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Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity

Seebacher, W. and Kaiser, M. and Mäser, P. and Saf, R. and Pferschy-Wenzig, E. M. and Weis, R.. (2023) Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity. Monatshefte fuÌ�r Chemie, 154. pp. 105-114.

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Abstract

Several 1-benzyl and 1,3-dibenzyl derivatives of tetrahydropyridinylidene salts with differing electron withdrawing substituents at the aromatic residues have been prepared. In addition, the amine moiety in position 4 was varied. The new compounds were investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxicity. They were characterized using FT-IR, HRMS and NMR spectroscopy. Structure-activity relationships including reported compounds are discussed. Graphical abstract: [Figure not available: see fulltext.]. © 2022, The Author(s).
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel and Mäser, Pascal
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:0026-9247
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:13 Feb 2023 09:08
Deposited On:13 Feb 2023 09:08

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