Precursor-directed diversification of cyclic tetrapeptidic pseudoxylallemycins

Guo, Huijuan and Schmidt, Alexander and Stephan, Philipp and Raguž, Luka and Braga, Daniel and Kaiser, Marcel and Dahse, Hans-Martin and Weigel, Christiane and Lackner, Gerald and Beemelmanns, Christine. (2018) Precursor-directed diversification of cyclic tetrapeptidic pseudoxylallemycins. ChemBioChem, 19 (21). pp. 2307-2311.

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Cyclic peptides containing non-proteinogenic amino acids often exhibit a broad bioactivity spectrum and many have entered clinical trials with good prospects for drug development. We recently reported the discovery of six cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), from a termite-associated Pseudoxylaria sp. X802. These compounds contain a rare O-homoallenyl-l-tyrosine moiety and show promising antimicrobial activity against the Gram-negative pathogenic bacterium Pseudomonas aeruginosa. To perform more detailed structure-activity studies, we pursued a precursor-directed diversification strategy. Herein, we report the purification, identification, and testing of 21 new pseudoxylallemycin derivatives.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:15 Nov 2018 15:31
Deposited On:15 Nov 2018 15:31

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