N-oxide alkaloids from Crinum amabile (Amaryllidaceae)

Tallini, Luciana R. and Torras-Claveria, Laura and Borges, Warley de Souza and Kaiser, Marcel and Viladomat, Francesc and Zuanazzi, José Angelo S. and Bastida, Jaume. (2018) N-oxide alkaloids from Crinum amabile (Amaryllidaceae). Molecules, 23 (6). E1277.

[img] PDF - Published Version
Available under License CC BY (Attribution).


Official URL: https://edoc.unibas.ch/65032/

Downloads: Statistics Overview


Natural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. In this study, twenty-three alkaloids were identified from; Crinum amabile; by GC-MS and two new structures (augustine; N; -oxide and buphanisine; N; -oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from; C. amabile; gave better results than the reference drugs, so it was possible to conclude that the; N; -oxide group does not increase their therapeutic potential.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
edoc DOI:
Last Modified:05 Sep 2018 08:44
Deposited On:05 Sep 2018 08:44

Repository Staff Only: item control page