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Activity of diimidazoline amides against African trypanosomiasis

Dong, Yuxiang and Wang, Xiaofang and Cal, Monica and Kaiser, Marcel and Vennerstrom, Jonathan L.. (2014) Activity of diimidazoline amides against African trypanosomiasis. Bioorganic & medicinal chemistry letters, Vol. 24, H. 3. pp. 944-948.

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Official URL: http://edoc.unibas.ch/dok/A6233626

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Abstract

We identified several diimidazoline mono- and diamides that were as potent as pentamidine against Trypanosoma brucei rhodesiense in vitro. All of these were also less cytotoxic than pentamidine, but none was as effective as the latter in a T. brucei rhodesiense-infected mouse model. A single imidazoline may be sufficient for high antitrypanosomal activity provided that a second weak base functional group is present.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0960-894X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:18 Jul 2014 09:10
Deposited On:18 Jul 2014 09:10

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