PGC-1alpha modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle

Dinulovic, Ivana and Furrer, Regula and Di Fulvio, Sabrina and Ferry, Arnaud and Beer, Markus and Handschin, Christoph. (2016) PGC-1alpha modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle. Skeletal Muscle, 6. p. 38.

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BACKGROUND: Skeletal muscle tissue has an enormous regenerative capacity that is instrumental for a successful defense against muscle injury and wasting. The peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) exerts therapeutic effects in several muscle pathologies, but its role in damage-induced muscle regeneration is unclear.
METHODS: Using muscle-specific gain- and loss-of-function models for PGC-1alpha in combination with the myotoxic agent cardiotoxin (CTX), we explored the role of this transcriptional coactivator in muscle damage and inflammation.
RESULTS: Interestingly, we observed PGC-1alpha-dependent effects at the early stages of regeneration, in particular regarding macrophage accumulation and polarization from the pro-inflammatory M1 to the anti-inflammatory M2 type, a faster resolution of necrosis and protection against the development of fibrosis after multiple CTX-induced injuries.
CONCLUSIONS: PGC-1alpha exerts beneficial effects on muscle inflammation that might contribute to the therapeutic effects of elevated muscle PGC-1alpha in different models of muscle wasting.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:BioMed Central
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Nov 2016 13:20
Deposited On:29 Nov 2016 13:19

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