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Transporters of Trypanosoma brucei : phylogeny, physiology, pharmacology

Schmidt, Remo S. and Macêdo, Juan P. and Steinmann, Michael E. and Salgado, Amaia González and Bütikofer, Peter and Sigel, Erwin and Rentsch, Doris and Mäser, Pascal. (2018) Transporters of Trypanosoma brucei : phylogeny, physiology, pharmacology. The FEBS journal, 285 (6). pp. 1012-1023.

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Official URL: https://edoc.unibas.ch/69226/

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Abstract

Trypanosoma brucei comprise the causative agents of sleeping sickness, T. b. gambiense and T. b. rhodesiense, as well as the livestock-pathogenic T. b. brucei. The parasites are transmitted by the tsetse fly and occur exclusively in sub-Saharan Africa. T. brucei are not only lethal pathogens but have also become model organisms for molecular parasitology. We focus here on membrane transport proteins of T. brucei, their contribution to homeostasis and metabolism in the context of a parasitic lifestyle, and their pharmacological role as potential drug targets or routes of drug entry. Transporters and channels in the plasma membrane are attractive drug targets as they are accessible from the outside. Alternatively, they can be exploited to selectively deliver harmful substances into the trypanosome's interior. Both approaches require the targeted transporter to be essential: in the first case to kill the trypanosome, in the second case to prevent drug resistance due to loss of the transporter. By combining functional and phylogenetic analyses, we were mining the T. brucei predicted proteome for transporters of pharmacological significance. Here, we review recent progress in the identification of transporters of lipid precursors, amino acid permeases and ion channels in T. brucei.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Mäser, Pascal
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Blackwell
ISSN:1742-464X
Note:Publication type according to Uni Basel Research Database: Journal item
Identification Number:
Last Modified:01 Mar 2019 12:43
Deposited On:01 Mar 2019 12:43

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