Items where Division is "05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)"
Number of items at this level: 151. 2023Furrer, Regula and Hawley, John A. and Handschin, Christoph. (2023) The molecular athlete: exercise physiology from mechanisms to medals. Physiological Reviews, 103 (3). pp. 1693-1787. Furrer, Regula and Heim, Barbara and Schmid, Svenia and Dilbaz, Sedat and Adak, Volkan and Nordström, Karl J. V. and Ritz, Danilo and Steurer, Stefan A. and Walter, Jörn and Handschin, Christoph. (2023) Molecular control of endurance training adaptation in male mouse skeletal muscle. Nature Metabolism. Handschin, Christoph. (2023) Churchill was wrong - do sports! Swiss Medical Forum, 23 (26). p. 1175. Leuchtmann, Aurel B. and Afifi, Yasmine and Ritz, Danilo and Handschin, Christoph. (2023) Effects of high-resistance wheel running on hallmarks of endurance and resistance training adaptations in mice. Physiological Reports, 11 (11). e15701. Schneider-Heieck, Konstantin. Characterization of transcriptional modulators involved in exercise-induced adaptive remodeling of skeletal muscle. 2023, Doctoral Thesis, University of Basel, Faculty of Science. Thürkauf, Marco. Deciphering the function of candidate genes in skeletal muscle aging using AAV-CRISPR/Cas9. 2023, Doctoral Thesis, University of Basel, Faculty of Science. de Smalen, Laura M. and Börsch, Anastasiya and Leuchtmann, Aurel B. and Gill, Jonathan F. and Ritz, Danilo and Zavolan, Mihaela and Handschin, Christoph. (2023) Impaired age-associated mitochondrial translation is mitigated by exercise and PGC-1α. Proceedings of the National Academy of Sciences (PNAS), 120 (36). e2302360120. 2022Furrer, Regula and Handschin, Christoph. (2022) Drugs, clocks and exercise in ageing: hype and hope, fact and fiction. Journal of Physiology, 601 (11). pp. 2057-2068. Ham, Daniel J. and Börsch, Anastasiya and Chojnowska, Kathrin and Lin, Shuo and Leuchtmann, Aurel B. and Ham, Alexander S. and Thürkauf, Marco and Delezie, Julien and Furrer, Regula and Burri, Dominik and Sinnreich, Michael and Handschin, Christoph and Tintignac, Lionel A. and Zavolan, Mihaela and Mittal, Nitish and Rüegg, Markus A.. (2022) Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. Nature Communications, 13. p. 2025. Leuchtmann, Aurel B. and Furrer, Regula and Steurer, Stefan A. and Schneider-Heieck, Konstantin and Karrer-Cardel, Bettina and Sagot, Yves and Handschin, Christoph. (2022) Interleukin-6 potentiates endurance training adaptation and improves functional capacity in old mice. Journal of Cachexia, Sarcopenia and Muscle, 13 (2). pp. 1164-1176. Mansingh, Shivani and Handschin, Christoph. (2022) Time to Train: The Involvement of the Molecular Clock in Exercise Adaptation of Skeletal Muscle. Frontiers in Physiology, 13. p. 902031. Pérez-Schindler, Joaquín and Vargas-Fernández, Elyzabeth and Karrer-Cardel, Bettina and Ritz, Danilo and Schmidt, Alexander and Handschin, Christoph. (2022) Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity. Scientific Reports, 12. p. 11477. Schmid, Svenia and Heim-Kupr, Barbara and Pérez-Schindler, Joaquín and Mansingh, Shivani and Beer, Markus and Mittal, Nitish and Ehrenfeuchter, Nikolaus and Handschin, Christoph. (2022) PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds. Molecular metabolism. p. 101643. Streese, Lukas and Liffert, Jeannine and Vilser, Walthard and Handschin, Christoph and Hanssen, Henner. (2022) In-vivo assessment of retinal vessel diameters and observer variability in mice: A methodological approach. PloS one, 17 (7). e0271815. 30 May 2021Ham, Daniel J. and Börsch, Anastasyia and Chojnowska, Kathrin and Lin, Shuo and Leuchtmann, Aurel B. and Ham, Alexander S. and Thürkauf, Marco and Delezie, Julien and Furrer, Regula and Burri, Dominik and Sinnreich, Michael and Handschin, Christoph and Tintignac, Lionel A. and Zavolan, Mihaela and Mittal, Nitish and Rüegg, Markus A.. (2021) Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle. 2021Battey, Edmund and Furrer, Regula and Ross, Jacob and Handschin, Christoph and Ochala, Julien and Stroud, Matthew J.. (2021) PGC-1α regulates myonuclear accretion after moderate endurance training. Journal of Cellular Physiology, Jul 28. Furrer, Regula and Jauch, Annaïse J. and Rao, Tata Nageswara and Dilbaz, Sedat and Rhein, Peter and Steurer, Stefan A. and Recher, Mike and Skoda, Radek C. and Handschin, Christoph. (2021) Remodeling of metabolism and inflammation by exercise ameliorates tumor-associated anemia. Science Advances, 7 (37). eabi4852. Leuchtmann, Aurel