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Caloric restriction and exercise "mimetics'': Ready for prime time?

Handschin, Christoph. (2015) Caloric restriction and exercise "mimetics'': Ready for prime time? Pharmacological research, 103. pp. 158-166.

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Abstract

Exercise and diet are powerful interventions to prevent and ameliorate various pathologies. The development of pharmacological agents that confer exercise- or caloric restriction-like phenotypic effects is thus an appealing therapeutic strategy in diseases or even when used as life-style and longevity drugs. Such so-called exercise or caloric restriction "mimetics" have so far mostly been described in pre-clinical, experimental settings with limited translation into humans. Interestingly, many of these compounds activate related signaling pathways, most often postulated to act on the common downstream effector peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in skeletal muscle. In this review, resveratrol and other exercise- and caloric restriction "mimetics" are discussed with a special focus on feasibility, chances and limitations of using such compounds in patients as well as in healthy individuals.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Article, refereed
Article Subtype:Review Article
Publisher:Elsevier
ISSN:1096-1186
Note:Publication type according to Uni Basel Research Database: Journal item
Language:English
Identification Number:
Last Modified:29 Sep 2017 09:25
Deposited On:02 Feb 2016 10:08

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