PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds

Schmid, Svenia and Heim-Kupr, Barbara and Pérez-Schindler, Joaquín and Mansingh, Shivani and Beer, Markus and Mittal, Nitish and Ehrenfeuchter, Nikolaus and Handschin, Christoph. (2022) PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds. Molecular metabolism. p. 101643.

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Official URL: https://edoc.unibas.ch/90317/

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Skeletal muscle is a pivotal organ for the coordination of systemic metabolism, constituting one of the largest storage site for glucose, lipids and amino acids. Tight temporal orchestration of protein breakdown in times of fasting has to be balanced with preservation of muscle mass and function. However, the molecular mechanisms that control the fasting response in muscle are poorly understood.; We now have identified a role for the peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) in the regulation of catabolic pathways in this context in muscle-specific loss-of-function mouse models.; Muscle-specific knockouts for PGC-1β experience mitigated muscle atrophy in fasting, linked to reduced expression of myostatin, atrogenes, activation of AMP-dependent protein kinase (AMPK) and other energy deprivation signaling pathways. At least in part, the muscle fasting response is modulated by a negative effect of PGC-1β on the nuclear factor of activated T-cells 1 (NFATC1).; Collectively, these data highlight the complex regulation of muscle metabolism and reveal a new role for muscle PGC-1β in the control of proteostasis in fasting.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Zavolan)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Imaging Core Facility (Biehlmaier)
UniBasel Contributors:Handschin, Christoph and Ehrenfeuchter, Nikolaus and Mansingh, Shivani and Mittal , Nitish and Schmid, Svenia
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Dec 2022 10:39
Deposited On:06 Dec 2022 08:51

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