100 years of Suramin

Wiedemar, Natalie and Hauser, Dennis A. and Mäser, Pascal. (2020) 100 years of Suramin. Antimicrobial agents and chemotherapy, 64 (3). e01168-19.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/76123/

Downloads: Statistics Overview


Suramin is 100 years old and is still being used to treat the first stage of acute human sleeping sickness, caused by; Trypanosoma brucei; rhodesiense; Suramin is a multifunctional molecule with a wide array of potential applications, from parasitic and viral diseases to cancer, snakebite, and autism. Suramin is also an enigmatic molecule: What are its targets? How does it get into cells in the first place? Here, we provide an overview of the many different candidate targets of suramin and discuss its modes of action and routes of cellular uptake. We reason that, once the polypharmacology of suramin is understood at the molecular level, new, more specific, and less toxic molecules can be identified for the numerous potential applications of suramin.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Wiedemar, Natalie and Hauser, Dennis and Mäser, Pascal
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society for Microbiology
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Mar 2020 08:22
Deposited On:27 Mar 2020 08:22

Repository Staff Only: item control page