B. and Adak, Volkan and Dilbaz, Sedat and Handschin, Christoph. (2021) The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations. Frontiers in Physiology, 12. p. 709807. Maier, Geraldine and Delezie, Julien and Westermark, Pål O. and Santos, Gesa and Ritz, Danilo and Handschin, Christoph. (2021) Transcriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle. Journal of Physiology, Jun 18. epub ahead of print. Pérez-Schindler, Joaquín and Kohl, Bastian and Schneider-Heieck, Konstantin and Leuchtmann, Aurel B. and Henríquez-Olguín, Carlos and Adak, Volkan and Maier, Geraldine and Delezie, Julien and Sakoparnig, Thomas and Vargas-Fernández, Elyzabeth and Karrer-Cardel, Bettina and Ritz, Danilo and Schmidt, Alexander and Hondele, Maria and Jensen, Thomas E. and Hiller, Sebastian and Handschin, Christoph. (2021) RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates. Proceedings of the National Academy of Sciences of the United States of America, 118 (36). e2105951118. Sjögren, Rasmus J. O. and Rizo-Roca, David and Chibalin, Alexander V. and Chorell, Elin and Furrer, Regula and Katayama, Shintaro and Harada, Jun and Karlsson, Håkan K. R. and Handschin, Christoph and Moritz, Thomas and Krook, Anna and Näslund, Erik and Zierath, Juleen R.. (2021) Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes. Diabetologia, 64 (9). pp. 2077-2091. April 2020Leuchtmann, Aurel B. and Handschin, Christoph. (2020) Pharmacological targeting of age-related changes in skeletal muscle tissue. Pharmacological Research, 154. p. 104191. 2020Battilana, Fabienne and Steurer, Stefan and Rizzi, Giorgio and Delgado, Ana C. and Tan, Kelly R. and Handschin, Christoph. (2020) Exercise-linked improvement in age-associated loss of balance is associated with increased vestibular input to motor neurons. Aging Cell, 19 (12). e13274. Delezie, Julien and Gill, Jonathan F. and Santos, Gesa and Karrer-Cardel, Bettina and Handschin, Christoph. (2020) PGC-1β-expressing POMC neurons mediate the effect of leptin on thermoregulation in the mouse. Scientific Reports, 10 (1). p. 16888. Flach, Martin. Modification of tau pathology by yeast prion seeding and tau oligomer expression. 2020, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science. Furrer, Regula and Handschin, Christoph. (2020) Lifestyle vs. pharmacological interventions for healthy aging. Aging, 12 (1). pp. 5-7. Ham, Daniel J. and Börsch, Anastasiya and Lin, Shuo and Thürkauf, Marco and Weihrauch, Martin and Reinhard, Judith R. and Delezie, Julien and Battilana, Fabienne and Wang, Xueyong and Kaiser, Marco S. and Guridi, Maitea and Sinnreich, Michael and Rich, Mark M. and Mittal, Nitish and Tintignac, Lionel A. and Handschin, Christoph and Zavolan, Mihaela and Rüegg, Markus A.. (2020) The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia. Nature Communications, 11 (1). p. 4510. Maier, Geraldine. Investigating the role of the circadian clock and timed exercise on mouse skeletal muscle function. 2020, Doctoral Thesis, University of Basel, Faculty of Science. Panajatovic, Miljenko Valentin and Singh, François and Roos, Noëmi Johanna and Duthaler, Urs and Handschin, Christoph and Krähenbühl, Stephan and Bouitbir, Jamal. (2020) PGC-1α plays a pivotal role in simvastatin-induced exercise impairment in mice. Acta physiologica (Oxford, England), 228 (4). e13402. 2019Agudelo, Leandro Z. and Ferreira, Duarte M. S. and Dadvar, Shamim and Cervenka, Igor and Ketscher, Lars and Izadi, Manizheh and Zhengye, Liu and Furrer, Regula and Handschin, Christoph and Venckunas, Tomas and Brazaitis, Marius and Kamandulis, Sigitas and Lanner, Johanna T. and Ruas, Jorge L.. (2019) Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance. Nature communications, 10 (1). p. 2767. Brinkkoetter, Paul T. and Bork, Tillmann and Salou, Sarah and Liang, Wei and Mizi, Athanasia and Özel, Cem and Koehler, Sybille and Hagmann, H. Henning and Ising, Christina and Kuczkowski, Alexander and Schnyder, Svenia and Abed, Ahmed and Schermer, Bernhard and Benzing, Thomas and Kretz, Oliver and Puelles, Victor G. and Lagies, Simon and Schlimpert, Manuel and Kammerer, Bernd and Handschin, Christoph and Schell, Christoph and Huber, Tobias B.. (2019) Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Reports, 27 (5). pp. 1551-1566.e5. Delezie, Julien and Weihrauch, Martin and Maier, Geraldine and Tejero, Rocío and Ham, Daniel J. and Gill, Jonathan F. and Karrer-Cardel, Bettina and Rüegg, Markus A. and Tabares, Lucía and Handschin, Christoph. (2019) BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle. Proceedings