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Antiparasitic chaiyaphumines from Entomopathogenic xenorhabdus sp. PB61.4

Grundmann, Florian and Kaiser, Marcel and Schiell, Matthias and Batzer, Andreas and Kurz, Michael and Thanwisai, Aunchalee and Chantratita, Narisara and Bode, Helge B.. (2014) Antiparasitic chaiyaphumines from Entomopathogenic xenorhabdus sp. PB61.4. Journal of natural products, Vol. 77, H. 4. pp. 779-783.

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Official URL: http://edoc.unibas.ch/dok/A6263150

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Abstract

A new class of four depsipentapeptides called chaiyaphumines A-D (1-4) was isolated from Xenorhabdus sp. PB61.4. Their structures were elucidated by detailed 1D and 2D NMR experiments and by a Marfey's analysis following flash hydrolysis of the peptide. Verification of the structure was achieved by three-dimensional modeling using NOE-derived distance constraints, molecular dynamics, and energy minimization. Chaiyaphumine A (1) showed good activity against Plasmodium falciparum (IC50 of 0.61 μM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Society of Pharmacognosy
ISSN:0163-3864
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:18 Jul 2014 09:10
Deposited On:18 Jul 2014 09:10

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