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The biology of PGC-1α and its therapeutic potential

Handschin, C.. (2009) The biology of PGC-1α and its therapeutic potential. Trends in Pharmacological Sciences, 30 (6). pp. 322-329.

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Abstract

In eukaryotes, cellular and systemic metabolism is primarily controlled by mitochondrial activity. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is an important regulator of mitochondrial biogenesis and function. Furthermore, PGC-1α controls many of the phenotypic adaptations of oxidative tissues to external and internal perturbations. By contrast, dysregulated metabolic plasticity is involved in the etiology of numerous diseases. Accordingly, modulation of PGC-1α levels and activity has recently been proposed as a therapeutic option for several pathologies. However, pharmacological interventions aimed at PGC-1α have to overcome inherent limitations of targeting a coactivator protein. Here, I focus on the recent breakthroughs in the identification of physiological and pathophysiological contexts involving PGC-1α. In addition, perspectives regarding the therapeutic importance of PGC-1α-controlled cellular and systemic metabolism are outlined.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0165-6147
e-ISSN:1873-3735
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:14 Nov 2017 14:30
Deposited On:22 Mar 2012 13:20

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