Browse by Basel Contributors ID

2023

Kruth, S. and Zimmermann, C. J. M. and Kuhr, K. and HIller, W. and Lütz, S. and Pietruszka, J. and Kaiser, M. and Nett, M.. (2023) Generation of aurachin derivatives by whole-cell biotransformation and evaluation of their antiprotozoal properties. Molecules, 28. p. 1066.

Seebacher, W. and Kaiser, M. and Mäser, P. and Saf, R. and Pferschy-Wenzig, E. M. and Weis, R.. (2023) Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity. Monatshefte fuÌ�r Chemie, 154. pp. 105-114.

Li, J. and Tajuddeen, N. and Feineis, D. and Mudogo, V. and Kaiser, M. and Seo, E. J. and Efferth, T. and Bringmann, G.. (2023) Jozibrevine D from Ancistrocladus ileboensis, the fifth alkaloid in a series of six possible atropo-diastereomeric naphthylisoquinoline dimers, showing antiparasitic and antileukemic activities. Bioorganic & medicinal chemistry letters, 86. p. 129258.

Rao, S. P. S. and Gould, M. K. and Noeske, J. and Saldivia, M. and Jumani, R. S. and Ng, P. S. and Rene, O. and Chen, Y. L. and Kaiser, M. and Ritchie, R. and Francisco, A. F. and Johnson, N. and Patra, D. and Cheung, H. and Deniston, C. and Schenk, A. D. and Cortopassi, W. A. and Schmidt, R. S. and Wiedemar, N. and Thomas, B. and Palkar, R. and Ghafar, N. A. and Manoharan, V. and Luu, C. and Gable, J. E. and Wan, K. F. and Myburgh, E. and Mottram, J. C. and Barnes, W. and Walker, J. and Wartchow, C. and Aziz, N. and Osborne, C. and Wagner, J. and Sarko, C. and Kelly, J. M. and Manjunatha, U. H. and Mäser, P. and Jiricek, J. and Lakshminarayana, S. B. and Barrett, M. P. and Diagana, T. T.. (2023) Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380 (6652). pp. 1349-1356.

Sevik Kilicaslan, O. and Cretton, S. and Hausmann, E. and Quirós-Guerrero, L. and Karimou, S. and Kaiser, M. and Mäser, P. and Christen, P. and Cuendet, M.. (2023) Antiprotozoal activity of natural products from Nigerien plants used in folk medicine. Front Pharmacol, 14. p. 1190241.

2022

Beilstein, S. and El Phil, R. and Sahraoui, S. S. and Scapozza, L. and Kaiser, M. and Mäser, P.. (2022) Laboratory selection of trypanosomatid pathogens for drug resistance. Pharmaceuticals (Basel), 15 (2). p. 135.

Bernhard, S. and Kaiser, M. and Burri, C. and Mäser, P.. (2022) Fexinidazole for human African trypanosomiasis, the fruit of a successful public-private partnership. Diseases, 10 (4). p. 90.

Dolensky, J. and Hinteregger, C. and Leitner, A. and Seebacher, W. and Saf, R. and Belaj, F. and Mäser, P. and Kaiser, M. and Weis, R.. (2022) Antiprotozoal activity of azabicyclo-nonanes linked to tetrazole or sulfonamide cores. Molecules, 27 (19). p. 6217.

Gaudry, A. and Huber, F. and Nothias, L. F. and Cretton, S. and Kaiser, M. and Wolfender, J. L. and Allard, P. M.. (2022) MEMO: mass spectrometry-based sample vectorization to explore chemodiverse datasets. Front Bioinform, 2. p. 842964.

Hsu, C. S. and Gonçalves, C. and Tona, V. and Pons, A. and Kaiser, M. and Maulide, N.. (2022) Leveraging electron-deficient iminium intermediates in a general synthesis of valuable amines. Angewandte Chemie, 61 (20). e202115435.

Koester, D. C. and Marx, V. M. and Williams, S. and Jiricek, J. and Dauphinais, M. and René, O. and Miller, S. L. and Zhang, L. and Patra, D. and Chen, Y. L. and Cheung, H. and Gable, J. and Lakshminarayana, S. B. and Osborne, C. and Galarneau, J. R. and Kulkarni, U. and Richmond, W. and Bretz, A. and Xiao, L. and Supek, F. and Wiesmann, C. and Honnappa, S. and Be, C. and Mäser, P. and Kaiser, M. and Ritchie, R. and Barrett, M. P. and Diagana, T. T. and Sarko, C. and Rao, S. P. S.. (2022) Discovery of novel quinoline-based proteasome inhibitors for Human African Trypanosomiasis (HAT). Journal of medicinal chemistry, 65. 11776−11787.

Lombe, B. K. and Winand, L. and Diettrich, J. and Tobermann, M. and Hiller, W. and Kaiser, M. and Nett, M.. (2022) Discovery, biosynthetic origin, and heterologous production of massinidine, an antiplasmodial alkaloid. Organic letters, 24 (15). pp. 2935-2939.

Mabuza, J. M. and Kaiser, M. and Bapela, M. J.. (2022) In vitro antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from Pappea capensis EckI & Zeyh. (Sapindaceae). J Ethnopharmacol, 298. p. 115659.

Majer, T. and Bhattarai, K. and Straetener, J. and Pohlmann, J. and Cahill, P. and Zimmermann, M. O. and Hübner, M. P. and Kaiser, M. and Svenson, J. and Schindler, M. and Brötz-Oesterhelt, H. and Boeckler, F. M. and Gross, H.. (2022) Discovery of Ircinianin Lactones B and C: two new cyclic sesterterpenes from the marine sponge Ircinia wistarii. Mar Drugs, 20 (8). p. 532.

Mousavi, A. and Foroumadi, P. and Emamgholipour, Z. and Mäser, P. and Kaiser, M. and Foroumadi, A.. (2022) 2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: in vitro and in vivo study. Molecules, 27. p. 5559.

Ragu�, L. and Peng, C. C. and Kaiser, M. and Görls, H. and Beemelmanns, C.. (2022) A modular approach to the antifungal sphingofungin family: concise total synthesis of sphingofungin A and C. Angewandte Chemie, 61 (5). e202112616.

Ren, R. and Wang, X. and Leas, D. A. and Häberli, C. and Cal, M. and Dong, Y. and Kaiser, M. and Keiser, J. and Vennerstrom, J. L.. (2022) Antischistosomal tetrahydro-γ-carboline sulfonamides. Bioorganic & medicinal chemistry letters, 59. p. 128546.

Scheiber, N. and Blaser, G. and Pferschy-Wenzig, E. M. and Kaiser, M. and Mäser, P. and Presser, A.. (2022) Efficient oxidative dearomatisations of substituted phenols using hypervalent iodine (iii) reagents and antiprotozoal evaluation of the resulting cyclohexadienones against T. b. rhodesiense and P. falciparum Strain NF54. Molecules, 27 (19). p. 6559.

Sevik Kilicaslan, O. and Cretton, S. and Quiros-Guerrero, L. and Bella, M. A. and Kaiser, M. and Mäser, P. and Ndongo, J. T. and Cuendet, M.. (2022) Isolation and structural elucidation of compounds from Pleiocarpa bicarpellata and their in vitro antiprotozoal activity. Molecules, 27 (7). p. 2200.

Sykes, M. L. and Kennedy, E. K. and Read, K. D. and Kaiser, M. and Avery, V. M.. (2022) Temporal and wash-out studies identify medicines for malaria venture pathogen box compounds with fast-acting activity against both Trypanosoma cruzi and Trypanosoma brucei. Microorganisms, 10 (7). p. 1287.

Hermann, T. and Wallner, R. and Dolensky, J. and Seebacher, W. and Pferschy-Wenzig, E. -M. and Kaiser, M. and Mäser, P. and Weis, R.. (2022) New derivatives of the multi-stage active Malaria Box compound MMV030666 and their antiplasmodial potencies. Pharmaceuticals (Basel), 15 (12). p. 1503.

Hinteregger, C. and Dolensky, J. and Seebacher, W. and Saf, R. and Mäser, P. and Kaiser, M. and Weis, R.. (2022) Synthesis and antiprotozoal activity of azabicyclo-nonane pyrimidine hybrids. Molecules, 28. p. 307.

2021

Bevkal, Shubha and Naguleswaran, Arunasalam and Rehmann, Ruth and Kaiser, Marcel and Heller, Manfred and Roditi, Isabel. (2021) An Alba-domain protein required for proteome remodelling during trypanosome differentiation and host transition. PLoS Pathogens, 17. e1009239.

Brown, R. W. and Abdel-Megeed, A. M. and Keller, P. A. and Jones, A. J. and Sykes, M. L. and Kaiser, M. and Baell, J. B. and Avery, V. M. and Hyland, C. J. T.. (2021) Investigation of thiazolyl-benzothiophenamides as potential agents for African sleeping sickness. RSC Medicinal Chemistry, 11 (12). pp. 1413-1422.

Brand, M. and Wang, L. and Agnello, S. and Gazzola, S. and Gall, F. M. and Raguz, L. and Kaiser, M. and Schmidt, R. S. and Ritschl, A. and Jelk, J. and Hemphill, A. and Mäser, P. and Butikofer, P. and Adams, M. and Riedl, R.. (2021) Antiprotozoal structure-activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action. Angewandte Chemie, 60 (28). pp. 15613-15621.

Boberg, M. and Cal, M. and Kaiser, M. and Jansson-Lofmark, R. and Mäser, P. and Ashton, M.. (2021) Enantiospecific antitrypanosomal in vitro activity of eflornithine. PLoS Negl Trop Dis, 15 (7). e0009583.

Flittner, D. and Kaiser, M. and Mäser, P. and Lopes, N. P. and Schmidt, T. J.. (2021) The alkaloid-enriched fraction of; The alkaloid-enriched fraction of Pachysandra terminalis (Buxaceae) shows prominent activity against Trypanosoma brucei rhodesiensePachysandra terminalis; (Buxaceae) shows prominent activity against; Trypanosoma brucei rhodesiense. Molecules, 26 (3). p. 591.

Fesser, A. and Kaiser, M. and Mäser, P.. (2021) Neue Parameter für die Wirkstofftestung gegen Trypanosoma cruzi. Biospektrum (Heidelb), 27 (2). pp. 168-170.

Doganc, F. and Celik, I. and Eren, G. and Kaiser, M. and Brun, R. and Goker, H.. (2021) Synthesis, in vitro antiprotozoal activity, molecular docking and molecular dynamics studies of some new monocationic guanidinobenzimidazoles. European journal of medicinal chemistry, 221. p. 113545.

Cretton, S. and Genta-Jouve, G. and Kaiser, M. and Mäser, P. and Muñoz, O. and Bürgi, T. and Cuendet, M. and Christen, P.. (2021) Hygroline derivatives from Schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities. Phytochemistry, 192. p. 112957.

Hoffelner, M. H. and Seebacher, W. and Kaiser, M. and Mäser, P. and Pferschy-Wenzig, E. M. and Saf, R. and Belaj, F. and Kretschmer, N. and Alajlani, M. and Brantner, A. and Bauer, R. and Weis, R.. (2021) Unexpected ring‑opening of 2,3‑dihydropyridines. Monatshefte für Chemie, 152. pp. 1347-1359.

Hochegger, P. and Dolensky, J. and Seebacher, W. and Saf, R. and Kaiser, M. and Mäser, P. and Weis, R.. (2021) 8-amino-6-methoxyquinoline-tetrazole hybrids: Impact of linkers on antiplasmodial activity. Molecules, 26 (18). p. 5530.

Hermann, T. and Hochegger, P. and Dolensky, J. and Seebacher, W. and Pferschy-Wenzig, E. M. and Saf, R. and Kaiser, M. and Mäser, P. and Weis, R.. (2021) Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity. Pharmaceuticals (Basel), 14. p. 1109.

Greve, H. L. and Kaiser, M. and Mäser, P. and Schmidt, T. J.. (2021) Boswellic acids show in vitro activity against Leishmania donovani. Molecules, 26 (12). p. 3651.

Lombe, B. K. and Feineis, D. and Mudogo, V. and Kaiser, M. and Bringmann, G.. (2021) Spirombandakamine A3 and cyclombandakamines A8 and A9, polycyclic naphthylisoquinoline dimers, with antiprotozoal activity, from a Congolese Ancistrocladus plant. Journal of natural products, 84 (4). pp. 1335-1344.

Llurba Montesino, N. and Kaiser, M. and Mäser, P. and Schmidt, T. J.. (2021) Nucleic acid amplification techniques for the detection of Schistosoma mansoni infection in humans and the intermediate snail host: a structured review and meta-analysis of diagnostic accuracy. Molecules, 26 (11). p. 3226.

Leas, D. A. and Sanford, A. G. and Wu, J. and Cal, M. and Kaiser, M. and Wittlin, S. and Hemsley, R. M. and Darner, E. B. and Lui, L. M. and Davis, P. H. and Vennerstrom, J. L.. (2021) Diaryl ureas as an antiprotozoal chemotype. ACS Infect Dis, 7 (6). pp. 1578-1583.

Mahmoud, A. B. and Abd Algaffar, S. and van de Sande, W. and Khalid, S. and Kaiser, M. and Mäser, P.. (2021) Niclosamide is active in vitro against mycetoma pathogens. Molecules, 26 (13). p. 4005.

Mizukawa, Y. and Ikegami-Kawai, M. and Horiuchi, M. and Kaiser, M. and Kojima, M. and Sakanoue, S. and Miyagi, S. and Nanga Chick, C. and Togashi, H. and Tsubuki, M. and Ihara, M. and Usuki, T. and Itoh, I.. (2021) Quest for a potent antimalarial drug lead: synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines. Bioorganic & medicinal chemistry, 33. p. 116018.

Rocha-Hasler, M. and de Oliveira, G. M. and da Gama, A. N. and Fiuza, L. F. A. and Fesser, A. F. and Cal, M. and Rocchetti, R. and Peres, R. B. and Guan, X. L. and Kaiser, M. and Soeiro, M. N. C. and Mäser, P.. (2021) Combination with tomatidine improves the potency of posaconazole against Trypanosoma cruzi. Front Cell Infect Microbiol, 11. p. 617917.

Petritsch, M. and Seebacher, W. and Mohsin, N. U. and Dolensky, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Belaj, F. and Saf, R. and Kretschmer, N. and Alajlani, M. and Brantner, A. and Bauer, R. and Schuhly, W. and Weis, R.. (2021) Preparation of new 1,3-dibenzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. Eur J Med Chem, 210. p. 112969.

Seebacher, W. and Mohsin, N. U. A. and Dolensky, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Saf, R. and Schuster, D. and Temml, V. and Weis, R.. (2021) Modifications and hybrids of 1,2,3,4‑tetrahydropyridinium salts and their antiprotozoal potencies. Monatshefte fuÌ�r Chemie, 152. pp. 1347-1359.

Uth, J. F. and Borgel, F. and Lehmkuhl, K. and Schepmann, D. and Kaiser, M. and Jabor, V. A. P. and Nonato, M. C. and Krauth-Siegel, R. L. and Schmidt, T. J. and Wunsch, B.. (2021) Synthesis and biological evaluation of natural-product-inspired, aminoalkyl-substituted 1-benzopyrans as novel antiplasmodial agents. Journal of medicinal chemistry, 64 (9). pp. 6397-6409.

Szabó, L. U. and Kaiser, M. and Mäser, P. and Schmidt, T. J.. (2021) Identification of antiprotozoal compounds from Buxus sempervirens L. by PLS-prediction. Molecules, 26 (20). p. 6181.

Szabó, L. U. and Kaiser, M. and Mäser, P. and Schmidt, T. J.. (2021) Antiprotozoal Nor-triterpene alkaloids from Buxus sempervirens L. Antibiotics (Basel), 10 (6). p. 696.

Zhao, L. and Le Chapelain, C. and Brachmann, A. O. and Kaiser, M. and Groll, M. and Bode, H. B.. (2021) Activation, structure, biosynthesis and bioactivity of glidobactin-like proteasome inhibitors from Photorhabdus laumondii. Chembiochem, 22 (9). pp. 1582-1588.

Winand, L. and Schneider, P. and Kruth, S. and Greven, N.-J- and Hiller, W. and Kaiser, M. and Pietruszka, J. and Nett, M.. (2021) Mutasynthesis of physostigmines in Myxococcus xanthus. Organic letters, 23 (16). pp. 6563-6567.

2020

Tasdemir, Deniz and MacIntosh, Andrew J. J. and Stergiou, Polyxeni and Kaiser, Marcel and Mansour, Nuha R. and Bickle, Quentin and Huffman, Michael A.. (2020) Antiprotozoal and antihelminthic properties of plants ingested by wild Japanese macaques (Macaca fuscata yakui) in Yakushima Island. Journal of Ethnopharmacology, 247. p. 112270.