of the National Academy of Sciences (PNAS), 116 (32). pp. 16111-16120. Furrer, Regula and Handschin, Christoph. (2019) Muscle Wasting Diseases: Novel Targets and Treatments. Annual review of pharmacology and toxicology, 59. pp. 315-339. Gill, Jonathan F. and Delezie, Julien and Santos, Gesa and McGuirk, Shawn and Schnyder, Svenia and Frank, Stephan and Rausch, Martin and St-Pierre, Julie and Handschin, Christoph. (2019) Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging. Aging cell, 18 (5). e12993. Krämer, Anne I. and Handschin, Christoph. (2019) How Epigenetic Modifications Drive the Expression and Mediate the Action of PGC-1α in the Regulation of Metabolism. International journal of molecular sciences, 20 (21). E5449. Nageswara Rao, Tata and Hansen, Nils and Hilfiker, Julian and Rai, Shivam and Majewska, Julia-Magdalena and Lekovic, Danijela and Gezer, Deniz and Andina, Nicola and Galli, Serena and Cassel, Teresa and Geier, Florian and Delezie, Julien and Nienhold, Ronny and Hao-Shen, Hui and Beisel, Christian and Di Palma, Serena and Dimeloe, Sarah and Trebicka, Jonel and Wolf, Dominik and Gassmann, Max and Fan, Teresa W.-M. and Lane, Andrew N. and Handschin, Christoph and Dirnhofer, Stefan and Kröger, Nicolaus and Hess, Christoph and Radimerski, Thomas and Koschmieder, Steffen and Cokic, Vladan P. and Skoda, Radek C.. (2019) JAK2 mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms. Blood, 134 (21). pp. 1832-1846. Weihrauch, Martin. Identification of novel synaptic components by transcriptome profiling of the murine neuromuscular junction. 2019, Doctoral Thesis, University of Basel, Faculty of Science. 2018Baum, Oliver and Aaldijk, Dea and Engeli, Anna Lena and Spree, Matthias and Summermatter, Serge and Handschin, Christoph and Zakrzewicz, Andreas. (2018) Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice. Nitric Oxide: Biology and Chemistry, 77. pp. 35-43. Delezie, Julien and Handschin, Christoph. (2018) Endocrine Crosstalk Between Skeletal Muscle and the Brain. Frontiers in Neurology, 9. p. 698. Della Verde, Giacomo. Role of fms-like tyrosine kinase 3 in cardiac health and disease. 2018, Doctoral Thesis, University of Basel, Faculty of Science. Gill, Jonathan F. and Santos, Gesa and Schnyder, Svenia and Handschin, Christoph. (2018) PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice. Aging Cell, 17 (1). e12697. Haralampieva, Deana and Salemi, Souzan and Betzel, Thomas and Dinulovic, Ivana and Krämer, Stefanie D. and Schibli, Roger and Sulser, Tullio and Handschin, Christoph and Ametamey, Simon M. and Eberli, Daniel. (2018) Injected Human Muscle Precursor Cells Overexpressing PGC-1α. Enhance Functional Muscle Regeneration after Trauma. Stem cells international, 2018. p. 4658503. Heim-Kupr, Barbara. Molecular mechanisms of the transcriptional regulation by PGC-1α/β in skeletal muscle. 2018, Doctoral Thesis, University of Basel, Faculty of Science. Pérez-Schindler, Joaquín and Handschin, Christoph. (2018) Physiological Regulation of Skeletal Muscle Mass: Resistance Exercise- Mediated Muscle Hypertrophy. In: Nutrition and Skeletal Muscle. London, pp. 139-150. Ruiz, Alexis and Dror, Erez and Handschin, Christoph and Furrer, Regula and Perez-Schindler, Joaquin and Bachmann, Christoph and Treves, Susan and Zorzato, Francesco. (2018) Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance. Scientific Reports, 8 (1). p. 636. Weihrauch, Martin and Handschin, Christoph. (2018) Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls. Biochemical pharmacology, 147. pp. 211-220. Whitehead, Natasha and Gill, Jonathan F. and Brink, Marijke and Handschin, Christoph. (2018) Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart. Frontiers in Physiology, 9. p. 242. 2017Dinulovic, Ivana and Furrer, Regula and Handschin, Christoph. (2017) Plasticity of the Muscle Stem Cell Microenvironment. Advances in experimental medicine and biology, 1041. pp. 141-169. Furrer, Regula and Eisele, Petra S. and Schmidt, Alexander and Beer, Markus and Handschin, Christoph. (2017) Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP. Scientific Reports, 7. p. 40789. Furrer, Regula and Handschin, Christoph. (2017) Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle. In: Hormones, Metabolism and the Benefits of Exercise. Cham, pp. 57-66. Handschin, Christoph. (2017) Muskeln: mehr als nur "schön anzusehen". In: natura obscura. 