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Antiprotozoal germacranolide sesquiterpene lactones from Tanacetum sonbolii

Mofidi Tabatabaei, Sahar and Nejad Ebrahimi, Samad and Salehi, Peyman and Sonboli, Ali and Tabefam, Marzieh and Kaiser, Marcel and Hamburger, Matthias and Moridi Farimani, Mahdi. (2019) Antiprotozoal germacranolide sesquiterpene lactones from Tanacetum sonbolii. Planta medica, 85 (5). pp. 424-430.

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Official URL: https://edoc.unibas.ch/69922/

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Abstract

A phytochemical investigation of extracts from flowers and aerial parts of; Tanacetum sonbolii; afforded 7 new germacranolide sesquiterpene lactones. The structures were established by a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, and electronic circular dichroism. The; in vitro; antiprotozoal activity of the compounds against; Trypanosoma brucei rhodesiense; and cytotoxicity against rat myoblast (L6) cells were determined. Compounds 4: and 5: showed IC; 50; values of 5.1 and 10.2 µM and selectivity indices of 3.9 and 4.0, respectively.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
UniBasel Contributors:Kaiser, Marcel and Hamburger, Matthias
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Hippokrates-Verl.
ISSN:0032-0943
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:11 Aug 2020 15:57
Deposited On:01 Apr 2019 09:43

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