Babanezhad Harikandei, K. and Salehi, P. and Ebrahimi, S. N. and Bararjanian, M. and Kaiser, M. and Al-Harrasi , A.. (2020) Synthesis, in-vitro antiprotozoal activity and molecular docking study of isothiocyanate derivatives. Bioorganic & medicinal chemistry, 28 (1). p. 115185.

Dawidowski, Maciej and Kalel, Vishal C. and Napolitano, Valeria and Fino, Roberto and Schorpp, Kenji and Emmanouilidis, Leonidas and Lenhart, Dominik and Ostertag, Michael and Kaiser, Marcel and Kolonko, Marta and Tippler, Bettina and Schliebs, Wolfgang and Dubin, Grzegorz and Mäser, Pascal and Tetko, Igor V. and Hadian, Kamyar and Plettenburg, Oliver and Erdmann, Ralf and Sattler, Michael and Popowicz, Grzegorz M.. (2020) Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity. Journal of medicinal chemistry, 63 (2). pp. 847-879.

Rao, Srinivasa P. S. and Lakshminarayana, Suresh B. and Jiricek, Jan and Kaiser, Marcel and Ritchie, Ryan and Myburgh, Elmarie and Supek, Frantisek and Tuntland, Tove and Nagle, Advait and Molteni, Valentina and Mäser, Pascal and Mottram, Jeremy C. and Barrett, Michael P. and Diagana, Thierry T.. (2020) Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of african trypanosomiasis. Tropical medicine and infectious disease, 5. p. 28.

Hagen, James P. and Darner, Grant and Anderson, Samuel and Higgins, Katie and Leas, Derek A. and Mitra, Ananya and Mashinson, Victoria and Wol, Tasloach and Vera-Esquivel, Carlos and Belter, Bret and Cal, Monica and Kaiser, Marcel and Wallick, Alexander and Warner, Rosalie C. and Davis, Paul H.. (2020) Activity of diphenyl ether benzyl amines against Human African Trypanosomiasis. Bioorganic chemistry, 97. p. 103590.

Ponzi, Simona and Bresciani, Alberto and Kaiser, Marcel and Nardi, Valentina and Nizi, Emanuela and Ontoria, Jesus M. and Pace, Paola and Paonessa, Giacomo and Summa, Vincenzo and Harper, Steven. (2020) Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors. Bioorganic & medicinal chemistry letters, 30 (8). p. 127052.

Kaiser, M. and Mäser, P.. (2020) In Vitro drug efficacy testing against Trypanosoma brucei. In: Trypanosomatids. Methods and Protocols, 2116. New York, pp. 781-789.

Harrison, Justin R. and Sarkar, Sandipan and Hampton, Shahienaz and Riley, Jennifer and Stojanovski, Laste and Sahlberg, Christer and Appelqvist, Pia and Erath, Jessey and Mathan, Vinodhini and Rodriguez, Ana and Kaiser, Marcel and Pacanowska, Dolores Gonzalez and Read, Kevin D. and Johansson, Nils Gunnar and Gilbert, Ian H.. (2020) Discovery and optimization of a compound series active against Trypanosoma cruzi, the causative agent of chagas disease. Journal of medicinal chemistry, 63 (6). pp. 3066-3089.

Zhao, L. and Vo, T. D. and Kaiser, M. and Bode, H. B.. (2020) Phototemtide A, a cyclic lipopeptide heterologously expressed from Photorhabdus temperata Meg1, shows selective antiprotozoal activity. ChemBioChem, 21 (9). pp. 1288-1292.

Mahmoud, Abdelhalim Babiker and Danton, Ombeline and Kaiser, Marcel and Han, Sohee and Moreno, Aitor and Abd Algaffar, Shereen and Khalid, Sami and Oh, Won Keun and Hamburger, Matthias and Mäser, Pascal. (2020) Lignans, amides, and saponins from Haplophyllum tuberculatum and their antiprotozoal activity. Molecules, 25 (12). p. 2825.

Mahmoud, Abdelhalim Babiker and Mäser, Pascal and Kaiser, Marcel and Hamburger, Matthias and Khalid, Sami. (2020) Mining sudanese medicinal plants for antiprotozoal agents. Frontiers in pharmacology, 11. p. 865.

Greve, Hippolyt L. and Kaiser, Marcel and Schmidt, Thomas J.. (2020) Investigation of antiplasmodial effects of terpenoid compounds isolated from myrrh. Planta medica, 86 (9). pp. 643-654.

Bernal, Freddy A. and Gerhards, Marcel and Kaiser, Marcel and Wünsch, Bernhard and Schmidt, Thomas J.. (2020) (+/-)-trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: synthesis, in vitro evaluation and SAR analysis. European journal of medicinal chemistry, 205. p. 112493.

Fesser, Anna F. and Braissant, Olivier and Olmo, Francisco and Kelly, John M. and Mäser, Pascal and Kaiser, Marcel. (2020) Non-invasive monitoring of drug action: a new live in vitro assay design for Chagas' disease drug discovery. PLoS Neglected Tropical Diseases, 14 (7). e0008487.

Chung, J. H. and Tang, A. H. and Geraghty, K. and Corcilius, L. and Kaiser, M. and Payne, R.J.. (2020) Total synthesis and antitrypanosomal activity of janadolide and simplified analogues. Organic letters, 22. pp. 3089-3093.

Mahmoud, Abdelhalim Babiker and Danton, Ombeline and Kaiser, Marcel and Khalid, Sami and Hamburger, Matthias and Mäser, Pascal. (2020) HPLC-based activity profiling for antiprotozoal compounds in Croton gratissimus and Cuscuta hyalina. Frontiers in Pharmacology, 11. p. 1246.

Zadali, Reza and Ebrahimi, Samad Nejad and Tofighi, Zahra and Es-haghi, Ali and Hamburger, Matthias and Kaiser, Marcel and D'Ambola, Massimiliano and De Tommasi, Nunziatina and Hadjiakhoondi, Abbas. (2020) Antiprotozoal activity of diterpenoids isolated from Zhumeria majdae - absolute configuration by circular dichroism. DARU Journal of Pharmaceutical Sciences, 28 (2). pp. 455-462.

Bernal, Freddy A. and Kaiser, Marcel and Wünsch, Bernhard and Schmidt, Thomas J.. (2020) Structure-activity relationships of cinnamate ester analogues as potent antiprotozoal agents. ChemMedChem, 15. pp. 68-78.

Cretton, S. and Kaiser, M. and Karimou, S. and Ebrahimi, S. N. and Mäser, P. and Cuendet, M. and Christen, P.. (2020) Pyridine-4(1H)-one alkaloids from Waltheria indica as antitrypanosomatid agents. Journal of natural products, 83 (11). pp. 3363-3371.

Hoffelner, M. and Hassan, U. and Seebacher, W. and Dolensky, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Saf, R. and Weis, R.. (2020) New 2‑aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities. Monatshefte für Chemie, 151. pp. 1375-1385.

Kalt, M. M. and Schuehly, W. and Saf, R. and Ochensberger, S. and Solnier, J. and Bucar, F. and Kaiser, M. and Presser, A.. (2020) Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents. Eur J Med Chem, 207. p. 112837.

Robinson, W. J. and Taylor, A. E. and Lauga-Cami, S. and Weaver, G. W. and Arroo, R. R. J. and Kaiser, M. and Gul, S. and Kuzikov, M. and Ellinger, B. and Singh, K. and Schirmeister, T. and Botana, A. and Eurtivong, C. and Bhambra, A. S.. (2020) The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines. Eur J Med Chem, 209. p. 112871.

Saldivia, M. and Fang, E. and Ma, X. and Myburgh, E. and Carnielli, JBT. and Bower-Lepts, C. and Brown, E. and Ritchie, R. and Lakshminarayana, SB. and Chen, YL. and Patra, D. and Ornelas, E. and Koh, HXY. and Williams, SL. and Supek, F. and Paape, D. and McCulloch, R. and Kaiser, M. and Barrett, MP. and Jiricek, J. and Diagana, TT. and Mottram, JC. and Rao, SPS.. (2020) Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nat Microbiol, 5 (10). pp. 1207-1216.

Soroury, S. and Alilou, M. and Gelbrich, T. and Tabefam, M. and Danton, O. and Ebrahimi, S. N. and Kaiser, M. and Hamburger, M. and Stuppner, H. and Moridi Farimani, M.. (2020) Unusual derivatives from Hypericum scabrum. Scientific Reports, 10. p. 22181.

2019

Saccoliti, Francesco and Madia, Valentina Noemi and Tudino, Valeria and De Leo, Alessandro and Pescatori, Luca and Messore, Antonella and De Vita, Daniela and Scipione, Luigi and Brun, Reto and Kaiser, Marcel and Mäser, Pascal and Calvet Alvarez, Claudia Magalhaes and Jennings, Gareth K. and Podust, Larissa M. and Pepe, Giacomo and Cirilli, Roberto and Faggi, Cristina and Di Marco, Annalise and Battista, Maria Rosaria and Summa, Vincenzo and Costi, Roberta and Di Santo, Roberto. (2019) Design, synthesis, and biological evaluation of new 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives as antiprotozoal agents. Journal of Medicinal Chemistry, 62 (3). pp. 1330-1347.

Smeilus, T. and Mousavizadh, F. and Kriger, J. and Tu, X. and Kaiser, M. and Giannis, A.. (2019) Synthesis and biological investigation of (+)-3-hydroxymethylartemisinin. Journal of Organic Chemistry, 15. pp. 567-570.

Galkina, Anna and Krause, Nico and Lenz, Mairin and Daniliuc, Constantin G. and Kaiser, Marcel and Schmidt, Thomas J.. (2019) Antitrypanosomal activity of sesquiterpene lactones from Helianthus tuberosus L. including a new furanoheliangolide with an unusual structure. Molecules, 24 (6). p. 1068.

Mofidi Tabatabaei, Sahar and Nejad Ebrahimi, Samad and Salehi, Peyman and Sonboli, Ali and Tabefam, Marzieh and Kaiser, Marcel and Hamburger, Matthias and Moridi Farimani, Mahdi. (2019) Antiprotozoal germacranolide sesquiterpene lactones from Tanacetum sonbolii. Planta medica, 85 (5). pp. 424-430.

Hochegger, Patrick and Faist, Johanna and Seebacher, Werner and Saf, Robert and Mäser, Pascal and Kaiser, Marcel and Weis, Robert. (2019) Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity. Bioorganic & medicinal chemistry, 27 (10). pp. 2052-2065.

Mohsin, N. U. A. and Seebacher, W. and Hochegger, P. and Faist, J. and Saf, R. and Kaiser, M. and Mäser, P. and Weis, R.. (2019) Synthesis of new 1-benzyl tetrahydropyridin-4-ylidene piperidinium salts and their antiplasmodial and antitrypanosomal activities. Medicinal chemistry research, 28 (5). pp. 742-753.

Mufusama, J. P. and Feineis, D. and Mudodo, V. and Kaiser, M. and Brun, R. and Bringmann, G.. (2019) Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,80'-coupled monomeric alkaloids, ikelacongolines A-D, from a Congolese Ancistrocladus liana. RSC advances, 9 (21). pp. 12034-12046.

Kimani, Njogu M. and Backhaus, Solveig and Matasyoh, Josphat C. and Kaiser, Marcel and Herrmann, Fabian C. and Schmidt, Thomas J. and Langer, Klaus. (2019) Preparation of sesquiterpene lactone-loaded pla nanoparticles and evaluation of their antitrypanosomal activity. Molecules, 24 (11). E2110.

Tshitenge, Dieudonné Tshitenge and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2019) An unusually broad series of seven cyclombandakamines, bridged dimeric naphthylisoquinoline alkaloids from the congolese liana ancistrocladus ealaensis. Scientific reports, 9. p. 9812.

Babanezhad Harikandei, Kosar and Salehi, Peyman and Ebrahimi, Samad Nejad and Bararjanian, Morteza and Kaiser, Marcel and Khavasi, Hamid Reza and Al-Harrasi, Ahmed. (2019) N-substituted noscapine derivatives as new antiprotozoal agents: synthesis, antiparasitic activity and molecular docking study. Bioorganic chemistry, 91. p. 103116.

De Gasparo, Raoul and Halgas, Ondrej and Harangozo, Dora and Kaiser, Marcel and Pai, Emil F. and Krauth-Siegel, R. Luise and Diederich, François. (2019) Targeting a large active site : structure-based design of nanomolar inhibitors of Trypanosoma brucei trypanothione reductase. Chemistry - A European Journal, 25 (49). pp. 11416-11421.

Shi, Yan-Ni and Pusch, Stefan and Shi, Yi-Ming and Richter, Christian and Maciá-Vicente, Jose G. and Schwalbe, Harald and Kaiser, Marcel and Opatz, Till and Bode, Helge B.. (2019) (+/-)-Alternarlactones A and B, two antiparasitic alternariol-like dimers from the fungus Alternaria alternata p1210 isolated from the halophyte Salicornia sp. Journal of Organic Chemistry, 84 (17). pp. 11203-11209.

Vu Van , T. and Pham-Duc , P. and Winkler, M. S. and Zurbrügg, C. and Zinsstag, J. and Tran, B. H. and Nguyen-Viet , H.. (2019) New derivatives of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Monatshefte für Chemie, 150 (11). pp. 1959-1972.

Tshitenge, Dieudonné Tshitenge and Bruhn, Torsten and Feineis, Doris and Schmidt, David and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Würthner, Frank and Awale, Suresh and Bringmann, Gerhard. (2019) Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana; Ancistrocladus ealaensis; , Targeting Pancreatic Cancer Cells. Journal of natural products, 82 (11). pp. 3150-3164.

Fayez, Shaimaa and Li, Jun and Feineis, Doris and Aké Assi, Laurent and Kaiser, Marcel and Brun, Reto and Anany, Mohamed A. and Wajant, Harald and Bringmann, Gerhard. (2019) A Near-Complete Series of Four Atropisomeric Jozimine A; 2; -Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from; Ancistrocladus abbreviatus;. Journal of natural products, 82 (11). pp. 3033-3046.

Pérez-Moreno , G. and Sánchez-Carrasco , P. and Ruiz-Pérez , L.M. and Johansson, N. G. and Muller, S. and Baragaña, B. and Hampton, S. E. and Gilbert, I. H. and Kaiser, M. and Sarkar, S. and Pandurangan, T. and Kumar, V. and Gonzalez-Pacanowska , D.. (2019) Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity. Malaria journal, 18. p. 392.

Tasdemir, D. and Kaiser, M. and Demirci, B. and Demirci, F. and Baser, K. H. C.. (2019) Antiprotozoal activity of turkish Origanum onites essential oil and its components. Molecules, 24 (23). p. 4421.

Wang, X. and Cal, M. and Kaiser, M. and Buckner, F. S. and Lepesheva, G. I. and Sanford, A. G. and Wallick, A. I. and Davis, P. H. and Vennerstrom, J. L.. (2019) A new chemotype with promise against Trypanosoma cruzi. Bioorganic & medicinal chemistry letters, 30. p. 126778.

Zhao, L. and Awori, R. M. and Kaiser, M. and Gross, J. and Opatz, T. and Bode, H. B.. (2019) Structure, biosynthesis, and bioactivity of photoditritide from Photorhabdus temperata meg1. Journal of natural products, 82 (12). pp. 3499-3503.

2018

Cretton, Sylvian and Oyarzún, Alejandra and Righi, Davide and Sahib, Lamia and Kaiser, Marcel and Christen, Philippe and Fajardo, Victor. (2018) A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea. Natural Product Research, 32 (6). pp. 695-701.

Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Hochegger, P. and Kaiser, M. and Mäser, P. and Saf, R. and Weis, R.. (2018) The antiplasmodial and antitrypanosomal activities of novel piperazine derivatives of 3-azabicyclo[3.2.2]nonanes. Monatshefte für Chemie, 149 (1). pp. 99-109.

Schies, C. and Seupel, R. and Feineis, D. and Gehrold, A. and Schraut, M. and Kaiser, M. and Brun, R. and Bringmann, G.. (2018) Biomimetic total synthesis of mbandakamine A and further antiplasmodial naphthylisoquinoline dimers. ChemistrySelect, 3. pp. 940-945.

Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2018) Sesquiterpene lactones from Vernonia cinerascens sch. bip. and their in vitro antitrypanosomal activity. Molecules: A Journal of Synthetic Chemistry and Natural Product Chemistry , 23 (2). E248.

Levatić, Jurica and Pavić, Kristina and Perković, Ivana and Uzelac, Lidija and Ester, Katja and Kralj, Marijeta and Kaiser, Marcel and Rottmann, Matthias and Supek, Fran and Zorc, Branka. (2018) Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity. European journal of medicinal chemistry, 146. pp. 651-667.

Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2018) Antiprotozoal sesquiterpene lactones and other constituents from Tarchonanthus camphoratus and Schkuhria pinnata. Journal of natural products, 81 (1). pp. 124-130.

