Drug discovery for kinetoplastid diseases : future directions

Rao, Srinivasa P. S. and Barrett, Michael P. and Dranoff, Glenn and Faraday, Christopher J. and Gimpelewicz, Claudio R. and Hailu, Asrat and Jones, Catherine L. and Kelly, John M. and Lazdins-Helds, Janis K. and Mäser, Pascal and Mengel, Jose and Mottram, Jeremy C. and Mowbray, Charles E. and Sacks, David L. and Scott, Phillip and Späth, Gerald F. and Tarleton, Rick L. and Spector, Jonathan M. and Diagana, Thierry T.. (2019) Drug discovery for kinetoplastid diseases : future directions. ACS infectious diseases, 5 (2). pp. 152-157.

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Kinetoplastid parasites have caused human disease for millennia. Significant achievements have been made toward developing new treatments for leishmaniasis (particularly on the Indian subcontinent) and for human African trypanosomiasis (HAT). Moreover, the sustained decrease in the incidence of HAT has made the prospect of elimination a tantalizing reality. Despite the gains, no new chemical or biological entities to treat kinetoplastid diseases have been registered in more than three decades, and more work is needed to discover safe and effective therapies for patients with Chagas disease and leishmaniasis. Advances in tools for drug discovery and novel insights into the biology of the host-parasite interaction may provide opportunities for accelerated progress. Here, we summarize the output from a gathering of scientists and physicians who met to discuss the current status and future directions in drug discovery for kinetoplastid diseases.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Mäser, Pascal
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:ACS Publications
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Mar 2019 12:52
Deposited On:12 Mar 2019 12:52

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