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4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity

Weis, R. and Seebacher, W. and Brun, R. and Kaiser, M. and Saf, R. and Faist, J.. (2014) 4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity. Monatshefte für Chemie, Vol. 145, H. 2. pp. 311-317.

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Official URL: http://edoc.unibas.ch/dok/A6263110

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Abstract

A new series of 4-aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates have been prepared. Their activities against the multiresistant K-1 strain of Plasmodium falciparum and Trypanosoma brucei rhodesiense were determined and compared with the results for ethanoate and propanoate analogs. Several structure-activity relationships were detected. The antiprotozoal activities were influenced by the kind of both amino substituents and by the chain length of the acid moiety. The butanoates exhibited higher antiplasmodial potency than their analogs with shorter chain length. Representative compounds of the propanoate and butanoate series were the most active antitrypanosomal compounds
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Brun, Reto and Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:0026-9247
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:18 Jul 2014 09:09
Deposited On:18 Jul 2014 07:42

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