De Gasparo, Raoul and Brodbeck-Persch, Elke and Bryson, Steve and Hentzen, Nina B. and Kaiser, Marcel and Pai, Emil F. and Krauth-Siegel, R. Luise and Diederich, François. (2018) Biological evaluation and x-ray co-crystal structures of cyclohexylpyrrolidine ligands for trypanothione reductase, an enzyme from the redox metabolism of trypanosoma. ChemMedChem, 13 (9). pp. 957-967.

Ebiloma, Godwin U. and Ayuga, Teresa Díaz and Balogun, Emmanuel O. and Gil, Lucía Abad and Donachie, Anne and Kaiser, Marcel and Herraiz, Tomás and Inaoka, Daniel K. and Shiba, Tomoo and Harada, Shigeharu and Kita, Kiyoshi and de Koning, Harry P. and Dardonville, Christophe. (2018) Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense. European journal of medicinal chemistry, 150. pp. 385-402.

Giroud, Maude and Dietzel, Uwe and Anselm, Lilli and Banner, David and Kuglstatter, Andreas and Benz, Jörg and Blanc, Jean-Baptiste and Gaufreteau, Delphine and Liu, Haixia and Lin, Xianfeng and Stich, August and Kuhn, Bernd and Schuler, Franz and Kaiser, Marcel and Brun, Reto and Schirmeister, Tanja and Kisker, Caroline and Diederich, François and Haap, Wolfgang. (2018) Repurposing a library of human cathepsin L ligands : identification of macrocyclic lactams as potent rhodesain and Trypanosoma brucei inhibitors. Journal of medicinal chemistry, 61 (8). pp. 3350-3369.

Giroud, Maude and Kuhn, Bernd and Saint-Auret, Sarah and Kuratli, Christoph and Martin, Rainer E. and Schuler, Franz and Diederich, François and Kaiser, Marcel and Brun, Reto and Schirmeister, Tanja and Haap, Wolfgang. (2018) 2 H-1,2,3-Triazole-based dipeptidyl nitriles : potent, selective, and Trypanocidal rhodesain inhibitors by structure-based design. Journal of medicinal chemistry, 61 (8). pp. 3370-3388.

Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Kretschmer, N. and Bauer, R. and Saf, R. and Kaiser, M. and Mäser, P. and Weis, R.. (2018) Modifications on tetrahydropyridin-4-ylidene ammonium salts and their antiprotozoal activities. Monatshefte für Chemie, 149 (4). pp. 801-812.

Zhang, Huaisheng and Collins, Jasmine and Nyamwihura, Rogers and Ware, Shelbi and Kaiser, Marcel and Ogungbe, Ifedayo Victor. (2018) Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent. Bioorganic & medicinal chemistry, 28 (9). pp. 1647-1651.

Wesche, Frank and Adihou, Hélène and Kaiser, Astrid and Wurglics, Mario and Schubert-Zsilavecz, Manfred and Kaiser, Marcel and Bode, Helge B.. (2018) Combined approach of backbone amide linking and on-resin n-methylation for the synthesis of bioactive and metabolically stable peptides. Journal of medicinal chemistry, 61 (9). pp. 3930-3938.

Farimani, Mahdi M. and Khodaei, Bahareh and Moradi, Hanzaleh and Aliabadi, Abbas and Ebrahimi, Samad N. and De Mieri, Maria and Kaiser, Marcel and Hamburger, Matthias. (2018) Phytochemical study of Salvia leriifolia roots : rearranged abietane diterpenoids with antiprotozoal activity. Journal of natural products, 81 (6). pp. 1384-1390.

Tallini, Luciana R. and Torras-Claveria, Laura and Borges, Warley de Souza and Kaiser, Marcel and Viladomat, Francesc and Zuanazzi, José Angelo S. and Bastida, Jaume. (2018) N-oxide alkaloids from Crinum amabile (Amaryllidaceae). Molecules, 23 (6). E1277.

Tabefam, Marzieh and Moridi Farimani, Mahdi and Danton, Ombeline and Ramseyer, Justine and Kaiser, Marcel and Ebrahimi, Samad Nejad and Salehi, Peyman and Batooli, Hoosien and Potterat, Olivier and Hamburger, Matthias. (2018) Antiprotozoal diterpenes from Perovskia abrotanoides. Planta Medica, 84 (12-13). pp. 913-919.

Guo, H. and Benndorf, R. and Konig, S. and Leichnitz, D. and Weigel, C. and Peschel, G. and Berthel, P. and Kaiser, M. and Steinbeck, C. and Werz, O. and Pulsen, M. and Beemelmanns, C.. (2018) Expanding the rubterolone Family : intrinsic reactivity and directed diversification of PKS-derived pyrans. Chemistry - A European Journal, 24 (44). pp. 11319-11324.

Zhao, Lei and Kaiser, Marcel and Bode, Helge B.. (2018) Rhabdopeptide/Xenortide-like peptides from Xenorhabdus innexi with terminal amines showing potent antiprotozoal activity. Organic Letters, 20 (17). pp. 5116-5120.

O' Donovan, Daniel H. and Aillard, Paul and Berger, Martin and de la Torre, Aurélien and Petkova, Desislava and Knittl-Frank, Christian and Geerdink, Danny and Kaiser, Marcel and Maulide, Nuno. (2018) C-H activation enables a concise total synthesis of quinine and analogues with enhanced antimalarial activity. Angewandte Chemie (International ed. in English), 57 (33). pp. 10737-10741.

Royo, Santiago and Schirmeister, Tanja and Kaiser, Marcel and Jung, Sascha and Rodríguez, Santiago and Bautista, José Manuel and González, Florenci V.. (2018) Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates. Bioorganic & medicinal chemistry, 26 (16). pp. 4624-4634.

Guo, Huijuan and Schmidt, Alexander and Stephan, Philipp and Raguž, Luka and Braga, Daniel and Kaiser, Marcel and Dahse, Hans-Martin and Weigel, Christiane and Lackner, Gerald and Beemelmanns, Christine. (2018) Precursor-directed diversification of cyclic tetrapeptidic pseudoxylallemycins. ChemBioChem, 19 (21). pp. 2307-2311.

Zhao, Lei and Cai, Xiaofeng and Kaiser, Marcel and Bode, Helge B.. (2018) Methionine-containing rhabdopeptide/xenortide-like peptides from heterologous expression of the biosynthetic gene cluster kj12ABC in Escherichia coli. Journal of natural products, 81 (10). pp. 2292-2295.

Presser, Armin and Lainer, Gunda and Kretschmer, Nadine and Schuehly, Wolfgang and Saf, Robert and Kaiser, Marcel and Kalt, Marc-Manuel. (2018) Synthesis of jacaranone-derived nitrogenous cyclohexadienones and their antiproliferative and antiprotozoal activities. Molecules, 23 (11). E2902.

Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Nogueira, Mauro S. and Trossini, Gustavo H. G. and Schmidt, Thomas J.. (2018) Complementary quantitative structure-activity relationship models for the antitrypanosomal activity of sesquiterpene lactones. International journal of molecular sciences, 19 (12). p. 3271.

Ferrigno, Federica and Biancofiore, Ilaria and Malancona, Savina and Ponzi, Simona and Paonessa, Giacomo and Graziani, Rita and Bresciani, Alberto and Gennari, Nadia and Di Marco, Annalise and Kaiser, Marcel and Summa, Vincenzo and Harper, Steven and Ontoria, Jesus M.. (2018) Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitro. Bioorganic & medicinal chemistry letters, 28 (23-24). pp. 3689-3692.

Tabefam, M. and Farimani, M. M. and Danton, O. and Ramseyer, J. and Ebrahimi, S. N. and Neuburger, M. and Kaiser, M. and Salehi, P. and Potterat, O. and Hamburger, M.. (2018) Antiprotozoal isoprenoids from Salvia hydrangea. Journal of natural products, 81. pp. 2682-2691.

Uliassi, Elisa and Piazzi, Lorna and Belluti, Federica and Mazzanti, Andrea and Kaiser, Marcel and Brun, Reto and Moraes, Carolina B. and Freitas-Junior, Lucio H. and Gul, Sheraz and Kuzikov, Maria and Ellinger, Bernhard and Borsari, Chiara and Costi, Maria Paola and Bolognesi, Maria Laura. (2018) Development of a focused library of triazole-linked privileged-structure-based conjugates leading to the discovery of novel phenotypic hits against protozoan parasitic infections. ChemMedChem, 13 (7). pp. 678-683.

Saccoliti, Francesco and Madia, Valentina Noemi and Tudino, Valeria and De Leo, Alessandro and Pescatori, Luca and Messore, Antonella and De Vita, Daniela and Scipione, Luigi and Brun, Reto and Kaiser, Marcel and Mäser, Pascal and Calvet, Claudia Magalhaes and Jennings, Gareth K. and Podust, Larissa M. and Costi, Roberta and Di Santo, Roberto. (2018) Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents. European journal of medicinal chemistry, 156. pp. 53-60.

Tshitenge, Dieudonné Tshitenge and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas and Bringmann, Gerhard. (2018) Mbandakamine-type naphthylisoquinoline dimers and related alkaloids from the central African liana ancistrocladus ealaensis with antiparasitic and antileukemic activities. Journal of natural products, 81 (4). pp. 918-933.

Shi, Y. M. and Richter, C. and Challinor, V. L. and Grun, P. Girela Del Rio and Kaiser, M. and Schuffler, A. and Piepenbring, M. and Schwalbe, H. and Bode, H. B.. (2018) Georatusin, a specific antiparasitic polyketide-peptide hybrid from the gungus Geomyces auratus. Organic Letters, 20 (6). pp. 1563-1567.

Krieger, Johannes and Smeilus, Toni and Kaiser, Marcel and Seo, Ean-Jeong and Efferth, Thomas and Giannis, Athanassios. (2018) Total synthesis and biological investigation of (-)-artemisinin : the antimalarial activity of artemisinin is not stereospecific. Angewandte Chemie, 57 (27). pp. 8293-8296.

2017

Bapela, M. J. and Kaiser, M. and Meyer, J. J. M.. (2017) Antileishmanial activity of selected South African plant species. South African journal of botany, 108. pp. 342-345.

Faist, Johanna and Hinteregger, Clemens and Seebacher, Werner and Saf, Robert and Mäser, Pascal and Kaiser, Marcel and Weis, Robert. (2017) New derivatives of 7-chloroquinolin-4-amine with antiprotozoal activity. Bioorganic & medicinal chemistry, 25 (3). pp. 941-948.

Kuzma, Ł and Kaiser, M. and Wysokińska, H.. (2017) The production and antiprotozoal activity of abietane diterpenes in Salvia austriaca hairy roots grown in shake flasks and bioreactor. Preparative biochemistry, 47 (1). pp. 58-66.

Ndjakou Lenta, B. and Ngatchou, J. and Frese, M. and Ladoh-Yemeda, F. and Nardella, F. and Michalek, C. and Wibberg, D. and Ngouela, S. and Tsamo, E. and Kaiser, M. and Kalinowski, J. and Sewald, N.. (2017) Purpureone, an antileishmanial ergochrome from the endophytic fungus Purpureocillium lilacinum. Zeitschrift für Naturforschung. Sect. B, Chemical sciences, 71 (11). pp. 1159-1167.

Cai, Xiaofeng and Challinor, Victoria L. and Zhao, Lei and Reimer, Daniela and Adihou, Hélène and Grün, Peter and Kaiser, Marcel and Bode, Helge B.. (2017) Biosynthesis of the antibiotic nematophin and its elongated derivatives in entomopathogenic bacteria. Organic letters, 19 (4). pp. 806-809.

De Mieri, Maria and Monteleone, Giannicola and Ismajili, Isidor and Kaiser, Marcel and Hamburger, Matthias. (2017) Antiprotozoal activity-based profiling of a dichloromethane extract from anthemis nobilis flowers. Journal of Natural Products, 80 (2). pp. 459-470.

Li, Jun and Seupel, Raina and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Brünnert, Daniela and Chatterjee, Manik and Seo, Ean-Jeong and Efferth, Thomas and Bringmann, Gerhard. (2017) Dioncophyllines C2, D2, and F and related naphthylisoquinoline alkaloids from the congolese liana Ancistrocladus ileboensis with potent activities against Plasmodium falciparum and against multiple myeloma and leukemia cell lines. Journal of natural products, 80 (2). pp. 443-458.

Dawidowski, M. and Emmanouilidis, L. and Kalel, V. C. and Tripsianes, K. and Schorpp, K. and Hadian, K. and Kaiser, M. and Mäser, P. and Kolonko, M. and Tanghe, S. and Rodriguez, A. and Schliebs, W. and Erdmann, R. and Sattler, M. and Popowicz, G. M.. (2017) Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites. Science, 355 (6332). pp. 1416-1420.

Kimani, Njogu M. and Matasyoh, Josphat C. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Anti-trypanosomatid elemanolide sesquiterpene lactones from Vernonia lasiopus O. Hoffm. Molecules, 22 (4). E597.

Cai, Xiaofeng and Nowak, Sarah and Wesche, Frank and Bischoff, Iris and Kaiser, Marcel and Fürst, Robert and Bode, Helge B.. (2017) Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design. Nature Chemistry, 9 (4). pp. 379-386.

Seebacher, W. and Belaj, F. and Faist, J. and Saf, R. and Bucar, F. and Turek, I. and Branter, A. and Alajlani, M. and Kaiser, M. and Mäser, P. and Weis, R.. (2017) Synthesis of new pyrido-benzodiazepine salts and their antimicrobial activities. Monatshefte für Chemie, 148 (2). pp. 263-274.

Cai, Xiaofeng and Shi, Yi-Ming and Pöhlmann, Nicole and Revermann, Ole and Bahner, Isabel and Pidot, Sacha J. and Wesche, Frank and Lackner, Helmut and Büchel, Claudia and Kaiser, Marcel and Richter, Christian and Schwalbe, Harald and Stinear, Timothy P. and Zeeck, Axel and Bode, Helge B.. (2017) Structure and biosynthesis of isatropolones, bioactive amine-scavenging fluorescent natural products from streptomyces Go66. Angewandte Chemie International Edition, 56 (18). pp. 4945-4949.

Hochegger, Patrick and Faist, Johanna and Seebacher, Werner and Saf, Robert and Mäser, Pascal and Kaiser, Marcel and Weis, Robert. (2017) New derivatives of quinoline-4-carboxylic acid with antiplasmodial activity. Bioorganic & medicinal chemistry, 25 (7). pp. 2251-2259.

Tran, Huu-Anh and Zheng, Zhaoyan and Wen, Xianghui and Manivannan, Srinivasan and Pastor, Arnaud and Kaiser, Marcel and Brun, Reto and Snyder, Floyd F. and Back, Thomas G.. (2017) Synthesis and activity of nucleoside-based antiprotozoan compounds. Bioorganic & medicinal chemistry, 25 (7). pp. 2091-2104.

Althaus, Julia B. and Malyszek, Claudine and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Alkamides from Anacyclus pyrethrum L. and their in vitro antiprotozoal activity. Molecules, 22 (5). p. 796.

Nnadi, Charles Okeke and Nwodo, Ngozi Justina and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense. Molecules, 22 (7). E1129.

Bruno, Stefano and Uliassi, Elisa and Zaffagnini, Mirko and Prati, Federica and Bergamini, Christian and Amorati, Riccardo and Paredi, Gianluca and Margiotta, Marilena and Conti, Paola and Costi, Maria Paola and Kaiser, Marcel and Cavalli, Andrea and Fato, Romana and Bolognesi, Maria Laura. (2017) Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule. Chemical Biology and Drug Design, 90 (2). pp. 225-235.

Bringmann, Gerhard and Seupel, Raina and Feineis, Doris and Xu, Minjuan and Zhang, Guoliang and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas. (2017) Antileukemic ancistrobenomine B and related 5,1'-coupled naphthylisoquinoline alkaloids from the Chinese liana Ancistrocladus tectorius. Fitoterapia, 121. pp. 76-85.

Tshitenge, Dieudonné Tshitenge and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2017) Antiplasmodial ealapasamines A-C,'mixed' naphthylisoquinoline dimers from the Central African liana Ancistrocladus ealaensis. Scientific Reports, 7. p. 5767.

Smyrniotopoulos, Vangelis and Merten, Christian and Kaiser, Marcel and Tasdemir, Deniz. (2017) Bifurcatriol, a new antiprotozoal acyclic diterpene from the brown alga Bifurcaria bifurcata. Marine drugs, 15 (8). p. 245.

Cadelis, Melissa M. and Bourguet-Kondracki, Marie-Lise and Dubois, Joëlle and Kaiser, Marcel and Brunel, Jean Michel and Barker, David and Copp, Brent R.. (2017) Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase. Bioorganic & medicinal chemistry, 25 (16). pp. 4433-4443.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Kaiser, Marcel. (2017) The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines. European Journal of Medicinal Chemistry, 138. pp. 1106-1113.

