Browse by Basel Contributors ID
2023Brüderlin, Mitchell and Böhm, Raphael and Fadel, Firas and Hiller, Sebastian and Schirmer, Tilman and Dubey, Badri N.. (2023) Structural features discriminating hybrid histidine kinase Rec domains from response regulator homologs. Nature communications, 14 (1). p. 1002. Dubey, Badri Nath and Shyp, Viktoriya and Fucile, Geoffrey and Sondermann, Holger and Jenal, Urs and Schirmer, Tilman. (2023) Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization. Scientific reports, 13 (1). p. 2727. 2022Agustoni, Elia and Teixeira, Raphael Dias and Huber, Markus and Flister, Susanne and Hiller, Sebastian and Schirmer, Tilman. (2022) Acquisition of enzymatic progress curves in real time by quenching-free ion exchange chromatography. Analytical biochemistry, 639. p. 114523. 2021Dietz, Nikolaus and Huber, Markus and Sorg, Isabel and Goepfert, Arnaud and Harms, Alexander and Schirmer, Tilman and Dehio, Christoph. (2021) Structural basis for selective AMPylation of Rac-subfamily GTPases by Bartonella effector protein 1 (Bep1). Proceedings of the National Academy of Sciences, 118 (12). e2023245118. Teixeira, Raphael D. and Holzschuh, Fabian and Schirmer, Tilman. (2021) Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase. Nature Communications, 12. p. 2162. Perkins, Arden and Tudorica, Dan A. and Teixeira, Raphael D. and Schirmer, Tilman and Zumwalt, Lindsay and Ogba, O. Maduka and Cassidy, C. Keith and Stansfeld, Phillip J. and Guillemin, Karen. (2021) A Bacterial Inflammation Sensor Regulates c-di-GMP Signaling, Adhesion, and Biofilm Formation. mBio, 12 (3). e0017321. Schirmer, Tilman and de Beer, Tjaart A. P. and Tamegger, Stefanie and Harms, Alexander and Dietz, Nikolaus and Dranow, David M. and Edwards, Thomas E. and Myler, Peter J. and Phan, Isabelle and Dehio, Christoph. (2021) Evolutionary Diversification of Host-Targeted; Bartonella; Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module. Microorganisms, 9 (8). p. 23. Reinders, Alberto and Sellner, Benjamin and Fadel, Firas and van Berkum, Margo and Kaczmarczyk, Andreas and Ozaki, Shogo and Rueher, Johanna and Manfredi, Pablo and Sangermani, Matteo and Harms, Alexander and Perez, Camilo and Schirmer, Tilman and Jenal, Urs. (2021) Digital control of c-di-GMP in E. coli balances population-wide developmental transitions and phage sensitivity. Shyp, Viktoriya and Dubey, Badri Nath and Böhm, Raphael and Hartl, Johannes and Nesper, Jutta and Vorholt, Julia A. and Hiller, Sebastian and Schirmer, Tilman and Jenal, Urs. (2021) Reciprocal growth control by competitive binding of nucleotide second messengers to a metabolic switch in Caulobacter crescentus. Nature Microbiology, 6 (1). pp. 59-72. 2020Perkins, Arden and Tudorica, Dan A. and D. Teixeira, Raphael and Schirmer, Tilman and Zumwalt, Lindsay and Ogba, O. Maduka and Cassidy, C. Keith and Stansfeld, Phillip J. and Guillemin, Karen. (2020) A bacterial inflammation sensor regulates c-di-GMP signaling, adhesion, and biofilm formation. Teixeira, Raphael D. and Holzschuh, Fabian and Schirmer, Tilman. (2020) Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase. Dietz, Nikolaus Balthasar and Huber, Markus and Sorg, Isabel and Goepfert, Arnaud and Harms, Alexander and Schirmer, Tilman and Dehio, Christoph. (2020) Structural basis for selective targeting of Rac subfamily GTPases by a bacterial effector protein. Dubey, Badri N. and Agustoni, Elia and Böhm, Raphael and Kaczmarczyk, Andreas and Mangia, Francesca and von Arx, Christoph and Jenal, Urs and Hiller, Sebastian and Plaza-Menacho, Iván and Schirmer, Tilman. (2020) Hybrid histidine kinase activation by cyclic di-GMP-mediated domain liberation. Proceedings of the National Academy of Sciences of the United States of America, 117 (2). pp. 1000-1008. Kaczmarczyk, Andreas and Hempel, Antje M. and von Arx, Christoph and Böhm, Raphael and Dubey, Badri N. and Nesper, Jutta and Schirmer, Tilman and Hiller, Sebastian and Jenal, Urs. (2020) Precise Timing of Transcription by c-di-GMP Coordinates Cell Cycle and Morphogenesis in Caulobacter. Nature Communications, 11 (1). p. 816. Hee, Chee-Seng and Habazettl, Judith and Schmutz, Christoph and Schirmer, Tilman and Jenal, Urs and Grzesiek, Stephan. (2020) Intercepting second-messenger signaling by rationally designed peptides sequestering c-di-GMP. Proceedings of the National Academy of Sciences of the United States of America, 117 (29). pp. 17211-17220. 