200 Naturforschende - 200 Naturphänomene - 200 Jahre Naturforschende Gesellschaft in Basel. Basel, p. 85. Haralampieva, Deana and Salemi, Souzan and Dinulovic, Ivana and Sulser, Tullio and Ametamey, Simon and Handschin, Christoph and Eberli, Daniel. (2017) Human muscle precursor cells overexpressing PGC-1α enhance early skeletal muscle tissue formation. Cell Transplantation, 26 (6). pp. 1103-1114. Kupr, Barbara and Schnyder, Svenia and Handschin, Christoph. (2017) Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations. Cold Spring Harbor perspectives in medicine, 7 (6). a029835. Ross, Jacob Alexander and Pearson, Adam and Levy, Yotam and Cardel, Bettina and Handschin, Christoph and Ochala, Julien. (2017) Exploring the Role of PGC-1α in Defining Nuclear Organisation in Skeletal Muscle Fibres. Journal of Cellular Physiology, 232 (6). pp. 1270-1274. Schnyder, Svenia. Regulation of skeletal muscle and kidney metabolism by the PGC-1 family of transcriptional coactivators. 2017, Doctoral Thesis, University of Basel, Faculty of Science. Schnyder, Svenia and Kupr, Barbara and Handschin, Christoph. (2017) Coregulator-mediated control of skeletal muscle plasticity - A mini-review. Biochimie, 136. pp. 49-54. Schnyder, Svenia and Svensson, Kristoffer and Cardel, Bettina and Handschin, Christoph. (2017) Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice. American Journal of Physiology. Endocrinology and Metabolism, 312 (5). E437-E446. 2016Dinulovic, Ivana and Furrer, Regula and Beer, Markus and Ferry, Arnaud and Cardel, Bettina and Handschin, Christoph. (2016) Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche. Skeletal Muscle, 6 (1). p. 39. Dinulovic, Ivana and Furrer, Regula and Di Fulvio, Sabrina and Ferry, Arnaud and Beer, Markus and Handschin, Christoph. (2016) PGC-1alpha modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle. Skeletal Muscle, 6. p. 38. Dinulovic, Ivana and Furrer, Regula and Di Fulvio, Sabrina and Ferry, Arnaud and Beer, Markus and Handschin, Christoph. (2016) PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle. Skeletal muscle, 6 (38). pp. 1-11. Gill, Jonathan F. and Delezie, Julien and Santos, Gesa and Handschin, Christoph. (2016) PGC-1α expression in murine AgRP neurons regulates food intake and energy balance. Molecular metabolism, 5 (7). pp. 580-588. Gill, Jonathan François. Neuronal control of energy balance and modulation of muscle aging by the transcriptional coactivator PGC-1α. 2016, Doctoral Thesis, University of Basel, Faculty of Science. Haralampieva, Deana and Betzel, Thomas and Dinulovic, Ivana and Salemi, Souzan and Stoelting, Meline and Krämer, Stefanie D. and Schibli, Roger and Sulser, Tullio and Handschin, Christoph and Eberli, Daniel and Ametamey, Simon M.. (2016) Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering. Journal of Nuclear Medicine, 57 (9). pp. 1467-1473. Restelli, Lisa Michelle. Metabolic consequences of neuronal mitochondrial fission ablation. 2016, Doctoral Thesis, University of Basel, Faculty of Science. Salatino, Silvia and Kupr, Barbara and Baresic, Mario and van Nimwegen, Erik and Handschin, Christoph. (2016) The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells. Molecular Endocrinology, 30 (7). pp. 809-825. Stölting, Meline N. L. and Arnold, Anne Sophie and Haralampieva, Deana and Handschin, Christoph and Sulser, Tullio and Eberli, Daniel. (2016) Magnetic stimulation supports muscle and nerve regeneration after trauma in mice. Muscle and Nerve, 53 (4). pp. 598-607. Svensson, Kristoffer and Albert, Verena and Cardel, Bettina and Salatino, Silvia and Handschin, Christoph. (2016) Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice. FASEB Journal, 30 (5). pp. 1976-1986. Svensson, Kristoffer and Schnyder, Svenia and Cardel, Bettina and Handschin, Christoph. (2016) Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice. PLoS ONE, 11 (7). e0158716. 2015Eisele, Petra Sabine and Furrer, Regula and Beer, Markus and Handschin, Christoph. (2015) The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo. Biochemical and Biophysical Research Communications, 464 (3). pp. 692-697. Furrer, Regula and Handschin, Christoph. (2015) Exercise and PGC-1α in inflammation and chronic disease. Deutsche Zeitschrift für Sportmedizin, 66 (12). pp. 317-320. Handschin, Christoph. (2015) Caloric restriction and exercise "mimetics'': Ready for prime time? Pharmacological research, 103. pp. 158-166. Handschin, Christoph and Mortezavi, Ashkan and Plock, Jan and Eberli, Daniel. (2015) External physical and biochemical stimulation to enhance skeletal muscle bioengineering. Advanced drug delivery reviews, Vol. 82-83. pp. 168-175. Kupr, Barbara and