldine and Kegler, Carsten and Kaiser, Marcel and Waterfield, Nick R. and Bode, Helge B.. (2015) Insect-specific production of new GameXPeptides in Photorhabdus luminescens TTO1, widespread natural products in entomopathogenic bacteria. ChemBioChem : a European journal of chemical biology, Vol. 16, H. 2. pp. 205-208.

Nollmann, Friederike I. and Heinrich, Antje K. and Brachmann, Alexander O. and Morisseau, Christophe and Mukherjee, Krishnendu and Casanova-Torres, Ángel M. and Strobl, Frederic and Kleinhans, David and Kinski, Sebastian and Schultz, Katharina and Beeton, Michael L. and Kaiser, Marcel and Chu, Ya-Yun and Phan Ke, Long and Thanwisai, Aunchalee and Bozhüyük, Kenan A. J. and Chantratita, Narisara and Götz, Friedrich and Waterfield, Nick R. and Vilcinskas, Andreas and Stelzer, Ernst H. K. and Goodrich-Blair, Heidi and Hammock, Bruce D. and Bode, Helge B.. (2015) A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. ChemBioChem, Vol. 16, H. 5. pp. 766-771.

Nwodo, Ngozi and Okoye, Festus and Lai, Daowan and Debbab, Abdesammed and Kaiser, Marcel and Brun, Reto and Proksch, Peter. (2015) Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves. BMC complementary and alternative medicine, Vol. 15 , 82.

Ongarora, Dennis S. B. and Strydom, Natasha and Wicht, Kathryn and Njoroge, Mathew and Wiesner, Lubbe and Egan, Timothy J. and Wittlin, Sergio and Jurva, Ulrik and Masimirembwa, Collen M. and Chibale, Kelly. (2015) Antimalarial benzoheterocyclic 4-aminoquinolines : structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies. Bioorganic & medicinal chemistry, 23 (17). pp. 5419-5432.

Papadopoulou, Maria V. and Bloomer, William D. and Lepesheva, Galina I. and Rosenzweig, Howard S. and Kaiser, Marcel and Aguilera-Venegas, Benjamín and Wilkinson, Shane R. and Chatelain, Eric and Ioset, Jean-Robert. (2015) Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. Journal of medicinal chemistry, 58 (3). pp. 1307-1319.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and O'Shea, Ivan P. and Wilkinson, Shane R. and Kaiser, Marcel. (2015) 3-Nitrotriazole-based piperazides as potent antitrypanosomal agents. European journal of medicinal chemistry, 103. pp. 325-334.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and O'Shea, Ivan P. and Wilkinson, Shane R. and Kaiser, Marcel and Chatelain, Eric and Ioset, Jean-Robert. (2015) Discovery of potent nitrotriazole-based antitrypanosomal agents : in vitro and in vivo evaluation. Bioorganic & medicinal chemistry, 23 (19). pp. 6467-6476.

Phillips, Margaret A. and Lotharius, Julie and Marsh, Kennan and White, John and Dayan, Anthony and White, Karen L. and Njoroge, Jacqueline W. and El Mazouni, Farah and Lao, Yanbin and Kokkonda, Sreekanth and Tomchick, Diana R. and Deng, Xiaoyi and Laird, Trevor and Bhatia, Sangeeta N. and March, Sandra and Ng, Caroline L. and Fidock, David A. and Wittlin, Sergio and Lafuente-Monasterio, Maria and Benito, Francisco Javier Gamo and Alonso, Laura Maria Sanz and Martinez, Maria Santos and Jimenez-Diaz, Maria Belen and Bazaga, Santiago Ferrer and Angulo-Barturen, Iñigo and Haselden, John N. and Louttit, James and Cui, Yi and Sridhar, Arun and Zeeman, Anna-Marie and Kocken, Clemens and Sauerwein, Robert and Dechering, Koen and Avery, Vicky M. and Duffy, Sandra and Delves, Michael and Sinden, Robert and Ruecker, Andrea and Wickham, Kristina S. and Rochford, Rosemary and Gahagen, Janet and Iyer, Lalitha and Riccio, Ed and Mirsalis, Jon and Bathhurst, Ian and Rueckle, Thomas and Ding, Xavier and Campo, Brice and Leroy, Didier and Rogers, M. John and Rathod, Pradipsinh K. and Burrows, Jeremy N. and Charman, Susan A.. (2015) A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Science translational medicine, Vol. 7, H. 296 , 296ra111.

Prati, Federica and Bergamini, Christian and Molina, Maria Teresa and Falchi, Federico and Cavalli, Andrea and Kaiser, Marcel and Brun, Reto and Fato, Romana and Bolognesi, Maria Laura. (2015) 2-Phenoxy-1,4-naphthoquinones : from a multitarget antitrypanosomal to a potential antitumor profile. Journal of medicinal chemistry, 58 (16). pp. 6422-6434.

Rahmani, Raphaël and Ban, Kung and Jones, Amy J. and Ferrins, Lori and Ganame, Danny and Sykes, Melissa L. and Avery, Vicky M. and White, Karen L. and Ryan, Eileen and Kaiser, Marcel and Charman, Susan A. and Baell, Jonathan B.. (2015) 6-Arylpyrazine-2-carboxamides : a new core for Trypanosoma brucei inhibitors. Journal of medicinal chemistry, 58 (17). pp. 6753-6765.

Rodenko, Boris and Wanner, Martin J. and Alkhaldi, Abdulsalam A. M. and Ebiloma, Godwin U. and Barnes, Rebecca L. and Kaiser, Marcel and Brun, Reto and McCulloch, Richard and Koomen, Gerrit-Jan and de Koning, Harry P.. (2015) Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy. Antimicrobial agents and chemotherapy, 59 (11). pp. 6708-6716.

Royo, Santiago and Rodríguez, Santiago and Schirmeister, Tanja and Kesselring, Jochen and Kaiser, Marcel and González, Florenci V.. (2015) Dipeptidyl enoates as potent rhodesain inhibitors that display a dual mode of action. ChemMedChem, 10 (9). pp. 1484-1487.

Rusman, Yudi and Held, Benjamin W. and Blanchette, Robert A. and Wittlin, Sergio and Salomon, Christine E.. (2015) Soudanones A-G : antifungal isochromanones from the ascomycetous fungus Cadophora sp. isolated from an iron mine. Journal of natural products, Vol. 78, H. 6. pp. 1456-1460.

Ríos Martínez, Carlos H. and Miller, Florence and Ganeshamoorthy, Kayathiri and Glacial, Fabienne and Kaiser, Marcel and de Koning, Harry P. and Eze, Anthonius A. and Lagartera, Laura and Herraiz, Tomás and Dardonville, Christophe. (2015) A new nonpolar n-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 890-904.

Seebacher, W. and Faist, J. and Belaj, F. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2015) Synthesis of new tetrahydropyridinylidene ammonium salts and their antprotozoal potency. Monatshefte für Chemie, 146 (8). pp. 1299-1308.

Seebacher, Werner and Wolkinger, Volker and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Bucar, Franz and Gröblacher, Barbara and Brantner, Adelheid and Merino, Virginia and Kalia, Yogeshvar and Scapozza, Leonardo and Perozzo, Remo and Weis, Robert. (2015) Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Bioorganic & medicinal chemistry letters, Vol. 25, H. 7. pp. 1390-1393.

Shaban, E. and Wicht, K. J. and Wang, N. and Mei, Z. W. and Hayashi, I. and El Gokha, A. A. A. and Kaiser, M. and El Sayed, I. E. and Egan, T. J. and Inokuchi, T.. (2015) Synthesis and antimalarial activity of some neocryptolepine analogues carrying a multifunctional linear and branched carbon-side chains. Heterocycles, Vol. 89, H. 4. pp. 1055-1064.

Shameer, Sanu and Logan-Klumpler, Flora J. and Vinson, Florence and Cottret, Ludovic and Merlet, Benjamin and Achcar, Fiona and Boshart, Michael and Berriman, Matthew and Breitling, Rainer and Bringaud, Frédéric and Bütikofer, Peter and Cattanach, Amy M. and Bannerman-Chukualim, Bridget and Creek, Darren J. and Crouch, Kathryn and de Koning, Harry P. and Denise, Hubert and Ebikeme, Charles and Fairlamb, Alan H. and Ferguson, Michael A. J. and Ginger, Michael L. and Hertz-Fowler, Christiane and Kerkhoven, Eduard J. and Mäser, Pascal and Michels, Paul A. M. and Nayak, Archana and Nes, David W. and Nolan, Derek P. and Olsen, Christian and Silva-Franco, Fatima and Smith, Terry K. and Taylor, Martin C. and Tielens, Aloysius G. M. and Urbaniak, Michael D. and van Hellemond, Jaap J. and Vincent, Isabel M. and Wilkinson, Shane R. and Wyllie, Susan and Opperdoes, Fred R. and Barrett, Michael P. and Jourdan, Fabien. (2015) TrypanoCyc : a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43 (D1). D637-D644.

Steinmann, Michael E. and González-Salgado, Amaia and Bütikofer, Peter and Mäser, Pascal and Sigel, Erwin. (2015) A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes. The FASEB journal, Vol. 29, H. 8. pp. 3228-3237.

Tasdemir, Deniz and Tierney, Michelle and Sen, Rupashree and Bergonzi, Maria Camilla and Demirci, Betül and Bilia, Anna Rita and Baser, Kemal Hüsnü Can and Brun, Reto and Chatterjee, Mitali. (2015) Antiprotozoal effect of Artemisia indica extracts and essential oil. Planta medica, 81 (12-13). pp. 1029-1037.

Thao, Nguyen Phuong and Luyen, Bui Thi Thuy and Brun, Reto and Kaiser, Marcel and Van Kiem, Phan and Van Minh, Chau and Schmidt, Thomas J. and Kang, Jong Seong and Kim, Young Ho. (2015) Anti-protozoal activities of cembrane-type diterpenes from Vietnamese soft corals. Molecules, Vol. 20, H. 7. pp. 12459-12468.

Thuita, John K. and Wolf, Kristina K. and Murilla, Grace A. and Bridges, Arlene S. and Boykin, David W. and Mutuku, James N. and Liu, Qiang and Jones, Susan K. and Gem, Charles O. and Ching, Shelley and Tidwell, Richard R. and Wang, Michael Z. and Paine, Mary F. and Brun, Reto. (2015) Chemotherapy of second stage human African trypanosomiasis : comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys. PLoS neglected tropical diseases, Vol. 9, H. 2 , e3409.

Wang, X. and Dong, Y. and Cal, M. and Kasier, M. and Wittling, S. and Vennerstrom, J. L.. (2015) Antiprotozoal selectivity of diimidazoline N-phenylbenzamides. ACS infectious diseases, 1. pp. 135-139.