2019Stampfli, Anja R. and Goncharenko, Kristina V. and Meury, Marcel and Dubey, Badri N. and Schirmer, Tilman and Seebeck, Florian P.. (2019) An Alternative Active Site Architecture for O2 Activation in the Ergothioneine Biosynthetic EgtB from Chloracidobacterium thermophilum. Journal of American Chemical Society, 141 (13). pp. 5275-5285 . 2017Stanger, Frédéric V. and de Beer, Tjaart A. P. and Dranow, David M. and Schirmer, Tilman and Phan, Isabelle and Dehio, Christoph. (2017) The BID Domain of Type IV Secretion Substrates Forms a Conserved Four-Helix Bundle Topped with a Hook. Structure , 25 (1). pp. 203-211. Nesper, Jutta and Hug, Isabelle and Kato, Setsu and Hee, Chee-Seng and Habazettl, Judith Maria and Manfredi, Pablo and Grzesiek, Stephan and Schirmer, Tilman and Emonet, Thierry and Jenal, Urs. (2017) Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators. eLife, 6. e28842. 2016Reinders, Alberto and Hee, Chee-Seng and Ozaki, Shogo and Mazur, Adam and Boehm, Alex and Schirmer, Tilman and Jenal, Urs. (2016) Expression and Genetic Activation of Cyclic Di-GMP-Specific Phosphodiesterases in Escherichia coli. Journal of Bacteriology, 198 (3). pp. 448-462. Stanger, Frédéric V. and Burmann, Björn M. and Harms, Alexander and Aragão, Hugo and Mazur, Adam and Sharpe, Timothy and Dehio, Christoph and Hiller, Sebastian and Schirmer, Tilman. (2016) Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification. Proceedings of the National Academy of Sciences of the United States of America, 113 (5). E529-E537. Schirmer, Tilman. (2016) C-di-GMP Synthesis: Structural Aspects of Evolution, Catalysis and Regulation. Journal of molecular biology, 428 (19). pp. 3683-3701. Stanger, Frédéric V. and Harms, Alexander and Dehio, Christoph and Schirmer, Tilman. (2016) Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin. PLoS ONE, 11 (9). e0163654. Dubey, Badri N. and Lori, Christian and Ozaki, Shogo and Fucile, Geoffrey and Plaza-Menacho, Ivan and Jenal, Urs and Schirmer, Tilman. (2016) Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking. Science Advances, 2 (9). e1600823. 2015Harms, Alexander and Stanger, Frédéric Valentin and Scheu, Patrick Daniel and de Jong, Imke Greet and Goepfert, Arnaud and Glatter, Timo and Gerdes, Kenn and Schirmer, Tilman and Dehio, Christoph. (2015) Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology. Cell Reports, 12 (9). pp. 1497-1507. Lori, Christian and Ozaki, Shogo and Steiner, Samuel and Böhm, Raphael and Abel, Sören and Dubey, Badri N. and Schirmer, Tilman and Hiller, Sebastian and Jenal, Urs. (2015) Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication. Nature, Vol. 523, H. 7559. pp. 236-239. Bosshart, Andreas and Hee, Chee Seng and Bechtold, Matthias and Schirmer, Tilman and Panke, Sven. (2015) Directed Divergent Evolution of a Thermostable D-Tagatose Epimerase towards Improved Activity for Two Hexose Substrates. ChemBioChem, 16 (4). pp. 592-601. 2014Sundriyal, Amit and Massa, Claudia and Samoray, Dietrich and Zehender, Fabian and Sharpe, Timothy and Jenal, Urs and Schirmer, Tilman. (2014) Inherent regulation of EAL domain-catalyzed hydrolysis of second messenger c-di-GMP. Journal of Biological Chemistry, 289 (10). pp. 6978-6990. Hutter, C. A. J. and Lehner, R. and Wirth, Ch. and Condemine, G. and Peneff, C. and Schirmer, T.. (2014) Structure of the oligogalacturonate-specific KdgM porin. Acta Crystallographica Section D: Biological Crystallography, 70 (6). pp. 1770-1778. Stanger, Frédéric V. and Dehio, Christoph and Schirmer, Tilman. (2014) Structure of the N-terminal gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis. PLoS