Pagliero, Romina J. and Kaiser, Marcel and Brun, Reto and Nieto, Marcelo J. and Mazzieri, María R.. (2017) Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles. Bioorganic & medicinal chemistry, 27 (17). pp. 3945-3949.

Tallini, Luciana R. and Andrade, Jean Paulo de and Kaiser, Marcel and Viladomat, Francesc and Nair, Jerald J. and Zuanazzi, José Angelo S. and Bastida, Jaume. (2017) Alkaloid constituents of the amaryllidaceae plant amaryllis belladonna L. Molecules, 22 (9). p. 1437.

Bode, Edna and He, Yue and Vo, Tien Duy and Schultz, Roland and Kaiser, Marcel and Bode, Helge B.. (2017) Biosynthesis and function of simple amides in Xenorhabdus doucetiae. Environmental Microbiology, 19 (11). pp. 4564-4575.

Mohsin, Noor-Ul-Amin and Seebacher, Werner and Faist, Johanna and Hochegger, Patrick and Kaiser, Marcel and Mäser, Pascal and Belaj, Ferdinand and Saf, Robert and Kretschmer, Nadine and Alajlani, Muaaz and Turek, Ivana and Brantner, Adelheid and Bauer, Rudolf and Bucar, Franz and Weis, Robert. (2017) Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities. European journal of medicinal chemistry, 143. pp. 97-106.

Chianese, Giuseppina and Silber, Johanna and Luciano, Paolo and Merten, Christian and Erpenbeck, Dirk and Topaloglu, Bülent and Kaiser, Marcel and Tasdemir, Deniz. (2017) Antiprotozoal linear furanosesterterpenoids from the marine sponge Ircinia oros. Journal of natural products, 80 (9). pp. 2566-2571.

Greve, Hippolyt L. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2017) Terpenoids from the oleo-gum-resin of Boswellia serrata and their antiplasmodial effects In Vitro. Planta medica, 83 (14-15). pp. 1214-1226.

Pearce, A. Norrie and Kaiser, Marcel and Copp, Brent R.. (2017) Synthesis and antimalarial evaluation of artesunate-polyamine and trioxolane-polyamine conjugates. European journal of medicinal chemistry, 140. pp. 595-603.

De Mieri, M. and Smiesko, M. and Ismajili, I. and Kaiser, M. and Hamburger, M.. (2017) Acid-induced rearrangement of epoxygermacranolides: synthesis of furanoheliangolides and cadinanes from nobilin. Molecules, 22 (12). E2252.

Tallini, Luciana R. and Osorio, Edison H. and Santos, Vanessa Dias Dos and Borges, Warley de Souza and Kaiser, Marcel and Viladomat, Francesc and Zuanazzi, José Angelo S. and Bastida, Jaume. (2017) Hippeastrum reticulatum (Amaryllidaceae): alkaloid profiling, biological activities and molecular docking. Molecules, 22 (12). E2191.

Steiniger, Charlotte and Hoffmann, Sylvester and Mainz, Andi and Kaiser, Marcel and Voigt, Kerstin and Meyer, Vera and Süssmuth, Roderich D.. (2017) Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering. Chemical Science, 8 (11). pp. 7834-7843.

Li, Jun and Seupel, Raina and Bruhn, Torsten and Feineis, Doris and Kaiser, Marcel and Brun, Reto and Mudogo, Virima and Awale, Suresh and Bringmann, Gerhard. (2017) Jozilebomines A and B, naphthylisoquinoline dimers from the congolese liana ancistrocladus ileboensis, with antiausterity activities against the PANC-1 human pancreatic cancer cell line. Journal of natural products, 80 (10). pp. 2807-2817.

Greve, H. L. and Kaiser, M. and Brun, R. and Schmidt, Tj. (2017) Erratum: terpenoids from the oleo-gum-resin of boswellia serrata and their antiplasmodial effects in vitro. Planta medica, 83 (14-15). E4.

2016

Kedzierska, Ewa and Orzelska, Jolanta and Perković, Ivana and Knežević, Danijel and Fidecka, Sylwia and Kaiser, Marcel and Zorc, Branka. (2016) Pharmacological effects of primaquine ureas and semicarbazides on the central nervous system in mice and antimalarial activity in vitro. Fundamental and clinical pharmacology, 30. pp. 58-69.

Faist, J. and Seebacher, W. and Saf, R. and Brun, R. and Kaiser, M. and Weis, R.. (2016) New derivatives of bicyclic diamines with antiprotozoal activity. Monatshefte für Chemie, 147 (2). pp. 369-381.

Pirttimaa, Minni and Nasereddin, Abedelmajeed and Kopelyanskiy, Dmitry and Kaiser, Marcel and Yli-Kauhaluoma, Jari and Oksman-Caldentey, Kirsi-Marja and Brun, Reto and Jaffe, Charles L. and Moreira, Vânia M. and Alakurtti, Sami. (2016) Abietane-type diterpenoid amides with highly potent and selective activity against Leishmania donovani and Trypanosoma cruzi. Journal of natural products, 79 (2). pp. 362-368.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Wilkinson, Shane R. and Szular, Joanna and Kaiser, Marcel. (2016) Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds. European journal of medicinal chemistry, 117. pp. 179-186.

Silveira, Narjara and Saar, Julia and Santos, Alan Diego C. and Barison, Andersson and Sandjo, Louis P. and Kaiser, Marcel and Schmidt, Thomas J. and Biavatti, Maique W.. (2016) A new alkamide with an endoperoxide structure from acmella ciliata (asteraceae) and its in vitro antiplasmodial activity. Molecules, 21 (6). pp. 1-10.

Houël, Emeline and Nardella, Flore and Jullian, Valérie and Valentin, Alexis and Vonthron-Sénécheau, Catherine and Villa, Pascal and Obrecht, Adeline and Kaiser, Marcel and Bourreau, Eliane and Odonne, Guillaume and Fleury, Marie and Bourdy, Geneviève and Eparvier, Véronique and Deharo, Eric and Stien, Didier. (2016) Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians. Journal of ethnopharmacology, 187. pp. 241-248.

Zheng, Zhaoyan and Tran, Huu-Anh and Manivannan, Srinivasan and Wen, Xianghui and Kaiser, Marcel and Brun, Reto and Snyder, Floyd F. and Back, Thomas G.. (2016) Novel nucleoside-based antimalarial compounds. Bioorganic & medicinal chemistry letters, 26 (12). pp. 2861-2865.

Vanden Eynde, J. J. and Mayence, A. and Mottamal, M. and Bacchi, C. J. and Yarlett, N. and Kaiser, M. and Brun, R. and Huang, T. L.. (2016) Alkanediamide-linked bisbenzamidines are promising antiparasitic agents. Pharmaceuticals, 9 (2). pp. 1-11.

Vahermo, M. and Krogerus, S. and Nasereddin, A. and Kaiser, M. and Brun, R. and Jaffe, C. L. and Yli-Kauhaluoma, J. and Moreira, V. M.. (2016) Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania denovani and Trypanosoma cruzi. MedChemComm, 7 (3). pp. 457-463.

Cal, Monica and Ioset, Jean-Robert and Fügi, Matthia A. and Mäser, Pascal and Kaiser, Marcel. (2016) Assessing anti-T. cruzi candidates in vitro for sterile cidality. International journal for parasitology. Drugs and drug resistance, 6 (3). pp. 165-170.

Nogueira, Mauro S. and Da Costa, Fernando B. and Brun, Reto and Kaiser, Marcel and Schmidt, Thomas J.. (2016) Ent-pimarane and ent-kaurane diterpenes from Aldama discolor (asteraceae) and their antiprotozoal activity. Molecules, 21 (9). p. 1237.

Atay, Irem and Kirmizibekmez, Hasan and Kaiser, Marcel and Akaydin, Galip and Yesilada, Erdem and Tasdemir, Deniz. (2016) Evaluation of in vitro antiprotozoal activity of Ajuga laxmannii and its secondary metabolites. Pharmaceutical biology, 54 (9). pp. 1808-1814.

Ahmad, Sarfraz and Seebacher, Werner and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2016) The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, 39 (10). pp. 1391-1403.

Mir Mohseni, M. and Hover, T. and Barra, L. and Kaiser, M. and Dorrestein, P. C. and Dickschat, J. S. and Schaberle, T. F.. (2016) Discovery of a mosaic-like biosynthetic assembly line with a decarboxylative off-loading mechanism through a combination of genome mining and imaging. Angewandte Chemie. International edition in English, 55 (43). pp. 13611-13614.

Bringmann, Gerhard and Seupel, Raina and Feineis, Doris and Zhang, Guoliang and Xu, Minjuan and Wu, Jun and Kaiser, Marcel and Brun, Reto and Seo, Ean-Jeong and Efferth, Thomas. (2016) Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from the Chinese liana Ancistrocladus tectorius. Fitoterapia, 115. pp. 1-8.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Wilkinson, Shane R. and Szular, Joanna and Kaiser, Marcel. (2016) Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity. European journal of medicinal chemistry, 123. pp. 895-904.

Karaaslan, Cigdem and Kaiser, Marcel and Brun, Reto and Göker, Hakan. (2016) Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenz-imidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense. Bioorganic and Medicinal Chemistry, 24 (18). pp. 4038-4044.

Faist, Johanna and Seebacher, Werner and Saf, Robert and Brun, Reto and Kaiser, Marcel and Weis, Robert. (2016) Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead. Bioorganic & medicinal chemistry, 24 (16). pp. 3781-3789.

Hiltensperger, Georg and Hecht, Nina and Kaiser, Marcel and Rybak, Jens-Christoph and Hoerst, Alexander and Dannenbauer, Nicole and Müller-Buschbaum, Klaus and Bruhn, Heike and Esch, Harald and Lehmann, Leane and Meinel, Lorenz and Holzgrabe, Ulrike. (2016) Quinolone amides as anti-trypanosomal lead compounds with in vivo activity. Antimicrobial agents and chemotherapy, 60 (8). pp. 4442-4452.

Wolkinger, V. and Ahmad, S. and Seebacher, W. and Faist, J. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2016) New diaryl-substituted azabicyclo[3.2.2]nonanes and their antiprotozoal potencies. Monatshefte für Chemie, 147 (10). pp. 1721-1735.

Seupel, Raina and Hertlein-Amslinger, Barbara and Gulder, Tanja and Stawski, Philipp and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard. (2016) Directed synthesis of all four pure stereoisomers of the N,C-Coupled naphthylisoquinoline alkaloid ancistrocladinium A. Organic letters, 18 (24). pp. 6508-6511.

Russell, Stephanie and Rahmani, Raphaël and Jones, Amy J. and Newson, Harriet L. and Neilde, Kevin and Cotillo, Ignacio and Rahmani Khajouei, Marzieh and Ferrins, Lori and Qureishi, Sana and Nguyen, Nghi and Martinez-Martinez, Maria S. and Weaver, Donald F. and Kaiser, Marcel and Riley, Jennifer and Thomas, John and De Rycker, Manu and Read, Kevin D. and Flematti, Gavin R. and Ryan, Eileen and Tanghe, Scott and Rodriguez, Ana and Charman, Susan A. and Kessler, Albane and Avery, Vicky M. and Baell, Jonathan B. and Piggott, Matthew J.. (2016) Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides. Journal of Medicinal Chemistry, 59 (21). pp. 9686-9720.

2015

Nollmann, Friederike I. and Dauth, Christina and Mulley, Geraldine and Kegler, Carsten and Kaiser, Marcel and Waterfield, Nick R. and Bode, Helge B.. (2015) Insect-specific production of new GameXPeptides in Photorhabdus luminescens TTO1, widespread natural products in entomopathogenic bacteria. ChemBioChem : a European journal of chemical biology, Vol. 16, H. 2. pp. 205-208.

Ríos Martínez, Carlos H. and Miller, Florence and Ganeshamoorthy, Kayathiri and Glacial, Fabienne and Kaiser, Marcel and de Koning, Harry P. and Eze, Anthonius A. and Lagartera, Laura and Herraiz, Tomás and Dardonville, Christophe. (2015) A new nonpolar n-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 890-904.

Shaban, E. and Wicht, K. J. and Wang, N. and Mei, Z. W. and Hayashi, I. and El Gokha, A. A. A. and Kaiser, M. and El Sayed, I. E. and Egan, T. J. and Inokuchi, T.. (2015) Synthesis and antimalarial activity of some neocryptolepine analogues carrying a multifunctional linear and branched carbon-side chains. Heterocycles, Vol. 89, H. 4. pp. 1055-1064.

Papadopoulou, Maria V. and Bloomer, William D. and Lepesheva, Galina I. and Rosenzweig, Howard S. and Kaiser, Marcel and Aguilera-Venegas, Benjamín and Wilkinson, Shane R. and Chatelain, Eric and Ioset, Jean-Robert. (2015) Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. Journal of medicinal chemistry, 58 (3). pp. 1307-1319.

Montalvo-Quirós, Sandra and Taladriz-Sender, Andrea and Kaiser, Marcel and Dardonville, Christophe. (2015) Antiprotozoal activity and DNA binding of dicationic acridones. Journal of medicinal chemistry, 58 (4). pp. 1940-1949.

De Mieri, M. and Kaiser, M. and Brun, R. and Thormann, U. and Imanidis, G. and Hamburger, M.. (2015) Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin. Bioorganic & medicinal chemistry, 23 (7). pp. 1521-1529.

Inahashi, Yuki and Iwatsuki, Masato and Ishiyama, Aki and Matsumoto, Atsuko and Hirose, Tomoyasu and Oshita, Jun and Sunazuka, Toshiaki and Panbangred, Watanalai and Takahashi, Yoko and Kaiser, Marcel and Otoguro, Kazuhiko and O̅mura, Satoshi. (2015) Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, actinoallomurus fulvus MK10-036. Organic letters, Vol. 17, H. 4. pp. 864-867.

Bode, Edna and Brachmann, Alexander O. and Kegler, Carsten and Simsek, Rukayye and Dauth, Christina and Zhou, Qiuqin and Kaiser, Marcel and Klemmt, Petra and Bode, Helge B.. (2015) Simple "on-demand" production of bioactive natural products. ChemBioChem, Vol. 16, H. 7. pp. 1115-1119.

Nwodo, Ngozi and Okoye, Festus and Lai, Daowan and Debbab, Abdesammed and Kaiser, Marcel and Brun, Reto and Proksch, Peter. (2015) Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves. BMC complementary and alternative medicine, Vol. 15 , 82.

Nollmann, Friederike I. and Heinrich, Antje K. and Brachmann, Alexander O. and Morisseau, Christophe and Mukherjee, Krishnendu and Casanova-Torres, Ángel M. and Strobl, Frederic and Kleinhans, David and Kinski, Sebastian and Schultz, Katharina and Beeton, Michael L. and Kaiser, Marcel and Chu, Ya-Yun and Phan Ke, Long and Thanwisai, Aunchalee and Bozhüyük, Kenan A. J. and Chantratita, Narisara and Götz, Friedrich and Waterfield, Nick R. and Vilcinskas, Andreas and Stelzer, Ernst H. K. and Goodrich-Blair, Heidi and Hammock, Bruce D. and Bode, Helge B.. (2015) A photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase. ChemBioChem, Vol. 16, H. 5. pp. 766-771.

Manos-Turvey, A. and Watson, E. E. and Sykes, M. L. and Jones, A. J. and Baell, J. B. and Kaiser, M. and Avery, V. M. and Payne, R. J.. (2015) Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. MedChemComm, Vol. 6, H. 3. pp. 403-406.

Seebacher, Werner and Wolkinger, Volker and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Bucar, Franz and Gröblacher, Barbara and Brantner, Adelheid and Merino, Virginia and Kalia, Yogeshvar and Scapozza, Leonardo and Perozzo, Remo and Weis, Robert. (2015) Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Bioorganic & medicinal chemistry letters, Vol. 25, H. 7. pp. 1390-1393.

Ellendorff, Therese and Brun, Reto and Kaiser, Marcel and Sendker, Jandirk and Schmidt, Thomas J.. (2015) PLS-prediction and confirmation of hydrojuglone glucoside as the antitrypanosomal constituent of "Juglans spp.". Molecules, Vol. 20, H. 6. pp. 10082-10094.

Kaiser, Marcel and Maes, Louis and Tadoori, Leela Pavan and Spangenberg, Thomas and Ioset, Jean-Robert. (2015) Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids. Journal of biomolecular screening, Vol. 20, H. 5. pp. 634-645.

Thao, Nguyen Phuong and Luyen, Bui Thi Thuy and Brun, Reto and Kaiser, Marcel and Van Kiem, Phan and Van Minh, Chau and Schmidt, Thomas J. and Kang, Jong Seong and Kim, Young Ho. (2015) Anti-protozoal activities of cembrane-type diterpenes from Vietnamese soft corals. Molecules, Vol. 20, H. 7. pp. 12459-12468.