Witschel, Matthias C. and Rottmann, Matthias and Schwab, Anatol and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Seet, Michael and Tonazzi, Sandro and Schwertz, Geoffrey and Stelzer, Frank and Mietzner, Thomas and McNamara, Case and Thater, Frank and Freymond, Céline and Jaruwat, Aritsara and Pinthong, Chatchadaporn and Riangrungroj, Pinpunya and Oufir, Mouhssin and Hamburger, Matthias and Mäser, Pascal and Sanz-Alonso, Laura M. and Charman, Susan and Wittlin, Sergio and Yuthavong, Yongyuth and Chaiyen, Pimchai and Diederich, François. (2015) Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) : co-crystal structures of pyrazolopyrans with potent blood-and liver-stage activities. Journal of Medicinal Chemistry, 58 (7). pp. 3117-3130.

de Macêdo, Juan P. and Schumann Burkard, Gabriela and Niemann, Moritz and Barrett, Michael P. and Vial, Henri and Mäser, Pascal and Roditi, Isabel and Schneider, André and Bütikofer, Peter. (2015) An atypical mitochondrial carrier that mediates drug action in Trypanosoma brucei. PLoS Pathogens, Vol. 11, H. 5 , e1004875.

2014

Althaus, Julia B. and Jerz, Gerold and Winterhalter, Peter and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2014) Antiprotozoal activity of Buxus sempervirens and activity-guided isolation of O-tigloylcyclovirobuxeine-B as the main constituent active against Plasmodium falciparum. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 19, H. 5. pp. 6184-6201.

Althaus, Julia B. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2014) Antiprotozoal activity of achillea ptarmica (Asteraceae) and its main alkamide constituents. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 19, H. 5. pp. 6428-6438.

Bapela, M. Johanna and Meyer, J. J. Marion and Kaiser, Marcel. (2014) In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 156. pp. 370-373.

Belluti, Federica and Uliassi, Elisa and Veronesi, Giacomo and Bergamini, Christian and Kaiser, Marcel and Brun, Reto and Viola, Angelo and Fato, Romana and Michels, Paul A. M. and Krauth-Siegel, R. Luise and Cavalli, Andrea and Bolognesi, Maria Laura. (2014) Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi. ChemMedChem : chemistry enabling drug discovery, Vol. 9, H. 2. pp. 371-382.

Burri, C. and Chappuis, F. and Brun, R.. (2014) Human African trypanosomiasis. In: Manson's Tropical Diseases. - 23rd ed.. [Edinburgh], pp. 606-621.

Carballeira, Néstor M. and Bwalya, Angela Gono and Itoe, Maurice Ayamba and Andricopulo, Adriano D. and Cordero-Maldonado, María Lorena and Kaiser, Marcel and Mota, Maria M. and Crawford, Alexander D. and Guido, Rafael V. C. and Tasdemir, Deniz. (2014) 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes. Bioorganic & medicinal chemistry letters, Vol. 24, H. 17. pp. 4151-4157.

Carvalho, Samir Aquino and Kaiser, Marcel and Brun, Reto and Silva, Edson Ferreira da and Fraga, Carlos Alberto Manssour. (2014) Antiprotozoal activity of (e)-cinnamic N-acylhydrazone derivatives. Molecules, Vol. 19, H. 12. pp. 20374-20381.

Cretton, Sylvian and Breant, Lise and Pourrez, Lucie and Ambuehl, Chiara and Marcourt, Laurence and Ebrahimi, Samad Nejad and Hamburger, Matthias and Perozzo, Remo and Karimou, Soumana and Kaiser, Marcel and Cuendet, Muriel and Christen, Philippe. (2014) Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica. Journal of natural products, Vol. 77, H. 10. pp. 2304-2311.

D. A. Silva, Cristiane França and Batista, Denise DA Gama Jaen and Batista, Marcos Meuser and Lionel, Jessica and Hammer, Erica Ripoll and Brun, Reto and Soeiro, Maria DE Nazaré Correia. (2014) In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi. Parasitology, Vol. 141, H. 3. pp. 367-373.

Dandapani, S. and Germain, A. R. and Jewett, I. and Le Quement, S. and Marie, JC. and Muncipinto, G. and Duvall, J. R. and Carmody, L. C. and Perez, J. R. and Engel, J. C. and Gut, J. and Kellar, D. and Siqueira-Neto, J. L. and McKerrow, J. H. and Kaiser, M. and Rodriquez, A. and Palmer, M. A. and Foley, M. and Schreiber, S. L. and Munoz, B.. (2014) Diversity-oriented synthesis yields a new drug lead for treatment of Chagas disease. ACS medicinal chemistry letters, Vol. 5, H. 2. pp. 149-153.

Dong, Yuxiang and Wang, Xiaofang and Cal, Monica and Kaiser, Marcel and Vennerstrom, Jonathan L.. (2014) Activity of diimidazoline amides against African trypanosomiasis. Bioorganic & medicinal chemistry letters, Vol. 24, H. 3. pp. 944-948.

Ferrins, Lori and Gazdik, Michelle and Rahmani, Raphaël and Varghese, Swapna and Sykes, Melissa L. and Jones, Amy J. and Avery, Vicky M. and White, Karen L. and Ryan, Eileen and Charman, Susan A. and Kaiser, Marcel and Bergström, Christel A. S. and Baell, Jonathan B.. (2014) Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei. Journal of medicinal chemistry, 57 (15). pp. 6393-6402.

Fuchs, Sebastian W. and Grundmann, Florian and Kurz, Michael and Kaiser, Marcel and Bode, Helge B.. (2014) Fabclavines : bioactive peptide-polyketide-polyamino hybrids from Xenorhabdus. ChemBioChem : a European journal of chemical biology, Vol. 15, H. 4. pp. 512-516.

Fügi, Matthias. Membrane therapy for chagas' disease. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Fügi, Matthias A. and Gunasekera, Kapila and Ochsenreiter, Torsten and Guan, Xueli and Wenk, Markus R. and Mäser, Pascal. (2014) Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack. Journal of Lipid Research, 55 (5). pp. 929-938.

Fügi, Matthias A. and Kaiser, Marcel and Tanner, Marcel and Schneiter, Roger and Mäser, Pascal and Guan, Xue Li. (2014) Match-making for posaconazole through systems thinking. Trends in parasitology, Vol. 31, H. 2. pp. 46-51.

Giordani, Federica and Buschini, Annamaria and Baliani, Alessandro and Kaiser, Marcel and Brun, Reto and Barrett, Michael P. and Pellacani, Claudia and Poli, Paola and Gilbert, Ian H.. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 58, H. 10. pp. 5747-5757.

González Cabrera, Diego and Le Manach, Claire and Douelle, Frederic and Younis, Yassir and Feng, Tzu-Shean and Paquet, Tanya and Nchinda, Aloysius T. and Street, Leslie J. and Taylor, Dale and de Kock, Carmen and Wiesner, Lubbe and Duffy, Sandra and White, Karen L. and Zabiulla, K. Mohammed and Sambandan, Yuvaraj and Bashyam, Sridevi and Waterson, David and Witty, Michael J. and Charman, Susan A. and Avery, Vicky M. and Wittlin, Sergio and Chibale, Kelly. (2014) 2,4-diaminothienopyrimidines as orally active antimalarial agents. Journal of medicinal chemistry, 57 (3). pp. 1014-1022.

Grundmann, Florian and Kaiser, Marcel and Schiell, Matthias and Batzer, Andreas and Kurz, Michael and Thanwisai, Aunchalee and Chantratita, Narisara and Bode, Helge B.. (2014) Antiparasitic chaiyaphumines from Entomopathogenic xenorhabdus sp. PB61.4. Journal of natural products, Vol. 77, H. 4. pp. 779-783.

Hanna, J. N. and Ntie-Kang, F. and Kaiser, M. and Brun, R. and Efange, S. M. N.. (2014) 1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials : synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation. RSC advances, Vol. 4, H. 44 ,22856-22865.

Harms, Henrik and Rempel, Viktor and Kehraus, Stefan and Kaiser, Marcel and Hufendiek, Peter and Müller, Christa E. and König, Gabriele M.. (2014) Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors. Journal of natural products, Vol. 77, H. 3. pp. 673-677.

Hata, Y. and De Mieri, M. and Ebrahimi, S. N. and Mokoka, T. and Fouche, G. and Kaiser, M. and Brun, R. and Potterat, O. and Hamburger, M.. (2014) Identification of two new phenathrenones and a saponin as antiprotozoal constituents of Drypetes gerrardii. Phytochemistry letters, Vol. 10. pp. 133-140.

Hata, Yoshie and Ebrahimi, Samad Nejad and De Mieri, Maria and Zimmermann, Stefanie and Mokoka, Tsholofelo and Naidoo, Dashnie and Fouche, Gerda and Maharaj, Vinesh and Kaiser, Marcel and Brun, Reto and Potterat, Olivier and Hamburger, Matthias. (2014) Antitrypanosomal isoflavan quinones from Abrus precatorius. Fitoterapia, Vol. 93. pp. 81-87.

Julianti, Tasqiah and De Mieri, Maria and Zimmermann, Stefanie and Ebrahimi, Samad N. and Kaiser, Marcel and Neuburger, Markus and Raith, Melanie and Brun, Reto and Hamburger, Matthias. (2014) HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L. Journal of ethnopharmacology, Vol. 155, H. 1. pp. 426-434.

Kronenwerth, M. and Dauth, C. and Kaiser, M. and Pemberton, I. and Bode, H. B.. (2014) Facile synthesis of cyclohexanediones and dialkylresorcinols : bioactive natural products from entomopathogenic bacteria. European journal of organic chemistry, H. 36. pp. 8026-8028.

Kronenwerth, Max and Bozhüyük, Kenan A. J. and Kahnt, Astrid S. and Steinhilber, Dieter and Gaudriault, Sophie and Kaiser, Marcel and Bode, Helge B.. (2014) Characterisation of taxlllaids A-G : natural products from Xenorhabdus indica. Chemistry : a European journal, Vol. 20, H. 52. pp. 17478-17487.

Kronenwerth, Max and Brachmann, Alexander O. and Kaiser, Marcel and Bode, Helge B.. (2014) Bioactive derivatives of isopropylstilbene from mutasynthesis and chemical synthesis. ChemBioChem : a European journal of chemical biology, Vol. 15, H. 18. pp. 2689-2691.