ONE, Vol. 9, H. 9 , e107289. Ozaki, Shogo and Schalch-Moser, Annina and Zumthor, Ludwig and Manfredi, Pablo and Ebbensgaard, Anna and Schirmer, Tilman and Jenal, Urs. (2014) Activation and polar sequestration of PopA, a c-di-GMP effector protein involved in Caulobacter crescentus cell cycle control. Molecular Microbiology, 94 (3). pp. 580-594. Munoz-Robles, Victor and Dürrenberger, Marc and Tillmann, Heinisch and Lledos, Agustí and Schirmer, Tilman and Ward, Thomas R. and Maréchal, Jean-Didier. (2014) Structural, Kinetic, and Docking Studies of Artificial Imine Reductases Based on Biotin–Streptavidin Technology: An Induced Lock-and-Key Hypothesis. Journal of the American Chemical Society, 136 (44). pp. 15676-15683. 2013Zimbron, Jeremy M. and Heinisch, Tillmann and Schmid, Maurus and Hamels, Didier and Nogueira, Elisa S. and Schirmer, Tilman and Ward, Thomas R.. (2013) A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology. Journal of the American Chemical Society, 135 (14). pp. 5384-5388. Goepfert, Arnaud and Stanger, Frédéric V. and Dehio, Christoph and Schirmer, Tilman. (2013) Conserved inhibitory mechanism and competent ATP binding mode for adenylyltransferases with fic fold. PLoS ONE, Vol. 8, H. 5 , e64901. Goepfert, Arnaud and Harms, Alexander and Schirmer, Tilman and Dehio, Christoph. (2013) Type II Toxin-Antitoxin Loci: The fic Family. In: Prokaryotic Toxin-Antitoxins. Heidelberg, pp. 177-187. Monnard, Fabien W. and Nogueira, Elisa S. and Heinisch, Tillmann and Schirmer, Tilman and Ward, Thomas R.. (2013) Human Carbonic Anhydrase II as Host Protein for the Creation of Artificial Metalloenzymes : the Asymmetric Transfer Hydrogenation of Imines. Chemical Science, 4 (6). p. 3269. 2012Gentner, Martin and Allan, Martin G. and Zaehringer, Franziska and Schirmer, Tilman and Grzesiek, Stephan. (2012) Oligomer formation of the bacterial second messenger c-di-GMP : reaction rates and equilibrium constants indicate a monomeric state at physiological concentrations. The journal of the American Chemical Society, 134 (2). pp. 1019-1029. Engel, Philipp and Goepfert, Arnaud and Stanger, Frédéric V. and Harms, Alexander and Schmidt, Alexander and Schirmer, Tilman and Dehio, Christoph. (2012) Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. Nature, 482 (7383). pp. 107-110. Giri, Janhavi and Tang, John M. and Wirth, Christophe and Peneff, Caroline M. and Eisenberg, Bob. (2012) Single-channel measurements of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. European biophysics journal, 41 (3). pp. 259-271. 2011Palanivelu, D. V. and Goepfert, A. and Meury, M. and Guye, P. and Dehio, C. and Schirmer, T.. (2011) Fic domain catalyzed adenylylation: Insight provided by the structural analysis of the type IV secretion system effector BepA. Protein Science, 20 (3). pp. 492-499. Abel, Sören and Chien, Peter and Wassmann, Paul and Schirmer, Tilman and Kaever, Volkhard and Laub, Michael T. and Baker, Tania A. and Jenal, Urs. (2011) Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks. Molecular cell, Vol. 43, H. 4. pp. 550-560. Borer, Aline S. and Wassmann, Paul and Schmidt, Margit and Hoffman, Donald R. and Zhou, Jing-Jiang and Wright, Christine and Schirmer, Tilman and Marković-Housley, Zora. (2011) Crystal structure of Sol i 2 : a major allergen from fire ant venom. Journal of molecular biology, Vol. 415, H. 4. pp. 635-648. Monnard, Fabien W. and Heinisch, Tillmann and Nogueira, Elisa S. and Schirmer, Tilman and Ward, Thomas R.. (2011) Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor. Chemical Communications, 47 (29). pp. 8238-8240. Köhler, Valentin and Mao, Jincheng and Heinisch, Tillmann and Pordea, Anca and Sardo, Alessia and Wilson, Yvonne and Knörr, Livia and Creus, Marc and Prost, Jean-Christophe and Schirmer, Tilman and Ward, Thomas R.. (2011) OsO4⋅Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective cis-Dihydroxylation of Olefins. Angewandte Chemie International Edition, 50 (46). pp. 10863-10866. Dürrenberger, Marc and Heinisch, Tillmann and Wilson, Yvonne and Rossel, Thibaud and Nogueira, Elisa and Knörr, Livia and Mutschler, Annette and Kersten, Karoline and Zimbron, Mallcom and Pierron, Julien and Schirmer, Tilman and Ward, Thomas R.. (2011) Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines. Angewandte Chemie International Edition, 50 (13). pp. 3026-3029. 