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Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes

Handschin, C. and Mootha, V. K.. (2005) Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes. Drug Discovery Today. Therapeutic Strategies, 2 (2). pp. 151-156.

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Official URL: http://edoc.unibas.ch/dok/A5258721

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Abstract

Recent studies have shown that reduced mitochondrial content and function in skeletal muscle are common features of type 2 diabetes. Here, we review the molecular mechanisms involved in the regulation of mitochondrial genes in skeletal muscle, focusing on a key transcriptional network consisting of ERRα and PGC-1α. We describe how knowledge of this transcriptional circuit can be translated to the development of novel therapies for type 2 diabetes.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin)
UniBasel Contributors:Handschin, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1740-6773
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:14 Nov 2017 14:38
Deposited On:22 Mar 2012 13:20

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