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Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle

Furrer, Regula and Handschin, Christoph. (2017) Optimized Engagement of Macrophages and Satellite Cells in the Repair and Regeneration of Exercised Muscle. In: Hormones, Metabolism and the Benefits of Exercise. Cham, pp. 57-66.

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Abstract

Recurring contraction-relaxation cycles exert a massive mechanical load on muscle fibers. Training adaptation therefore entails the promotion of a series of biological programs aimed at inducing a better stress response but also at optimizing repair processes. Muscle regeneration is controlled by an intricate, tightly coordinated engagement of muscle fibers, satellite cells, macrophages and other cell types. In this review, we discuss some of the recent insights into the regulation of muscle repair and regeneration in exercised muscle, elucidate the role of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in this context, and speculate about potential implications for the treatment of muscle diseases.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Book Section, refereed
Book Section Subtype:Book Chapter
Publisher:Springer
ISBN:978-3-319-72789-9
e-ISBN:978-3-319-72790-5
Series Name:Research and Perspectives in Endocrine Interactions
Note:Publication type according to Uni Basel Research Database: Book item
Language:English
Identification Number:
Last Modified:23 Mar 2018 15:28
Deposited On:23 Mar 2018 15:28

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