Kuhen, Kelli L. and Chatterjee, Arnab K. and Rottmann, Matthias and Gagaring, Kerstin and Borboa, Rachel and Buenviaje, Jennifer and Chen, Zhong and Francek, Carolyn and Wu, Tao and Nagle, Advait and Barnes, S. Whitney and Plouffe, David and Lee, Marcus C. S. and Fidock, David A. and Graumans, Wouter and van de Vegte-Bolmer, Marga and van Gemert, Geert J. and Wirjanata, Grennady and Sebayang, Boni and Marfurt, Jutta and Russell, Bruce and Suwanarusk, Rossarin and Price, Ric N. and Nosten, Francois and Tungtaeng, Anchalee and Gettayacamin, Montip and Sattabongkot, Jetsumon and Taylor, Jennifer and Walker, John R. and Tully, David and Patra, Kailash P. and Flannery, Erika L. and Vinetz, Joseph M. and Renia, Laurent and Sauerwein, Robert W. and Winzeler, Elizabeth A. and Glynne, Richard J. and Diagana, Thierry T.. (2014) KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrobial agents and chemotherapy, Vol. 58, H. 9. pp. 5060-5067.

Kunfermann, Andrea and Witschel, Matthias and Illarionov, Boris and Martin, René and Rottmann, Matthias and Höffken, H. Wolfgang and Seet, Michael and Eisenreich, Wolfgang and Knölker, Hans-Joachim and Fischer, Markus and Bacher, Adelbert and Groll, Michael and Diederich, François. (2014) Pseudilins : halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD. Angewandte Chemie. International edition in English, Vol. 53, H. 8. pp. 2235-2239.

Le Manach, Claire and Gonzàlez Cabrera, Diego and Douelle, Frederic and Nchinda, Aloysius T. and Younis, Yassir and Taylor, Dale and Wiesner, Lubbe and White, Karen L. and Ryan, Eileen and March, Corinne and Duffy, Sandra and Avery, Vicky M. and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Charman, Susan A. and Street, Leslie J. and Chibale, Kelly. (2014) Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library : part 1. Journal of medicinal chemistry, 57 (6). pp. 2789-2798.

Le Manach, Claire and Paquet, Tanya and Gonzàlez Cabrera, Diego and Younis, Yassir and Taylor, Dale and Wiesner, Lubbe and Lawrence, Nina and Schwager, Sylva and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Street, Leslie J. and Chibale, Kelly. (2014) Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library : part 2. Journal of medicinal chemistry, 57 (21). pp. 8839-8848.

Leven, Michael and Held, Jana and Duffy, Sandra and Tschan, Serena and Sax, Sibylle and Kamber, Jolanda and Frank, Walter and Kuna, Krystina and Geffken, Detlef and Siethoff, Christoph and Barth, Stéphane and Avery, Vicky M. and Wittlin, Sergio and Mordmüller, Benjamin and Kurz, Thomas. (2014) Blood schizontocidal and gametocytocidal activity of 3-hydroxy-N'-arylidenepropanehydrazonamides. Journal of medicinal chemistry, 57 (19). pp. 7971-7976.

Liu, Zong-Ying and Wenzler, Tanja and Brun, Reto and Zhu, Xiaohua and Boykin, David W.. (2014) Synthesis and antiparasitic activity of new bis-arylimidamides : DB766 analogs modified in the terminal groups. European journal of medicinal chemistry, 83. pp. 167-173.

Lüscher, Alexandra and Lamprea-Burgunder, Estelle and Graf, Fabrice E. and de Koning, Harry P. and Mäser, Pascal. (2014) Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity. International journal for parasitology : drugs and drug resistance, Vol. 4, H. 1. pp. 55-63.

Mathieu, Christoph and Salgado, Amaia González and Wirdnam, Corina and Meier, Stefan and Grotemeyer, Marianne Suter and Inbar, Ehud and Mäser, Pascal and Zilberstein, Dan and Sigel, Erwin and Bütikofer, Peter and Rentsch, Doris. (2014) Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids. Biochemical journal, Vol. 463, Pt. 1. pp. 9-18.

Mizukawa, Yuki and Ge, Jian-Feng and Bakar Md, Abu and Itoh, Isamu and Scheurer, Christian and Wittlin, Sergio and Brun, Reto and Matsuoka, Hiroyuki and Ihara, Masataka. (2014) Novel synthetic route for antimalarial benzo[a]phenoxazine derivative SSJ-183 and two active metabolites. Bioorganic & medicinal chemistry, 22 (14). pp. 3749-3752.

Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Belaj, F. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2014) Synthesis of antiprotozoal diamines by regioselective insertion of nitrogen into a bicyclic ring system. Monatshefte für Chemie, Vol. 145, H. 8. pp. 1319-1327.

Mokoka, Tsholofelo A. and Peter, Xolani K. and Fouche, Gerda and Moodley, Nivan and Adams, Michael and Hamburger, Matthias and Kaiser, Marcel and Brun, Reto and Maharaj, Vinesh and Koorbanally, Neil. (2014) Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Buch. ex Benth. (Lamiaceae). South African journal of botany, Vol. 90. pp. 93-95.

Munday, Jane C. and Eze, Anthonius A. and Baker, Nicola and Glover, Lucy and Clucas, Caroline and Aguinaga Andrés, David and Natto, Manal J. and Teka, Ibrahim A. and McDonald, Jennifer and Lee, Rebecca S. and Graf, Fabrice E. and Ludin, Philipp and Burchmore, Richard J. S. and Turner, C. Michael R. and Tait, Andy and MacLeod, Annette and Mäser, Pascal and Barrett, Michael P. and Horn, David and De Koning, Harry P.. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. The journal of antimicrobial chemotherapy, Vol. 69, H. 3. pp. 651-663.

Ngamgwe, R. F. and Yankam, R. and Chouna, J. R. and Lanz, C. and Furrer, J. and Schürch, S. and Kaiser, M. and Lenta, B. N. and Ngouela, S. and Tsamo, E. and Brenneisen, R.. (2014) Procerenone: a Fatty Acid Triterpenoid from the Fruit Pericarp of Omphalocarpum procerum (Sapotaceae). Iranian Journal of Pharmaceutical Research, 13 (4). pp. 1425-1430.

Nwodo, Ngozi Justina and Okoye, Festus Basden C. and Lai, Daowan and Debbab, Abdessamad and Brun, Reto and Proksch, Peter. (2014) Two trypanocidal dipeptides from the roots of Zapoteca portoricensis (Fabaceae). Molecules, Vol. 19, H. 5. pp. 5470-5477.

Orhan, Ilkay Erdogan and Sener, Bilge and Kaiser, Marcel and Brun, Reto and Tasdemir, Deniz. (2014) Antiprotozoal activity and cytotoxicity of Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus extracts. Turkish journal of biochemistry, Vol. 38, H. 4. pp. 403-408.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Wilkinson, Shane R. and Kaiser, Marcel. (2014) Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents. European journal of medicinal chemistry, 87. pp. 79-88.

Patrick, Donald A. and Bakunov, Stanislav A. and Bakunova, Svetlana M. and Wenzler, Tanja and Brun, Reto and Tidwell, Richard R.. (2014) Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues. Bioorganic & medicinal chemistry, 22 (1). pp. 559-576.

Persch, Elke and Bryson, Steve and Todoroff, Nickolay K. and Eberle, Christian and Thelemann, Jonas and Dirdjaja, Natalie and Kaiser, Marcel and Weber, Maria and Derbani, Hassan and Brun, Reto and Schneider, Gisbert and Pai, Emil F. and Krauth-Siegel, R. Luise and Diederich, François. (2014) Binding to large enzyme pockets : small-molecule inhibitors of trypanothione reductase. ChemMedChem, Vol. 9, H. 8. pp. 1880-1891.

Portmann, Cyril and Sieber, Simon and Wirthensohn, Silvan and Blom, Judith F. and Da Silva, Laeticia and Baudat, Emilie and Kaiser, Marcel and Brun, Reto and Gademann, Karl. (2014) Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251. Journal of natural products, Vol. 77, H. 3. pp. 557-562.

Reimer, Daniela and Nollmann, Friederike I. and Schultz, Katharina and Kaiser, Marcel and Bode, Helge B.. (2014) Xenortide biosynthesis by entomopathogenic xenorhabdus nematophila. Journal of natural products, 77 (8). pp. 1976-1980.

Reker, Daniel and Seet, Michael and Pillong, Max and Koch, Christian P. and Schneider, Petra and Witschel, Matthias C. and Rottmann, Matthias and Freymond, Céline and Brun, Reto and Schweizer, Bernd and Illarionov, Boris and Bacher, Adelbert and Fischer, Markus and Diederich, François and Schneider, Gisbert. (2014) Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. Angewandte Chemie, Jg. 53, Nr. 27. pp. 7079-7084.

Ríos Martínez, Carlos H. and Lagartera, Laura and Kaiser, Marcel and Dardonville, Christophe. (2014) Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines. European journal of medicinal chemistry, 81. pp. 481-491.

Schmidt, Thomas J. and Da Costa, Fernando B. and Lopes, Norberto P. and Kaiser, Marcel and Brun, Reto. (2014) In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense. Antimicrobial agents and chemotherapy, Vol. 58, H. 1. pp. 325-332.

Sistrom, Mark and Evans, Benjamin and Bjornson, Robert and Gibson, Wendy and Balmer, Oliver and Mäser, Pascal and Aksoy, Serap and Caccone, Adalgisa. (2014) Comparative genomics reveals multiple genetic backgrounds of human pathogenicity in the Trypanosoma brucei complex. Genome biology and evolution, Vol. 6, H. 10. pp. 2811-2819.

Tatipaka, Hari Babu and Gillespie, J. Robert and Chatterjee, Arnab K. and Norcross, Neil R. and Hulverson, Matthew A. and Ranade, Ranae M. and Nagendar, Pendem and Creason, Sharon A. and McQueen, Joshua and Duster, Nicole A. and Nagle, Advait and Supek, Frantisek and Molteni, Valentina and Wenzler, Tanja and Brun, Reto and Glynne, Richard and Buckner, Frederick S. and Gelb, Michael H.. (2014) Substituted 2-phenylimidazopyridines : a new class of drug leads for human African trypanosomiasis. Journal of medicinal chemistry, 57 (3). pp. 828-835.

Urbán, Patricia and Valle-Delgado, Juan José and Mauro, Nicolò and Marques, Joana and Manfredi, Amedea and Rottmann, Matthias and Ranucci, Elisabetta and Ferruti, Paolo and Fernàndez-Busquets, Xavier. (2014) Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium. Journal of controlled release : official journal of the Controlled Release Society, Vol. 177. pp. 84-95.

Usuki, Toyonobu and Sato, Makiko and Hara, Shihori and Yoshimoto, Yukiko and Kondo, Ryosuke and Zimmermann, Stefanie and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2014) Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives. Bioorganic & medicinal chemistry letters, Vol. 24, H. 3. pp. 794-798.

Wang, Jiayi and Kaiser, Marcel and Copp, Brent R.. (2014) Investigation of indolglyoxamide and indolacetamide analogues of polyamines as antimalarial and antitrypanosomal agents. Marine drugs, Vol. 12, H. 6. pp. 3138-3160.

