edoc

Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes

Ahmad, Sarfraz and Seebacher, Werner and Wolkinger, Volker and Presser, Armin and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2015) Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, Vol. 38, H. 8. pp. 1455-1467.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6428793

Downloads: Statistics Overview

Abstract

Some antimalarial agents in use typically bear basic side chains as ligands. Such ligands were attached to the amino substituent of a bridgehead atom of already antiprotozoal active 3-azabicyclo[3.2.2]nonanes. Structure verification was done by NMR measurements. The new compounds were tested for their antiplasmodial and antitrypanosomal activities against Plasmodium falciparum K 1 (multiresistant) and Trypanosoma brucei rhodesiense as well as for their cytotoxicity against L6 cells. Their activities are compared to those of already prepared compounds and structure-activity relationships are discussed.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel and Brun, Reto
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer]
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:02 Oct 2015 10:01
Deposited On:02 Oct 2015 10:01

Repository Staff Only: item control page