2010Kim, D. and Hunt, J. F. and Schirmer, T.. (2010) Making, breaking, and sensing of cyclic Di-GMP : structural, thermodynamic, and evolutionary principles. In: The second messenger cyclic Di-GMP. Washington, D.C, pp. 76-95. Zimbron, Jeremy M. and Sardo, Alessia and Heinisch, Tillmann and Wohlschlager, Therese and Gradinaru, Julieta and Massa, Claudia and Schirmer, Tilman and Creus, Marc and Ward, Thomas R.. (2010) Chemo-Genetic Optimization of DNA Recognition by Metallodrugs using a Presenter-Protein Strategy. Chemistry - A European Journal, 16 (43). pp. 12883-12889. Mittermann, Irene and Zidarn, Mihaela and Silar, Mira and Markovic-Housley, Zora and Aberer, Werner and Korosec, Peter and Kosnik, Mitja and Valenta, Rudolf. (2010) Recombinant allergen-based IgE testing to distinguish bee and wasp allergy. The Journal of Allergy and Clinical Immunology, Vol. 125, H. 6 , S. 1300-1307.e3. Zähringer, Franziska and Massa, Claudia and Schirmer, Tilman. (2010) Efficient Enzymatic Production of the Bacterial Second Messenger c-di-GMP by the Diguanylate Cyclase YdeH from E. coli. Applied biochemistry and biotechnology, Vol. 163, H. 1. p. 71. 2009Wirth, Christophe and Condemine, Guy and Boiteux, Céline and Bernèche, Simon and Schirmer, Tilman and Peneff, Caroline M.. (2009) NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family. Journal of molecular biology, Vol. 394, H. 4. pp. 718-731. Minasov, George and Padavattan, Sivaraman and Shuvalova, Ludmilla and Brunzelle, Joseph S. and Miller, Darcie J. and Baslé, Arnaud and Massa, Claudia and Collart, Frank R. and Schirmer, Tilman and Anderson, Wayne F.. (2009) Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains. Journal of biological chemistry, Vol. 284, H. 19. pp. 13174-13184. Padavattan, Sivaraman and Flicker, Sabine and Schirmer, Tilman and Madritsch, Christoph and Randow, Stefanie and Reese, Gerald and Vieths, Stefan and Lupinek, Christian and Ebner, Christof and Valenta, Rudolf and Markovic-Housley, Zora. (2009) High-affinity IgE recognition of a conformational epitope of the major respiratory allergen Phl p 2 as revealed by X-ray crystallography. Journal of immunology, Vol. 182, H. 4. pp. 2141-2151. Boehm, Alex and Steiner, Samuel and Zaehringer, Franziska and Casanova, Alain and Hamburger, Fabienne and Ritz, Daniel and Keck, Wolfgang and Ackermann, Martin and Schirmer, Tilman and Jenal, Urs. (2009) Second messenger signaling governs Escherichia coli biofilm induction upon ribosomal stress. Molecular microbiology, Vol. 72, H. 6. pp. 1500-1516. Markovic-Housley, Zora and Basle, Arnaud and Padavattan, Sivaraman and Maderegger, Bernhard and Schirmer, Tilman and Hoffmann-Sommergruber, Karin. (2009) Structure of the major carrot allergen Dau c 1. Acta crystallographica. Section D, Biological crystallography, Vol. 65, Pt. 11. pp. 1206-1212. Schirmer, Tilman and Jenal, Urs. (2009) Structural and mechanistic determinants of c-di-GMP signalling. Nature Reviews Microbiology, Vol. 7. pp. 724-735. 2008Padavattan, S. and Schmidt, M. and Hoffman, D. R. and Markovic-Housley, Z.. (2008) Crystal structure of the major allergen from fire ant venom, Sol i 3. Journal of molecular biology, Vol. 383, H. 1. pp. 178-185. 