Synthesis of novel diazabicycles and their antiprotozoal activities

Wolkinger, V. and Weis, R. and Belaj, F. and Kaiser, M. and Brun, R. and Saf, R. and Seebacher, W.. (2009) Synthesis of novel diazabicycles and their antiprotozoal activities. Australian journal of chemistry, Vol. 62, H. 9. pp. 1166-1172.

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Official URL: http://edoc.unibas.ch/dok/A5843345

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We describe the synthesis of new diaryl substituted diazabicyclo[3.2.1] octanes from diazepanes which were prepared by the reduction of diazepanones. The formation of the bicyclic system was optimized by microwave irradiation and the structures of the new compounds were established by single crystal structure analysis and NMR spectroscopy. All new compounds were tested for their potencies against Plasmodium falciparum K-1 and Trypanosoma b. rhodesiense, the causative organisms of malaria tropica and the East African form of sleeping sickness
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Brun, Reto and Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Commonwealth Scientific and Industrial Research Organization
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:08 Nov 2012 16:13
Deposited On:14 Sep 2012 06:41

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