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In vitro antileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes from Parinari excelsa

Attioua, B. and Yeo, D. and Lagnika, L. and Harisolo, R. and Antheaume, C. and Weniger, B. and Kaiser, M. and Lobstein, A. and Vonthron-Sénécheau, C.. (2012) In vitro antileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes from Parinari excelsa. Pharmaceutical biology, Vol. 50, H. 7. pp. 801-806.

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Official URL: http://edoc.unibas.ch/dok/A6094235

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Abstract

Context: Parinari excelsa Sabine (Chrysobalanaceae) is an indigenous tree from West and Eastern Africa. This tree is used in Ivory Coast as an antimalaria remedy. Objective: The in vitro antiplasmodial and antileishmanial activities of the stem bark, the leaf and the major compounds from the stem bark were investigated. Materials and methods: The leaves and stem bark from P. excelsa were separately collected, air-dried and powdered. Two extracts (methylene chloride and methanol) were realized for both powders. Every extract was tested for its antiplasmodial and antileishmanial activities. Only the stem bark crude extracts were fractionated by column chromatography and their major components were analyzed by NMR, HRESIMS and IR methods. The compounds were tested for their antiplasmodial and antileishmanial activities. Results: The comparison of the IC(50) values of the crude extracts were in this ordrer: 3.41 (IC(50) of PeBMc) >4.10 (IC(50) of PeBMc) >4.42 (IC(50) of PeLMe) against P. falciparum and 5.19 (IC(50) of PeBMc) >12.32 (IC(50) of PeBMe) >19.33 (IC(50) of PeLMc) >32.37 (IC(50) of PeLMe) against L. donovani. The stem bark crude extracts were the most active against both parasites. Their fractionation leaded to a new ventiloquinone, five triterpenes and one chlorogenic acid. All these compounds were isolated for the first time from P. excelsa. High activities were observed with (3beta)-3-hydroxyolean-12-en-28-oic acid (IC(50) = 8.2 microM) and 3beta-hydroxyolean-5,12-dien-28-oic acid (IC(50) = 7.7 microM) against L. donovani. With the antiplasmodial activity, the best activity was observed with 16beta-hydroxylupane-1,20(29)-dien-3-one (IC(50) = 28.3 microM). Discussion and conclusion: These findings demonstrated that the constituents of P. excelsa stem bark have in vitro antiplasmodial and antileishmanial activities
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Informa Healthcare
ISSN:1388-0209
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Jul 2013 07:43
Deposited On:19 Jul 2013 07:40

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