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In vitro Screening of Traditional South African Malaria Remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum

Mokoka, Tsholofelo A. and Zimmermann, Stefanie and Julianti, Tasqiah and Hata, Yoshie and Moodley, Nivan and Cal, Monica and Adams, Michael and Kaiser, Marcel and Brun, Reto and Koorbanally, Neil and Hamburger, Matthias. (2011) In vitro Screening of Traditional South African Malaria Remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. Planta medica, Vol. 77, H. 14. pp. 1663-1667.

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Official URL: http://edoc.unibas.ch/dok/A6001466

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Abstract

Three hundred extracts were prepared from plants traditionally used in South Africa to treat malaria and screened IN VITRO for activity against TRYPANOSOMA BRUCEI RHODESIENSE, TRYPANOSOMA CRUZI, LEISHMANIA DONOVANI, and PLASMODIUM FALCIPARUM. For the 43 extracts which inhibited the growth of one or more parasites to more than 95 % at 9.7 µg/mL, the IC (50) values against all four protozoal parasites and cytotoxic IC (50)s against rat myoblast L6 cells were determined. Amongst the most notable results are the activities of AGATHOSMA APICULATA (IC (50) of 0.3 µg/mL) against PLASMODIUM FALCIPARUM, as well as SALVIA REPENS and MAYTENUS UNDATA against LEISHMANIA DONOVANI with IC (50)s of 5.4 µg/mL and 5.6 µg/mL, respectively. This screening is the starting point for a HPLC-based activity profiling project in antiprotozoal lead discovery.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Zimmermann, Stefanie and Brun, Reto
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Thieme
ISSN:0032-0943
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Oct 2012 15:31
Deposited On:11 Oct 2012 15:18

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