Wang, N. and Wicht, K. J. and Shaban, E. and Ngoc, T. A. and Wang, M. Q. and Hayashi, I. and Hossain, M. I. and Takemasa, Y. and Kaiser, M. and El Sayed, I. E. T. and Egan, T. J. and Inokuchi, T.. (2014) Synthesis and evaluation of artesunate-indoloquinoline hybrids as antimalarial drug candidates. MedChemComm : Medicinal chemistry communications, Vol. 5, H. 7. pp. 927-931.

Wang, Ning and Wicht, Kathryn J. and Imai, Kento and Wang, Ming-Qi and Anh Ngoc, Tran and Kiguchi, Ryo and Kaiser, Marcel and Egan, Timothy J. and Inokuchi, Tsutomu. (2014) Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues : SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11. Bioorganic & medicinal chemistry, 22 (9). pp. 2629-2642.

Wang, Tai and Bisson, William H. and Mäser, Pascal and Scapozza, Leonardo and Picard, Didier. (2014) Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors. Journal of medicinal chemistry, 57 (6). pp. 2524-2535.

Weis, R. and Seebacher, W. and Brun, R. and Kaiser, M. and Saf, R. and Faist, J.. (2014) 4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity. Monatshefte für Chemie, Vol. 145, H. 2. pp. 311-317.

Wenzler, Tanja and Yang, Sihyung and Patrick, Donald A. and Braissant, Olivier and Ismail, Mohamed A. and Tidwell, Richard R. and Boykin, David W. and Wang, Michael Zhuo and Brun, Reto. (2014) In vitro and In vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness. Antimicrobial agents and chemotherapy, Vol. 58, H. 8. pp. 4452-4463.

Wube, Abraham and Hüfner, Antje and Seebacher, Werner and Kaiser, Marcel and Brun, Reto and Bauer, Rudolf and Bucar, Franz. (2014) 1,2-substituted 4-(1H)-quinolones : synthesis, antimalarial and antitrypanosomal activities in vitro. Molecules, Vol. 19, H. 9. pp. 14204-14220.

Yang, Sihyung and Wenzler, Tanja and Miller, Patrik N. and Wu, Huali and Boykin, David W. and Brun, Reto and Wang, Michael Zhuo. (2014) Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 58, H. 7. pp. 4064-4074.

Zimmermann, S. and Fouche, G. and de Mieri, M. and Yoshimoto, Y. and Usuki, R. and Nthambeleni, R. and van der Westhuyzen, C. and Kaiser, M. and Hamburger, M. and Adams, M.. (2014) Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products. Molecules, 19 (3). pp. 3523-3538.

de Meijere, Armin and Kozhushkov, Sergei I. and Yufit, Dmitrii S. and Grosse, Christian and Kaiser, Marcel and Raev, Vitaly A.. (2014) (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues. Beilstein journal of organic chemistry, Vol. 10. pp. 2844-2857.

2013

Abiodun, Oyindamola O. and Brun, Reto and Wittlin, Sergio. (2013) In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains. Malaria journal, Vol. 12 , 43.

Ali, J. A. M. and Creek, D. J. and Burgess, K. and Allison, H. C. and Field, M. C. and Mäser, P. and de Koning, H. P.. (2013) Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines. Molecular pharmacology : an international journal, Vol. 83, H. 2. pp. 439-453.

Aureggi, V. and Ehmke, V. and Wieland, J. and Schweizer, W. B. and Bernet, B. and Bur, D. and Meyer, S. and Rottmann, M. and Freymond, C. and Brun, R. and Breit, B. and Diederich, F.. (2013) Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes. Chemistry : a European journal, Vol. 19, H. 1. pp. 155-164.

Baker, Nicola and de Koning, Harry P. and Mäser, Pascal and Horn, David. (2013) Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. Trends in parasitology, Vol. 29, H. 3. pp. 110-118.

Balmer, Oliver and Pfiffner, Lukas and Schied, Johannes and Willareth, Martin and Leimgruber, Andrea and Luka, Henryk and Traugott, Michael. (2013) Noncrop flowering plants restore top-down herbivore control in agricultural fields. Ecology and Evolution, 3 (8). pp. 2634-2646.

Belluti, Federica and Perozzo, Remo and Lauciello, Leonardo and Colizzi, Francesco and Kostrewa, Dirk and Bisi, Alessandra and Gobbi, Silvia and Rampa, Angela and Bolognesi, Maria Laura and Recanatini, Maurizio and Brun, Reto and Scapozza, Leonardo and Cavalli, Andrea. (2013) Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). Journal of medicinal chemistry, 56 (19). pp. 7516-7526.

Belz, Elodie and Kölliker, Mathias and Balmer, Oliver. (2013) Olfactory attractiveness of flowering plants to the parasitoid Microplitis mediator: potential implications for biological control. BioControl, 58 (2). pp. 163-173.

Bringmann, G. and Zhang, G. and Büttner, T. and Bauckmann, G. and Kupfer, T. and Braunschweig, H. and Brun, R. and Mudogo, V.. (2013) Jozimine A2 : the first dimeric dioncophyllaceae-type naphthylisoquinoline alkaloid, with three chiral axes and high antiplasmodial activity. Chemistry : a European journal, Vol. 19, H. 3. pp. 916-923.

Bringmann, Gerhard and Lombe, Blaise Kimbadi and Steinert, Claudia and Ioset, Karine Ndjoko and Brun, Reto and Turini, Florian and Heubl, Günther and Mudogo, Virima. (2013) Mbandakamines A and B, unsymmetrically coupled dimeric naphthylisoquinoline alkaloids, from a Congolese ancistrocladus species. Organic letters, Vol. 15, H. 11. pp. 2590-2593.

Bringmann, Gerhard and Zhang, Guoliang and Olschläger, Tobias and Stich, August and Wu, Jun and Chatterjee, Manik and Brun, Reto. (2013) Highly selective antiplasmodial naphthylisoquinoline alkaloids from Ancistrocladus tectorius. Phytochemistry : an international journal of plant biochemistry, Vol. 91. pp. 220-228.

Brunner, R. and Ng, C. L. and Aissaoui, H. and Akabas, M. H. and Boss, C. and Brun, R. and Callaghan, P. S. and Corminboeuf, O. and Fidock, D. A. and Frame, I. J. and Heidmann, B. and Le Bihan, A. and Jeno, P. and Mattheis, C. and Moes, S. and Muller, I. B. and Paguio, M. and Roepe, P. D. and Siegrist, R. and Voss, Till S. and Welford, R. W. and Wittlin, S. and Binkert, C.. (2013) UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. Journal of biological chemistry, Vol. 288, H. 31. pp. 22576-22583.

Bruno, M. and Trucchi, B. and Monti, D. and Romeo, S. and Kaiser, M. and Verotta, L.. (2013) Synthesis of a potent antimalarial agent through natural products conjugation. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 2. pp. 221-225.

Chianese, Giuseppina and Scala, Fernando and Calcinai, Barbara and Cerrano, Carlo and Dien, Henny A. and Kaiser, Marcel and Tasdemir, Deniz and Taglialatela-Scafati, Orazio. (2013) Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity. Marine drugs, Vol. 11, H. 9. pp. 3297-3308.

Ciana, C. L. and Siegrist, R. and Aissaoui, H. and Marx, L. and Racine, S. and Meyer, S. and Binkert, C. and de Kanter, R. and Fischli, C. and Wittlin, S. and Boss, C.. (2013) Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 3. pp. 658-662.

Dürüst, Y. and Altug, C. and Kaiser, M. and Fronczek, F. R. and Tasdemir, D.. (2013) Synthesis, crystal structure, and in vitro antiprotozoal activity of some 5-phenyl(methyl)sulfonyl-substituted dihydroisoxazoles. Monatshefte für Chemie, Vol. 144, H. 5. pp. 707-716.

Ebrahimi, Samad N. and Zimmermann, Stefanie and Zaugg, Janine and Smiesko, Martin and Brun, Reto and Hamburger, Matthias. (2013) Abietane Diterpenoids from Salvia sahendica - Antiprotozoal Activity and Determination of Their Absolute Configurations. Planta medica, Vol. 79, H. 2. pp. 150-156.

Ehmke, Veronika and Winkler, Edwin and Banner, David W. and Haap, Wolfgang and Schweizer, W. Bernd and Rottmann, Matthias and Kaiser, Marcel and Freymond, Céline and Schirmeister, Tanja and Diederich, François. (2013) Optimization of triazine nitriles as rhodesain inhibitors : structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 6. pp. 967-975.

Endeshaw, Molla and Zhu, Xiaohua and He, Shanshan and Pandharkar, Trupti and Cason, Emily and Mahasenan, Kiran V. and Agarwal, Hitesh and Li, Chenglong and Munde, Manoj and Wilson, W. David and Bahar, Mark and Doskotch, Raymond W. and Kinghorn, A. Douglas and Kaiser, Marcel and Brun, Reto and Drew, Mark E. and Werbovetz, Karl A.. (2013) 8,8-dialkyldihydroberberines with potent antiprotozoal activity. Journal of natural products, Vol. 76, H. 3. pp. 311-315.

Faist, Johanna and Seebacher, Werner and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2013) Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 21 (17). pp. 4988-4996.

Farimani, Mahdi Moridi and Ebrahimi, Samad Nejad and Salehi, Peyman and Bahadori, Mir Babak and Sonboli, Ali and Khavasi, Hamid Reza and Zimmermann, Stefanie and Kaiser, Marcel and Hamburger, Matthias. (2013) Antitrypanosomal Triterpenoid with an ε-Lactone E-Ring from Salvia urmiensis. Journal of natural products, 76 (9). pp. 1806-1809.

Ferrins, Lori and Rahmani, Raphaël and Sykes, Melissa L. and Jones, Amy J. and Avery, Vicky M. and Teston, Eliott and Almohaywi, Basmah and Yin, Jiexiang and Smith, Jason and Hyland, Chris and White, Karen L. and Ryan, Eileen and Campbell, Michael and Charman, Susan A. and Kaiser, Marcel and Baell, Jonathan B.. (2013) 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis. European journal of medicinal chemistry, 66. pp. 450-465.

Friggeri, L. and Scipione, L. and Costi, R. and Kaiser, M. and Moraca, F. and Zamperini, C. and Botta, B. and Di Santo, R. and De Vita, D. and Brun, R. and Tortorella, S.. (2013) New promising compounds with in vitro nanomolar activity against Trypanosoma cruzi. ACS medicinal chemistry letters, Vol. 4, H. 6. pp. 538-541.

Gallé, Jean-Baptiste and Attioua, Barthélémy and Kaiser, Marcel and Rusig, Anne-Marie and Lobstein, Annelise and Vonthron-Sénécheau, Catherine. (2013) Eleganolone, a diterpene from the french marine alga Bifurcaria bifurcata inhibits growth of the human pathogens Trypanosoma brucei and Plasmodium falciparum. Marine drugs, Vol. 11, H. 3. pp. 599-610.

