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DMSO-mediated ligand dissociation : renaissance for biological activity of N-heterocyclic-[Ru(η(6) -arene)Cl2 ] drug candidates

Patra, Malay and Joshi, Tanmaya and Pierroz, Vanessa and Ingram, Katrin and Kaiser, Marcel and Ferrari, Stefano and Spingler, Bernhard and Keiser, Jennifer and Gasser, Gilles. (2013) DMSO-mediated ligand dissociation : renaissance for biological activity of N-heterocyclic-[Ru(η(6) -arene)Cl2 ] drug candidates. Chemistry : a European journal, Vol. 19, H. 44. pp. 14768-14772.

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Official URL: http://edoc.unibas.ch/dok/A6243534

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Abstract

Slipped under the radar? (1) H NMR spectroscopic examination revealed that [Ru(η(6) -arene)Cl2 (L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO, a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Helminth Drug Development (Keiser)
UniBasel Contributors:Kaiser, Marcel and Keiser, Jennifer
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-VCH Verlag
ISSN:0947-6539
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 May 2014 08:34
Deposited On:23 May 2014 08:34

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