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A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

Nollmann, Friederike I. and Heinrich, Antje K. and Brachmann, Alexander O. and Morisseau, Christophe and Mukherjee, Krishnendu and Casanova-Torres, Ángel M. and Strobl, Frederic and Kleinhans, David and Kinski, Sebastian and Schultz, Katharina and Beeton, Michael L. and Kaiser, Marcel and Chu, Ya-Yun and Phan Ke, Long and Thanwisai, Aunchalee and Bozhüyük, Kenan A. J. and Chantratita, Narisara and Götz, Friedrich and Waterfield, Nick R. and Vilcinskas, Andreas and Stelzer, Ernst H. K. and Goodrich-Blair, Heidi and Hammock, Bruce D. and Bode, Helge B.. (2015) A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. ChemBioChem, Vol. 16, H. 5. pp. 766-771.

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Official URL: http://edoc.unibas.ch/dok/A6373527

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Abstract

Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-VCH
ISSN:1439-4227
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Jun 2015 08:53
Deposited On:05 Jun 2015 08:53

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