Keller, Lena and Plaza, Alberto and Dubiella, Christian and Groll, Michael and Kaiser, Marcel and Müller, Rolf. (2015) Macyranones : structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome. The journal of the American Chemical Society, Vol. 137, H. 25. pp. 8121-8130.

Kaiser, Marcel and Mäser, Pascal and Tadoori, Leela Pavan and Ioset, Jean-Robert and Brun, Reto. (2015) Antiprotozoal activity profiling of approved drugs : a starting point toward drug repositioning. PLoS ONE, Vol. 10, H. 8 , e0135556.

Montesino, Núria Llurba and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2015) Search for antiprotozoal activity in herbal medicinal preparations : new natural leads against neglected tropical diseases. Molecules, Vol. 20, H. 8. pp. 14118-14138.

Ahmad, Sarfraz and Seebacher, Werner and Wolkinger, Volker and Presser, Armin and Faist, Johanna and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2015) Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes. Archives of pharmacal research, Vol. 38, H. 8. pp. 1455-1467.

Herrmann, Fabian C. and Lenz, Mairin and Jose, Joachim and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2015) In silico identification and in vitro activity of novel natural inhibitors of Trypanosoma brucei glyceraldehyde-3-phosphate-dehydrogenase. Molecules, Vol. 20, H. 9. pp. 16154-16169.

Bode, Helge B. and Brachmann, Alexander O. and Jadhav, Kirtikumar B. and Seyfarth, Lydia and Dauth, Christina and Fuchs, Sebastian W. and Kaiser, Marcel and Waterfield, Nick R. and Sack, Holger and Heinemann, Stefan H. and Arndt, Hans-Dieter. (2015) Structure elucidation and activity of kolossin A, the D-/L-Pentadecapeptide product of a giant nonribosomal peptide synthetase. Angewandte Chemie, Jg. 54, Nr. 35. pp. 10352-10355.

Cheikh-Ali, Zakaria and Glynou, Kyriaki and Ali, Tahir and Ploch, Sebastian and Kaiser, Marcel and Thines, Marco and Bode, Helge B. and Maciá-Vicente, Jose G.. (2015) Diversity of exophillic acid derivatives in strains of an endophytic Exophiala sp. Phytochemistry : an international journal of plant biochemistry, 118. pp. 83-93.

Cretton, Sylvian and Bréant, Lise and Pourrez, Lucie and Ambuehl, Chiara and Perozzo, Remo and Marcourt, Laurence and Kaiser, Marcel and Cuendet, Muriel and Christen, Philippe. (2015) Chemical constituents from Waltheria indica exert in vitro activity against Trypanosoma brucei and T. cruzi. Fitoterapia, 105. pp. 55-60.

Hemberger, Yasmin and Zhang, Guoliang and Brun, Reto and Kaiser, Marcel and Bringmann, Gerhard. (2015) Highly antiplasmodial non-natural oxidative products of dioncophylline A: synthesis, absolute configuration, and conformational stability. Chemistry, a European journal, 21 (41). pp. 14507-14518.

Woodland, Andrew and Thompson, Stephen and Cleghorn, Laura A. T. and Norcross, Neil and De Rycker, Manu and Grimaldi, Raffaella and Hallyburton, Irene and Rao, Bhavya and Norval, Suzanne and Stojanovski, Laste and Brun, Reto and Kaiser, Marcel and Frearson, Julie A. and Gray, David W. and Wyatt, Paul G. and Read, Kevin D. and Gilbert, Ian H.. (2015) Discovery of inhibitors of Trypanosoma brucei by phenotypic screening of a focused protein kinase library. ChemMedChem, 10 (11). pp. 1809-1820.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and O'Shea, Ivan P. and Wilkinson, Shane R. and Kaiser, Marcel. (2015) 3-Nitrotriazole-based piperazides as potent antitrypanosomal agents. European journal of medicinal chemistry, 103. pp. 325-334.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and O'Shea, Ivan P. and Wilkinson, Shane R. and Kaiser, Marcel and Chatelain, Eric and Ioset, Jean-Robert. (2015) Discovery of potent nitrotriazole-based antitrypanosomal agents : in vitro and in vivo evaluation. Bioorganic & medicinal chemistry, 23 (19). pp. 6467-6476.

Daeppen, Christophe and Kaiser, Marcel and Neuburger, Markus and Gademann, Karl. (2015) Preparation of antimalarial endoperoxides by a formal [2 + 2 + 2] cycloaddition. Organic letters, 17 (21). pp. 5420-5423.

Mital, Alka and Murugesan, Dinakaran and Kaiser, Marcel and Yeates, Clive and Gilbert, Ian H.. (2015) Discovery and optimisation studies of antimalarial phenotypic hits. European journal of medicinal chemistry, 103. pp. 530-538.

Wang, X. and Dong, Y. and Cal, M. and Kasier, M. and Wittling, S. and Vennerstrom, J. L.. (2015) Antiprotozoal selectivity of diimidazoline N-phenylbenzamides. ACS infectious diseases, 1. pp. 135-139.

Royo, Santiago and Rodríguez, Santiago and Schirmeister, Tanja and Kesselring, Jochen and Kaiser, Marcel and González, Florenci V.. (2015) Dipeptidyl enoates as potent rhodesain inhibitors that display a dual mode of action. ChemMedChem, 10 (9). pp. 1484-1487.

Rodenko, Boris and Wanner, Martin J. and Alkhaldi, Abdulsalam A. M. and Ebiloma, Godwin U. and Barnes, Rebecca L. and Kaiser, Marcel and Brun, Reto and McCulloch, Richard and Koomen, Gerrit-Jan and de Koning, Harry P.. (2015) Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy. Antimicrobial agents and chemotherapy, 59 (11). pp. 6708-6716.

Prati, Federica and Bergamini, Christian and Molina, Maria Teresa and Falchi, Federico and Cavalli, Andrea and Kaiser, Marcel and Brun, Reto and Fato, Romana and Bolognesi, Maria Laura. (2015) 2-Phenoxy-1,4-naphthoquinones : from a multitarget antitrypanosomal to a potential antitumor profile. Journal of medicinal chemistry, 58 (16). pp. 6422-6434.

Rahmani, Raphaël and Ban, Kung and Jones, Amy J. and Ferrins, Lori and Ganame, Danny and Sykes, Melissa L. and Avery, Vicky M. and White, Karen L. and Ryan, Eileen and Kaiser, Marcel and Charman, Susan A. and Baell, Jonathan B.. (2015) 6-Arylpyrazine-2-carboxamides : a new core for Trypanosoma brucei inhibitors. Journal of medicinal chemistry, 58 (17). pp. 6753-6765.

Jones, Amy J. and Kaiser, Marcel and Avery, Vicky M.. (2015) Identification and characterization of FTY720 for the treatment of human African trypanosomiasis. Antimicrobial agents and chemotherapy, 60 (3). pp. 1859-1861.

Seebacher, W. and Faist, J. and Belaj, F. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2015) Synthesis of new tetrahydropyridinylidene ammonium salts and their antprotozoal potency. Monatshefte für Chemie, 146 (8). pp. 1299-1308.

2014

Mokoka, Tsholofelo A. and Peter, Xolani K. and Fouche, Gerda and Moodley, Nivan and Adams, Michael and Hamburger, Matthias and Kaiser, Marcel and Brun, Reto and Maharaj, Vinesh and Koorbanally, Neil. (2014) Antileishmanial activity of 12-methoxycarnosic acid from Salvia repens Buch. ex Benth. (Lamiaceae). South African journal of botany, Vol. 90. pp. 93-95.

Zimmermann, S. and Fouche, G. and de Mieri, M. and Yoshimoto, Y. and Usuki, R. and Nthambeleni, R. and van der Westhuyzen, C. and Kaiser, M. and Hamburger, M. and Adams, M.. (2014) Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products. Molecules, 19 (3). pp. 3523-3538.

Hata, Yoshie and Ebrahimi, Samad Nejad and De Mieri, Maria and Zimmermann, Stefanie and Mokoka, Tsholofelo and Naidoo, Dashnie and Fouche, Gerda and Maharaj, Vinesh and Kaiser, Marcel and Brun, Reto and Potterat, Olivier and Hamburger, Matthias. (2014) Antitrypanosomal isoflavan quinones from Abrus precatorius. Fitoterapia, Vol. 93. pp. 81-87.

Weis, R. and Seebacher, W. and Brun, R. and Kaiser, M. and Saf, R. and Faist, J.. (2014) 4-Aminobicyclo[2.2.2]octan-2-yl 4-aminobutanoates with antiprotozoal activity. Monatshefte für Chemie, Vol. 145, H. 2. pp. 311-317.

Usuki, Toyonobu and Sato, Makiko and Hara, Shihori and Yoshimoto, Yukiko and Kondo, Ryosuke and Zimmermann, Stefanie and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2014) Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives. Bioorganic & medicinal chemistry letters, Vol. 24, H. 3. pp. 794-798.

Harms, Henrik and Rempel, Viktor and Kehraus, Stefan and Kaiser, Marcel and Hufendiek, Peter and Müller, Christa E. and König, Gabriele M.. (2014) Indoloditerpenes from a marine-derived fungal strain of Dichotomomyces cejpii with antagonistic activity at GPR18 and cannabinoid receptors. Journal of natural products, Vol. 77, H. 3. pp. 673-677.

Dandapani, S. and Germain, A. R. and Jewett, I. and Le Quement, S. and Marie, JC. and Muncipinto, G. and Duvall, J. R. and Carmody, L. C. and Perez, J. R. and Engel, J. C. and Gut, J. and Kellar, D. and Siqueira-Neto, J. L. and McKerrow, J. H. and Kaiser, M. and Rodriquez, A. and Palmer, M. A. and Foley, M. and Schreiber, S. L. and Munoz, B.. (2014) Diversity-oriented synthesis yields a new drug lead for treatment of Chagas disease. ACS medicinal chemistry letters, Vol. 5, H. 2. pp. 149-153.

Grundmann, Florian and Kaiser, Marcel and Schiell, Matthias and Batzer, Andreas and Kurz, Michael and Thanwisai, Aunchalee and Chantratita, Narisara and Bode, Helge B.. (2014) Antiparasitic chaiyaphumines from Entomopathogenic xenorhabdus sp. PB61.4. Journal of natural products, Vol. 77, H. 4. pp. 779-783.

Althaus, Julia B. and Jerz, Gerold and Winterhalter, Peter and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2014) Antiprotozoal activity of Buxus sempervirens and activity-guided isolation of O-tigloylcyclovirobuxeine-B as the main constituent active against Plasmodium falciparum. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 19, H. 5. pp. 6184-6201.

Schmidt, Thomas J. and Da Costa, Fernando B. and Lopes, Norberto P. and Kaiser, Marcel and Brun, Reto. (2014) In Silico prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against Trypanosoma brucei rhodesiense. Antimicrobial agents and chemotherapy, Vol. 58, H. 1. pp. 325-332.

Althaus, Julia B. and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J.. (2014) Antiprotozoal activity of achillea ptarmica (Asteraceae) and its main alkamide constituents. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 19, H. 5. pp. 6428-6438.

Orhan, Ilkay Erdogan and Sener, Bilge and Kaiser, Marcel and Brun, Reto and Tasdemir, Deniz. (2014) Antiprotozoal activity and cytotoxicity of Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus extracts. Turkish journal of biochemistry, Vol. 38, H. 4. pp. 403-408.

Fuchs, Sebastian W. and Grundmann, Florian and Kurz, Michael and Kaiser, Marcel and Bode, Helge B.. (2014) Fabclavines : bioactive peptide-polyketide-polyamino hybrids from Xenorhabdus. ChemBioChem : a European journal of chemical biology, Vol. 15, H. 4. pp. 512-516.

Dong, Yuxiang and Wang, Xiaofang and Cal, Monica and Kaiser, Marcel and Vennerstrom, Jonathan L.. (2014) Activity of diimidazoline amides against African trypanosomiasis. Bioorganic & medicinal chemistry letters, Vol. 24, H. 3. pp. 944-948.

Wang, Ning and Wicht, Kathryn J. and Imai, Kento and Wang, Ming-Qi and Anh Ngoc, Tran and Kiguchi, Ryo and Kaiser, Marcel and Egan, Timothy J. and Inokuchi, Tsutomu. (2014) Synthesis, β-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues : SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11. Bioorganic & medicinal chemistry, 22 (9). pp. 2629-2642.

Belluti, Federica and Uliassi, Elisa and Veronesi, Giacomo and Bergamini, Christian and Kaiser, Marcel and Brun, Reto and Viola, Angelo and Fato, Romana and Michels, Paul A. M. and Krauth-Siegel, R. Luise and Cavalli, Andrea and Bolognesi, Maria Laura. (2014) Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against Trypanosoma brucei and Trypanosoma cruzi. ChemMedChem : chemistry enabling drug discovery, Vol. 9, H. 2. pp. 371-382.

Julianti, Tasqiah and De Mieri, Maria and Zimmermann, Stefanie and Ebrahimi, Samad N. and Kaiser, Marcel and Neuburger, Markus and Raith, Melanie and Brun, Reto and Hamburger, Matthias. (2014) HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant Carica papaya L. Journal of ethnopharmacology, Vol. 155, H. 1. pp. 426-434.

Wang, Jiayi and Kaiser, Marcel and Copp, Brent R.. (2014) Investigation of indolglyoxamide and indolacetamide analogues of polyamines as antimalarial and antitrypanosomal agents. Marine drugs, Vol. 12, H. 6. pp. 3138-3160.

Ferrins, Lori and Gazdik, Michelle and Rahmani, Raphaël and Varghese, Swapna and Sykes, Melissa L. and Jones, Amy J. and Avery, Vicky M. and White, Karen L. and Ryan, Eileen and Charman, Susan A. and Kaiser, Marcel and Bergström, Christel A. S. and Baell, Jonathan B.. (2014) Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei. Journal of medicinal chemistry, 57 (15). pp. 6393-6402.

Carballeira, Néstor M. and Bwalya, Angela Gono and Itoe, Maurice Ayamba and Andricopulo, Adriano D. and Cordero-Maldonado, María Lorena and Kaiser, Marcel and Mota, Maria M. and Crawford, Alexander D. and Guido, Rafael V. C. and Tasdemir, Deniz. (2014) 2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes. Bioorganic & medicinal chemistry letters, Vol. 24, H. 17. pp. 4151-4157.

Wang, N. and Wicht, K. J. and Shaban, E. and Ngoc, T. A. and Wang, M. Q. and Hayashi, I. and Hossain, M. I. and Takemasa, Y. and Kaiser, M. and El Sayed, I. E. T. and Egan, T. J. and Inokuchi, T.. (2014) Synthesis and evaluation of artesunate-indoloquinoline hybrids as antimalarial drug candidates. MedChemComm : Medicinal chemistry communications, Vol. 5, H. 7. pp. 927-931.

Ríos Martínez, Carlos H. and Lagartera, Laura and Kaiser, Marcel and Dardonville, Christophe. (2014) Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines. European journal of medicinal chemistry, 81. pp. 481-491.

Persch, Elke and Bryson, Steve and Todoroff, Nickolay K. and Eberle, Christian and Thelemann, Jonas and Dirdjaja, Natalie and Kaiser, Marcel and Weber, Maria and Derbani, Hassan and Brun, Reto and Schneider, Gisbert and Pai, Emil F. and Krauth-Siegel, R. Luise and Diederich, François. (2014) Binding to large enzyme pockets : small-molecule inhibitors of trypanothione reductase. ChemMedChem, Vol. 9, H. 8. pp. 1880-1891.

Portmann, Cyril and Sieber, Simon and Wirthensohn, Silvan and Blom, Judith F. and Da Silva, Laeticia and Baudat, Emilie and Kaiser, Marcel and Brun, Reto and Gademann, Karl. (2014) Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251. Journal of natural products, Vol. 77, H. 3. pp. 557-562.

Giordani, Federica and Buschini, Annamaria and Baliani, Alessandro and Kaiser, Marcel and Brun, Reto and Barrett, Michael P. and Pellacani, Claudia and Poli, Paola and Gilbert, Ian H.. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human african trypanosomiasis. Antimicrobial agents and chemotherapy, Vol. 58, H. 10. pp. 5747-5757.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Wilkinson, Shane R. and Kaiser, Marcel. (2014) Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents. European journal of medicinal chemistry, 87. pp. 79-88.

Ngamgwe, R. F. and Yankam, R. and Chouna, J. R. and Lanz, C. and Furrer, J. and Schürch, S. and Kaiser, M. and Lenta, B. N. and Ngouela, S. and Tsamo, E. and Brenneisen, R.. (2014) Procerenone: a Fatty Acid Triterpenoid from the Fruit Pericarp of Omphalocarpum procerum (Sapotaceae). Iranian Journal of Pharmaceutical Research, 13 (4). pp. 1425-1430.

