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Cinnamoylphenethyl Amides from Polygonum hyrcanicum Possess Anti-Trypanosomal Activity

Moradi-Afrapoli, Fahimeh and Yassa, Nargues and Zimmermann, Stefanie and Saeidnia, Soodabeh and Hadjiakhoondia, Abbas and Ebrahimi, Samad N. and Hamburger, Matthias. (2012) Cinnamoylphenethyl Amides from Polygonum hyrcanicum Possess Anti-Trypanosomal Activity. Natural Product Communications, 7 (6). pp. 753-755.

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Official URL: http://edoc.unibas.ch/dok/A6043789

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Abstract

A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC50 = 3.7 microg/mL). Bioassay-guided fractionation of the extract resulted in isolation of cinnamoylphenethyl amides, including N-trans-caffeoyltyramine (1), N-trans-p-coumaroyltyramine (7), and N-trans-feruloyltyramine (8) as the main active constituents (IC50s ranging from 2.2 to 13.3 microM). Some structurally related, but less active compounds, such as cannabisin B (2), tyrosol (3), p-coumaric acid (4), ferulic acid (5), and N-cis-feruloyltyramine (6) were also identified, along with N-trans-3,4-dimethoxycinnamoyldopamine (9). Cytotoxicity of the active compounds in L6 cells was determined, and selectivity indices (SI) of 7.9 to 33.4 were calculated
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Hamburger, Matthias and Ebrahimi, Samad Nejad and Zimmermann, Stefanie and Moradiafrapoli, Fahimeh
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Natural Product
ISSN:1934-578X
e-ISSN:1555-9475
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Nov 2017 07:28
Deposited On:04 Jan 2013 08:35

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