Graf, Fabrice E. and Ludin, Philipp and Wenzler, Tanja and Kaiser, Marcel and Brun, Reto and Pyana, Patient Pati and Büscher, Philippe and de Koning, Harry P. and Horn, David and Mäser, Pascal. (2013) Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. PLoS neglected tropical diseases, Vol. 7, H. 10 , e2475.

Greganova, Eva and Steinmann, Michael and Mäser, Pascal and Fankhauser, Niklaus. (2013) In silico ionomics segregates parasitic from free-living eukaryotes. Genome biology and evolution, Vol. 5, H. 10. pp. 1902-1909.

Grundmann, F. and Kaiser, M. and Kurz, M. and Schiell, M. and Batzer, A. and Bode, H. B.. (2013) Structure determination of the bioactive depsipeptide xenobactin from Xenorhabdus sp. PB30.3. RSC advances, Vol. 3, H. 44. pp. 22072-22077.

Géneau, Celine and Wäckers, Felix and Luka, Henryk and Balmer, Oliver. (2013) Effects of extrafloral and floral nectar of Centaurea cyanus on the parasitoid wasp Microplitis mediator : olfactory attractiveness and parasitization rates. Biological control, Vol. 66, H. 1. pp. 16-20.

Hampton, Shahienaz E. and Schipani, Alessandro and Bosch-Navarrete, Cristina and Recio, Eliseo and Kaiser, Marcel and Kahnberg, Pia and González-Pacanowska, Dolores and Johansson, Nils Gunnar and Gilbert, Ian H.. (2013) Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase. Bioorganic & medicinal chemistry, 21 (18). pp. 5876-5885.

Hao, Hong-Dong and Wittlin, Sergio and Wu, Yikang. (2013) Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides. Chemistry : a European journal, Vol. 19, H. 23. pp. 7605-7619.

Harel, Dipak and Schepmann, Dirk and Brun, Reto and Schmidt, Thomas J. and Wünsch, Bernhard. (2013) Enantioselective synthesis of encecaline-derived potent antimalarial agents. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 11, H. 42. pp. 7342-7349.

Harel, Dipak and Schepmann, Dirk and Prinz, Helge and Brun, Reto and Schmidt, Thomas J. and Wünsch, Bernhard. (2013) Natural product derived antiprotozoal agents : synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives. Journal of medicinal chemistry, 56 (18). pp. 7442-7448.

Hata, Yoshie and Raith, Melanie and Ebrahimi, Samad Nejad and Zimmermann, Stefanie and Mokoka, Tsholofelo and Naidoo, Dashnie and Fouche, Gerda and Maharaj, Vinesh and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias. (2013) Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus. Planta Medica, 79 (6). pp. 492-498.

Hossain, Md Imran and Switalska, Marta and Peng, Wei and Takashima, Mariko and Wang, Ning and Kaiser, Marcel and Wietrzyk, Joanna and Dan, Shingo and Yamori, Takao and Inokuchi, Tsutomu. (2013) Design, synthesis, and in vitro cancer cell growth inhibition evaluation and antimalarial testing of trioxanes installed in cyclic 2-enoate substructures. European journal of medicinal chemistry, 69. pp. 294-309.

Hu, Laixing and Patel, Alpa and Bondada, Lavanya and Yang, Sihyung and Wang, Michael Zhuo and Munde, Manoj and Wilson, W. David and Wenzler, Tanja and Brun, Reto and Boykin, David W.. (2013) Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues. Bioorganic & medicinal chemistry, 21 (21). pp. 6732-6741.

Hwang, J. Y. and Smithson, S. C. and Zhu, F. and Holbrook, G. and Connelly, M. C. and Kaiser, M. and Brun, R. and Guy, R. K.. (2013) Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for Human African Trypanosomiasis (HAT). Journal of medicinal chemistry, 56 (7). pp. 2850-2860.

Hwang, Jong Yeon and Smithson, David C. and Holbrook, Gloria and Zhu, Fangyi and Connelly, Michele C. and Kaiser, Marcel and Brun, Reto and Kiplin Guy, R.. (2013) Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 14. pp. 4127-4131.

Kemp, Louise E. and Rusch, Marion and Adibekian, Alexander and Bullen, Hayley E. and Graindorge, Arnault and Freymond, Céline and Rottmann, Matthias and Braun-Breton, Catherine and Baumeister, Stefan and Porfetye, Arthur T. and Vetter, Ingrid R. and Hedberg, Christian and Soldati-Favre, Dominique. (2013) Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in toxoplasma gondii. Journal of biological chemistry, Vol. 288, H. 38. pp. 27002-27018.

Lam, Cary F. C. and Pearce, A. Norrie and Tan, Shen H. and Kaiser, Marcel and Copp, Brent R.. (2013) Discovery and evaluation of thiazinoquinones as anti-protozoal agents. Marine drugs, Vol. 11, H. 9. pp. 3472-3499.

Liew, L. P. P. and Kaiser, M. and Copp, B. R.. (2013) Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 2. pp. 452-454.

Liew, Lydia P. P. and Pearce, A. Norrie and Kaiser, Marcel and Copp, Brent R.. (2013) Synthesis and in vitro and in vivo evaluation of antimalarial polyamines. European journal of medicinal chemistry, 69. pp. 22-31.

Lu, Wen-Jie and Wicht, Kathryn J. and Wang, Li and Imai, Kento and Mei, Zhen-Wu and Kaiser, Marcel and El Sayed, Ibrahim El Tantawy and Egan, Timothy J. and Inokuchi, Tsutomu. (2013) Synthesis and antimalarial testing of neocryptolepine analogues : addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines. European journal of medicinal chemistry, 64. pp. 498-511.

Lödige, Melanie and Lewis, Matthew D. and Paulsen, Eleonora S. and Esch, Harald L. and Pradel, Gabriele and Lehmann, Leane and Brun, Reto and Bringmann, Gerhard and Mueller, Ann-Kristin. (2013) A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages. International journal of medical microbiology, Vol. 303, H. 8. pp. 539-547.

Macêdo, Juan P. and Schmidt, Remo S. and Mäser, Pascal and Rentsch, Doris and Vial, Henri J. and Sigel, Erwin and Bütikofer, Peter. (2013) Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms. Molecular & biochemical parasitology, Vol. 190, H. 1. pp. 16-22.

Malebo, H. M. and Wenzler, T. and Cal, M. and Swaleh, S. M. and Omolo, M. O. and Hassanali, A. and Sequin, U. and Häussinger, D. and Dalsgaard, P. and Hamburger, M. and Brun, R. and Ndiege, I. O.. (2013) Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae). BMC complementary and alternative medicine, Vol. 13 , 48.

Malebo, Hamisi M. and Wenzler, Tanja and Cal, Monical and Swaleh, Sauda M. and Hassanali, Ahmed and Sequin, Urs and Machocho, Alex K and Haeussinger, Daniel and Dalsgaard, Petur and Omolo, Maurice O. and Hamburger, Matthias and Brun, Reto and Ndiege, Isaiah O.. (2013) Anti-protozoal and structure-activity relationships of chemical constituents of Acridocarpus chloropterus Oliver (Malpighiaceae) from Tanzania. International Journal of Natural Products Research, 3 (4). pp. 74-81.

McKeever, C. and Kaiser, M. and Rozas, I.. (2013) Aminoalkyl derivatives of guanidine di-aromatic minor groove binders with antiprotozoal activity. Journal of medicinal chemistry, 56 (3). pp. 700-711.

McNamara, Case W. and Lee, Marcus C. S. and Lim, Chek Shik and Lim, Siau Hoi and Roland, Jason and Nagle, Advait and Simon, Oliver and Yeung, Bryan K. S. and Chatterjee, Arnab K. and McCormack, Susan L. and Manary, Micah J. and Zeeman, Anne-Marie and Dechering, Koen J. and Kumar, T. R. Santha and Henrich, Philipp P. and Gagaring, Kerstin and Ibanez, Maureen and Kato, Nobutaka and Kuhen, Kelli L. and Fischli, Christoph and Rottmann, Matthias and Plouffe, David M. and Bursulaya, Badry and Meister, Stephan and Rameh, Lucia and Trappe, Joerg and Haasen, Dorothea and Timmerman, Martijn and Sauerwein, Robert W. and Suwanarusk, Rossarin and Russell, Bruce and Renia, Laurent and Nosten, Francois and Tully, David C. and Kocken, Clemens H. M. and Glynne, Richard J. and Bodenreider, Christophe and Fidock, David A. and Diagana, Thierry T. and Winzeler, Elizabeth A.. (2013) Targeting Plasmodium PI(4)K to eliminate malaria. Nature, Vol. 504, H. 7479. pp. 248-253.

Mei, Zhen-Wu and Wang, Li and Lu, Wen-Jie and Pang, Cui-Qing and Maeda, Tsukasa and Peng, Wei and Kaiser, Marcel and El Sayed, Ibrahim and Inokuchi, Tsutomu. (2013) Synthesis and in vitro antimalarial testing of neocryptolepines : SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines. Journal of medicinal chemistry, 56 (4). pp. 1431-1442.

Moehrle, J. J. and Duparc, S. and Siethoff, C. and van Giersbergen, P. L. and Craft, J. C. and Arbe-Barnes, S. and Charman, S. A. and Gutierrez, M. and Wittlin, S. and Vennerstrom, J. L.. (2013) First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials. British journal of clinical pharmacology, Vol. 75, H. 2. pp. 535-548.

Mokoka, Tsholofelo A. and Xolani, Peter K. and Zimmermann, S. and Hata, Y. and Adams, M. and Kaiser, M. and Moodley, N. and Maharaj, Y. and Koorbanally, Neil A. and Hamburger, M. and Brun, R. and Fouche, G.. (2013) Antiprotozoal Screening of 60 South African Plants, and the Identification of the Antitrypanosomal Germacranolides Schkuhrin I and II. Planta medica, Vol. 79, H. 14. pp. 1380-1384.

Molette, J. and Routier, J. and Abla, N. and Besson, D. and Bombrun, A. and Brun, R. and Burt, H. and Georgi, K. and Kaiser, M. and Nwaka, S. and Muzerelle, M. and Scheer, A.. (2013) Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties. ACS medicinal chemistry letters, Vol. 4, H. 11. pp. 1037-1041.

Moradi-Afrapoli, Fahimeh and Ebrahimi, Samad Nejad and Smiesko, Martin and Raith, Melanie and Zimmermann, Stefanie and Nadjafi, Farsad and Brun, Reto and Hamburger, Matthias. (2013) Bisabololoxide derivatives from Artemisia persica, and determination of their absolute configurations by ECD. Phytochemistry, Vol. 85. pp. 143-152.