Handschin, Christoph. (2015) Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle. Frontiers in physiology, 6. p. 325. Schnyder, Svenia and Handschin, Christoph. (2015) Skeletal muscle as an endocrine organ : PGC-1α, myokines and exercise. Bone, Vol. 80, H. 11. pp. 115-125. Soler, Fernando and Fernández-Belda, Francisco and Pérez-Schindler, Joaquín and Handschin, Christoph and Fuente, Teodomiro and Hernandez-Cascales, Jesús. (2015) PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects. Experimental biology and medicine, Vol. 240, H. 9. pp. 1205-1213. Svensson, Kristoffer and Schnyder, Svenia and Albert, Verena and Cardel, Bettina and Quagliata, Luca and Terracciano, Luigi M. and Handschin, Christoph. (2015) Resveratrol and SRT1720 elicit differential effects in metabolic organs and modulate systemic parameters independently of skeletal muscle peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α). Journal of biological chemistry, 290 (26). pp. 16059-16076. 2014Arnold, Anne-Sophie and Gill, Jonathan and Christe, Martine and Ruiz, Rocío and McGuirk, Shawn and St-Pierre, Julie and Tabares, Lucía and Handschin, Christoph. (2014) Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α. Nature communications, Vol. 5 , Article Nr. 3569. Baresic, Mario and Salatino, Silvia and Kupr, Barbara and van Nimwegen, Erik and Handschin, Christoph. (2014) Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program. Molecular and cellular biology, Vol. 34, H. 16. pp. 2996-3012. Eisele, Petra S. and Handschin, Christoph. (2014) Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Seminars in immunopathology, Vol. 36, no. 1. pp. 27-53. Morand, Réjane and Bouitbir, Jamal and Felser, Andrea and Hench, Jürgen and Handschin, Christoph and Frank, Stephan and Krähenbühl, Stephan. (2014) Effect of carnitine, acetyl-, and propionylcarnitine supplementation on the body carnitine pool, skeletal muscle composition, and physical performance in mice. European journal of nutrition, 53 (6). pp. 1313-1325. Pérez-Schindler, Joaquín and Svensson, Kristoffer and Vargas-Fernández, Elyzabeth and Santos, Gesa and Wahli, Walter and Handschin, Christoph. (2014) The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet. Diabetologia, Vol. 57, no. 11. pp. 2405-2412. Svensson, Kristoffer and Handschin, Christoph. (2014) MicroRNAs emerge as modulators of NAD+-dependent energy metabolism in skeletal muscle. Diabetes, Vol. 63, H. 5. pp. 1451-1453. Svensson, Kristoffer and Handschin, Christoph. (2014) Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases. Drug discovery today, Vol. 19, H. 7. pp. 1024-1029. 2013Bentzinger, C. Florian and Lin, Shuo and Romanino, Klaas and Castets, Perrine and Guridi, Maitea and Summermatter, Serge and Handschin, Christoph and Tintignac, Lionel A. and Hall, Michael N. and Rüegg, Markus A.. (2013) Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skeletal Muscle, 3 (1). p. 6. Eisele, Petra S. and Salatino, Silvia and Sobek, Jens and Hottiger, Michael O. and Handschin, Christoph. (2013) The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. Journal of Biological Chemistry, 288 (4). pp. 2246-2260. Pérez-Schindler, Joaquín and Handschin, Christoph. (2013) New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases. Drug Discovery Today. Disease Models, 10 (2). e79-e85. Pérez-Schindler, Joaquín and Summermatter, Serge and Santos, Gesa and Zorzato, Francesco and Handschin, Christoph. (2013) The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling. Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, H. 50. pp. 20314-20319. Stölting, Meline Nogueira Lucena and Ferrari, Stefano and Handschin, Christoph and Becskei, Attila and Provenzano, Maurizio and Sulser, Tullio and Eberli, Daniel. (2013) Myoblasts inhibit prostate cancer growth by paracrine secretion of tumor necrosis factor-α. Journal of Urology, 189 (5). pp. 1952-1959. Summermatter, Serge and Santos, Gesa and Pérez-Schindler, Joaquín and Handschin, Christoph. (2013) Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A. Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, H. 21. pp. 8738-8743. Summermatter, Serge and Shui, Guanghou and Maag, Daniela and Santos, Gesa and Wenk, Markus R. and Handschin, Christoph. (2013) PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner. Diabetes, Vol. 62, H. 1. pp. 85-95. 