2007Paul, Ralf and Abel, Sören and Wassmann, Paul and Beck, Andreas and Heerklotz, Heiko and Jenal, Urs. (2007) Activation of the diguanylate cyclase PleD by phosphorylation-mediated dimerization. Journal of biological chemistry, Vol. 282, H. 40. pp. 29170-29177. Padavattan, Sivaraman and Schirmer, Tilman and Schmidt, Margit and Akdis, Cezmi and Valenta, Rudolf and Mittermann, Irene and Soldatova, Lyudmila and Slater, Jay and Mueller, Ulrich and Markovic-Housley, Zora. (2007) Identification of a B-cell epitope of hyaluronidase, a major bee venom allergen, from its crystal structure in complex with a specific Fab. Journal of molecular biology, Vol. 368, H. 3. pp. 742-752. Wassmann, P. and Chan, C. and Paul, R. and Beck, A. and Heerklotz, H. and Jenal, U. and Schirmer, T.. (2007) Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition. Structure: with folding and design, Vol. 15, H. 8. pp. 915-927. Soldatova, Lyudmila N. and Tsai, Chaoming and Dobrovolskaia, Ekaterina and Marković-Housley, Zora and Slater, Jay E.. (2007) Characterization of the N-glycans of recombinant bee venom hyaluronidase (Api m 2) expressed in insect cells. Allergy and asthma proceedings, Vol. 28, no. 2. pp. 210-215. 2006Baslé, Arnaud and Rummel, Gabriele and Storici, Paola and Rosenbusch, Juerg P. and Schirmer, Tilman. (2006) Crystal structure of osmoporin OmpC from E. coli at 2.0 A. Journal of molecular biology, Vol. 362, H. 5. pp. 933-942. Palanivelu, D. V. and Kozono, D. E. and Engel, A. and Suda, K. and Lustig, A. and Agre, P. and Schirmer, T.. (2006) Co-axial association of recombinant eye lens aquaporin-0 observed in loosely packed 3D crystals. Journal of molecular biology, Vol. 355, H. 4. pp. 605-611. Ma, Y. and Gadermaier, G. and Bohle, B. and Bolhaar, S. and Knulst, A. and Markovic-Housley, Z. and Breiteneder, H. and Briza, P. and Hoffmann-Sommergruber, K. and Ferreira, F.. (2006) Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1. International Archives of Allergy and Immunology, 139 (1). pp. 53-62. Miedema, Henk and Vrouenraets, Maarten and Wierenga, Jenny and Eisenberg, Bob and Schirmer, Tilman and Baslé, Arnaud and Meijberg, Wim. (2006) Conductance and selectivity fluctuations in D127 mutants of the bacterial porin OmpF. European biophysics journal, Vol. 36, H. 1. pp. 13-22. 2005Hui, Kwok-Min and Orriss, George L. and Schirmer, Tilman and Magnadóttir, Bergljót and Schifferli, Jürg A. and Inal, Jameel M.. (2005) Expression of functional recombinant von Willebrand factor-A domain from human complement C2 : a potential binding site for C4 and CRIT. The Biochemical Journal, Vol. 389, Pt. 3. pp. 863-868. Karamloo, Fariba and Schmid-Grendelmeier, Peter and Kussebi, Fatimah and Akdis, Mübeccel and Salagianni, Maria and von Beust, Barbara R. and Reimers, Andrea and Zumkehr, Judith and Soldatova, Lyudmilla and Housley-Markovic, Zora and Müller, Ulrich and Kündig, Thomas and Kemeny, David M. and Spangfort, Michael D. and Blaser, Kurt and Akdis, Cezmi A.. (2005) Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes. European Journal of Immunology, Vol. 35, H. 11. pp. 3268-3276. Markova, Michaela and Peneff, Caroline and Hewlins, Michael J. E. and Schirmer, Tilman and John, Robert A.. (2005) Determinants of substrate specificity in omega-aminotransferases. Journal of Biological Chemistry, Vol. 280, H. 43. pp. 36409-36416. Schirmer, Tilman and Hoffimann-Sommergrube, Karin and Susani, Markus and Breiteneder, Heimo and Marković-Housley, Zora. (2005) Crystal structure of the major celery allergen Api g 1 : molecular analysis of cross-reactivity. Journal of molecular biology, Vol. 351, H. 5. pp. 1101-1109. Philippsen, Ansgar and Schirmer, Tilman and Stein, Martin A. and Giffhorn, Friedrich and Stetefeld, Jörg. (2005) Structure of zinc-independent sorbitol dehydrogenase from Rhodobacter sphaeroides at 2.4 A resolution. Acta Crystallographica. Section D, Biological Crystallography, Vol. 61, Pt. 4. pp. 374-379. Kussebi, F. and Karamloo, F. and Rhyner, C. and Schmid-Grendelmeier, P. and Salagianni, M. and Mannhart, C. and Akdis, M. and Soldatova, L. and Markovic-Housley, Z. and von Beust, B. R. and Kundig, T. and Kemeny, D. M. and Blaser, K. and Crameri, R. and Akdis, C. A.. (2005) A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy. The journal of allergy and clinical immunology, Vol. 115, H. 2. pp. 323-329. 