Hata, Y. and de Mieri, M. and Ebrahimi, S. N. and Mokoka, T. and Fouche, G. and Kaiser, M. and Brun, R. and Potterat, O. and Hamburger, M.. (2014) Identification of two new phenanthrenones and a saponin as antiprotozoal constituents of Drypetes gerrardii. Phytochemistry letters, Vol. 10. pp. 133-140.

Usuki, T. and Sato, M. and Hara, S. and Yoshimoto, Y. and Kondo, R. and Zimmermann, S. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2014) Antitrypanosomal structure-activity-relationship study of semisynthetic cynaropicrin derivatives. Bioorganic and Medicinal Chemistry Letters, 24 (3). pp. 794-798.

Bapela, M. Johanna and Meyer, J. J. Marion and Kaiser, Marcel. (2014) In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 156. pp. 370-373.

Kronenwerth, Max and Brachmann, Alexander O. and Kaiser, Marcel and Bode, Helge B.. (2014) Bioactive derivatives of isopropylstilbene from mutasynthesis and chemical synthesis. ChemBioChem : a European journal of chemical biology, Vol. 15, H. 18. pp. 2689-2691.

Carvalho, Samir Aquino and Kaiser, Marcel and Brun, Reto and Silva, Edson Ferreira da and Fraga, Carlos Alberto Manssour. (2014) Antiprotozoal activity of (e)-cinnamic N-acylhydrazone derivatives. Molecules, Vol. 19, H. 12. pp. 20374-20381.

Cretton, Sylvian and Breant, Lise and Pourrez, Lucie and Ambuehl, Chiara and Marcourt, Laurence and Ebrahimi, Samad Nejad and Hamburger, Matthias and Perozzo, Remo and Karimou, Soumana and Kaiser, Marcel and Cuendet, Muriel and Christen, Philippe. (2014) Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica. Journal of natural products, Vol. 77, H. 10. pp. 2304-2311.

Kronenwerth, Max and Bozhüyük, Kenan A. J. and Kahnt, Astrid S. and Steinhilber, Dieter and Gaudriault, Sophie and Kaiser, Marcel and Bode, Helge B.. (2014) Characterisation of taxlllaids A-G : natural products from Xenorhabdus indica. Chemistry : a European journal, Vol. 20, H. 52. pp. 17478-17487.

de Meijere, Armin and Kozhushkov, Sergei I. and Yufit, Dmitrii S. and Grosse, Christian and Kaiser, Marcel and Raev, Vitaly A.. (2014) (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues. Beilstein journal of organic chemistry, Vol. 10. pp. 2844-2857.

Kaiser, Marcel. New drugs against trypanosomatid parasites : rediscovery of fexinidazole. 2014, Doctoral Thesis, University of Basel, Faculty of Science.

Ayyari, Mahdi and Salehi, Peyman and Ebrahimi, Samad Nejad and Zimmermann, Stefanie and Portmann, Lena and Krauth-Siegel, R. Luise and Kaiser, Marcel and Brun, Reto and Rezadoost, Hassan and Rezazadeh, Shamsali and Hamburger, Matthias. (2014) Antitrypanosomal isothiocyanate and thiocarbamate glycosides from Moringa peregrina. Planta Medica, 80 (1). pp. 86-89.

Wube, Abraham and Hüfner, Antje and Seebacher, Werner and Kaiser, Marcel and Brun, Reto and Bauer, Rudolf and Bucar, Franz. (2014) 1,2-substituted 4-(1H)-quinolones : synthesis, antimalarial and antitrypanosomal activities in vitro. Molecules, Vol. 19, H. 9. pp. 14204-14220.

Fügi, Matthias A. and Kaiser, Marcel and Tanner, Marcel and Schneiter, Roger and Mäser, Pascal and Guan, Xue Li. (2014) Match-making for posaconazole through systems thinking. Trends in parasitology, Vol. 31, H. 2. pp. 46-51.

Kronenwerth, M. and Dauth, C. and Kaiser, M. and Pemberton, I. and Bode, H. B.. (2014) Facile synthesis of cyclohexanediones and dialkylresorcinols : bioactive natural products from entomopathogenic bacteria. European journal of organic chemistry, H. 36. pp. 8026-8028.

Hata, Y. and De Mieri, M. and Ebrahimi, S. N. and Mokoka, T. and Fouche, G. and Kaiser, M. and Brun, R. and Potterat, O. and Hamburger, M.. (2014) Identification of two new phenathrenones and a saponin as antiprotozoal constituents of Drypetes gerrardii. Phytochemistry letters, Vol. 10. pp. 133-140.

Mohsin, N. U. A. and Seebacher, W. and Faist, J. and Belaj, F. and Saf, R. and Kaiser, M. and Brun, R. and Weis, R.. (2014) Synthesis of antiprotozoal diamines by regioselective insertion of nitrogen into a bicyclic ring system. Monatshefte für Chemie, Vol. 145, H. 8. pp. 1319-1327.

Hanna, J. N. and Ntie-Kang, F. and Kaiser, M. and Brun, R. and Efange, S. M. N.. (2014) 1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials : synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation. RSC advances, Vol. 4, H. 44 ,22856-22865.

Reimer, Daniela and Nollmann, Friederike I. and Schultz, Katharina and Kaiser, Marcel and Bode, Helge B.. (2014) Xenortide biosynthesis by entomopathogenic xenorhabdus nematophila. Journal of natural products, 77 (8). pp. 1976-1980.

2013

Hata, Yoshie and Raith, Melanie and Ebrahimi, Samad Nejad and Zimmermann, Stefanie and Mokoka, Tsholofelo and Naidoo, Dashnie and Fouche, Gerda and Maharaj, Vinesh and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias. (2013) Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus. Planta Medica, 79 (6). pp. 492-498.

Liew, L. P. P. and Kaiser, M. and Copp, B. R.. (2013) Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead compounds. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 2. pp. 452-454.

McKeever, C. and Kaiser, M. and Rozas, I.. (2013) Aminoalkyl derivatives of guanidine di-aromatic minor groove binders with antiprotozoal activity. Journal of medicinal chemistry, 56 (3). pp. 700-711.

Bruno, M. and Trucchi, B. and Monti, D. and Romeo, S. and Kaiser, M. and Verotta, L.. (2013) Synthesis of a potent antimalarial agent through natural products conjugation. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 2. pp. 221-225.

Hwang, J. Y. and Smithson, S. C. and Zhu, F. and Holbrook, G. and Connelly, M. C. and Kaiser, M. and Brun, R. and Guy, R. K.. (2013) Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for Human African Trypanosomiasis (HAT). Journal of medicinal chemistry, 56 (7). pp. 2850-2860.

Murugesan, D. and Mital, A. and Kaiser, M. and Shackleford, D. M. and Morizzi, J. and Katneni, K. and Campbell, M. and Hudson, A. and Charman, S. A. and Yeates, C. and Gilbert, I. H.. (2013) Discovery and structure-activity relationships of pyrrolone antimalarials. Journal of medicinal chemistry, 56 (7). pp. 2975-2990.

Gallé, Jean-Baptiste and Attioua, Barthélémy and Kaiser, Marcel and Rusig, Anne-Marie and Lobstein, Annelise and Vonthron-Sénécheau, Catherine. (2013) Eleganolone, a diterpene from the french marine alga Bifurcaria bifurcata inhibits growth of the human pathogens Trypanosoma brucei and Plasmodium falciparum. Marine drugs, Vol. 11, H. 3. pp. 599-610.

Endeshaw, Molla and Zhu, Xiaohua and He, Shanshan and Pandharkar, Trupti and Cason, Emily and Mahasenan, Kiran V. and Agarwal, Hitesh and Li, Chenglong and Munde, Manoj and Wilson, W. David and Bahar, Mark and Doskotch, Raymond W. and Kinghorn, A. Douglas and Kaiser, Marcel and Brun, Reto and Drew, Mark E. and Werbovetz, Karl A.. (2013) 8,8-dialkyldihydroberberines with potent antiprotozoal activity. Journal of natural products, Vol. 76, H. 3. pp. 311-315.

Graf, Fabrice E. and Ludin, Philipp and Wenzler, Tanja and Kaiser, Marcel and Brun, Reto and Pyana, Patient Pati and Büscher, Philippe and de Koning, Harry P. and Horn, David and Mäser, Pascal. (2013) Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. PLoS neglected tropical diseases, Vol. 7, H. 10 , e2475.

Mokoka, Tsholofelo A. and Xolani, Peter K. and Zimmermann, S. and Hata, Y. and Adams, M. and Kaiser, M. and Moodley, N. and Maharaj, Y. and Koorbanally, Neil A. and Hamburger, M. and Brun, R. and Fouche, G.. (2013) Antiprotozoal Screening of 60 South African Plants, and the Identification of the Antitrypanosomal Germacranolides Schkuhrin I and II. Planta medica, Vol. 79, H. 14. pp. 1380-1384.

Farimani, Mahdi Moridi and Ebrahimi, Samad Nejad and Salehi, Peyman and Bahadori, Mir Babak and Sonboli, Ali and Khavasi, Hamid Reza and Zimmermann, Stefanie and Kaiser, Marcel and Hamburger, Matthias. (2013) Antitrypanosomal Triterpenoid with an ε-Lactone E-Ring from Salvia urmiensis. Journal of natural products, 76 (9). pp. 1806-1809.

Zimmermann, Stefanie and Oufir, Mouhssin and Leroux, Alejandro and Krauth-Siegel, R. Luise and Becker, Katja and Kaiser, Marcel and Brun, Reto and Hamburger, Matthias and Adams, Michael. (2013) Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei. Bioorganic & medicinal chemistry, 21 (22). pp. 7202-7209.

Hwang, Jong Yeon and Smithson, David C. and Holbrook, Gloria and Zhu, Fangyi and Connelly, Michele C. and Kaiser, Marcel and Brun, Reto and Kiplin Guy, R.. (2013) Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 23, H. 14. pp. 4127-4131.

Faist, Johanna and Seebacher, Werner and Kaiser, Marcel and Brun, Reto and Saf, Robert and Weis, Robert. (2013) Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 21 (17). pp. 4988-4996.

Molette, J. and Routier, J. and Abla, N. and Besson, D. and Bombrun, A. and Brun, R. and Burt, H. and Georgi, K. and Kaiser, M. and Nwaka, S. and Muzerelle, M. and Scheer, A.. (2013) Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties. ACS medicinal chemistry letters, Vol. 4, H. 11. pp. 1037-1041.

Chianese, Giuseppina and Scala, Fernando and Calcinai, Barbara and Cerrano, Carlo and Dien, Henny A. and Kaiser, Marcel and Tasdemir, Deniz and Taglialatela-Scafati, Orazio. (2013) Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity. Marine drugs, Vol. 11, H. 9. pp. 3297-3308.

Liew, Lydia P. P. and Pearce, A. Norrie and Kaiser, Marcel and Copp, Brent R.. (2013) Synthesis and in vitro and in vivo evaluation of antimalarial polyamines. European journal of medicinal chemistry, 69. pp. 22-31.

Hossain, Md Imran and Switalska, Marta and Peng, Wei and Takashima, Mariko and Wang, Ning and Kaiser, Marcel and Wietrzyk, Joanna and Dan, Shingo and Yamori, Takao and Inokuchi, Tsutomu. (2013) Design, synthesis, and in vitro cancer cell growth inhibition evaluation and antimalarial testing of trioxanes installed in cyclic 2-enoate substructures. European journal of medicinal chemistry, 69. pp. 294-309.

Murugesan, Dinakaran and Kaiser, Marcel and White, Karen L. and Norval, Suzanne and Riley, Jennifer and Wyatt, Paul G. and Charman, Susan A. and Read, Kevin D. and Yeates, Clive and Gilbert, Ian H.. (2013) Structure-activity relationship studies of pyrrolone antimalarial agents. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 9. pp. 1537-1544.

Zhou, Qiuqin and Grundmann, Florian and Kaiser, Marcel and Schiell, Matthias and Gaudriault, Sophie and Batzer, Andreas and Kurz, Michael and Bode, Helge B.. (2013) Structure and biosynthesis of xenoamicins from entomopathogenic xenorhabdus. Chemistry : a European journal, Vol. 19, H. 49. pp. 16772-16779.

Lu, Wen-Jie and Wicht, Kathryn J. and Wang, Li and Imai, Kento and Mei, Zhen-Wu and Kaiser, Marcel and El Sayed, Ibrahim El Tantawy and Egan, Timothy J. and Inokuchi, Tsutomu. (2013) Synthesis and antimalarial testing of neocryptolepine analogues : addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines. European journal of medicinal chemistry, 64. pp. 498-511.

Lam, Cary F. C. and Pearce, A. Norrie and Tan, Shen H. and Kaiser, Marcel and Copp, Brent R.. (2013) Discovery and evaluation of thiazinoquinones as anti-protozoal agents. Marine drugs, Vol. 11, H. 9. pp. 3472-3499.

Spavieri, Jasmine and Allmendinger, Andrea and Kaiser, Marcel and Itoe, Maurice Ayamba and Blunden, Gerald and Mota, Maria M. and Tasdemir, Deniz. (2013) Assessment of dual life stage antiplasmodial activity of british seaweeds. Marine drugs, Vol. 11, H. 10. pp. 4019-4034.

Hampton, Shahienaz E. and Schipani, Alessandro and Bosch-Navarrete, Cristina and Recio, Eliseo and Kaiser, Marcel and Kahnberg, Pia and González-Pacanowska, Dolores and Johansson, Nils Gunnar and Gilbert, Ian H.. (2013) Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase. Bioorganic & medicinal chemistry, 21 (18). pp. 5876-5885.

Reimer, Daniela and Cowles, Kimberly N. and Proschak, Anna and Nollmann, Friederike I. and Dowling, Andrea J. and Kaiser, Marcel and Constant, Richard Ffrench- and Goodrich-Blair, Heidi and Bode, Helge B.. (2013) Rhabdopeptides as insect-specific virulence factors from entomopathogenic bacteria. ChemBioChem : a European journal of chemical biology, Vol. 14, H. 15. pp. 1991-1997.

Grundmann, F. and Kaiser, M. and Kurz, M. and Schiell, M. and Batzer, A. and Bode, H. B.. (2013) Structure determination of the bioactive depsipeptide xenobactin from Xenorhabdus sp. PB30.3. RSC advances, Vol. 3, H. 44. pp. 22072-22077.

Wang, N. and Wicht, K. J. and Wang, L. and Lu, W. J. and Misumi, R. and Wang, M. Q. and El Gokha, A. A. and Kaiser, M. and El Sayed, T. and Egan, T. J. and Inokuchi, T.. (2013) Synthesis and in vitro testing of antimalarial activity of non-natural-type neocryptolepines : structure-activity relationship study of 2,11- and 9,11-disubstituted 6-methylindolo[2,3-b]quinolines. Chemical and pharmaceutical bulletin, Vol. 61, H. 12. pp. 1282-1290.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Kaiser, Marcel and Chatelain, Eric and Ioset, Jean-Robert. (2013) Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents. Bioorganic & medicinal chemistry, 21 (21). pp. 6600-6607.

Friggeri, L. and Scipione, L. and Costi, R. and Kaiser, M. and Moraca, F. and Zamperini, C. and Botta, B. and Di Santo, R. and De Vita, D. and Brun, R. and Tortorella, S.. (2013) New promising compounds with in vitro nanomolar activity against Trypanosoma cruzi. ACS medicinal chemistry letters, Vol. 4, H. 6. pp. 538-541.

Papadopoulou, Maria V. and Bloomer, William D. and Rosenzweig, Howard S. and Ashworth, Rachel and Wilkinson, Shane R. and Kaiser, Marcel and Andriani, Grasiella and Rodriguez, Ana. (2013) Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs : in vivo studies. Future medicinal chemistry, Vol. 5, H. 15. pp. 1763-1776.

Dürüst, Y. and Altug, C. and Kaiser, M. and Fronczek, F. R. and Tasdemir, D.. (2013) Synthesis, crystal structure, and in vitro antiprotozoal activity of some 5-phenyl(methyl)sulfonyl-substituted dihydroisoxazoles. Monatshefte für Chemie, Vol. 144, H. 5. pp. 707-716.

Mei, Zhen-Wu and Wang, Li and Lu, Wen-Jie and Pang, Cui-Qing and Maeda, Tsukasa and Peng, Wei and Kaiser, Marcel and El Sayed, Ibrahim and Inokuchi, Tsutomu. (2013) Synthesis and in vitro antimalarial testing of neocryptolepines : SAR study for improved activity by introduction and modifications of side chains at C2 and C11 on indolo[2,3-b]quinolines. Journal of medicinal chemistry, 56 (4). pp. 1431-1442.

Ferrins, Lori and Rahmani, Raphaël and Sykes, Melissa L. and Jones, Amy J. and Avery, Vicky M. and Teston, Eliott and Almohaywi, Basmah and Yin, Jiexiang and Smith, Jason and Hyland, Chris and White, Karen L. and Ryan, Eileen and Campbell, Michael and Charman, Susan A. and Kaiser, Marcel and Baell, Jonathan B.. (2013) 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis. European journal of medicinal chemistry, 66. pp. 450-465.