2012Arnold, Anne-Sophie and Christe, Martine and Handschin, Christoph. (2012) A functional motor unit in the culture dish : co-culture of spinal cord explants and muscle cells. Journal of visualized experiments, H. 62 , e3616. Handschin, Christoph and Meyer, Urs A.. (2012) Warum reagiert mein Patient anders auf dieses Medikament? : Pharmakogenomik und personalisierte Medizin in der Praxis. Swiss medical forum = Schweizerisches Medizin-Forum, Vol. 12, H. 22. pp. 425-433. Meyer-Gerspach, Anne Christin. Gut induced biomarkers of appetite and satiety. 2012, Doctoral Thesis, University of Basel, Faculty of Science. Pérez-Schindler, Joaquín and Summermatter, Serge and Salatino, Silvia and Zorzato, Francesco and Beer, Markus and Balwierz, Piotr J. and van Nimwegen, Erik and Feige, Jérôme N. and Auwerx, Johan and Handschin, Christoph. (2012) The Corepressor NCoR1 Antagonizes PGC-1α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism. Molecular and cellular biology, Vol. 32, H. 24. pp. 4913-4924. Summermatter, S. and Handschin, C.. (2012) PGC-1α and exercise in the control of body weight. International journal of obesity and related metabolic disorders, Vol. 36, H. 11. pp. 1428-1435. Summermatter, Serge and Thurnheer, Raphael and Santos, Gesa and Mosca, Barbara and Baum, Oliver and Treves, Susan and Hoppeler, Hans and Zorzato, Francesco and Handschin, Christoph. (2012) Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type. American Journal of Physiology, 302 (1). C88-99. 2011Arnold, A. -S. and Egger, A. and Handschin, C.. (2011) PGC-1α and Myokines in the aging muscle : a mini-review. Gerontology, Vol. 57, H. 1. pp. 37-43. Handschin, C.. (2011) Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) improves skeletal muscle mitochondrial function and insulin sensitivity. Diabetologia, Vol. 54, no. 6. pp. 1270-1272. Handschin, Christoph and Spiegelman, Bruce M.. (2011) PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. Cell metabolism, Vol. 13, H. 4. p. 351. Romanino, Klaas and Mazelin, Laetitia and Albert, Verena and Conjard-Duplany, Agnès and Lin, Shuo and Bentzinger, C. Florian and Handschin, Christoph and Puigserver, Pere and Zorzato, Francesco and Schaeffer, Laurent and Gangloff, Yann-Gaël and Rüegg, Markus A.. (2011) Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, H. 51. pp. 20808-20813. Summermatter, S. and Troxler, H. and Santos, G. and Handschin, C.. (2011) Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity. Biochemical and biophysical research communications, Vol. 408, H. 1. pp. 180-185. 2010Burch, N. and Arnold, A. S. and Item, F. and Summermatter, S. and Brochmann Santana Santos, G. and Christe, M. and Boutellier, U. and Toigo, M. and Handschin, C.. (2010) Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle. PLoS ONE, Vol. 5, H. 6 , e10970. Handschin, C.. (2010) Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha. Journal of receptors and signal transduction, Vol. 30, H. 6. pp. 376-384. Handschin, Christoph and Summermatter, Serge and LeBrasseur, Nathan K. and Lin, Jiandie and Spiegelman, Bruce M.. (2010) For a pragmatic approach to exercise studies. Journal of Applied Physiology, 108 (1). pp. 222-225. Harach, Taoufiq. Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase. 2010, Doctoral Thesis, University of Basel, Faculty of Science. Stein, S. and Lohmann, C. and Handschin, C. and Stenfeldt, E. and Boren, J. and Luscher, T. F. and Matter, C. M.. (2010) ApoE−/− PGC-1α−/− mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. PLoS ONE, Vol. 5, H. 10 , e13539. Stein, Sokrates and Schäfer, Nicola and Breitenstein, Alexander and Besler, Christian and Winnik, Stephan and Lohmann, Christine and Heinrich, Kathrin and Brokopp, Chad E. and Handschin, Christoph and Landmesser, Ulf and Tanner, Felix C. and Lüscher, Thomas F. and Matter, Christian M.. (2010) SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging, Vol. 2, H. 6. pp. 353-360. Summermatter, S. and Baum, O. and Santos, G. and Hoppeler, H. and Handschin, C.. (2010) Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway. Journal of Biological Chemistry, 285 (43). pp. 32793-32800. 2009Handschin, C.. (2009) PGC-1a in muscle links metabolism to inflammation. Proceedings of the Australian Physiological Society, Vol. 40. pp. 11-16. Handschin, C.. (2009) Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation. Clinical and experimental pharmacology and physiology, Vol. 36, H. 12. pp. 1139-1143. Handschin, C.. (2009) The biology of PGC-1α and its therapeutic potential. Trends in Pharmacological Sciences, 30 (6). pp. 322-329. Zenhaeusern, G. and Gubser, P. and Eisele, P. and Gasser, O. and Steinhuber, A. and Trampuz, A. and Handschin, C. and Luster, A. D. and Hess, C.. (2009) A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells. Blood, 113 (1). pp. 95-99. 