Antiprotozoal, antimycobacterial and cytotoxic potential of some british green algae

Spavieri, J. and Kaiser, M. and Casey, R. and Hingley-Wilson S., and Lalvani, A. and Blunden, G. and Tasdemir, D.. (2010) Antiprotozoal, antimycobacterial and cytotoxic potential of some british green algae. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 24, H. 7. pp. 1095-1098.

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Official URL: http://edoc.unibas.ch/dok/A5842819

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In the continuation of our search for natural sources for antiprotozoal and antitubercular molecules, we have screened the crude extracts of four green marine algae (Cladophora rupestris, Codium fragile ssp. tomentosoides, Ulva intestinalis and Ulva lactuca) collected from the Dorset area of England. Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani and Mycobacterium tuberculosis were used as test organisms in the in vitro assays. The selective toxicity of the extracts was also determined toward mammalian skeletal myoblast (L6) cells. The crude seaweed extracts had no activity against M. tuberculosis, but showed antiprotozoal activity against at least two protozoan species. All algal extracts were active against T. brucei rhodesiense, with C. rupestris being the most potent one (IC(50) value 3.7 mug/ml), whilst only C. rupestris and U. lactuca had moderate trypanocidal activity against T. cruzi (IC(50) values 80.8 and 34.9 mug/ml). Again, all four extracts showed leishmanicidal activity with IC(50) values ranging between 12.0 and 20.2 mug/ml. None of the extracts showed cytotoxicity toward L6 cells, indicating that their antiprotozoal activity is specific. This is the first study reporting antiprotozoal and antimycobacterial activity of British marine algae. Copyright (c) 2009 John Wiley & Sons, Ltd
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:John Wiley
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 07:19
Deposited On:14 Sep 2012 06:48

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