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Structure of the major carrot allergen Dau c 1

Markovic-Housley, Zora and Basle, Arnaud and Padavattan, Sivaraman and Maderegger, Bernhard and Schirmer, Tilman and Hoffmann-Sommergruber, Karin. (2009) Structure of the major carrot allergen Dau c 1. Acta crystallographica. Section D, Biological crystallography, Vol. 65, Pt. 11. pp. 1206-1212.

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Official URL: http://edoc.unibas.ch/dok/A5262581

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Abstract

Dau c 1 is a major allergen of carrot ( Daucus carota) which displays IgE cross-reactivity with the homologous major birch-pollen allergen Bet v 1. The crystal structure of Dau c 1 has been determined to a resolution of 2.7 angstrom, revealing tight dimers. The structure of Dau c 1 is similar to those of the major allergens from celery, Api g 1, and birch pollen, Bet v 1. Electron density has been observed in the hydrophobic cavity of each monomer and has been modelled with polyethylene glycol oligomers of varying length. Comparison of the surface topology and physicochemical properties of Dau c 1 and Bet v 1 revealed that they may have some, but not all, epitopes in common. This is in agreement with the observation that the majority of carrot-allergic patients have Bet v 1 cross-reactive IgE antibodies, whereas others have Dau c 1-specific IgE antibodies which do not recognize Bet v 1.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Schirmer)
UniBasel Contributors:Schirmer, Tilman and Housley-Markovic, Zora
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:0907-4449
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:14 Sep 2012 06:50
Deposited On:22 Mar 2012 13:24

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