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Triterpenoids with rare carbon skeletons from Salvia hydrangea : antiprotozoal activity and absolute configurations

Moridi Farimani M., and Bahadori, M. B. and Taheri, S. and Ebrahimi, S. N. and Zimmermann, S. and Brun, R. and Amin, G. and Hamburger, M.. (2011) Triterpenoids with rare carbon skeletons from Salvia hydrangea : antiprotozoal activity and absolute configurations. Journal of Natural Products, Vol. 74, H. 10. pp. 2200-2205.

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Official URL: http://edoc.unibas.ch/dok/A6002380

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Abstract

Salvadione C (1) and perovskone B (2), two new triterpenoids with rare carbon skeletons, were isolated from an antiplasmodial n-hexane extract of Salvia hydrangea . The absolute configuration was determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. In vitro activity against Plasmodium falciparum K1 strain, Trypanosoma brucei rhodesiense STIB 900 strain, and cytotoxicity in rat myoblast (L6) cells were determined. Compounds 1 and 2 showed in vitro antiplasmodial activity, with IC(50) values of 1.43 and 0.18 muM and selectivity indices (SI) of 86.2 and 69.6, respectively. IC(50) values against T. brucei rhodesiense were found to be 4.33 and 15.92 muM, respectively
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Ebrahimi, Samad Nejad and Zimmermann, Stefanie and Hamburger, Matthias and Brun, Reto
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Society of Pharmacognosy
ISSN:0163-3864
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:22
Deposited On:14 Sep 2012 07:15

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