Greve, H. L. and Kaiser, M. and Mäser, P. and Schmidt, T. J.. (2021) Boswellic acids show in vitro activity against Leishmania donovani. Molecules, 26 (12). p. 3651.
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Abstract
In continuation of our search for leads from medicinal plants against protozoal pathogens, we detected antileishmanial activity in polar fractions of a dichloromethane extract from Boswellia serrata resin. 11-keto-beta-boswellic acid (KBA) could be isolated from these fractions and was tested in vitro against Leishmania donovani axenic amastigotes along with five further boswellic acid derivatives. 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) showed the strongest activity with an IC50 value of 0.88 microM against axenic amastigotes but was inactive against intracellular amastigotes in murine macrophages.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Kaiser, Marcel and Mäser, Pascal |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| ISSN: | 1420-3049 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
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| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 20 Dec 2022 11:57 |
| Deposited On: | 20 Dec 2022 11:57 |
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