Zhao, Lei and Kaiser, Marcel and Bode, Helge B.. (2018) Rhabdopeptide/Xenortide-like peptides from Xenorhabdus innexi with terminal amines showing potent antiprotozoal activity. Organic Letters, 20 (17). pp. 5116-5120.
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Official URL: https://edoc.unibas.ch/65593/
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Abstract
Seven new rhabdopeptide/xenortide-like peptides (RXPs) (1-7) with putrescine or ammonia as the C-terminal amines were isolated from Xenorhabdus innexi DSM 16336. Their chemical structures were elucidated by high-resoultion mass spectroscopy (HR-MS) and one-dimensional (1D) and two-dimensional (2D) NMR. They were evaluated for their activities against protozoan parasites and cytotoxicity against rat skeletal myoblasts (L6 cells). All tested compounds exhibited strong effects against Trypanosoma brucei rhodesiense and Plasmodium falciparum, with IC; 50; values of 0.07-6.25 and 0.091-3.16 μM, respectively, making them the most active RXP derivatives known to date.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser) |
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| UniBasel Contributors: | Kaiser, Marcel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Chemical Society |
| ISSN: | 1523-7060 |
| e-ISSN: | 1523-7052 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 15 Nov 2018 09:56 |
| Deposited On: | 15 Nov 2018 09:56 |
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