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Using yeast synthetic lethality to inform drug combination for Malaria

Subramaniam, Suvitha and Schmid, Christoph D. and Guan, Xue Li and Mäser, Pascal. (2018) Using yeast synthetic lethality to inform drug combination for Malaria. Antimicrobial Agents and Chemotherapy, 62 (4). e01533-17.

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Official URL: https://edoc.unibas.ch/63911/

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Abstract

Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of; Plasmodium falciparum; that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as; P. falciparum; calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Subramaniam, Suvitha and Guan, Xueli and Mäser, Pascal
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society for Microbiology
ISSN:0066-4804
e-ISSN:1098-6596
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:07 Sep 2018 13:26
Deposited On:03 Jul 2018 08:32

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