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Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle

Kupr, Barbara and Handschin, Christoph. (2015) Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle. Frontiers in physiology, 6. p. 325.

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Abstract

Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors involved in the regulation and coordination of relevant transcriptional programs have been identified in recent years. For example, the peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a central regulatory nexus in the adaptation of muscle to endurance training. Intriguingly, PGC-1α integrates numerous signaling pathways and translates their activity into various transcriptional programs. This selectivity is in part controlled by differential expression of PGC-1α variants and post-translational modifications of the PGC-1α protein. PGC-1α-controlled activation of transcriptional networks subsequently enables a spatio-temporal specification and hence allows a complex coordination of changes in metabolic and contractile properties, protein synthesis and degradation rates and other features of trained muscle. In this review, we discuss recent advances in our understanding of PGC-1α-regulated skeletal muscle cell plasticity in health and disease.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Article, refereed
Article Subtype:Book Review
Publisher:Frontiers Media
ISSN:1664-042X
Note:Publication type according to Uni Basel Research Database: Journal item
Language:English
Identification Number:
Last Modified:30 Jun 2016 11:00
Deposited On:15 Mar 2016 13:25

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