Shi, Yan-Ni and Pusch, Stefan and Shi, Yi-Ming and Richter, Christian and Maciá-Vicente, Jose G. and Schwalbe, Harald and Kaiser, Marcel and Opatz, Till and Bode, Helge B.. (2019) (+/-)-Alternarlactones A and B, two antiparasitic alternariol-like dimers from the fungus Alternaria alternata p1210 isolated from the halophyte Salicornia sp. Journal of Organic Chemistry, 84 (17). pp. 11203-11209.
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Official URL: https://edoc.unibas.ch/71980/
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Abstract
Two new dimeric compounds of the alternariol class, (±)-alternarlactones A (; 1; ) and B (; 2; ), were isolated along with 11 known compounds from the fungus; Alternaria alternata; P1210. Their structures were elucidated with the assistance of long-range HSQMBC to address inadequate cross-peaks in HMBC that result from the highly dense quaternary carbons, as well as theoretical calculations. All isolated altenuisol derivatives were screened for their antiparasitic activities, which provide a preliminary structure-activity relationship of this class of compounds against neglected tropical diseases.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Kaiser, Marcel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Chemical Society |
| ISSN: | 0022-3263 |
| e-ISSN: | 1520-6904 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 18 Sep 2019 08:38 |
| Deposited On: | 18 Sep 2019 08:38 |
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