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Xenortide biosynthesis by entomopathogenic xenorhabdus nematophila

Reimer, Daniela and Nollmann, Friederike I. and Schultz, Katharina and Kaiser, Marcel and Bode, Helge B.. (2014) Xenortide biosynthesis by entomopathogenic xenorhabdus nematophila. Journal of natural products, 77 (8). pp. 1976-1980.

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Official URL: http://edoc.unibas.ch/41960/

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Abstract

The biosynthesis gene cluster of the xenortides and a new derivative, xenortide D, which is produced in only trace amounts, was identified in Xenorhabdus nematophila. The structure of xenortide D was elucidated using a combination of labeling experiments followed by MS analysis and was confirmed by synthesis. Bioactivity tests revealed a weak activity of tryptamine-carrying xenortides against Plasmodium falciparum and Trypanosoma brucei.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society of Pharmacognosy
ISSN:0163-3864
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Jun 2016 11:03
Deposited On:19 Apr 2016 09:47

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