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Come, sweet death : targeting glycosomal protein import for antitrypanosomal drug development

Kalel, Vishal C. and Mäser, Pascal and Sattler, Michael and Erdmann, Ralf and Popowicz, Grzegorz M.. (2018) Come, sweet death : targeting glycosomal protein import for antitrypanosomal drug development. Current Opinion in Microbiology, 46. pp. 116-122.

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Official URL: https://edoc.unibas.ch/67065/

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Abstract

Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids' glycosomal transport components as targets for new trypanocidal therapies.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Mäser, Pascal
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1369-5274
e-ISSN:1879-0364
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:17 Dec 2018 08:49
Deposited On:17 Dec 2018 08:49

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