2004Chan, C. and Paul, R. and Samoray, D. and Amiot, N. C. and Giese, B. and Jenal, U. and Schirmer, T.. (2004) Structural basis of activity and allosteric control of diguanylate cyclase. Proceedings of the National Academy of Sciences of the United States of America, 101 (49). pp. 17084-17089. Storici, Paola and Qiu, Jian and Schirmer, Tilman and Silverman, Richard B.. (2004) Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography. Biochemistry, Vol. 43, H. 44. pp. 14057-14063. Paul, R. and Weiser, S. and Amiot, N. C. and Chan, C. and Schirmer, T. and Giese, B. and Jenal, U.. (2004) Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain. Genes & development, Vol. 18, H. 6. pp. 715-727. Storici, Paola and De Biase, Daniela and Bossa, Francesco and Bruno, Stefano and Mozzarelli, Andrea and Peneff, Caroline and Silverman, Richard B. and Schirmer, Tilman. (2004) Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin. Journal of Biological Chemistry, 279 (1). pp. 363-373. Schirmer, Tilman. (2004) Structure-Function Relationships in Sugar-Specific Porins. In: Bacterial and Eukaryotic Porins: Structure, Function, Mechanism. Switzerland, pp. 169-181. 2003Orriss, George L. and Erni, Bernhard and Schirmer, Tilman. (2003) Crystal structure of the IIB(Sor) domain of the sorbose permease from Klebsiella pneumoniae solved to 1.75A resolution. Journal of molecular biology, Vol. 327, H. 5. pp. 1111-1119. Markovic-Housley, Z. and Degano, M. and Lamba, D. and von Roepenack-Lahaye, E. and Clemens, S. and Susani, M. and Ferreira, F. and Scheiner, O. and Breiteneder, H.. (2003) Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier. Journal of molecular biology, Vol. 325, H. 1. pp. 123-133. 2002Philippsen, A. and Im, W. and Engel, A. and Schirmer, T. and Roux, B. and Muller, D. J.. (2002) Imaging the electrostatic potential of transmembrane channels : atomic probe microscopy of OmpF porin. Biophysical journal, Vol. 82, H. 3. pp. 1667-1676. Sauer, Oliver and Roth, Michel and Schirmer, Tilman and Rummel, Gabriele and Kratky, Christoph. (2002) Low-resolution detergent tracing in protein crystals using xenon or krypton to enhance X-ray contrast. Acta Crystallographica. Section D, Biological Crystallography, Vol. 58, Pt. 1. pp. 60-69. Choi, Sun and Storici, Paola and Schirmer, Tilman and Silverman, Richard B.. (2002) Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase. Journal of the American Chemical Society, Vol. 124, H. 8. pp. 1620-1624. Rodríguez-Marañón, María José and Bush, Robin M. and Peterson, Ellena M. and Schirmer, Tilman and de la Maza, Luis M.. (2002) Prediction of the membrane-spanning beta-strands of the major outer membrane protein of Chlamydia. Protein Science, Vol. 11, H. 7. pp. 1854-1861. Dutzler, Raimund and Schirmer, Tilman and Karplus, Martin and Fischer, Stefan. (2002) Translocation mechanism of long sugar chains across the maltoporin membrane channel. Structure: with folding and design, Vol. 10, H. 9. pp. 1273-1284. Van Gelder, Patrick and Dumas, Fabrice and Bartoldus, Ingrid and Saint, Nathalie and Prilipov, Alexei and Winterhalter, Mathias and Wang, Yanfei and Philippsen, Ansgar and Rosenbusch, Jürg P. and Schirmer, Tilman. (2002) Sugar transport through maltoporin of Escherichia coli : role of the greasy slide. Journal of Bacteriology, 184 (11). pp. 2994-2999. 2001Van Gelder, P. and Dutzler, R. and Dumas, F. and Koebnik, R. and Schirmer, T.. (2001) Sucrose transport through maltoporin mutants of Escherichia coli. Protein engineering, Vol. 14, H. 11. pp. 943-948. Phale, P. S. and Philippsen, A. and Widmer, C. and Phale, V. P. and Rosenbusch, J. P. and Schirmer, T.. (2001) Role of charged residues at the OmpF porin channel constriction probed by mutagenesis and simulation. Biochemistry, 40 (21). pp. 6319-6325. Schirmer, T.. (2001) Membrane proteins with beta-barrel fold. Chimia, 55. pp. 493-496. 2000Markovic-Housley, Z. and Miglierini, G. and Soldatova, L. and Rizkallah, P. J. and Muller, U. and Schirmer, T.. (2000) Crystal structure of hyaluronidase, a major allergen of bee venom. Structure: with folding and design, Vol. 8, H. 10. pp. 1025-1035. 