Patra, Malay and Joshi, Tanmaya and Pierroz, Vanessa and Ingram, Katrin and Kaiser, Marcel and Ferrari, Stefano and Spingler, Bernhard and Keiser, Jennifer and Gasser, Gilles. (2013) DMSO-mediated ligand dissociation : renaissance for biological activity of N-heterocyclic-[Ru(η(6) -arene)Cl2 ] drug candidates. Chemistry : a European journal, Vol. 19, H. 44. pp. 14768-14772.

Ehmke, Veronika and Winkler, Edwin and Banner, David W. and Haap, Wolfgang and Schweizer, W. Bernd and Rottmann, Matthias and Kaiser, Marcel and Freymond, Céline and Schirmeister, Tanja and Diederich, François. (2013) Optimization of triazine nitriles as rhodesain inhibitors : structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 6. pp. 967-975.

2012

Zimmermann, S. and Thomi, S. and Kaiser, M. and Hamburger, M. and Adams, M.. (2012) Screening and HPLC-based activity profiling for new antiprotozoal leads from European plants. Scientia Pharmaceutica, 80 (1). pp. 205-213.

Zimmermann, S. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2012) Cynaropicrin : the first natural product with in vivo activity against Trypanosoma bruce rhodesiense. Planta medica, Vol. 78, H. 6. pp. 553-556.

Dastan, D. and Salehi, P. and Gohari, A. R. and Ebrahimi, S. N. and Zimmermann, S. and Kaiser, M. and Hamburger, M. and Khavasi, H. R.. (2012) Disesquiterpene and sesquiterpene coumarins from Ferula pseudalliacea, and determination of their absolute configurations. Phytochemistry, 78. pp. 170-178.

Ahmad, S. and Weis, R. and Faist, J. and Wolkinger, V. and Saf, R. and Belaj, F. and Brun, R. and Kaiser, M. and Seebacher, W.. (2012) Diarylcyclohexanones : synthons for new bicyclic compounds. Monatshefte für Chemie, Vol. 143, H. 1. pp. 145-152.

Witschel, M. and Rottmann, M. and Kaiser, M. and Brun, R.. (2012) Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. PLoS neglected tropical diseases, Vol. 6, H. 10 , e1805.

Carvalho, S. A. and Feitosa, L. O. and Soares, M. and Costa, T. E. and Henriques, M. G. and Salomao, K. and de Castro, S. L. and Kaiser, M. and Brun, R. and Wardell, J. L. and Wardell, S. M. and Trossini, G. H. and Andricopulo, A. D. and da Silva, E. F. and Fraga, C. A.. (2012) Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents. European journal of medicinal chemistry, 54. pp. 512-521.

Schmidt, T. J. and Rzeppa, S. and Kaiser, M. and Brun, R.. (2012) Larrea tridentata - absolute configuration of its epoxylignans and investigations on its antiprotozoal activity. Phytochemistry letters, Vol. 5, H. 3. pp. 632-637.

Faist, J. and Seebacher, W. and Saf, R. and Brun, R. and Kaiser, M. and Weis, R.. (2012) New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds. European journal of medicinal chemistry, 47 (1). pp. 510-519.

Ge, J. F. and Zhang, Q. Q. and Lu, J. M. and Kaiser, M. and Brun, R. and Ihara, M.. (2012) Synthesis of cyanine dyes and investigation of their in vitro antiprotozoal activities. MedChemComm, Vol. 3, H. 11. pp. 1435-1442.

Stec, J. and Huang, Q. and Pieroni, M. and Kaiser, M. and Fomovska, A. and Mui, E. and Witola, W. H. and Bettis, S. and McLeod, R. and Brun, R. and Kozikowski, A. P.. (2012) Synthesis, biological evaluation and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania. Journal of medicinal chemistry, 55 (7). pp. 3088-3100.

Mombelli, P. and Witschel, M. C. and van Zijl, A. W. and Geist, J. G. and Rottmann, M. and Freymond, C. and Röhl, F. and Kaiser, M. and Illarionova, V. and Fischer, M. and Siepe, I. and Schweizer, W. B. and Brun, R. and Diederich, F.. (2012) Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates. ChemMedChem, Vol. 7, H. 1. pp. 151-158.

Mäser, P. and Wittlin, S. and Rottmann, M. and Wenzler, T. and Kaiser, M. and Brun, R.. (2012) Antiparasitic agents : new drugs on the horizon. Current opinion in pharmacology, Vol. 12, H. 5. pp. 562-566.

Gökbulut, A. and Kaiser, M. and Brun, R. and Sarer, E. and Schmidt, T. J.. (2012) 9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity. Planta medica, Vol. 78, H. 3. pp. 225-229.

Brunner, R. and Aissaoui, H. and Boss, C. and Bozdech, Z. and Brun, R. and Corminboeuf, O. and Delahaye, S. and Fischli, C. and Heidmann, B. and Kaiser, M. and Kamber, J. and Meyer, S. and Papastogiannidis, P. and Siegrist, R. and Voss, Till S. and Welford, R. and Wittlin, S. and Binkert, C.. (2012) Identification of a new chemical class of antimalarials. Journal of infectious diseases, Vol. 206, no. 5. pp. 735-743.

Lizzi, F. and Veronesi, G. and Belluti, F. and Bergamini, C. and Lopez-Sanchez, A. and Kaiser, M. and Brun, R. and Krauth-Siegel, R. L. and Hall, D. and Rivas, L. and Bolognesi, M. L.. (2012) Conjugation of quinones with natural polyamines : towards an expanded anti-trypanosomatid profile. Journal of medicinal chemistry, 55 (23). pp. 10490-10500.

Chianese, G. and Fattorusso, E. and Scala, F. and Teta, R. and Calcinai, B. and Bavestrello, G. and Dien, H. A. and Kaiser, M. and Tasdemir, D. and Taglialatela-Scafati, O.. (2012) Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 10, H. 35. pp. 7197-7207.

Taladriz, A. and Healy, A. and Flores, Perez and Herrero, Garcia and Rios, Martinez and Alkhaldi, A. A. and Eze, A. A. and Kaiser, M. and de Koning, H. P. and Chana, A. and Dardonville, C.. (2012) Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes. Journal of medicinal chemistry, 55 (6). pp. 2606-2622.

Sykes, M. L. and Baell, J. B. and Kaiser, M. and Chatelain, E. and Moawad, S. R. and Ganame, D. and Ioset, J. R. and Avery, V. M.. (2012) Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign. PLoS neglected tropical diseases, Vol. 6, H. 11 , e1896.

Arán, V. J. and Kaiser, M. and Dardonville, C.. (2012) Discovery of nitroheterocycles active against African trypanosomes : in vitro screening and preliminary SAR studies. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 22, H. 14. pp. 4506-4516.

Dürüst, Y. and Karakus, H. and Kaiser, M. and Tasdemir, D.. (2012) Synthesis and anti-protozoal activity of novel dihydropyrrolo[3,4-d][1,2,3]triazoles. European journal of medicinal chemistry, 48. pp. 296-304.

Hiltensperger, G. and Jones, N. G. and Niedermeier, S. and Stich, A. and Kaiser, M. and Jung, J. and Puhl, S. and Damme, A. and Braunschweig, H. and Meinel, L. and Engstler, M. and Holzgrabe, U.. (2012) Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei. Journal of medicinal chemistry, 55 (6). pp. 2538-2548.

Attioua, B. and Yeo, D. and Lagnika, L. and Harisolo, R. and Antheaume, C. and Weniger, B. and Kaiser, M. and Lobstein, A. and Vonthron-Sénécheau, C.. (2012) In vitro antileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes from Parinari excelsa. Pharmaceutical biology, Vol. 50, H. 7. pp. 801-806.

Nollmann, Friederike I. and Dowling, Andrea and Kaiser, Marcel and Deckmann, Klaus and Grösch, Sabine and Ffrench-Constant, Richard and Bode, Helge B.. (2012) Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum. Beilstein journal of organic chemistry, Vol. 8. pp. 528-533.

McCracken, S. T. and Kaiser, M. and Boshoff, H. I. and Boyd, P. D. and Copp, B. R.. (2012) Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and photo-dimers. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 20 (4). pp. 1482-1493.

2011

Hata, Y. and Zimmermann, S. and Quitschau, M. and Kaiser, M. and Brun, R. and Hamburger, M. and Adams, M.. (2011) Antiplasmodial and antitrypanosomal activity of pyrethrins and pyrethroids. Journal of agricultural and food chemistry, Vol. 59, H. 17. pp. 9172-9176.

Julianti, Tasqiah and Hata Uribe, Yoshie and Zimmermann, Stefanie and Kaiser, Marcel and Hamburger, Matthias and Adams, Michael. (2011) Antitrypanosomal sesquiterpene lactones from Saussurea costus. Fitoterapia, 82 (7). pp. 955-959.

Jacobs, R. T. and Naré, B. and Wring, S. A. and Orr, M. D. and Chen, D. and Sligar, J. M. and Jenks, M. X. and Noe, R. A. and Bowling, T. S. and Mercer, L. T. and Rewerts, C. and Gaukel, E. and Owens, J. and Parham, R. and Randolph, R. and Beaudet, B. and Bacchi, C. J. and Yarlett, N. and Plattner, J. J. and Freund, Y. and Ding, C. and Akama, T. and Zhang, Y. K. and Brun, R. and Kaiser, M. and Scandale, I. and Don, R.. (2011) SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 Human African trypanosomiasis. PLoS neglected tropical diseases, Vol. 5, H. 6 , e1151.

Maas, M. and Hensel, A. and Batista da Costa F., and Brun, R. and Kaiser, M. and Schmidt, T. J.. (2011) An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatorium perfoliatum. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 7. pp. 635-644.

Shi, X. L. and Ge, J. F. and Liu, B. Q. and Kaiser, M. and Wittlin, S. and Brun, R. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 21, H. 19. pp. 5804-5807.

Lu, Y. T. and Arai, C. and Ge, J. F. and Ren, W. S. and Kaiser, M. and Wittlin, S. and Brun, R. and Lu, J. M. and Ihara, M.. (2011) Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides. Dyes and pigments : an international journal, Vol. 89, H. 1. pp. 44-48.

Bourdin Trunz B., and Jedrysiak, R. and Tweats, D. and Brun, R. and Kaiser, M. and Suwinski, J. and Torreele, E.. (2011) 1-aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis. European journal of medicinal chemistry, 46 (5). pp. 1524-1535.

Papadopoulou, M. V. and Bourdin, B. and Bloomer, W. D. and McKenzie, C. and Wilkinson, S. R. and Prasittichai, C. and Brun, R. and Kaiser, M. and Torreele, E.. (2011) Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents. Journal of medicinal chemistry, 54 (23). pp. 8214-8223.

Harel, D. and Khalid, S. A. and Kaiser, M. and Brun, R. and Wunsch, B. and Schmidt, T. J.. (2011) Encecalol angelate, an unstable chromene from Ageratum conyzoides L. : total synthesis and investigation of its antiprotozoal activity. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 137, H. 1. pp. 620-650.

Gachet, M. S. and Kunert, O. and Kaiser, M. and Brun, R. and Zehl, M. and Keller, W. and Munoz, R. A. and Bauer, R. and Schuehly, W.. (2011) Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. Journal of Natural Products, 74 (4). pp. 559-566.

Nieto, L. and Mascaraque, A. and Miller, F. and Glacial, F. and Rios Martinez C., and Kaiser, M. and Brun, R. and Dardonville, C.. (2011) Synthesis and antiprotozoal activity of N-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with improved human blood-brain barrier permeability. Journal of medicinal chemistry, 54 (2). pp. 485-494.

Chan, S. T. and Pearce, A. N. and Januario, A. H. and Page, M. J. and Kaiser, M. and McLaughlin, R. J. and Harper, J. L. and Webb, V. L. and Barker, D. and Copp, B. R.. (2011) Anti-inflammatory and antimalarial meroterpenoids from the New Zealand ascidian Aplidium scabellum. The journal of organic chemistry, Vol. 76, H. 21. pp. 9151-9160.

Chan, S. T. and Pearce, A. N. and Page, M. J. and Kaiser, M. and Copp, B. R.. (2011) Antimalarial beta-carbolines from the New Zealand ascidian Pseudodistoma opacum. Journal of natural products, Vol. 74, H. 9. pp. 1972-1979.

Ndakala, A. J. and Gessner, R. K. and Gitari, P. W. and October, N. and White, K. L. and Hudson, A. and Fakorede, F. and Shackleford, D. M. and Kaiser, M. and Yeates, C. and Charman, S. A. and Chibale, K.. (2011) Antimalarial Pyrido[1,2-a]benzimidazoles. Journal of medicinal chemistry, 54 (13). pp. 4581-4589.

Dua, V. K. and Verma, G. and Agarwal, D. D. and Kaiser, M. and Brun, R.. (2011) Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 136, H. 1. pp. 123-128.

Kirmizibekmez, H. and Atay, I. and Kaiser, M. and Brun, R. and Cartagena, M. M. and Carballeira, N. M. and Yesilada, E. and Tasdemir, D.. (2011) Antiprotozoal activity of Melampyrum arvense and its metabolites. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 25, H. 1. pp. 142-146.

Kaya, G. I. and Sarikaya, B. and Onur, M. A. and Somer, N. U. and Viladomat, F. and Codina, C. and Bastida, J. and Lauinger, I. L. and Kaiser, M. and Tasdemir, D.. (2011) Antiprotozoal alkaloids from Galanthus trojanus. Phytochemistry letters, Vol. 4, H. 3. pp. 301-305.

Broniatowska, B. and Allmendinger, A. and Kaiser, M. and Montamat-Sicotte D., and Hingley-Wilson S., and Lalvani, A. and Guiry, M. and Blunden, G. and Tasdemir, D.. (2011) Antiprotozoal, antitubercular and cytotoxic potential of cyanobacterial (blue-green algal) extracts from Ireland. Natural product communications, Vol. 6, H. 5. pp. 689-694.

Ruda, G. F. and Nguyen, C. and Ziemkowski, P. and Felczak, K. and Kasinathan, G. and Musso-Buendia A., and Sund, C. and Zhou, X. X. and Kaiser, M. and Ruiz-Perez L. M., and Brun, R. and Kulikowski, T. and Johansson, N. G. and Gonzalez-Pacanowska D., and Gilbert, I. H.. (2011) Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 309-320.

Eberle, C. and Lauber, B. S. and Fankhauser, D. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Diederich, F.. (2011) Improved inhibitors of trypanothione reductase by combination of motifs : synthesis, inhibitory potency, binding mode, and antiprotozoal activities. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 292-301.

Hampton, S. E. and Baragana, B. and Schipani, A. and Bosch-Navarrete C., and Musso-Buendia J. A., and Recio, E. and Kaiser, M. and Whittingham, J. L. and Roberts, S. M. and Shevtsov, M. and Brannigan, J. A. and Kahnberg, P. and Brun, R. and Wilson, K. S. and Gonzalez-Pacanowska D., and Johansson, N. G. and Gilbert, I. H.. (2011) Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 10. pp. 1816-1831.

Mayence, A. and Vanden Eynde J. J., and Kaiser, M. and Brun, R. and Yarlett, N. and Huang, T. L.. (2011) Bis(oxyphenylene)benzimidazoles: a novel class of anti-Plasmodium falciparum agents. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (24). pp. 7493-7500.

Kuhn-Nentwig, L. and Willems, J. and Seebeck, T. and Shalaby, T. and Kaiser, M. and Nentwig, W.. (2011) Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells. Amino Acids, 40 (1). pp. 69-76.

Baragana, B. and McCarthy, O. and Sanchez, P. and Bosch-Navarrete C., and Kaiser, M. and Brun, R. and Whittingham, J. L. and Roberts, S. M. and Zhou, X. X. and Wilson, K. S. and Johansson, N. G. and Gonzalez-Pacanowska D., and Gilbert, I. H.. (2011) Beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 19 (7). pp. 2378-2391.

Regalado, E. L. and Turk, T. and Tasdemir, D. and Gorjanc, M. and Kaiser, M. and Thomas, O. P. and Fernandez, R. and Amade, P.. (2011) Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifolium. Steroids : an international journal, Vol. 76, H. 12. pp. 1389-1396.

Hobbie, S. N. and Kaiser, M. and Schmidt, S. and Shcherbakov, D. and Janusic, T. and Brun, R. and Böttger, E. C.. (2011) Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma. PLoS neglected tropical diseases, Vol. 5, H. 5 , e1161.

Kaiser, M. and Bray, M. A. and Cal, M. and Trunz, B. B. and Torreele, E. and Brun, R.. (2011) Anti-trypanosomal activity of Fexinidazole: a new oral nitroimidazole drug candidate for the treatment of sleeping sickness. Antimicrobial agents and chemotherapy : AAC, Vol. 55, H. 12. pp. 5602-5608.

