PGC-1a in muscle links metabolism to inflammation

Handschin, C.. (2009) PGC-1a in muscle links metabolism to inflammation. Proceedings of the Australian Physiological Society, Vol. 40. pp. 11-16.

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Official URL: http://edoc.unibas.ch/dok/A6271983

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1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas in evolutionary terms, a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other life style-associated diseases has increased in relevance in Western societies in the last hundred years. 2. Traditionally, fat tissue has been considered as the major source of pro-inflammatory secreted factors in these pathologies. In recent years however, the contribution of other tissues to a disease-causing chronic inflammation has been increasingly appreciated. 3. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is one of the key regulatory factors in the active skeletal muscle. Aberrant expression of PGC-1α in inactive muscle fibres could link a sedentary life style, persistent systemic inflammation and the higher risk for many chronic diseases. Modulation of PGC-1α activity in skeletal muscle might accordingly have a broad therapeutic effect. Here, recent advances in the understanding of the role of muscle PGC-1α in health and disease are reviewed.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Article, refereed
Article Subtype:Book Review
Publisher:Australian Physiological Society
Note:Note: Additional publication or translation in: Clinical and experimental pharmacology and physiology, Vol. 36(Dec. 2009), pp. 1139-1143, with permission of the Australian Physiological Society -- Publication type according to Uni Basel Research Database: Journal item
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Last Modified:31 Dec 2015 10:56
Deposited On:18 Jul 2014 09:10

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