1999Schirmer, T. and Phale, P. S.. (1999) Brownian dynamics simulation of ion flow through porin channels. Journal of molecular biology, Vol. 294, H. 5. pp. 1159-1167. Storici, P. and Capitani, G. and De Biase, D. and Moser, M. and John, R. A. and Jansonius, J. N. and Schirmer, T.. (1999) Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy. Biochemistry, 38 (27). pp. 8628-8634. Storici, P. and Capitani, G. and Müller, R. and Schirmer, T. and Jansonius, J. N.. (1999) Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine. Journal of molecular biology, Vol. 285, H. 1. pp. 297-309. Dutzler, R. and Rummel, G. and Albertí, S. and Hernández-Allés, S. and Phale, P. and Rosenbusch, J. and Benedí, V. and Schirmer, T.. (1999) Crystal structure and functional characterization of OmpK36, the osmoporin of Klebsiella pneumoniae. Structure: with folding and design, Vol. 7, H. 4. pp. 425-434. 1998Schauder, S. and Nunn, R. S. and Lanz, R. and Erni, B. and Schirmer, T.. (1998) Crystal structure of the IIB subunit of a fructose permease (IIBLev) from Bacillus subtilis. Journal of molecular biology, Vol. 276, H. 3. pp. 591-602. Phale, P. S. and Philippsen, A. and Kiefhaber, T. and Koebnik, R. and Phale, V. P. and Schirmer, T. and Rosenbusch, J. P.. (1998) Stability of trimeric OmpF porin : the contributions of the latching loop L2. Biochemistry, Vol. 37, H. 45. pp. 15663-15670. Schirmer, T.. (1998) General and specific porins from bacterial outer membranes. Journal of Structural Biology, Vol. 121, H. 2. pp. 101-109. Penel, S. and Pebay-Peyroula, E. and Rosenbusch, J. and Rummel, G. and Schirmer, T. and Timmins, P. A.. (1998) Detergent binding in trigonal crystals of OmpF porin from Escherichia coli. Biochimie, Vol. 80, H. 5-6. pp. 543-551. Shen, B. W. and Hennig, M. and Hohenester, E. and Jansonius, J. N. and Schirmer, T.. (1998) Crystal structure of human recombinant ornithine aminotransferase. Journal of molecular biology, Vol. 277, H. 1. pp. 81-102. 1997Wang, Y. F. and Dutzler, R. and Rizkallah, P. J. and Rosenbusch, J. P. and Schirmer, T.. (1997) Channel specificity : structural basis for sugar discrimination and differential flux rates in maltoporin. Journal of Molecular Biology, 272 (1). pp. 56-63. Phale, P. S. and Schirmer, T. and Prilipov, A. and Lou, K. L. and Hardmeyer, A. and Rosenbusch, J. P.. (1997) Voltage gating of Escherichia coli porin channels : role of the constriction loop. Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, H. 13. pp. 6741-6745. 1996Lou, K. L. and Saint, N. and Prilipov, A. and Rummel, G. and Benson, S. A. and Rosenbusch, J. P. and Schirmer, T.. (1996) Structural and functional characterization of OmpF porin mutants selected for larger pore size. I.. Crystallographic analysis. Journal of Biological Chemistry, Vol. 271, H. 34. pp. 20669-20675. Saint, N. and Lou, K. L. and Widmer, C. and Luckey, M. and Schirmer, T. and Rosenbusch, J. P.. (1996) Structural and functional characterization of OmpF porin mutants selected for larger pore size. II.. Functional characterization. Journal of Biological Chemistry, Vol. 271, H. 34. pp. 20676-20680. Nunn, R. S. and Marković-Housley, Z. and Génovésio-Taverne, J. C. and Flükiger, K. and Rizkallah, P. J. and Jansonius, J. N. and Schirmer, T. and Erni, B.. (1996) Structure of the IIA domain of the mannose transporter from Escherichia coli at 1.7 angstroms resolution. Journal of molecular biology, Vol. 259, H. 3. pp. 502-511. Marković-Housley, Z. and Schirmer, T. and Hohenester, E. and Khomutov, A. R. and Khomutov, R. M. and Karpeisky, M. Y. and Sandmeier, E. and Christen, P. and Jansonius, J. N.. (1996) Crystal structures and solution studies of oxime adducts of mitochondrial aspartate aminotransferase. European journal of biochemistry, Vol. 236, H. 3. pp. 1025-1032. Saint, N. and Prilipov, A. and Hardmeyer, A. and Lou, K. L. and Schirmer, T. and Rosenbusch, J. P.. (1996) Replacement of the sole histidinyl residue in OmpF porin from E. coli by threonine (H21T) does not affect channel structure and function. Biochemical and Biophysical Research Communications, Vol. 223, H. 1. pp. 118-122. Chan, W. C. and Schirmer, T. and Ferenci, T.. (1996) Combinatorial mutagenesis analysis of residues in the channel constriction loop L3 and neighbouring beta-strands in the LamB glycoporin of Escherichia coli. Molecular Membrane Biology, Vol. 13, H. 1. pp. 41-48. Dutzler, R. and Wang, Y. F. and Rizkallah, P. and Rosenbusch, J. P. and Schirmer, T.. (1996) Crystal structures of various maltooligosaccharides bound to maltoporin reveal a specific sugar translocation pathway. Structure, Vol. 4, H. 2. pp. 127-134. 