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Georatusin, a specific antiparasitic polyketide-peptide hybrid from the gungus Geomyces auratus

Shi, Y. M. and Richter, C. and Challinor, V. L. and Grun, P. Girela Del Rio and Kaiser, M. and Schuffler, A. and Piepenbring, M. and Schwalbe, H. and Bode, H. B.. (2018) Georatusin, a specific antiparasitic polyketide-peptide hybrid from the gungus Geomyces auratus. Organic Letters, 20 (6). pp. 1563-1567.

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Official URL: https://edoc.unibas.ch/69274/

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Abstract

Georatusin (1), featuring a highly reduced, methylated polyketide moiety fused to a tryptophan by an amide and ester bond forming a 13-membered ring, was produced by the soil fungus Geomyces auratus. An HMQC-COSY spectrum was measured to build up the connectivities despite the overlapping proton signals. DQF-COSY, HETLOC, J-HMBC, and ROESY were implemented to determine the relative configuration of the flexible moiety. Georatusin (1) shows specific antiparasitic activities against Leishmania donovani and Plasmodium falciparum without obvious cytotoxicity. The biosynthesis of 1 was also proposed.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1523-7060
e-ISSN:1523-7052
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:05 Mar 2019 14:38
Deposited On:05 Mar 2019 14:38

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