Munigunti, Ranjith and Becker, Katja and Brun, Reto and Calderón, Angela I.. (2013) Determination of antiplasmodial activity and binding affinity of selected natural products towards PfTrxR and PfGR. Natural product communications, Vol. 8, H. 8. pp. 1135-1136.

Murugesan, D. and Mital, A. and Kaiser, M. and Shackleford, D. M. and Morizzi, J. and Katneni, K. and Campbell, M. and Hudson, A. and Charman, S. A. and Yeates, C. and Gilbert, I. H.. (2013) Discovery and structure-activity relationships of pyrrolone antimalarials. Journal of medicinal chemistry, 56 (7). pp. 2975-2990.

Murugesan, Dinakaran and Kaiser, Marcel and White, Karen L. and Norval, Suzanne and Riley, Jennifer and Wyatt, Paul G. and Charman, Susan A. and Read, Kevin D. and Yeates, Clive and Gilbert, Ian H.. (2013) Structure-activity relationship studies of pyrrolone antimalarial agents. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 9. pp. 1537-1544.

Nsumiwa, Samkele and Kuter, David and Wittlin, Sergio and Chibale, Kelly and Egan, Timothy J.. (2013) Structure-activity relationships for ferriprotoporphyrin IX association and β-hematin inhibition by 4-aminoquinolines using experimental and ab initio methods. Bioorganic & medicinal chemistry, 21 (13). pp. 3738-3748.

Obbo, C. J. D. and Makanga, B. and Mulholland, D. A. and Coombes, P. H. and Brun, R.. (2013) Antiprotozoal activity of Khaya anthotheca, (Welv.) C.D.C. A plant used by chimpanzees for self medication. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 147, H. 1. pp. 220-223.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Ashworth, Rachel and Wilkinson, Shane R. and Kaiser, Marcel and Andriani, Grasiella and Rodriguez, Ana. (2013) Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs : in vivo studies. Future medicinal chemistry, Vol. 5, H. 15. pp. 1763-1776.

Patra, Malay and Joshi, Tanmaya and Pierroz, Vanessa and Ingram, Katrin and Kaiser, Marcel and Ferrari, Stefano and Spingler, Bernhard and Keiser, Jennifer and Gasser, Gilles. (2013) DMSO-mediated ligand dissociation : renaissance for biological activity of N-heterocyclic-[Ru(η(6) -arene)Cl2 ] drug candidates. Chemistry : a European journal, Vol. 19, H. 44. pp. 14768-14772.

Patrick, Donald A. and Bakunov, Stanislav A. and Bakunova, Svetlana M. and Jones, Susan Kilgore and Wenzler, Tanja and Barszcz, Todd and Kumar, Arvind and Boykin, David W. and Werbovetz, Karl A. and Brun, Reto and Tidwell, Richard R.. (2013) Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives. European journal of medicinal chemistry, 67. pp. 310-324.

Patrick, Donald A. and Ismail, Mohamed A. and Arafa, Reem K. and Wenzler, Tanja and Zhu, Xiaohua and Pandharkar, Trupti and Jones, Susan Kilgore and Werbovetz, Karl A. and Brun, Reto and Boykin, David W. and Tidwell, Richard R.. (2013) Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. Journal of medicinal chemistry, 56 (13). pp. 5473-5494.

Pieretti, Simone and Haanstra, Jurgen R. and Mazet, Muriel and Perozzo, Remo and Bergamini, Christian and Prati, Federica and Fato, Romana and Lenaz, Giorgio and Capranico, Giovanni and Brun, Reto and Bakker, Barbara M. and Michels, Paul A. M. and Scapozza, Leonardo and Bolognesi, Maria Laura and Cavalli, Andrea. (2013) Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism. PLoS neglected tropical diseases, Vol. 7 , e2012.

Reimer, Daniela and Cowles, Kimberly N. and Proschak, Anna and Nollmann, Friederike I. and Dowling, Andrea J. and Kaiser, Marcel and Constant, Richard Ffrench- and Goodrich-Blair, Heidi and Bode, Helge B.. (2013) Rhabdopeptides as insect-specific virulence factors from entomopathogenic bacteria. ChemBioChem : a European journal of chemical biology, Vol. 14, H. 15. pp. 1991-1997.

Rogé, S. and Van Reet, N. and Odiwuor, S. and Tran, T. and Schildermans, K. and Vandamme, S. and Vandenberghe, I. and Vervecken, W. and Gillingwater, K. and Claes, F. and Devreese, B. and Guisez, Y. and Büscher, P.. (2013) Recombinant expression of trypanosome surface glycoproteins in Pichia pastoris for the diagnosis of Trypanosoma evansi infection. Veterinary parasitology : an international scientific journal, Vol. 197, H. 3-4. pp. 571-579.

Schleiferböck, Sarah and Scheurer, Christian and Ihara, Masataka and Itoh, Isamu and Bathurst, Ian and Burrows, Jeremy N. and Fantauzzi, Pascal and Lotharius, Julie and Charman, Susan A. and Morizzi, Julia and Shackleford, David M. and White, Karen L. and Brun, Reto and Wittlin, Sergio. (2013) In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models. Drug design, development and therapy, Vol. 7. pp. 1377-1384.

Spavieri, Jasmine and Allmendinger, Andrea and Kaiser, Marcel and Itoe, Maurice Ayamba and Blunden, Gerald and Mota, Maria M. and Tasdemir, Deniz. (2013) Assessment of dual life stage antiplasmodial activity of british seaweeds. Marine drugs, Vol. 11, H. 10. pp. 4019-4034.

Thuita, John K. and Wolf, Kristina K. and Murilla, Grace A. and Liu, Qiang and Mutuku, James N. and Chen, Yao and Bridges, Arlene S. and Mdachi, Raymond E. and Ismail, Mohamed A. and Ching, Shelley and Boykin, David W. and Hall, James Edwin and Tidwell, Richard R. and Paine, Mary F. and Brun, Reto and Wang, Michael Zhuo. (2013) Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 7, H. 6 , e2230.

Wang, N. and Wicht, K. J. and Wang, L. and Lu, W. J. and Misumi, R. and Wang, M. Q. and El Gokha, A. A. and Kaiser, M. and El Sayed, T. and Egan, T. J. and Inokuchi, T.. (2013) Synthesis and in vitro testing of antimalarial activity of non-natural-type neocryptolepines : structure-activity relationship study of 2,11- and 9,11-disubstituted 6-methylindolo[2,3-b]quinolines. Chemical and pharmaceutical bulletin, Vol. 61, H. 12. pp. 1282-1290.

Wang, X. and Dong, Y. and Wittlin, S. and Charman, S. A. and Chiu, F. C. and Chollet, J. and Katneni, K. and Mannila, J. and Morizzi, J. and Ryan, E. and Scheurer, C. and Steuten, J. and Santo, Tomas J. and Snyder, C. and Vennerstrom, J. L.. (2013) Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres. Journal of medicinal chemistry, 56 (6). pp. 2547-2555.

Wenzler, Tanja and Yang, Sihyung and Braissant, Olivier and Boykin, David W. and Brun, Reto and Wang, Michael Zhuo. (2013) Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 57, H. 11. pp. 5330-5343.

Younis, Yassir and Douelle, Frederic and González Cabrera, Diego and Le Manach, Claire and Nchinda, Aloysius T. and Paquet, Tanya and Street, Leslie J. and White, Karen L. and Zabiulla, K. Mohammed and Joseph, Jayan T. and Bashyam, Sridevi and Waterson, David and Witty, Michael J. and Wittlin, Sergio and Charman, Susan A. and Chibale, Kelly. (2013) Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity. Journal of medicinal chemistry, 56 (21). pp. 8860-8871.

Zhou, Qiuqin and Grundmann, Florian and Kaiser, Marcel and Schiell, Matthias and Gaudriault, Sophie and Batzer, Andreas and Kurz, Michael and Bode, Helge B.. (2013) Structure and biosynthesis of xenoamicins from entomopathogenic xenorhabdus. Chemistry : a European journal, Vol. 19, H. 49. pp. 16772-16779.

Zimmermann, Stefanie and Oufir, Mouhssin and Leroux, Alejandro and Krauth-Siegel, R. Luise and Becker, Katja and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2013) Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei. Bioorganic & medicinal chemistry, 21 (22). pp. 7202-7209.

da Silva, Cristiane Franca and Batista, Denise da Gama Jaen and Siciliano, Julianna Araujo and Batista, Marcos Meuser and Lionel, Jessica and de Souza, Elen Mello and Hammer, Erica Ripoll and da Silva, Patricia Bernardino and De Mieri, Maria and Adams, Michael and Zimmermann, Stefanie and Hamburger, Matthias and Brun, Reto and Schühly, Wolfgang and de Nazare, Maria Correia Soeiro. (2013) Activities of psilostachyin A and cynaropicrin against trypanosoma cruzi in vitro and in vivo. Antimicrobial Agents and Chemotherapy, 57 (11). pp. 5307-5314.

von Bargen, Katharina Walburga and Niehaus, Eva-Maria and Bergander, Klaus and Brun, Reto and Tudzynski, Bettina and Humpf, Hans-Ulrich. (2013) Structure elucidation and antimalarial activity of apicidin F : an apicidin-like compound produced by Fusarium fujikuroi. Journal of natural products, Vol. 76, H. 11. pp. 2136-2140.

2012

Abiodun, O. O. and Gbotosho, G. O. and Ajaiyeoba, E. O. and Brun, R. and Oduola, A. M.. (2012) Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine. Parasitology research, Vol. 110, H. 2. pp. 521-526.

Ahmad, S. and Weis, R. and Faist, J. and Wolkinger, V. and Saf, R. and Belaj, F. and Brun, R. and Kaiser, M. and Seebacher, W.. (2012) Diarylcyclohexanones : synthons for new bicyclic compounds. Monatshefte für Chemie, Vol. 143, H. 1. pp. 145-152.

Arán, V. J. and Kaiser, M. and Dardonville, C.. (2012) Discovery of nitroheterocycles active against African trypanosomes : in vitro screening and preliminary SAR studies. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 22, H. 14. pp. 4506-4516.

Attioua, B. and Yeo, D. and Lagnika, L. and Harisolo, R. and Antheaume, C. and Weniger, B. and Kaiser, M. and Lobstein, A. and Vonthron-Sénécheau, C.. (2012) In vitro antileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes from Parinari excelsa. Pharmaceutical biology, Vol. 50, H. 7. pp. 801-806.

Banerjee, M. and Farahat, A. A. and Kumar, A. and Wenzler, T. and Brun, R. and Munde, M. M. and Wilson, W. D. and Zhu, X. and Werbovetz, K. A. and Boykin, D. W.. (2012) Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides. European journal of medicinal chemistry, 55. pp. 449-454.

Brun, R. and Blum, J.. (2012) Human African trypanosomiasis. Infectious disease clinics of North America, Vol. 26, H. 2. pp. 261-273.

