Brown, R. W. and Abdel-Megeed, A. M. and Keller, P. A. and Jones, A. J. and Sykes, M. L. and Kaiser, M. and Baell, J. B. and Avery, V. M. and Hyland, C. J. T.. (2021) Investigation of thiazolyl-benzothiophenamides as potential agents for African sleeping sickness. RSC Medicinal Chemistry, 11 (12). pp. 1413-1422.
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Official URL: https://edoc.unibas.ch/82062/
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Abstract
African sleeping sickness is a potentially fatal neglected disease affecting sub-Saharan Africa. Highthroughput screening identified the thiazolyl-benzothiophenamide 1 to be active against the causative parasite, Trypanosoma brucei. This work establishes structure-activity relationships of 1, guiding the design of second generation derivatives. After screening against the clinically relevant species T. b. rhodesiense, the derivative 16 was identified as a suitable candidate for further investigation.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Kaiser, Marcel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 19 Dec 2022 09:42 |
| Deposited On: | 19 Dec 2022 09:42 |
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