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Facile synthesis of cyclohexanediones and dialkylresorcinols : bioactive natural products from entomopathogenic bacteria

Kronenwerth, M. and Dauth, C. and Kaiser, M. and Pemberton, I. and Bode, H. B.. (2014) Facile synthesis of cyclohexanediones and dialkylresorcinols : bioactive natural products from entomopathogenic bacteria. European journal of organic chemistry, H. 36. pp. 8026-8028.

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Official URL: http://edoc.unibas.ch/dok/A6348548

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Abstract

A synthesis for the recently identified, widespread bacterial natural product classes of dialkylresorcinols and cyclohexanediones was developed. The synthesis route is similar to the biosynthesis route in that the formation of the cyclohexanedione ring results from two parts, as exemplified by the synthesis of the multifunctional isopropylstilbenes identified in Photorhabdus luminescens. Testing of these compounds revealed good bioactivity against Trypanosoma brucei rhodesiense and T. cruzi, the causative agents of sleeping sickness and Chagas disease, respectively
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Wiley-VCH Verlag
ISSN:1434-193X
Note:Publication type according to Uni Basel Research Database: Journal item
Last Modified:10 Apr 2015 09:12
Deposited On:10 Apr 2015 09:12

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