Physiological Regulation of Skeletal Muscle Mass: Resistance Exercise- Mediated Muscle Hypertrophy

Pérez-Schindler, Joaquín and Handschin, Christoph. (2018) Physiological Regulation of Skeletal Muscle Mass: Resistance Exercise- Mediated Muscle Hypertrophy. In: Nutrition and Skeletal Muscle. London, pp. 139-150.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/66573/

Downloads: Statistics Overview


Skeletal muscle is one of the most abundant and metabolically active tissues in mammals. The enormous plasticity of muscle is linked to the relative levels of physical activity and pathological conditions (e.g., cancer), in which skeletal muscle atrophy and weakness exacerbate morbidity and mortality. Inversely, exercise enhances skeletal muscle integrity and function and thereby lowers the risk for many chronic diseases. Resistance training is of particular importance in the context of muscle disuse and aging. The adaptive response of muscle to resistance exercise in regard to muscle mass and strength differs from developmental growth. Molecularly, the activation of the mammalian target of rapamycin complex 1 (mTORC1) is considered an essential step in mechanical overload-mediated skeletal muscle hypertrophy. However, both the upstream control as well as the downstream effect of mTORC1 remain poorly understood, as are the mTORC1-independent processes that control protein synthesis. Therefore, the aim of this chapter is to discuss the main mechanisms involved in resistance exercise-mediated skeletal muscle hypertrophy, including mTORC1 activation, ribosomal biogenesis, and the potential role of satellite cells in this process.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Publisher:Academic Press
Note:Publication type according to Uni Basel Research Database: Book item
Identification Number:
Last Modified:15 Mar 2019 16:22
Deposited On:20 Nov 2018 13:51

Repository Staff Only: item control page