Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α

Handschin, C. and Lin, J. and Rhee, J. and Peyer, A. -K. and Chin, S. and Wu, P. -H. and Meyer, U. A. and Spiegelman, B. M.. (2005) Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria through PGC-1α. Cell, Vol. 122, H. 4. pp. 505-515.

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Official URL: http://edoc.unibas.ch/dok/A5258723

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Inducible hepatic porphyrias are inherited genetic disorders of enzymes of heme biosynthesis. The main clinical manifestations are acute attacks of neuropsychiatric symptoms frequently precipitated by drugs, hormones, or fasting, associated with increased urinary excretion of δ-aminolevulinic acid (ALA). Acute attacks are treated by heme infusion and glucose administration, but the mechanisms underlying the precipitating effects of fasting and the beneficial effects of glucose are unknown. We show that the rate-limiting enzyme in hepatic heme biosynthesis, 5-aminolevulinate synthase (ALAS-1), is regulated by the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). Elevation of PGC-1α in mice via adenoviral vectors increases the levels of heme precursors in vivo as observed in acute attacks. The induction of ALAS-1 by fasting is lost in liver-specific PGC-1α knockout animals, as is the ability of porphyrogenic drugs to dysregulate heme biosynthesis. These data show that PGC-1α links nutritional status to heme biosynthesis and acute hepatic porphyria.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Dec 2015 10:42
Deposited On:22 Mar 2012 13:20

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