Handschin, C. and Mootha, V. K.. (2005) Estrogen-related receptor α (ERRα) : a novel target in type 2 diabetes. Drug Discovery Today. Therapeutic Strategies, 2 (2). pp. 151-156.
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Abstract
Recent studies have shown that reduced mitochondrial content and function in skeletal muscle are common features of type 2 diabetes. Here, we review the molecular mechanisms involved in the regulation of mitochondrial genes in skeletal muscle, focusing on a key transcriptional network consisting of ERRα and PGC-1α. We describe how knowledge of this transcriptional circuit can be translated to the development of novel therapies for type 2 diabetes.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Associated Research Groups > Pharmakologie (Handschin) 05 Faculty of Science > Departement Biozentrum > Growth & Development > Growth & Development (Handschin) |
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| UniBasel Contributors: | Handschin, Christoph |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Elsevier |
| ISSN: | 1740-6773 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Identification Number: | |
| edoc DOI: | |
| Last Modified: | 14 Nov 2017 14:38 |
| Deposited On: | 22 Mar 2012 13:20 |
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