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Procerenone: a Fatty Acid Triterpenoid from the Fruit Pericarp of Omphalocarpum procerum (Sapotaceae)

Ngamgwe, R. F. and Yankam, R. and Chouna, J. R. and Lanz, C. and Furrer, J. and Schürch, S. and Kaiser, M. and Lenta, B. N. and Ngouela, S. and Tsamo, E. and Brenneisen, R.. (2014) Procerenone: a Fatty Acid Triterpenoid from the Fruit Pericarp of Omphalocarpum procerum (Sapotaceae). Iranian Journal of Pharmaceutical Research, 13 (4). pp. 1425-1430.

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Official URL: http://edoc.unibas.ch/dok/A6308533

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Abstract

Phytochemical investigation of a dichloromethane-methanol (1:1) extract of the fruit pericarp of Omphalocarpum procerum which exhibited antiplasmodial activity during preliminary screening led to the isolation of the new fatty ester triterpenoid 3 beta-hexadecanoyloxy-28-hydroxyolean-12-en-11-one (1), together with five known compounds 2-6. The structure of the new compound as well as those of the known compounds was established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1-4 were evaluated in-vitro for their cytotoxicity against L6 cell lines and antiprotozoal activities against Plasmodium falciparum, Leishmania donovani, Trypanosoma brucei rhodesiense and Trypanosoma cruzi (species responsible for human malaria, visceral leishmaniasis, African trypanosomiasis and Chagas disease, respectively). The tested compounds showed weak to moderate antiprotozoal activity and, no significant effect was detected regarding their cytotoxic potency.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Brenneisen, Rudolf and Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:School of Pharmacy, Shahid Beheshti University of Medical Sciences
ISSN:1735-0328
e-ISSN:1726-6890
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:11 Apr 2018 06:08
Deposited On:07 Nov 2014 08:28

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