Antitrypanosomal sesquiterpene lactones from Saussurea costus

Julianti, Tasqiah and Hata Uribe, Yoshie and Zimmermann, Stefanie and Kaiser, Marcel and Hamburger, Matthias and Adams, Michael. (2011) Antitrypanosomal sesquiterpene lactones from Saussurea costus. Fitoterapia, 82 (7). pp. 955-959.

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Official URL: http://edoc.unibas.ch/dok/A6002118

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In the course of a larger screen of 1800 plant and fungal extracts, the ethyl acetate extract of Saussurea costus roots potently inhibited the growth of Trypanosoma brucei rhodesiense. Subsequent HPLC based activity profiling led to the identification of the sesquiterpene lactones arbusculin B (1), alpha-cyclocostunolide (2), costunolide (3), and dehydrocostuslactone (4). They were tested for in vitro antitrypanosomal activities and cytotoxicity alongside the structurally related sesquiterpene lactones parthenolide (5), zaluzanin D (6), and eupatoriopicrin (7), and had IC(50)s between 0.8 and 22muM. Cytotoxic IC(50)s were from 1.6 to 19muM, and selectivity indices from 0.5 to 6.5
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel and Hamburger, Matthias and Adams, Michael and Zimmermann, Stefanie and Julianti, Tasqiah and Hata Uribe, Yoshie
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Apr 2017 10:00
Deposited On:11 Oct 2012 15:16

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