Brunner, R. and Aissaoui, H. and Boss, C. and Bozdech, Z. and Brun, R. and Corminboeuf, O. and Delahaye, S. and Fischli, C. and Heidmann, B. and Kaiser, M. and Kamber, J. and Meyer, S. and Papastogiannidis, P. and Siegrist, R. and Voss, Till S. and Welford, R. and Wittlin, S. and Binkert, C.. (2012) Identification of a new chemical class of antimalarials. Journal of infectious diseases, Vol. 206, no. 5. pp. 735-743.

Carvalho, S. A. and Feitosa, L. O. and Soares, M. and Costa, T. E. and Henriques, M. G. and Salomao, K. and de Castro, S. L. and Kaiser, M. and Brun, R. and Wardell, J. L. and Wardell, S. M. and Trossini, G. H. and Andricopulo, A. D. and da Silva, E. F. and Fraga, C. A.. (2012) Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents. European journal of medicinal chemistry, 54. pp. 512-521.

Chianese, G. and Fattorusso, E. and Scala, F. and Teta, R. and Calcinai, B. and Bavestrello, G. and Dien, H. A. and Kaiser, M. and Tasdemir, D. and Taglialatela-Scafati, O.. (2012) Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 10, H. 35. pp. 7197-7207.

Dastan, D. and Salehi, P. and Gohari, A. R. and Ebrahimi, S. N. and Zimmermann, S. and Kaiser, M. and Hamburger, M. and Khavasi, H. R.. (2012) Disesquiterpene and sesquiterpene coumarins from Ferula pseudalliacea, and determination of their absolute configurations. Phytochemistry, 78. pp. 170-178.

Delves, M. and Plouffe, D. and Scheurer, C. and Meister, S. and Wittlin, S. and Winzeler, E. A. and Sinden, R. E. and Leroy, D.. (2012) The activities of current antimalarial drugs on the life cycle stages of Plasmodium : a comparative study with human and rodent parasites. PLoS medicine, Vol. 9, H. 2 , e1001169.

Dürüst, Y. and Karakus, H. and Kaiser, M. and Tasdemir, D.. (2012) Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles. European journal of medicinal chemistry, 48. pp. 296-304.

Edlin, C. D. and Morgans, G. and Winks, S. and Duffy, S. and Avery, V. M. and Wittlin, S. and Waterson, D. and Burrows, J. and Bryans, J.. (2012) Identification and in-vitro ADME assessment of a series of novel anti-malarial agents suitable for hit-to-lead chemistry. ACS medicinal chemistry letters, Vol. 3, H. 7. pp. 570-573.

Ehmke, V. and Quinsaat, J. E. and Rivera-Fuentes, P. and Heindl, C. and Freymond, C. and Rottmann, M. and Brun, R. and Schirmeister, T. and Diederich, F.. (2012) Tuning and predicting biological affinity : aryl nitriles as cysteine protease inhibitors. Organic & biomolecular chemistry, Vol. 10, H. 30. pp. 5764-5768.

Eltschinger, S. and Greganova, E. and Heller, M. and Bütikofer, P. and Altmann, M.. (2012) Eukaryotic translation elongation factor 1A (eEF1A) domain I from S. cerevisiae is required but not sufficient for inter-species complementation. PLoS ONE, Vol. 7, H. 7 , e42338.

Faist, J. and Seebacher, W. and Saf, R. and Brun, R. and Kaiser, M. and Weis, R.. (2012) New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds. European journal of medicinal chemistry, 47 (1). pp. 510-519.

Farimani, M. M. and Taheri, S. and Ebrahimi, S. N. and Bahadori, M. B. and Khavasi, H. R. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2012) Hydrangenone, a new Isoprenoid with an unprecedented skeleton from Salvia hydrangea. Organic Letters, 14 (1). pp. 166-169.

Ge, J. F. and Zhang, Q. Q. and Lu, J. M. and Kaiser, M. and Brun, R. and Ihara, M.. (2012) Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities. MedChemComm, Vol. 3, H. 11. pp. 1435-1442.

Gemma, S. and Camodeca, C. and Sanna, Coccone and Joshi, B. P. and Bernetti, M. and Moretti, V. and Brogi, S. and Bonache, M. C. and Savini, L. and Taramelli, D. and Basilico, N. and Parapini, S. and Rottmann, M. and Brun, R. and Lamponi, S. and Caccia, S. and Guiso, G. and Summer, R. and Martin, R. and Saponara, S. and Gorelli, B. and Novellino, E. and Campiani, G. and Butini, S.. (2012) Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials : further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of medicinal chemistry, 55 (15). pp. 6948-6967.

Geneau, Celine E. and Wackers, Felix L. and Luka, Henryk and Daniel, Claudia and Balmer, Oliver. (2012) Selective flowers to enhance biological control of cabbage pests by parasitoids. Basic and applied ecology, Vol. 13, H. 1 , S. 85–93.

Godel, C. and Kumar, S. and Koutsovoulos, G. and Ludin, P. and Nilsson, D. and Comandatore, F. and Wrobel, N. and Thompson, M. and Schmid, C. D. and Goto, S. and Bringaud, F. and Wolstenholme, A. and Bandi, C. and Epe, C. and Kaminsky, R. and Blaxter, M. and Mäser, P.. (2012) The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets. The FASEB Journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, H. 11. pp. 4650-4661.

Gonzalez-Salgado, A. and Steinmann, M. E. and Greganova, E. and Rauch, M. and Mäser, P. and Sigel, E. and Bütikofer, P.. (2012) myo-inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei. Journal of biological chemistry, Vol. 287, H. 16. pp. 13313-13323.

González, Cabrera and Douelle, F. and Younis, Y. E. and Feng, T. S. and Lemanach, C. and Nchinda, A. T. and Street, L. J. and Scheurer, C. and Kamber, J. and White, K. L. and Montagnat, O. D. and Ryan, E. and Katneni, K. and Zabiulla, K. M. and Joseph, J. T. and Bashyam, S. and Waterson, D. and Witty, M. J. and Charman, S. A. and Wittlin, S. and Chibale, K.. (2012) Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines. Journal of medicinal chemistry, 55 (24). pp. 11022-11030.

Greganova, Eva and Bütikofer, Peter. (2012) Ethanolamine phosphoglycerol attachment to eEF1A is not essential for normal growth of Trypanosoma brucei. Scientific Reports, 2 (254).

Gökbulut, A. and Kaiser, M. and Brun, R. and Sarer, E. and Schmidt, T. J.. (2012) 9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity. Planta medica, Vol. 78, H. 3. pp. 225-229.

Hiltensperger, G. and Jones, N. G. and Niedermeier, S. and Stich, A. and Kaiser, M. and Jung, J. and Puhl, S. and Damme, A. and Braunschweig, H. and Meinel, L. and Engstler, M. and Holzgrabe, U.. (2012) Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei. Journal of medicinal chemistry, 55 (6). pp. 2538-2548.

Li, Y. and Hao, H. D. and Wittlin, S. and Wu, Y.. (2012) Simple analogues of Qinghaosu (Artemisinin). Chemistry : an Asian journal / an ACES journal, Vol. 7, H. 8. pp. 1881-1886.

Li, Y. and Wittlin, S. and Wu, Y.. (2012) Access to some UV chromophore-containing antimalarial trioxanes using hydrogen peroxide as source of the peroxy bonds. Heterocycles : an international journal for reviews and communications in heterocyclic chemistry, Vol. 84, H. 2. pp. 1217-1226.

Lizzi, F. and Veronesi, G. and Belluti, F. and Bergamini, C. and Lopez-Sanchez, A. and Kaiser, M. and Brun, R. and Krauth-Siegel, R. L. and Hall, D. and Rivas, L. and Bolognesi, M. L.. (2012) Conjugation of quinones with natural polyamines : towards an expanded anti-trypanosomatid profile. Journal of medicinal chemistry, 55 (23). pp. 10490-10500.

Ludin, Philipp and Woodcroft, Ben and Ralph, Stuart A. and Maeser, Pascal. (2012) In silicio prediction of antimalarial drug target candidates. International journal for parasitology: drugs and drug resistance, Vol. 2. pp. 191-199.

Marfurt, J. and Chalfein, F. and Prayoga, P. and Wabiser, F. and Wirjanata, G. and Sebayang, B. and Piera, K. A. and Wittlin, S. and Haynes, R. K. and Mohrle, J. J. and Anstey, N. M. and Kenangalem, E. and Price, R. N.. (2012) Comparative ex vivo activity of novel endoperoxides in multidrug-resistant Plasmodium falciparum and P. vivax. Antimicrobial agents and chemotherapy : AAC, Vol. 56, H. 10. pp. 5258-5263.

McCracken, S. T. and Kaiser, M. and Boshoff, H. I. and Boyd, P. D. and Copp, B. R.. (2012) Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 20 (4). pp. 1482-1493.

Mombelli, P. and Witschel, M. C. and van Zijl, A. W. and Geist, J. G. and Rottmann, M. and Freymond, C. and Röhl, F. and Kaiser, M. and Illarionova, V. and Fischer, M. and Siepe, I. and Schweizer, W. B. and Brun, R. and Diederich, F.. (2012) Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates. ChemMedChem, Vol. 7, H. 1. pp. 151-158.

Moradi-Afrapoli, Fahimeh and Yassa, Nargues and Zimmermann, Stefanie and Saeidnia, Soodabeh and Hadjiakhoondia, Abbas and Ebrahimi, Samad N. and Hamburger, Matthias. (2012) Cinnamoylphenethyl Amides from Polygonum hyrcanicum Possess Anti-Trypanosomal Activity. Natural Product Communications, 7 (6). pp. 753-755.

Mäser, P. and Wittlin, S. and Rottmann, M. and Wenzler, T. and Kaiser, M. and Brun, R.. (2012) Antiparasitic agents : new drugs on the horizon. Current opinion in pharmacology, Vol. 12, H. 5. pp. 562-566.

Nagle, A. and Wu, T. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Liu, B. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Chuan, T. and Alper, P. B. and Fischli, C. and Brun, R. and Lakshminarayana, S. B. and Rottmann, M. and Diagana, T. T. and Winzeler, E. A. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2012) Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of medicinal chemistry, 55 (9). pp. 4244-4273.

Nollmann, Friederike I. and Dowling, Andrea and Kaiser, Marcel and Deckmann, Klaus and Grösch, Sabine and Ffrench-Constant, Richard and Bode, Helge B.. (2012) Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum. Beilstein journal of organic chemistry, Vol. 8. pp. 528-533.

Oehring, S. C. and Woodcroft, B. J. and Moes, S. and Wetzel, J. and Dietz, O. and Pulfer, A. and Dekiwadia, C. and Maeser, P. and Flueck, C. and Witmer, K. and Brancucci, N. M. and Niederwieser, I. and Jenoe, P. and Ralph, S. A. and Voss, Till S.. (2012) Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Genome biology, Vol. 13, H. 11 , R108.