2008Choi, C. S. and Befroy, D. E. and Codella, R. and Kim, S. and Reznick, R. M. and Hwang, Y. -J. and Liu, Z. -X. and Lee, H. -Y. and Distefano, A. and Samuel, V. T. and Zhang, D. and Cline, G. W. and Handschin, C. and Lin, J. and Petersen, K. F. and Spiegelman, B. M. and Shulman, G. I.. (2008) Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, H. 50. pp. 19926-19931. Handschin, Christoph. (2008) Induction of drug metabolism : role for nuclear receptors. In: Nuclear Receptors as Drug Targets (Methods and Principles in Medicinal Chemistry, Vol. 39). Weinheim, pp. 453-468. Handschin, Christoph and Spiegelman, Bruce M.. (2008) The role of exercise and PGC1alpha in inflammation and chronic disease. Nature, Vol. 454. pp. 463-469. 2007Handschin, C. and Chin, S. and Li, P. and Liu, F. and Maratos-Flier, E. and Lebrasseur, N. K. and Yan, Z. and Spiegelman, B. M.. (2007) Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals. Journal of Biological Chemistry, 282 (41). pp. 30014-30021. Handschin, C. and Choi, C. S. and Chin, S. and Kim, S. and Kawamori, D. and Kurpad, A. J. and Neubauer, N. and Hu, J. and Mootha, V. K. and Kim, Y. -B. and Kulkarni, R. N. and Shulman, G. I. and Spiegelman, B. M.. (2007) Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk. Journal of Clinical Investigation, Vol. 117, H. 11. pp. 3463-3474. Handschin, C. and Kobayashi, Y. M. and Chin, S. and Seale, P. and Campbell, K. P. and Spiegelman, B. M.. (2007) PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes & development, Vol. 21, H. 7. pp. 770-783. Jager, S. and Handschin, C. and St-Pierre, J. and Spiegelman, B. M.. (2007) AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, H. 29. pp. 12017-12022. Matter, C. M. and Handschin, C.. (2007) RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome. Circulation, 115 (8). pp. 946-948. Rohas, L. M. and St-Pierre, J. and Uldry, M. and Jager, S. and Handschin, C. and Spiegelman, B. M.. (2007) A fundamental system of cellular energy homeostasis regulated by PGC-1α. Proceedings of the National Academy of Sciences of the United States of America, 104 (19). pp. 7933-7938. 2006Handschin, C. and Spiegelman, B. M.. (2006) Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism. Endocrine reviews, Vol. 27, H. 7. pp. 728-735. Rhee, J. and Ge, H. and Yang, W. and Fan, M. and Handschin, C. and Cooper, M. and Lin, J. and Li, C. and Spiegelman, B. M.. (2006) Partnership of PGC-1α and HNF4α in the regulation of lipoprotein metabolism. Journal of Biological Chemistry, 281 (21). pp. 14683-14690. Sandri, M. and Lin, J. and Handschin, C. and Yang, W. and Arany, Z. P. and Lecker, S. H. and Goldberg, A. L. and Spiegelman, B. M.. (2006) PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, H. 44. pp. 16260-16265. St-Pierre, J. and Drori, S. and Uldry, M. and Silvaggi, J. M. and Rhee, J. and Jager, S. and Handschin, C. and Zheng, K. and Lin, J. and Yang, W. and Simon, D. K. and Bachoo, R. and Spiegelman, B. M.. (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell, Vol. 127, H. 2. pp. 397-408. Wu, Z. and Huang, X. and Feng, Y. and Handschin, C. and Gullicksen, P. S. and Bare, O. and Labow, M. and Spiegelman, B. and Stevenson, S. C.. (2006) Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, H. 39. pp. 14379-14384. 2005Arany, Z. and He, H. and Lin, J. and Hoyer, K. and Handschin, C. and Toka, O. and Ahmad, F. and Matsui, T. and Chin, S. and Wu, P. -H. and Rybkin, I. I. and Shelton, J. M. and Manieri, M. and Cinti, S. and Schoen, F. J. and Bassel-Duby, R. and Rosenzweig, A. and Ingwall, J. S. and Spiegelman, B. M.. (2005) Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metabolism, Vol. 1, H. 4. pp. 259-271. Gnerre, C. and Schuster, G. U. and Roth, A. and Handschin, C. and Johansson, L. and Looser, R. and Parini, P. and Podvinec, M. and Robertsson, K. and Gustafsson, J. -A. and Meyer, U. A.. (2005) LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. Journal of Lipid Research, 46 (8). pp. 1633-1642. Handschin, C. and Gnerre, C. and Fraser, D. J. and Martinez-Jimenez, C. and Jover, R. and Meyer, U. A.. (2005) Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Archives of Biochemistry and Biophysics, 434 (1). pp. 75-85. Handschin, C. and Lin, J. and Rhee, J. and Peyer, A. -K. and Chin, S. and Wu, P. -H. and Meyer, U. A. and Spiegelman, B. M.. (2005) Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α. Cell, Vol. 122, H. 4. pp. 505-515. Handschin, C. and Meyer, U. A.. (2005) PXR and CAR: more than meets the