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Long-lasting and fast-acting in vivo efficacious antiplasmodial azepanylcarbazole amino alcohol

Abla, Nada and Bashyam, Sridevi and Charman, Susan A. and Greco, Béatrice and Hewitt, Philip and Jiménez-Díaz, Maria Belén and Katneni, Kasiram and Kubas, Holger and Picard, Didier and Sambandan, Yuvaraj and Sanz, Laura and Smith, Dennis and Wang, Tai and Willis, Paul and Wittlin, Sergio and Spangenberg, Thomas. (2017) Long-lasting and fast-acting in vivo efficacious antiplasmodial azepanylcarbazole amino alcohol. ACS medicinal chemistry letters, 8 (12). pp. 1304-1308.

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Official URL: http://edoc.unibas.ch/58322/

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Abstract

With ∼429,000 deaths in 2016, malaria remains a major infectious disease where the need to treat the fever symptoms, but also to provide relevant post-treatment prophylaxis, is of major importance. An azepanylcarbazole amino alcohol is disclosed with a long- and fast-acting in vivo antiplasmodial efficacy and meets numerous attributes of a desired post-treatment chemoprophylactic antimalarial agent. The synthesis, the parasitological characterization, and the animal pharmacokinetics and pharmacodynamics of this compound are presented along with a proposed target.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Wittlin, Sergio
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1948-5875
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:02 Feb 2018 10:05
Deposited On:02 Feb 2018 10:05

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