Zhao, L. and Awori, R. M. and Kaiser, M. and Gross, J. and Opatz, T. and Bode, H. B.. (2019) Structure, biosynthesis, and bioactivity of photoditritide from Photorhabdus temperata meg1. Journal of natural products, 82 (12). pp. 3499-3503.
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Official URL: https://edoc.unibas.ch/74040/
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Abstract
A new cyclic peptide photoditritide (1), containing two rare amino acid d-homoarginine residues, was isolated from Photorhabdus temperata Meg1 after the nonribosomal peptide synthetase encoding gene pdtS was activated via promoter exchange. The structure of 1 was elucidated by HR-MS and NMR experiments. The absolute configurations of amino acids were determined according to the advanced Marfey's method after hydrolysis of 1. Bioactivity testing of 1 revealed potent antimicrobial activity against Micrococcus luteus with an MIC value of 3.0 μM and weak antiprotozoal activity against Trypanosoma brucei rhodesiense with an IC50 value of 13 μM. Additionally, the biosynthetic pathway of 1 was also proposed.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Kaiser, Marcel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Society of Pharmacognosy |
| ISSN: | 0163-3864 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 05 Mar 2020 07:18 |
| Deposited On: | 05 Mar 2020 07:18 |
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