eye. In: Proceedings of the 15th Int. symposium on microsomes and drug oxidation. Bologna, pp. 17-21. Handschin, C. and Meyer, U. A.. (2005) Regulatory network of lipid-sensing nuclear receptors: : roles for CAR, PXR, LXR, and FXR. Archives of Biochemistry and Biophysics, 433 (2). pp. 387-396. Handschin, C. and Mootha, V. K.. (2005) Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes. Drug Discovery Today. Therapeutic Strategies, 2 (2). pp. 151-156. Lin, J. and Handschin, C. and Spiegelman, B. M.. (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism, Vol. 1, H. 6. pp. 361-370. Lin, J. and Yang, R. and Tarr, P. T. and Wu, P. -H. and Handschin, C. and Li, S. and Yang, W. and Pei, L. and Uldry, M. and Tontonoz, P. and Newgard, C. B. and Spiegelman, B. M.. (2005) Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP. Cell, Vol. 120, H. 2. pp. 261-273. 2004Fan, M. and Rhee, J. and St-Pierre, J. and Handschin, C. and Puigserver, P. and Lin, J. and Jaeger, S. and Erdjument-Bromage, H. and Tempst, P. and Spiegelman, B. M.. (2004) Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK. Genes & development, Vol. 18, H. 3. pp. 278-289. Handschin, C. and Blattler, S. and Roth, A. and Looser, R. and Oscarson, M. and Kaufmann, M. R. and Podvinec, M. and Gnerre, C. and Meyer, U. A.. (2004) The evolution of drug-activated nuclear receptors : one ancestral gene diverged into two xenosensor genes in mammals. Nuclear Receptor, Vol. 2, H. 1. p. 7. Mootha, Vamsi K. and Handschin, Christoph and Arlow, Dan and Xie, Xiaohui and St Pierre, Julie and Sihag, Smita and Yang, Wenli and Altshuler, David and Puigserver, Pere and Patterson, Nick and Willy, Patricia J. and Schulman, Ira G. and Heyman, Richard A. and Lander, Eric S. and Spiegelman, Bruce M.. (2004) Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America, 101 (17). pp. 6570-6575. Podvinec, M. and Handschin, C. and Looser, R. and Meyer, U. A.. (2004) Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proceedings of the National Academy of Sciences of the United States of America, 101 (24). pp. 9127-9132. 2003Handschin, C. and Meyer, U. A.. (2003) Induction of drug metabolism: the role of nuclear receptors. Pharmacological reviews, 55 (4). pp. 649-673. Handschin, C. and Meyer, U. A.. (2003) The molecular mechanism of induction of cytochromes P450 by drugs and other xenobiotics. In: Molecular Investigation of Metabolism and Transport of Drugs - from Animal to Human Tissue, 87. Halle (Saale), pp. 205-211. Handschin, C. and Rhee, J. and Lin, J. and Tarr, P. T. and Spiegelman, B. M.. (2003) An An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle. Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, H. 12. pp. 7111-7116. Handschin, Christoph and Podvinec, Michael and Meyer, Urs A.. (2003) In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. Drug news & perspectives, 16 (7). pp. 423-434. Sanyal, S. and Handschin, C. and Podvinec, M. and Song, K. -H. and Kim, H. -J. and Kim, J. -Y. and Seo, Y. -W. and Kim, S. -A. and Kwon, H. -B. and Lee, K. and Kim, W. -S. and Meyer, U. A. and Choi, H. -S.. (2003) Molecular cloning and characterization of chicken orphan nuclear receptor cTR2. General and Comparative Endocrinology, 132 (3). pp. 474-484. 2002Handschin, C. and Podvinec, M. and Amherd, R. and Looser, R. and Ourlin, J. -C. and Meyer, U. A.. (2002) Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. Journal of Biological Chemistry, 277 (33). pp. 29561-29567. Ourlin, J. -C. and Handschin, C. and Kaufmann, M. and Meyer, U. A.. (2002) A Link between cholesterol levels and phenobarbital induction of cytochromes P450. Biochemical and Biophysical Research Communications, 291 (2). pp. 378-384. Podvinec, M. and Kaufmann, M. R. and Handschin, C. and Meyer, U. A.. (2002) NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Molecular endocrinology, Vol. 16, H. 6. pp. 1269-1279. 2001Handschin, C. and Podvinec, M. and Looser, R. and Amherd, R. and Meyer, U. A.. (2001) Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Molecular pharmacology, 60 (4). pp. 681-689. Handschin, C. and Podvinec, M. and Stockli, J. and Hoffmann, K. and Meyer, U. A.. (2001) Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Molecular endocrinology, Vol. 15, H. 9. pp. 1571-1585. 2000Handschin, C. and Meyer, U. A.. (2000) A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line. Journal of Biological Chemistry, 275 (18). pp. 13362-13369. Handschin, C. and Podvinec, M. and Meyer, U. A.. (2000) CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 20. pp. 10769-10774. |
