edoc

New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases

Pérez-Schindler, Joaquín and Handschin, Christoph. (2013) New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases. Drug Discovery Today. Disease Models, 10 (2). e79-e85.

[img]
Preview
PDF - Accepted Version
Available under License CC BY-NC-ND (Attribution-NonCommercial-NoDerivatives).

622Kb

Official URL: http://edoc.unibas.ch/dok/A6174378

Downloads: Statistics Overview

Abstract

Skeletal muscle energy metabolism is severely impaired in insulin resistant and type 2 diabetic patients. In particular, deregulated transcription of oxidative metabolism genes has been linked to the development of non-communicable metabolic diseases. The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) is a key molecule in the regulation of oxidative metabolism in different tissues, including skeletal muscle. In this tissue, physical exercise is one of the most dominant physiological stimuli to induce PGC-1α. In addition, exercise training efficiently prevents the development of metabolic diseases. Hence, better knowledge about the regulation of PGC-1α by exercise would significantly help to design effective treatments for these diseases.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1740-6757
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Related URLs:
Identification Number:
Last Modified:14 Nov 2017 14:16
Deposited On:25 Oct 2013 08:33

Repository Staff Only: item control page