Schmidt, T. J. and Khalid, S. A. and Romanha, A. J. and Alves, T. Ma and Biavatti, M. W. and Brun, R. and Da Costa, F. B. and de Castro, S. L. and Ferreira, V. F. and de Lacerda, M. V. G. and Lago, J. H. G. and Leon, L. L. and Lopes, N. P. and das Neves Amorim, R. C. and Niehues, M. and Ogungbe, I. V. and Pohlit, A. M. and Scotti, M. T. and Setzer, W. N. and de N. C. Soeiro, M. and Steindel, M. and Tempone, A. G.. (2012) The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases : part I. Current medicinal chemistry, Vol. 19, H. 14. pp. 2128-2175.

Schmidt, T. J. and Khalid, S. A. and Romanha, A. J. and Alves, T. Ma and Biavatti, M. W. and Brun, R. and Da Costa, F. B. and de Castro, S. L. and Ferreira, V. F. and de Lacerda, M. V. G. and Lago, J. H. G. and Leon, L. L. and Lopes, N. P. and das Neves Amorim, R. C. and Niehues, M. and Ogungbe, I. V. and Pohlit, A. M. and Scotti, M. T. and Setzer, W. N. and de N. C. Soeiro, M. and Steindel, M. and Tempone, A. G.. (2012) The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases : part II. Current medicinal chemistry, Vol. 19, H. 14. pp. 2176-2228.

Schmidt, T. J. and Rzeppa, S. and Kaiser, M. and Brun, R.. (2012) Larrea tridentata - absolute configuration of its epoxylignans and investigations on its antiprotozoal activity. Phytochemistry letters, Vol. 5, H. 3. pp. 632-637.

Stec, J. and Huang, Q. and Pieroni, M. and Kaiser, M. and Fomovska, A. and Mui, E. and Witola, W. H. and Bettis, S. and McLeod, R. and Brun, R. and Kozikowski, A. P.. (2012) Synthesis, biological evaluation and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. Journal of medicinal chemistry, 55 (7). pp. 3088-3100.

Sykes, M. L. and Baell, J. B. and Kaiser, M. and Chatelain, E. and Moawad, S. R. and Ganame, D. and Ioset, J. R. and Avery, V. M.. (2012) Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign. PLoS neglected tropical diseases, Vol. 6, H. 11 , e1896.

Symula, R. E. and Beadell, J. S. and Sistrom, M. and Agbebakun, K. and Balmer, O. and Gibson, W. and Aksoy, S. and Caccone, A.. (2012) Trypanosoma brucei gambiense group 1 is distinguished by a unique amino acid substitution in the HpHb receptor implicated in human serum resistance. PLoS neglected tropical diseases, Vol. 6, H. 7 , e1728.

Taladriz, A. and Healy, A. and Flores, Perez and Herrero, Garcia and Rios, Martinez and Alkhaldi, A. A. and Eze, A. A. and Kaiser, M. and de Koning, H. P. and Chana, A. and Dardonville, C.. (2012) Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes. Journal of medicinal chemistry, 55 (6). pp. 2606-2622.

Thuita, J. K. and Wang, M. Z. and Kagira, J. M. and Denton, C. L. and Paine, M. F. and Mdachi, R. E. and Murilla, G. A. and Ching, S. and Boykin, D. W. and Tidwell, R. R. and Hall, J. E. and Brun, R.. (2012) Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 6, H. 7 , e1734.

Wenzler, T. and Steinhuber, A. and Wittlin, S. and Scheurer, C. and Brun, R. and Trampuz, A.. (2012) Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum. PLoS neglected tropical diseases, Vol. 6, H. 6 , e1668.

Witschel, M. and Rottmann, M. and Kaiser, M. and Brun, R.. (2012) Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. PLoS neglected tropical diseases, Vol. 6, H. 10 , e1805.

Wittlin, S. and Ekland, E. and Craft, J. C. and Lotharius, J. and Bathurst, I. and Fidock, D. A. and Fernandes, P.. (2012) In vitro and in vivo activity of Solithromycin (CEM-101) against Plasmodium species. Antimicrobial agents and chemotherapy : AAC, Vol. 56, H. 2. pp. 703-707.

Younis, Y. and Douelle, F. and Feng, T. S. and Cabrera, D. G. and Manach, C. L. and Nchinda, A. T. and Duffy, S. and White, K. L. and Shackleford, D. M. and Morizzi, J. and Mannila, J. and Katneni, K. and Bhamidipati, R. and Zabiulla, K. M. and Joseph, J. T. and Bashyam, S. and Waterson, D. and Witty, M. J. and Hardick, D. and Wittlin, S. and Avery, V. and Charman, S. A. and Chibale, K.. (2012) 3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential. Journal of medicinal chemistry, 55 (7). pp. 3479-3487.

Zimmermann, S. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2012) Cynaropicrin : the first natural product with in vivo activity against Trypanosoma bruce rhodesiense. Planta medica, Vol. 78, H. 6. pp. 553-556.

Zimmermann, S. and Thomi, S. and Kaiser, M. and Hamburger, M. and Adams, M.. (2012) Screening and HPLC-based activity profiling for new antiprotozoal leads from European plants. Scientia Pharmaceutica, 80 (1). pp. 205-213.

van Pelt-Koops, J. C. and Pett, H. E. and Graumans, W. and Vegte-Bolmer, Mv and van Gemert, G. J. and Rottmann, M. and Yeung, B. K. and Diagana, T. T. and Sauerwein, R. W.. (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrobial agents and chemotherapy, Vol. 56, H. 7. pp. 3544-3548.

2011

Arafa, R. K. and Wenzler, T. and Brun, R. and Chai, Y. and Wilson, D.. (2011) Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents. European journal of medicinal chemistry, 46 (12). pp. 5852-5860.

Attioua, B. and Lagnika, L. and Yeo, D. and Antheaume, C. and Kaiser, M. and Weniger, B. and Lobstein, A. and Vonthron-Sénécheau C., . (2011) In vitro antiplasmodial and antileishmanial activities of flavonoids form Anogeissus leiocarpus (Combretaceae). International journal of pharmaceutical sciences review and research, Vol. 11, H. 2 , 001.

Bakunov, S. A. and Bakunova, S. M. and Wenzler, T. and Ghebru, M. and Werbovetz, K. A. and Brun, R. and Tidwell, R. R.. (2011) Correction to synthesis and antiprotozoal activity of cationic1,4-diphenyl-1H-1,2,3-triazoles. Journal of medicinal chemistry, 54 (12). p. 4281.

Balmer, O. and Beadell, J. S. and Gibson, W. and Caccone, A.. (2011) Phylogeography and taxonomy of Trypanosoma brucei. PLoS neglected tropical diseases, Vol. 5, H. 2 , e961.

Balmer, O. and Tanner, M.. (2011) Prevalence and implications of multiple-strain infections. The Lancet infectious diseases, 11 (11). pp. 868-878.

Baragana, B. and McCarthy, O. and Sanchez, P. and Bosch-Navarrete C., and Kaiser, M. and Brun, R. and Whittingham, J. L. and Roberts, S. M. and Zhou, X. X. and Wilson, K. S. and Johansson, N. G. and Gonzalez-Pacanowska D., and Gilbert, I. H.. (2011) Beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (7). pp. 2378-2391.

Barker, R. H. Jr. and Urgaonkar, S. and Mazitschek, R. and Celatka, C. and Skerlj, R. and Cortese, J. F. and Tyndall, E. and Liu, H. and Cromwell, M. and Sidhu, A. B. and Guerrero-Bravo, J. E. and Crespo-Llado, K. N. and Serrano, A. E. and Lin, J. W. and Janse, C. J. and Khan, S. M. and Duraisingh, M. and Coleman, B. I. and Angulo-Barturen, I. and Jimenez-Diaz, M. B. and Magan, N. and Gomez, V. and Ferrer, S. and Martinez, M. S. and Wittlin, S. and Papastogiannidis, P. and O'Shea, T. and Klinger, J. D. and Bree, M. and Lee, E. and Levine, M. and Wiegand, R. C. and Munoz, B. and Wirth, D. F. and Clardy, J. and Bathurst, I. and Sybertz, E.. (2011) Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrobial agents and chemotherapy, 55 (6). pp. 2612-2622.

Baschong, Werner and Wittlin, Sergio and Inglis, Kirstine A. and Fairlamb, Alan H. and Croft, Simon L. and Kumar, T. R. Santha and Fidock, David A. and Brun, Reto. (2011) Triclosan is minimally effective in rodent malaria models. Nature medicine, Vol. 17. pp. 33-34.

Bouchikhi, F. and Anizon, F. and Brun, R. and Moreau, P.. (2011) Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis). Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 21. pp. 6319-6321.

Bourdin Trunz B., and Jedrysiak, R. and Tweats, D. and Brun, R. and Kaiser, M. and Suwinski, J. and Torreele, E.. (2011) 1-aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis. European journal of medicinal chemistry, 46 (5). pp. 1524-1535.

Bringmann, G. and Hertlein-Amslinger B., and Kajahn, I. and Dreyer, M. and Brun, R. and Moll, H. and Stich, A. and Ioset, K. N. and Schmitz, W. and Ngoc, L. H.. (2011) Phenolic analogs of the N,C-coupled naphthylisoquinoline alkaloid ancistrocladinium A, from Ancistrocladus cochinchinensis (Ancistrocladaceae), with improved antiprotozoal activities. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 1. pp. 89-93.

Broniatowska, B. and Allmendinger, A. and Kaiser, M. and Montamat-Sicotte D., and Hingley-Wilson S., and Lalvani, A. and Guiry, M. and Blunden, G. and Tasdemir, D.. (2011) Antiprotozoal, antitubercular and cytotoxic potential of cyanobacterial (blue-green algal) extracts from Ireland. Natural product communications, Vol. 6, H. 5. pp. 689-694.

Brun, R. and Don, R. and Jacobs, R. T. and Wang, M. Z. and Barrett, M. P.. (2011) Development of novel drugs for human African trypanosomiasis. Future microbiology, Vol. 6. pp. 677-691.

Brunner, Ralf Oskar. A novel antimalarial lead compound: in vitro properties and mode of action studies. 2011, Doctoral Thesis, University of Basel, Faculty of Science.

Chadwick, J. and Amewu, R. K. and Marti, F. and Bousejra-El Garah F., and Sharma, R. and Berry, N. G. and Stocks, P. A. and Burrell-Saward H., and Wittlin, S. and Rottmann, M. and Brun, R. and Taramelli, D. and Parapini, S. and Ward, S. A. and O'Neill P. M., . (2011) Antimalarial mannoxanes : hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 8. pp. 1357-1361.