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Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha

Handschin, C.. (2010) Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor gamma coactivator 1alpha. Journal of receptors and signal transduction, Vol. 30, H. 6. pp. 376-384.

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Official URL: http://edoc.unibas.ch/dok/A6001447

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Abstract

Exercise triggers a pleiotropic response in skeletal muscle, which results in a profound remodeling of this tissue. Physical activity-dependent muscle fiber plasticity is regulated by a number of distinct signaling pathways. Even though most of these pathways are activated by different stimuli and in a temporally and spatially separated manner during exercise, many of the major signal transduction events converge on the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) by post-translationally modifying the PGC-1alpha protein, modulating PGC-1alpha gene expression or both. In turn, depending on the cellular context, PGC-1alpha regulates specific gene programs. Ultimately, PGC-1alpha modulates most of the transcriptional adaptations of skeletal muscle to exercise. In this review, the regulation and function of this pivotal transcriptional coactivator in muscle are discussed.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Marcel Dekker
ISSN:0197-5110
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:31 Dec 2015 10:50
Deposited On:14 Sep 2012 07:15

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