1995Albertí, S. and Rodríquez-Quiñones, F. and Schirmer, T. and Rummel, G. and Tomás, J. M. and Rosenbusch, J. P. and Benedí, V. J.. (1995) A porin from Klebsiella pneumoniae : sequence homology, three-dimensional model, and complement binding. Infection and immunity, Vol. 63, H. 3. pp. 903-910. Schirmer, T. and Keller, T. A. and Wang, Y. F. and Rosenbusch, J. P.. (1995) Structural basis for sugar translocation through maltoporin channels at 3.1 A resolution. Science, Vol. 267, no. 5197. pp. 512-514. Cowan, S. W. and Garavito, R. M. and Jansonius, J. N. and Jenkins, J. A. and Karlsson, R. and König, N. and Pai, E. F. and Pauptit, R. A. and Rizkallah, P. J. and Rosenbusch, J. P.. (1995) The structure of OmpF porin in a tetragonal crystal form. Structure, Vol. 3, H. 10. pp. 1041-1050. 1994Jeanteur, D. and Schirmer, T. and Fourel, D. and Simonet, V. and Rummel, G. and Widmer, C. and Rosenbusch, J. P. and Pattus, F. and Pagès, J. M.. (1994) Structural and functional alterations of a colicin-resistant mutant of OmpF porin from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, H. 22. pp. 10675-10679. Karshikoff, A. and Spassov, V. and Cowan, S. W. and Ladenstein, R. and Schirmer, T.. (1994) Electrostatic properties of two porin channels from Escherichia coli. Journal of molecular biology, Vol. 240, H. 4. pp. 372-384. Cowan, S. W. and Schirmer, T.. (1994) Structures of non-specific diffusion pores from E.coli. New comprehensive biochemistry, Vol. 27. pp. 353-361. 1993Pflügl, G. and Kallen, J. and Schirmer, T. and Jansonius, J. N. and Zurini, M. G. and Walkinshaw, M. D.. (1993) X-ray structure of a decameric cyclophilin-cyclosporin crystal complex. Nature, Vol. 361. pp. 91-94. Schirmer, T. and Cowan, S. W.. (1993) Prediction of membrane-spanning beta-strands and its application to maltoporin. Protein Science, Vol. 2, H. 8. pp. 1361-1363. 1992Cowan, S. W. and Schirmer, T. and Rummel, G. and Steiert, M. and Ghosh, R. and Pauptit, R. A. and Jansonius, J. N. and Rosenbusch, J. P.. (1992) Crystal structures explain functional properties of two E. coli porins. Nature, Vol. 358. pp. 727-733. 1991Schirmer, T. and Roschenbusch, J. P.. (1991) Prokaryotic and eukaryotic porins. Current Opinion in Structural Biology, Vol. 1, H. 4. pp. 539-545. 1990Schirmer, T. and Evans, P. R.. (1990) Structural basis of the allosteric behaviour of phosphofructokinase. Nature, Vol. 343. pp. 140-145. 1987Schirmer, T. and Vincent, M. G.. (1987) Polarized absorption and fluorescence spectra of single crystals of C-phycocyanin. Biochimica et biophysica acta, Vol. 893, H. 3. pp. 379-385. Schirmer, T. and Bode, W. and Huber, R.. (1987) Refined three-dimensional structures of two cyanobacterial C-phycocyanins at 2.1 and 2.5 A resolution : a common principle of phycobilin-protein interaction. Journal of molecular biology, Vol. 196, H. 3. pp. 677-695. 1986Schirmer, T. and Huber, R. and Schneider, M. and Bode, W. and Miller, M. and Hackert, M. L.. (1986) Crystal structure analysis and refinement at 2.5 A of hexameric C-phycocyanin from the cyanobacterium Agmenellum quadruplicatum : the molecular model and its implications for light-harvesting. Journal of molecular biology, Vol. 188, H. 4. pp. 651-676. 1985Schirmer, T. and Bode, W. and Huber, R. and Sidler, W. and Zuber, H.. (1985) X-ray crystallographic structure of the light-harvesting biliprotein C-phycocyanin from the thermophilic cyanobacterium Mastigocladus laminosus and its resemblance to globin structures. Journal of molecular biology, Vol. 184, H. 2. pp. 257-277. |