Attioua, B. and Lagnika, L. and Yeo, D. and Antheaume, C. and Kaiser, M. and Weniger, B. and Lobstein, A. and Vonthron-Sénécheau C., . (2011) In vitro antiplasmodial and antileishmanial activities of flavonoids form Anogeissus leiocarpus (Combretaceae). International journal of pharmaceutical sciences review and research, Vol. 11, H. 2 , 001.

Finlayson, R. and Pearce, A. N. and Page, M. J. and Kaiser, M. and Bourguet-Kondracki, M. L. and Harper, J. L. and Webb, V. L. and Copp, B. R.. (2011) Didemnidines A and B, indole spermidine alkaloids from the New Zealand ascidian Didemnum sp. Journal of Natural Products, 74 (4). pp. 888-892.

Kirmizibekmez, H. and Atay, I. and Kaiser, M. and Yesilada, E. and Tasdemir, D.. (2011) In vitro antiprotozoal activity of extracts of five Turkish Lamiaceae species. Natural Product Communications , 6 (11). pp. 1697-1700.

Pyana, P. P. and Ngay Lukusa, I. and Mumba Ngoyi, D. and Van Reet, N. and Kaiser, M. and Karhemere Bin Shamamba, S. and Buscher, P.. (2011) Isolation of Trypanosoma brucei gambiense from cured and relapsed sleeping sickness patients and adaptation to laboratory mice. PLoS Neglected Tropical Diseases, 5 (4). e1025.

Schmidt, T. J. and Kaiser, M. and Brun, R.. (2011) Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata and evaluation of its antiprotozoal activity. Planta medica, 77 (8). pp. 849-850.

Vonthron-Sénécheau, C. and Kaiser, M. and Devambez, I. and Vastel, A. and Mussio, I. and Rusig, A. M.. (2011) Antiprotozoal activities of organic extracts from French marine seaweeds. Marine drugs , 9 (6). pp. 922-933.

2010

Gachet, M. S. and Kunert, O. and Kaiser, M. and Brun, R. and Munoz, R. A. and Bauer, R. and Schuhly, W.. (2010) Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum. Journal of Natural Products, Vol. 73, H. 4. pp. 553-556.

Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R. and Abdalla, W. E. and Schmidt, T. J.. (2010) The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L. Journal of Ethnopharmacology, Vol. 129, H. 1. pp. 127-130.

Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2010) Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities. European Journal of Medicinal Chemistry, 45 (1). pp. 179-185.

Bonazzi, S. and Barbaras, D. and Patiny, L. and Scopelliti, R. and Schneider, P. and Cole, S. T. and Kaiser, M. and Brun, R. and Gademann, K.. (2010) Antimalarial and antitubercular nostocarboline and eudistomin derivatives: Synthesis, in vitro and in vivo biological evaluation. Bioorganic and Medicinal Chemistry, 18 (4). pp. 1464-1476.

Adams, M. and Christen, M. and Plitzko, I. and Zimmermann, S. and Brun, R. and Hamburger, M.. (2010) Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. Journal of Natural Products, Vol. 73, H. 5. pp. 897-900.

Yang, M. and Arai, C. and Bakar, M. A. and Lu, J. and Ge, J. F. and Pudhom, K. and Takasu, K. and Kasai, K. and Kaiser, M. and Brun, R. and Yardley, V. and Itoh, I. and Ihara, M.. (2010) Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL). Journal of medicinal chemistry, 53 (1). pp. 368-373.

Link, Andreas and Heidler, Philipp and Kaiser, Marcel and Brun, Reto. (2010) Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites. Molecular Diversity, 14 (2). pp. 215-224.

Bringmann, G. and Bischof, S. K. and Müller, S. and Gulder, T. and Winter, C. and Stich, A. and Moll, H. and Kaiser, M. and Brun, R. and Dreher, J. and Baumann, K.. (2010) QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids. European journal of medicinal chemistry, 45 (11). pp. 5370-5383.

Gachet, M. S. and Lecaro, J. S. and Kaiser, M. and Brun, R. and Navarrete, H. and Munoz, R. A. and Bauer, R. and Schuhly, W.. (2010) Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs, Vol. 128, H. 1. pp. 184-197.

Mallari, J. P. and Zhu, F. and Lemoff, A. and Kaiser, M. and Lu, M. and Brun, R. and Guy, R. K.. (2010) Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (23). pp. 8302-8309.

Pacorel, B. and Leung, S. C. and Stachulski, A. V. and Davies, J. and Vivas, L. and Lander, H. and Ward, S. A. and Kaiser, M. and Brun, R. and O'Neill P. M., . (2010) Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin. Journal of medicinal chemistry, 53 (2). pp. 633-640.

Nare, B. and Wring, S. and Bacchi, C. and Beaudet, B. and Bowling, T. and Brun, R. and Chen, D. and Ding, C. and Freund, Y. and Gaukel, E. and Hussain, A. and Jarnagin, K. and Jenks, M. and Kaiser, M. and Mercer, L. and Mejia, E. and Noe, A. and Orr, M. and Parham, R. and Plattner, J. and Randolph, R. and Rattendi, D. and Rewerts, C. and Sligar, J. and Yarlett, N. and Don, R. and Jacobs, R.. (2010) Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late stage central nervous system African Trypanosomiasis. Antimicrobial agents and chemotherapy : AAC, Vol. 54, H. 10. pp. 4379-4388.

Ge, J. F. and Arai, C. and Yang, M. and Bakar, M. A. and Lu, J. and Ismail, N. S. M. and Wittlin, S. and Kaiser, M. and Brun, R. and Charman, S. A. and Nguyen, T. and Morizzi, J. and Itoh, I. and Ihara, M.. (2010) Discovery of novel benzo[a]phenoxazine SSJ-183 as a drug candidate for malaria. ACS medicinal chemistry letters, Vol. 1, H. 7. pp. 360-364.

Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2010) Dialkylaminoalkyl derivatives of bicyclic compounds with antiplasmodial activity. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (18). pp. 6796-6804.

Gigante, F. and Kaiser, M. and Brun, R. and Gilbert, I. H.. (2010) Design and preparation of sterol mimetics as potential antiparasitics. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 18 (20). pp. 7291-7301.

Orhan, Ilkay and Sener, Bilge and Kaiser, Marcel and Brun, Reto and Tasdemir, Deniz. (2010) Inhibitory activity of marine sponge-derived natural products against parasitic protozoa. Marine drugs, Vol. 8, H. 1. pp. 47-58.

Zohrabi-Kalantari, V. and Heidler, P. and Kaiser, M. and Brun, R. and Kamper, C. and Link, A.. (2010) Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5'-amino-5'-deoxyadenosines. Molecular Diversity, 14 (2). pp. 307-320.

Torreele, E. and BourdinTrunz, B. and Tweats, D. and Kaiser, M. and Brun, R. and Mazue, G. and Bray, M. A. and Pecoul, B.. (2010) Fexinidazole: a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS neglected tropical diseases, Vol. 4, H. 12 , e923.

Spavieri, J. and Kaiser, M. and Casey, R. and Hingley-Wilson S., and Lalvani, A. and Blunden, G. and Tasdemir, D.. (2010) Antiprotozoal, antimycobacterial and cytotoxic potential of some british green algae. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 24, H. 7. pp. 1095-1098.

Spavieri, J. and Allmendinger, A. and Kaiser, M. and Casey, R. and Hingley-Wilson S., and Lalvani, A. and Guiry, M. D. and Blunden, G. and Tasdemir, D.. (2010) Antimycobacterial, antiprotozoal and cytotoxic potential of twenty-one brown algae (Phaeophyceae) from British and Irish waters. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 24, H. 11. pp. 1724-1729.

Regalado, E. L. and Tasdemir, D. and Kaiser, M. and Cachet, N. and Amade, P. and Thomas, O. P.. (2010) Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium. Journal of natural products, Vol. 73, H. 8. pp. 1404-1410.

Fotie, J. and Kaiser, M. and Delfin, D. A. and Manley, J. and Reid, C. S. and Paris, J. M. and Wenzler, T. and Maes, L. and Mahasenan, K. V. and Li, C. and Werbovetz, K. A.. (2010) Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. Journal of medicinal chemistry, 53 (3). pp. 966-982.

Allmendinger, A. and Spavieri, J. and Kaiser, M. and Casey, R. and Hingley-Wilson S., and Lalvani, A. and Guiry, M. and Blunden, G. and Tasdemir, D.. (2010) Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae. Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives, Vol. 24, H. 7. pp. 1099-1103.

Scala, F. and Fattorusso, E. and Menna, M. and Taglialatela-Scafati O., and Tierney, M. and Kaiser, M. and Tasdemir, D.. (2010) Bromopyrrole alkaloids as lead compounds against protozoan parasites. Marine drugs, Vol. 8, H. 7. pp. 2162-2174.

Zohrabi-Kalantari, V. and Heidler, P. and Kaiser, M. and Brun, R. and Kamper, C. and Link, A.. (2010) Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N(6)-substituted 5 (`)-amino-5 (`)-deoxyadenosines. Molecular Diversity, 14 (2). pp. 307-320.

2009

Faist, J. and Seebacher, W. and Schlapper, C. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids. Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemenination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines, 17 (10). pp. 3595-3603.

Dardonville, C. and Fernandez-Fernandez C., and Gibbons, S. L. and Jagerovic, N. and Nieto, L. and Ryan, G. and Kaiser, M. and Brun, R.. (2009) Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 9. pp. 3815-3821.

Schlapper, C. and Seebacher, W. and Faist, J. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Antiplasmodial and antitrypanosomal activities of aminobicyclo[2.2.2]octyl omega-aminoalkanoates. European journal of medicinal chemistry, 44 (2). pp. 736-744.

McCarthy, O. and Musso-Buendia A., and Kaiser, M. and Brun, R. and Ruiz-Perez L. M., and Johansson, N. G. and Pacanowska, D. G. and Gilbert, I. H.. (2009) Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. European journal of medicinal chemistry, 44 (2). pp. 678-688.

Holloway, G. A. and Charman, W. N. and Fairlamb, A. H. and Brun, R. and Kaiser, M. and Kostewicz, E. and Novello, P. M. and Parisot, J. P. and Richardson, J. and Street, I. P. and Watson, K. G. and Baell, J. B.. (2009) Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 7. pp. 2824-2833.

Adams, M. and Plitzko, I. and Kaiser, M. and Brun, R. and Hamburger, M.. (2009) HPLC-profiling for antiplasmodial compounds-3-methoxycarpachromene from Pistacia atlantica. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 948.

Schmidt, T. J. and Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R.. (2009) Quantitative structure--antiprotozoal activity relationships of sesquiterpene lactones. Molecules : a journal of synthetic chemistry and natural product chemistry, Vol. 14, H. 6. pp. 2062-2076.

Baliani, A. and Peal, V. and Gros, L. and Brun, R. and Kaiser, M. and Barrett, M. P. and Gilbert, I. H.. (2009) Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Organic & biomolecular chemistry : an international journal of synthetic, physical and biomolecular organic chemistry, Vol. 7, H. 6. pp. 1154-1166.

Van Baelen G., and Hostyn, S. and Dhooghe, L. and Tapolcsanyi, P. and Matyus, P. and Lemiere, G. and Dommisse, R. and Kaiser, M. and Brun, R. and Cos, P. and Maes, L. and Hajos, G. and Riedl, Z. and Nagy, I. and Maes, B. U. and Pieters, L.. (2009) Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 20. pp. 7209-7217.

Pudhom, K. and Ge, M. F. and Arai, C. and Yang, M. and Kaiser, M. and Wittlin, S. and Brun, R. and Itoh, I. and Ihara, M.. (2009) Synthesis and biological properties of a rhodacyanine derivative, Ssj-127, having high efficacy against malaria protozoa. Heterocycles : an international journal for reviews and communications in heterocyclic chemistry, Vol. 77, H. 1. pp. 207-210.

Musonda, C. C. and Whitlock, G. A. and Witty, M. J. and Brun, R. and Kaiser, M.. (2009) Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 2. pp. 401-405.

Kuettel, S. and Mosimann, M. and Mäser, P. and Kaiser, M. and Brun, R. and Scapozza, L. and Perozzo, R.. (2009) Adenosine kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics. PLoS Neglected Tropical Diseases, Vol. 3, H. 8 , e506.

Faist, J. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) Bicyclic amido compounds with antiprotozoal activity. Monatshefte für Chemie = Chemical monthly : an international journal of chemistry, Vol. 140, H. 10. pp. 1261-1268.

Musonda, C. C. and Whitlock, G. A. and Witty, M. J. and Brun, R. and Kaiser, M.. (2009) Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 19, H. 2. pp. 481-484.

Gachet, M. S. and Schuhly, W. and Kunert, O. and Kaiser, M. and Brun, R. and Munoz, R. A. and Bauer, R.. (2009) Jacaranone derived glucosidic esters from Jacaranda glabra. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. pp. 901-902.

Stump, B. and Eberle, C. and Schweizer, W. B. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Lentz, D. and Diederich, F.. (2009) Pentafluorosulfanyl as a novel building block for enzyme inhibitors: trypanothione reductase inhibition and antiprotozoal activities of diarylamines. ChemBioChem : a European journal of chemical biology, Vol. 10, H. 1. pp. 79-83.

Gigante, F. and Kaiser, M. and Brun, R. and Gilbert, I. H.. (2009) SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 16. pp. 5950-5961.

Berger, H. and Seebacher, W. and Kaiser, M. and Brun, R. and Saf, R. and Weis, R.. (2009) SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols. Monatshefte für Chemie = Chemical monthly : an international journal of chemistry, Vol. 140, H. 5. pp. 495-502.

Link, A. and Heidler, P. and Kaiser, M. and Brun, R.. (2009) Synthesis of a series of N(6)-substituted adenosines with activity against trypanosomatid parasites. European Journal of Medicinal Chemistry, 44 (9). pp. 3665-3671.

Nour, A. M. and Khalid, S. A. and Kaiser, M. and Brun, R. and Abdallah, W. E. and Schmidt, T. J.. (2009) The antiprotozoal activity of sixteen asteraceae species native to Sudan and bioactivity-guided isolation of xanthanolides from Xanthium brasilicum. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 2. pp. 1363-1368.

Heidler, P. and Zohrabi-Kalantari V., and Kaiser, M. and Brun, R. and Emmrich, T. and Link, A.. (2009) Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine derivatives. Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 17, H. 4. pp. 1428-1436.

Riente, R. R. and Souza, V. P. and Carvalho, S. A. and Kaiser, M. and Brun, R. and da Silva E. F., . (2009) Leishmanicidal activity of new megazol derivatives. Medicinal chemistry, Vol. 5, H. 4. pp. 392-397.

Portmann, C. and Blom, J. F. and Kaiser, M. and Brun, R. and Juttner, F. and Gademann, K.. (2009) New antiplasmodial natural products from cyanobacteria: linking their ecological role to their therapeutic potential. Planta medica : Zeitschrift für Arzneipflanzenforschung : official organ of the Society for Medicinal Plant Research, Vol. 75, H. 9. p. 886.

Wolkinger, V. and Weis, R. and Belaj, F. and Kaiser, M. and Brun, R. and Saf, R. and Seebacher, W.. (2009) Synthesis of novel diazabicycles and their antiprotozoal activities. Australian journal of chemistry, Vol. 62, H. 9. pp. 1166-1172.

Eberle, C. and Burkhard, J. A. and Stump, B. and Kaiser, M. and Brun, R. and Krauth-Siegel R. L., and Diederich, F.. (2009) Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds. ChemMedChem : chemistry enabling drug discovery, Vol. 4, H. 12. pp. 2034-2044.

Barker, R. H. and Liu, H. and Hirth, B. and Celatka, C. A. and Fitzpatrick, R. and Xiang, Y. and Willert, E. K. and Phillips, M. A. and Kaiser, M. and Bacchi, C. J. and Rodriguez, A. and Yarlett, N. and Klinger, J. D. and Sybertz, E.. (2009) Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. Antimicrobial agents and chemotherapy : AAC, Vol. 53, H. 5. pp. 2052-2058.

Karioti, A. and Skaltsa, H. and Kaiser, M. and Tasdemir, D.. (2009) Trypanocidal, leishmanicidal and cytotoxic effects of anthecotulide-type linear sesquiterpene lactones from Anthemis auriculata. Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 16, H. 8. pp. 783-787.

2008

Portmann, C. and Blom, J. F. and Kaiser, M. and Brun, R. and Juttner, F. and Gademann, K.. (2008) Isolation of aerucyclamides C and D and structure revision of microcyclamide 7806A: heterocyclic ribosomal peptides from Microcystis aeruginosa PCC 7806 and their antiparasite evaluation. Journal of natural products, Vol. 71, H. 11. pp. 1891-1896.