Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL)

Yang, M. and Arai, C. and Bakar, M. A. and Lu, J. and Ge, J. F. and Pudhom, K. and Takasu, K. and Kasai, K. and Kaiser, M. and Brun, R. and Yardley, V. and Itoh, I. and Ihara, M.. (2010) Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL). Journal of medicinal chemistry, 53 (1). pp. 368-373.

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Official URL: http://edoc.unibas.ch/dok/A5842901

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Anti-Leishmania in vitro and in vivo activities of various rhodacyanine derivatives have been examined. Among them, the fluorinatied variant SJL-01 (8) showed IC(50) of 0.011 microM against Leishmania donovani strain MHOM/ET/67/L82 (selective index of <15000) and 95-97% inhibition against L. donovani strain MHOM/ET/67/HU in female BALB/c mice by 1.3-12.5 mg/kg x 5 iv administrations. Negative results on chromosomal aberration test and in vitro micronucleus test suggest that compound 8 is a hopeful candidate for visceral leishmaniasis (VL)
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Brun, Reto and Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Dec 2017 10:02
Deposited On:14 Sep 2012 06:46

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